Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Micronized L-Glutamine 500 mg Ingredients & Drug Interactions

by Natural Factors

Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Micronized L-Glutamine 500 mg is a dietary supplement by Natural Factors with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Micronized L-Glutamine 500 mg by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine, micronized (a form broken into smaller particles for absorption). The inactive ingredients are rice powder, a vegetarian capsule, and magnesium stearate (a common binder).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: restore plasma L-Glutamine levels after depletion.
  • We looked for evidence on: Critical illness (trauma), Exercise-induced muscle damage, Postoperative recovery, Wound healing, Oral mucositis, Chemotherapy-induced diarrhea — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma) (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Radiation-induced diarrhea.

L-glutamine is rated Effective for sickle cell disease. It's rated Possibly Effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

The evidence in our data supports its use most strongly for sickle cell disease; for the other conditions, the research suggests potential benefit but is less conclusive.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated when you take it by mouth. The most common side effects are gastrointestinal: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting.

Headache and musculoskeletal pain have also been reported. If you have kidney or liver disease, use this only under medical supervision.

During pregnancy, the safety data rates it Likely Safe. However, there isn't enough reliable safety information for supplemental doses while breastfeeding — talk with your doctor or pharmacist before taking it if you're nursing.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (seizure drugs), double-check with your doctor or pharmacist before adding this supplement — it may theoretically reduce how well they work, though this hasn't been documented in people yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may help with sickle cell disease and could support recovery after surgery or during critical illness, though the evidence is stronger for sickle cell. If you take seizure medications, check with your doctor or pharmacist before starting this supplement.

Most people tolerate it well, but watch for digestive side effects and talk with your own healthcare provider before taking it, especially if you have kidney or liver problems.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Micronized L-Glutamine 500 mg, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958028095
Net contents 180 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 75795
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Micronized L-Glutamine 500 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
068958028095
IngredientAmount% DV
L-Glutamine, Micronized500 mg--

Other ingredients: Rice powder, Vegetarian Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

isura Non-GMO - Mass spec Documentation - Lab tested

Purity & potency guaranteed

Suggested/Recommended/Usage/Directions

Suggested Usage: 1 capsule 2-3 times per day or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

General Statements

L-Glutamine is an amino acid that can be found throughout the body, primarily in the brain, gastrointestinal tract, muscles, and liver cells. Supplementing with L-Glutamine can help restore plasma L-Glutamine levels depleted after periods of physical stress and can accelerate recovery time. Additional benefits include immunity support and energy, as well as healthy digestive, and brain function.

Micronized technology greatly minimizes the particle size, thus allowing your body to more easily break down and absorb the glutamine. Natural Factors amino acids are the highest quality pharmaceutical grade products available. Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada. Recyclable container and label.

Healthy muscle tissue & immune system

Formulation

Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

Free form amino acid

General

R1

See for yourself

Micronized L-Glutamine 500 mg by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Micronized L-Glutamine 500 mg by Natural Factors

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

L-Glutamine, Micronized

Interacts with
50 drugs
500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine, Micronized monograph & interactions

Other (inactive) ingredients: Rice powder, Vegetarian Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Micronized L-Glutamine 500 mg by Natural Factors Drug Interactions

Want to check YOUR meds against Micronized L-Glutamine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Micronized L-Glutamine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine, Micronized1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Micronized L-Glutamine 500 mg, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Micronized L-Glutamine 500 mg by Natural Factors: Common Questions

Does Micronized L-Glutamine 500 mg by Natural Factors interact with any medications?
Yes. Based on its ingredients, Micronized L-Glutamine 500 mg has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Micronized L-Glutamine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's L-glutamine supposed to do?
L-glutamine is an amino acid your body uses for many functions. This product is effective for sickle cell disease and possibly helpful for recovery after surgery, wasting from HIV/AIDS, and critical illness from trauma.
Will I get side effects?
Most side effects are digestive — belching, bloating, constipation, diarrhea, nausea, or vomiting. Headache and muscle pain have also been reported, but they're less common. These typically happen at higher doses.
Is it safe if I'm pregnant or breastfeeding?
It's rated Likely Safe in pregnancy. However, there isn't enough safety data for breastfeeding — talk with your doctor or pharmacist before taking supplemental glutamine while nursing.
Can I take it if I have kidney or liver problems?
You should only use this under medical supervision if you have kidney or liver disease. Check with your doctor or pharmacist first.
What's 'micronized' mean?
Micronized means the glutamine particles are broken into smaller pieces to help your body absorb it better.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Micronized L-Glutamine 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Micronized L-Glutamine 500 mg label
Go deeper

The Full Monographs Behind Micronized L-Glutamine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Micronized L-Glutamine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring