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Dietary supplement

Micronized L-Glutamine 500 mg Ingredients & Drug Interactions

by Natural Factors

Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Micronized L-Glutamine 500 mg is a dietary supplement by Natural Factors with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Micronized L-Glutamine 500 mg by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: micronized L-glutamine at 500 mg per capsule. Micronized means it's been broken down into very fine particles to improve how your body absorbs it.

L-glutamine is an amino acid — one of the building blocks your body uses to make protein and support various functions, especially in the gut and immune system. The capsule also contains rice powder, vegetarian capsule material, and magnesium stearate as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: L-Glutamine supplementation for muscle and gut health.
  • We looked for evidence on: Exercise-induced muscle damage, Postoperative recovery, Wound healing, Oral mucositis, Chemotherapy-induced diarrhea, Radiation-induced diarrhea — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Effective" for Sickle cell disease (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting, Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Radiation-induced diarrhea.

The evidence supporting L-glutamine varies by use. It's rated Effective for sickle cell disease.

For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is Possibly Effective — meaning there's some promise, but we'd like more and better research to be sure.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated by healthy adults. The most common side effects from oral doses are digestive — belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting.

Headache and musculoskeletal pain have also been reported. If you have kidney or liver disease, use this only under medical supervision.

Rare cases of dizziness and, in people with bipolar disorder, mania or hypomania have been noted, though these are unusual. During pregnancy, L-glutamine is rated Likely Safe.

During breastfeeding, there isn't enough reliable safety data, so avoid supplement doses unless your doctor recommends them.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use anticonvulsant medications (seizure drugs). Glutamine may theoretically reduce their effectiveness, and while this hasn't been reported in humans, it's worth confirming with your doctor or pharmacist that the combination is right for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may help with sickle cell disease and possibly with HIV-related wasting or recovery after surgery or critical illness. If you take anticonvulsant (seizure) medications, check with your doctor or pharmacist before adding this supplement — it might interfere with how well your drugs work.

Most people tolerate it well, though digestive side effects are common at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Micronized L-Glutamine 500 mg, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958028200
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 75802
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Micronized L-Glutamine 500 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
068958028200
IngredientAmount% DV
L-Glutamine, Micronized500 mg--

Other ingredients: Rice powder, Vegetarian Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

isura Non-GMO - Mass spec Documentation - Lab tested

Purity & potency guaranteed

Suggested/Recommended/Usage/Directions

Suggested Usage: 1 capsule 2-3 times per day or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

General Statements

L-Glutamine is an amino acid that can be found throughout the body, primarily in the brain, gastrointestinal tract, muscles, and liver cells. Supplementing with L-Glutamine can help restore plasma L-Glutamine levels depleted after periods of physical stress and can accelerate recovery time. Additional benefits include immunity support and energy, as well as healthy digestive, and brain function.

Micronized technology greatly minimizes the particle size, thus allowing your body to more easily break down and absorb the glutamine. Natural Factors amino acids are the highest quality pharmaceutical grade products available. Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada. Recyclable container and label.

Healthy muscle tissue & immune system

Formulation

Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

Free form amino acid

General

R1

See for yourself

Micronized L-Glutamine 500 mg by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Micronized L-Glutamine 500 mg by Natural Factors

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

L-Glutamine, Micronized

Interacts with
50 drugs
500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine, Micronized monograph & interactions

Other (inactive) ingredients: Rice powder, Vegetarian Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Micronized L-Glutamine 500 mg by Natural Factors Drug Interactions

Want to check YOUR meds against Micronized L-Glutamine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Micronized L-Glutamine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine, Micronized1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Micronized L-Glutamine 500 mg, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Micronized L-Glutamine 500 mg by Natural Factors: Common Questions

Does Micronized L-Glutamine 500 mg by Natural Factors interact with any medications?
Yes. Based on its ingredients, Micronized L-Glutamine 500 mg has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Micronized L-Glutamine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's micronized L-glutamine supposed to do?
L-glutamine is an amino acid your body uses for protein and to support gut and immune function. Research shows it's effective for sickle cell disease and possibly helpful for HIV/AIDS-related wasting, recovery after surgery, and critical illness. Micronized means it's finely ground for better absorption.
What side effects might I get from this?
Most commonly, people report digestive issues like bloating, gas, nausea, diarrhea, or constipation. Headache and musculoskeletal pain have also been reported. At very high doses, dizziness can occur. These are usually mild, but if they bother you, lower your dose or stop and talk to your pharmacist.
Is it safe to take while I'm pregnant or breastfeeding?
L-glutamine is rated Likely Safe during pregnancy. While breastfeeding, there isn't enough data to know either way — talk with your doctor or pharmacist about whether this product is right for you at that time.
Are there any fillers or other ingredients I should know about?
Besides the active L-glutamine, the capsule contains rice powder, vegetarian capsule material, and magnesium stearate. If you're sensitive to any of these, let us know.
Can I take this if I have kidney or liver problems?
If you have kidney or liver disease, only use L-glutamine under medical supervision. Check with your doctor or pharmacist first to make sure it's safe for your situation.
Does it really work for what it claims?
For sickle cell disease, yes — the evidence is solid. For HIV/AIDS wasting, surgery recovery, and critical illness, the evidence is promising but not yet conclusive. Results may vary, and it's best used as part of an overall treatment plan.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Micronized L-Glutamine 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Micronized L-Glutamine 500 mg label
Go deeper

The Full Monographs Behind Micronized L-Glutamine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Micronized L-Glutamine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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