Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Afternoon Ingredients & Drug Interactions

by Cellucor

Afternoon label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Afternoon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Afternoon is a dietary supplement by Cellucor with 5 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,335 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacopa (Bacopa monnieri) leaf extract, L-Theanine, Capsimax Cayenne (Capsicum annuum) fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Afternoon by Cellucor

Ask about any prescription or over-the-counter medication and we check it for interactions with Afternoon by Cellucor — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Afternoon by Cellucor

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “SuperHD Fire Fuel Blend (Combination)” is a proprietary blend — the label gives one combined amount (455 mg) without saying how much of each component you get.

Afternoon contains five active ingredients. L-theanine is an amino acid that may support focus and calm.

The SuperHD Fire Fuel Blend is a proprietary combination whose component ingredients are listed separately. DygloFit (Dichrostachys glomerata fruit extract) is included, though we have no interaction data on file for it.

Capsimax Cayenne (Capsicum annuum fruit extract) is a concentrated form of the compound that gives chili peppers their heat. Toothed Clubmoss (Huperzia serrata aerial parts extract) contains huperzine A, which may support memory and cognitive function.

Backopa (Bacopa monnieri leaf extract) is an Ayurvedic herb traditionally used for cognitive support. The product also contains inactive ingredients including microcrystalline cellulose, capsule shell, vegetable magnesium stearate, and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Cognitive impairment, Attention deficit-hyperactivity disorder (ADHD), Age-related memory loss — and 2 related terms.
  • The strongest evidence on file: Theanine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Cognitive impairment.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Alzheimer disease.

L-theanine is possibly effective for cognitive function, but evidence is insufficient to rate it for age-related cognitive decline, Alzheimer disease, generalized anxiety, obsessive-compulsive disorder, or cancer. For toothed clubmoss and bacopa, effectiveness ratings are not established in the data we hold — no evidence summary is available for either ingredient.

Capsicum has stronger evidence: it's likely effective for postherpetic neuralgia (nerve pain after shingles) and diabetic nerve pain, and possibly effective for cluster headache, back pain, and nausea after surgery.

The evidence, ingredient by ingredient Theanine Capsicum Toothed Clubmoss Bacopa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated for short-term use in healthy adults, though long-term safety isn't well studied. Common side effects include headaches, drowsiness, and vivid dreams.

One case of facial tics was reported in a child, but the link to the ingredient was unclear. Capsicum in food amounts is considered safe, but concentrated supplements are less well studied; common effects include burning, bloating, gas, nausea, and flushing.

Bacopa is generally well tolerated, with gastrointestinal effects (nausea, diarrhea, cramps) reported in 12–30% of trial participants. Toothed clubmoss may cause dizziness, nausea, and sweating, and product quality varies widely.

For pregnancy: L-theanine, toothed clubmoss, and bacopa all lack sufficient safety data — the data advises against use during pregnancy and lactation. Capsicum in food amounts is likely safe during pregnancy and lactation, but concentrated supplement safety hasn't been established.

Side effects, ingredient by ingredient Theanine Capsicum Toothed Clubmoss Bacopa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Toothed Clubmoss, Bacopa, Capsicum, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,336 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Afternoon, check whether you're on any blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), diabetes medications, blood pressure drugs, theophylline (for breathing), anticholinergic or cholinergic medications, or any drug metabolized by CYP1A2, CYP2C19, CYP2C9, or CYP3A4 enzymes — a group that includes many common prescription drugs. Use the medication checker on this page with your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Afternoon is marketed for afternoon energy and cognitive support, combining ingredients with some evidence (especially capsicum) and others with limited data. The main concern is the breadth of medication interactions, particularly with blood thinners, diabetes drugs, blood pressure medications, and drugs your liver processes through CYP enzymes.

Check your exact medications before starting. If you're pregnant, breastfeeding, or taking any prescription, talk with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Afternoon, straight from the product label.

