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Dietary supplement

Maitake Mushroom 500 mg Ingredients & Drug Interactions

by Brain Forza

Maitake Mushroom 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake Mushroom 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake Mushroom 500 mg is a dietary supplement by Brain Forza with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Maitake mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maitake Mushroom 500 mg by Brain Forza

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake Mushroom 500 mg by Brain Forza — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maitake Mushroom 500 mg by Brain Forza

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: certified organic maitake mushroom at 500 mg per capsule. Maitake is a medicinal mushroom also known as Grifron-Pro when extracted in certain concentrated forms.

The capsule itself is an organic vegetarian capsule, which serves as the inactive container.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune system support and blood sugar health.
  • We looked for evidence on: Diabetes, Hypertension, Hyperlipidemia, immune function, glucose metabolism.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension.

The evidence we hold on maitake mushroom's effectiveness doesn't yet support confident claims for any particular use. We have ratings for hay fever, cancer-related anemia, laryngeal cancer, and chemotherapy-related diarrhea and fatigue—all marked as having insufficient reliable evidence.

That means the science isn't far enough along to say whether this mushroom works for these conditions, and you shouldn't assume it does on the basis of this product alone.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when eaten as food. As a concentrated supplement, its safety hasn't been fully studied, so use caution.

The most common side effects reported in clinical trials were gastrointestinal: a small number of trial participants experienced diarrhea, nausea, or stomach pain (epigastric pain). One person reported a rash and itching after two doses, though this resolved without treatment.

Because we don't have enough safety data, concentrated maitake supplements should be avoided during pregnancy and while breastfeeding—talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Brain Forza's Maitake Mushroom, double-check with your doctor or pharmacist if you take warfarin or any blood thinner, any antihypertensive (blood pressure) medication, or any antidiabetes drug. Maitake may strengthen the effects of all three drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake mushroom is a supplement with limited proven effectiveness for the conditions mentioned in the research we hold. Its main concern is with medications that thin your blood, lower your blood pressure, or control blood sugar—it may amplify their effects.

If you take warfarin, any blood pressure drug, or diabetes medication, check your exact prescriptions with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake Mushroom 500 mg, straight from the product label.

Brand Brain Forza
Barcode (UPC) 857056006162
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 244149
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake Mushroom 500 mg by Brain Forza, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
857056006162
IngredientAmount% DV
certified organic Maitake mushroom1500 mg--

Other ingredients: organic Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule three times daily with water or, 3 capsules once daily with water.

Formulation

GMP Produced Manufactured in a cGMP Certified Facility

Made and grown in the USA

For healthy blood sugar support & overall well-being Natural immune system support

Certified Organic by QAI

General Statements

Find/Tag us on Facebook, Twitter and Instagram to win free stuff! @ BrainForza

Formula

Maitake Mushroom, commonly known in North America as the "hen-of-the-woods", is a polypore mushroom that grows in clusters at the base of trees, most commonly oaks.

Maitake is known to contain a specific beta-glucan not present in any other mushroom. Our Maitake contains naturally high levels of this compound (around 25%) which is said to offer potent immunity support.

Made with full spectrum organic maitake mushroom Naturally high levels of Beta-Glucans

Seals/Symbols

Quality Assurance International Certified Organic

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Do not take this product if you are pregnant or nursing. Consult your healthcare provider if you are currently taking any prescription or receiving medical treatment.

Discontinue use if unusual symptoms occur.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake Mushroom 500 mg by Brain Forza label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake Mushroom 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake Mushroom 500 mg by Brain Forza

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Certified organic Maitake mushroom

Interacts with
260 drugs
1500 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Certified organic Maitake mushroom monograph & interactions

Other (inactive) ingredients: Organic Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake Mushroom 500 mg by Brain Forza Drug Interactions

Want to check YOUR meds against Maitake Mushroom 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

certified organic Maitake mushroom 260

Individual Drug Interactions

The ingredients in Maitake Mushroom 500 mg interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake Mushroom 500 mg interact with drugs. Each result below shows which ingredient is responsible. certified organic Maitake mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake Mushroom 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Maitake mushroom3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
certified organic Maitake mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake Mushroom 500 mg, from the product label.

Brain Forza

See all Brain Forza products
Name
Brain Forza Dietary Supplements Inc.
Street Address
6100 219th street SW, Ste 480
City
Mountlake Terrace
State
WA
ZipCode
98043
Web Address
www.brainforza.com
Pharmacist Counseling Corner

Maitake Mushroom 500 mg by Brain Forza: Common Questions

Does Maitake Mushroom 500 mg by Brain Forza interact with any medications?
Yes. Based on its ingredients, Maitake Mushroom 500 mg has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake Mushroom 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is maitake mushroom supposed to do?
Maitake is a medicinal mushroom that's been studied for hay fever, chemotherapy-related anemia and diarrhea, laryngeal cancer, and chronic fatigue. However, we don't have enough reliable evidence yet to say it works for any of these. More research is needed.
Can I take this if I'm pregnant or breastfeeding?
No—there isn't enough safety data on concentrated maitake supplements in pregnancy and breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you in those situations.
What side effects might I experience?
Maitake is generally well tolerated, but the most common side effects in clinical trials were stomach-related: diarrhea, nausea, and stomach pain. A small number of people also reported rash and itching, which cleared on its own.
Does this contain any fillers or additives?
The capsule itself is an organic vegetarian capsule. The active ingredient is the maitake mushroom; there are no other inactive ingredients listed.
If I'm on blood pressure or diabetes medication, can I take this?
Not without checking first. Maitake can lower blood pressure and blood glucose, so combining it with those medications might cause your pressure or sugar to drop too low. Talk with your doctor or pharmacist before you start it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maitake Mushroom 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake Mushroom 500 mg label
Go deeper

The Full Monographs Behind Maitake Mushroom 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake Mushroom 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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