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Dietary supplement

Mace Ingredients & Drug Interactions

by Herbal Terra

Mace label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mace against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mace is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for digestive upset and gas, flavoring and culinary spice, nausea.Based on those ingredients, 500 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Mace (Myristica fragrans) dried whole arils liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mace by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Mace by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mace by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: certified organic Mace, which is the dried, whole aril (seed covering) of the nutmeg plant in liquid extract form. The liquid also includes menstruum, a solvent used to extract the plant's active compounds.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Mace product and its label doesn't state a use — see Mace's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for mace doesn't support a strong claim for any particular use. Dysmenorrhea (menstrual cramps) and urinary incontinence both have insufficient reliable evidence to rate.

If you're considering mace for a health concern, it's worth talking with your pharmacist or doctor about what the actual evidence shows for your situation.

The evidence, ingredient by ingredient Mace

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At culinary spice levels, mace is generally well tolerated with no reported adverse effects. However, the product's safety notes caution against medicinal or large concentrated doses.

High intakes of the related herb nutmeg have caused serious cardiovascular, gastrointestinal, neurologic, and psychiatric effects — and theoretically mace could too, though no human cases of mace toxicity have been reported. Mace contains myristicin, a chemical structurally similar to hallucinogens, so very high doses could theoretically cause visual or auditory hallucinations, dizziness, drowsiness, or more severe neurologic symptoms.

Pregnancy safety data is limited and classified as possibly unsafe for medicinal use; food-level spice use is likely fine.

Side effects, ingredient by ingredient Mace

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mace.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 500 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use CNS depressants like sedatives, sleep aids, or opioids (Moderate risk); drugs metabolized by the CYP1A2 enzyme, including some antipsychotics (Moderate risk); immunosuppressants such as cyclosporine (Moderate risk); or phenobarbital (Moderate risk). The interaction checker below will help you find your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient mace extract may be worth considering if you've read about it for a specific reason, but the evidence for its health claims isn't established in our data. Before you start, especially if you take sedatives, antipsychotics, immunosuppressants, or phenobarbital, check your exact medications with the tool on this page.

High doses carry real safety concerns, so stick to appropriate amounts and talk with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mace, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 617503343208
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234969
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mace by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
617503343208
IngredientAmount% DV
certified organic Mace (Myristica fragrans) dried whole arils liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: India.

Manufactured in the USA in an FDA registered facility

Alcohol free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Myristica fragrans

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mace by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mace label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mace by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Certified organic Mace (Myristica fragrans) dried whole arils liquid extract

Interacts with
500 drugs
970 mg per serving

Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg. It is mostly used as a cooking spice and in traditional medic...

Certified organic Mace (Myristica fragrans) dried whole arils liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mace by Herbal Terra Drug Interactions

Want to check YOUR meds against Mace?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
500Drugs
500 Moderate

Ingredients driving the most interactions

certified organic Mace (Myristica fragrans) dried whole arils liquid extract 500

Individual Drug Interactions

The ingredients in Mace interact with 500 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mace interact with drugs. Each result below shows which ingredient is responsible. certified organic Mace (Myristica fragrans) dried whole arils liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mace with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Mace (Myristica fragrans) dried whole arils liquid extract4 drug types · 500 drugs

Cns Depressants

Several volatile oils in mace, such as methyleugenol, isoeugenol, safrole, myristicin, 1,8-cineole, and geranyl acetate, seem to have sedative effects. Evidence from animal research suggests that methyleugenol can induce anesthesia for a similar duration as pentobarbital. Due to the sedative effects of certain mace constituents, taking medicinal amounts of mace in combination with other CNS depressants may have additive effects. However, evidence from other animal research suggests that myristicin can reduce sleeping time in rats pretreated with phenobarbital. Until more is known, use medicinal amounts of mace cautiously in combination with CNS depressants. Some CNS depressants include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Animal research suggests that intraperitoneal injections of myristicin, a constituent of mace, can induce cytochrome P450 1A2 (CYP1A2) enzyme system. Theoretically, concomitant use of mace with drugs metabolized by CYP1A2 may increase the clearance of these drugs and reduce their effects. Some substrates of CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Immunosuppressants

Animal research suggests that mace lignans can suppress immune function. Theoretically, concomitant use might enhance the effects of immunosuppressant drugs. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence D
Phenobarbital (Luminal)

Evidence from animal research suggests that myristicin, a constituent of mace, can reduce sleeping time in rats pretreated with phenobarbital. Theoretically, concomitant use may decrease the therapeutic effects of phenobarbital.

Likelihood Probable Evidence D
certified organic Mace (Myristica fragrans) dried whole arils liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mace, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Mace by Herbal Terra: Common Questions

Does Mace by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Mace has a known interaction with 500 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mace contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is mace safe to use while pregnant?
Safety data for medicinal mace during pregnancy is limited and classified as possibly unsafe. Food-level spice use is likely fine, but concentrated supplements should be avoided. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist about whether this product is right for you.
What are the side effects of mace?
At appropriate amounts, mace is generally well tolerated with no reported adverse effects. However, high doses could theoretically cause severe effects similar to those reported with nutmeg — including cardiovascular, gastrointestinal, neurologic, and psychiatric symptoms, as well as visual or auditory hallucinations. Stick to the recommended dose and avoid concentrated amounts.
Can mace help with menstrual cramps or urinary incontinence?
The evidence we hold for mace doesn't support reliable claims for either dysmenorrhea (menstrual cramps) or urinary incontinence — both are rated as having insufficient reliable evidence. Your pharmacist or doctor can discuss other options that may work better for your situation.
Is this product a concentrated supplement or culinary spice?
This is a concentrated liquid extract, not a culinary spice. The safety cautions advise against concentrated supplements due to limited safety data — mace at food-level spice amounts is considered safe, but this product is a much stronger form.
What does mace actually come from?
Mace is the dried aril (seed covering) of the nutmeg plant. It's a spice commonly used in cooking, and this product extracts its active compounds into a liquid form for medicinal use.
Why does this product interact with so many medications?
Mace contains volatile oils and other compounds that can sedate your nervous system, activate a liver enzyme that clears many drugs, and potentially affect immune function. These effects can overlap with how dozens of common medications work, which is why the total interaction count is high. That's exactly why it's important to check your specific prescriptions before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mace label
Go deeper

The Full Monographs Behind Mace’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mace

Interacts with 500 drugs

Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg. It is mostly used as a cooking spice and in traditional medicine for digestion, but there is little s...

Read the full Mace monograph →
Sources

Sources & How We Checked

Mace's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mace 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
  3. Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. DOI
  4. Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. PubMed
  5. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
  6. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
  7. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
  8. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed
  9. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
  10. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
  11. Checker R, Chatterjee S, Sharma D, et al. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol. 2008;8(5):661-669. PubMed
  12. Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. PubMed
  13. Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80.
  14. Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. PubMed
  15. Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. PubMed
  16. Dooms-Goossens, A., Dubelloy, R., and Degreef, H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin 1990;8(1):89-93. DOI
  17. Anjum A, Sultana A. A randomized comparative study of herbal decoction of Cassia fistula Linn pod's pericarp and Myristica fragrans Houtt arils vs. mefenamic acid in spasmodic dysmenorrhoea. J Complement Integr Med. 2018;16(2):/j/jcim.2019.16.issue-2/jcim
  18. Najeeya AGF, Sultana A. Efficacy of mace (Arils of Myristica fragrans Houtt) plus PFMT on symptoms in mixed urinary incontinence: a randomized placebo-controlled trial. Integr Med Res. 2018;7(4):307-315.

See these in context on the Mace monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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