Brand Cellucor
Barcode (UPC) 842595100228
Net contents 56 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2018
DSLD ID 83117
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Afternoon by Cellucor, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
28
UPC/BARCODE
842595100228
IngredientAmount% DV
L-Theanine0 NP--
SuperHD Fire Fuel Blend (Combination)455 mg--
DygloFit (Dichrostachys glomerata) fruit extract0 NP--
Capsimax Cayenne (Capsicum annuum) fruit extract0 NP--
Toothed Clubmoss (Huperzia serrata) aerial parts extract0 NP--
Bacopa (Bacopa monnieri) leaf extract0 NP--

Other ingredients: Microcrystalline Cellulose, Capsule Shell, Vegetable Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take morning serving (1 red capsule) with 8-12 fl. oz. of water early to middle of morning. Take afternoon serving (1 orange capsule) with 8-12 fl. oz. of water 4-6 hours after morning serving. For best results, use for 8 weeks in combination with diet and exercise. Use only as directed.

Precautions

Use only as directed.

Warning: This product is only intended to be consumed by healthy adults, 18 years of age or older.

Do not use this product if you are pregnant or nursing. Before using this product, consult a licensed, qualified, health care professional, including but not limited to, if: you are taking antidepressants such as MAOI (Monoamine Oxidase Inhibitor) or SSRI, blood thinners, nonsteroidal anti-inflammatory drugs, pseudoephedrine, or you are taking any other dietary supplement, prescription drug or over-the-counter medication; or if, you suspect you have or have been treated for, diagnosed with or have a family history of, any medical condition, including but not limited to: high or low blood pressure, diabetes, anxiety, cardiovascular, psychiatric or seizure disorders, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, or difficulty urinating due to prostate enlargement.

Discontinue use 2 weeks prior to surgery. Immediately discontinue use and contact a medical doctor if you experience any adverse reaction to this product. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Brand IP Statement(s)

DygloFit is a trademark of Gateway Health Alliances, Inc. and is protected under U.S. Patents 8,241,682 and 8,623,432 and patents pending.

Cellucor, SuperHD, and SuperHR Fire are trademarks of and distributed by: Nutrabolt

DygloFit makes the difference DygloFit is a comprehensive, efficacious and mutli-dimensional weight loss ingredient that is exlusively licensed, patented and clinically studied. Subjects of multiple randomized. Double-blind, placebo-controlled human clinical trials experienced significant reductions in weight, waist size, hip size, and body fat percentage. How DygloFit reduced body fat Patented DygloFit (U.S. Patent # 8,361,523) possesses polyphenol glomerata which has multifunctional properties that help promote both healthy weight management and comprehensive metabolic wellness. This fruit has been revered as a culinary spice and for medicinal properties for hundreds of years in its native West Africa.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Daily 2 stage weight loss formula to match how you live. Mornings are not the same as afternoons and sometimes you don't want caffeine or other stimulants to help drive your energy. That's why we designed custom formulas for your morning and afternoon. Targeting fat loss, optimized performance, enhanced mental stamina and emotional well-being, while boosting your energy levels without the use of caffeine or other stimulants.

Morning & afternoon Weight loss formulation

4 week supply

Ignite your goals Extinguish your doubt

Formula

Afternoon Fuel your afternoon and stay sharp with Huperzine A and Bacopa Monnieri, traditionally used to enhance cognitive performance, while still experiencing the thermogenic effects of Capsimax and activating the multifunctional weight loss properties of clinically studied DygloFit.

With patented DygloFit

Formulation

Stimulant free

Stimulant free thermogenic response

FDA Statement of Identity

Dietary Supplement

General

104287

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Afternoon by Cellucor label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Afternoon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Afternoon by Cellucor

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

SuperHD Fire Fuel Blend (Combination)

455 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Capsule Shell, Vegetable Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Afternoon by Cellucor Drug Interactions

Want to check YOUR meds against Afternoon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,335Drugs
1,176 Moderate 159 Minor

Ingredients driving the most interactions

Bacopa (Bacopa monnieri) leaf extract 930
L-Theanine 565
Capsimax Cayenne (Capsicum annuum) fruit extract 239
Toothed Clubmoss (Huperzia serrata) aerial parts extract 219

Individual Drug Interactions

The ingredients in Afternoon interact with 1,335 drugs. Click any drug to see the details.

4 of the 5 ingredients in Afternoon interact with drugs. Each result below shows which ingredient is responsible. Bacopa (Bacopa monnieri) leaf extract L-Theanine Capsimax Cayenne (Capsicum annuum) fruit extract Toothed Clubmoss (Huperzia serrata) aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Afternoon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacopa (Bacopa monnieri) leaf extract8 drug types · 930 drugs

Anticholinergic Drugs

Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.

Likelihood Possible Evidence D
Cevimeline (Evoxac)

Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.

Likelihood Possible Evidence D
Bacopa (Bacopa monnieri) leaf extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Capsimax Cayenne (Capsicum annuum) fruit extract6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Capsimax Cayenne (Capsicum annuum) fruit extract full monograph & interactions

Toothed Clubmoss (Huperzia serrata) aerial parts extract2 drug types · 219 drugs

Anticholinergic Drugs

In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopolamine. Theoretically, concurrent use of anticholinergic drugs and toothed clubmoss might decrease the effectiveness of toothed clubmoss or the anticholinergic drug.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).

Likelihood Possible Evidence D
Cholinergic Drugs

Huperzine A, a constituent of toothed clubmoss, has demonstrated acetylcholinesterase inhibitory properties. Theoretically, concurrent use of toothed clubmoss with cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Likelihood Possible Evidence D
Toothed Clubmoss (Huperzia serrata) aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Afternoon, from the product label.

Cellucor

See all Cellucor products
Name
Nutrabolt
Street Address
3891 S. Traditions Dr.
City
Bryan
State
TX
ZipCode
77807
Phone Number
1.866.927.9686
Web Address
www.cellucor.com
Pharmacist Counseling Corner

Afternoon by Cellucor: Common Questions

Does Afternoon by Cellucor interact with any medications?
Yes. Based on its ingredients, Afternoon has a known interaction with 1,335 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Afternoon contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have caffeine?
The product facts don't list caffeine as an ingredient. If you're sensitive to stimulants or want to confirm, check the label directly or ask us.
What are the side effects I should watch for?
L-theanine may cause headaches, drowsiness, or vivid dreams. Capsicum often causes burning, bloating, gas, nausea, and flushing. Bacopa can trigger nausea, diarrhea, and abdominal cramps in some users. Toothed clubmoss may cause dizziness, nausea, and sweating. Stop and contact your doctor if you have any concerning symptoms.
Is this safe during pregnancy?
No. Three of the active ingredients — L-theanine, toothed clubmoss, and bacopa — lack sufficient safety data, and the facts advise against use during pregnancy. Capsicum in food amounts is considered likely safe, but supplement safety hasn't been established. Talk with your pharmacist or doctor.
Can I take this while breastfeeding?
The data advises against it. L-theanine, toothed clubmoss, and bacopa all lack sufficient breastfeeding safety information. Capsicum at food amounts is likely safe, but concentrated supplement safety isn't well established. Check with your pharmacist or doctor before using.
How long does it take to work?
The product facts don't include information about how quickly the ingredients work or how long you should take it. Talk with us or the manufacturer for that timeline.
What does DygloFit do?
DygloFit is a Dichrostachys glomerata fruit extract included in the formula, but the product facts don't describe its specific role or benefits.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Afternoon label
Go deeper

The Full Monographs Behind Afternoon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph → Herb & supplement monograph

Toothed Clubmoss

Interacts with 219 drugs

Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's disease. Some early research is promising, but the...

Read the full Toothed Clubmoss monograph → Herb & supplement monograph

Bacopa

Interacts with 930 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph →
Sources

Sources & How We Checked

Afternoon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 110 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Capsicum 89 references
  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  2. Cooper RL, Cooper MM. Red pepper-induced dermatitis in breast-fed infants. Dermatol 1996;93:61-2. PubMed
  3. Millqvist E. Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms. Allergy 2000;55:546-50. DOI
  4. Locock RA. Capsicum. Can Pharm J 1985;118:517-9.
  5. Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004;328:991. PubMed
  6. Schmulson MJ, Valdovinos MA, Milke P. Chili pepper and rectal hyperalgesia in irritable bowel syndrome. Am J Gastroenterol 2003;98:1214-5. PubMed
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