Mucuna Pruriens Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Mucuna Pruriens Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Mucuna Pruriens Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for parkinson's disease symptoms, male fertility and libido, mood and stress support.Based on those ingredients, 193 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Mucuna pruriens Fruit Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Mucuna Pruriens Extract by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Mucuna Pruriens Extract by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Mucuna Pruriens Extract by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Mucuna pruriens Fruit Extract, Powder. Mucuna pruriens is a plant that naturally contains levodopa (L-dopa), a compound your body converts to dopamine.
There are no other active ingredients in this formula.
Does it work?
Couldn't assess
The evidence on Mucuna pruriens for anxiety, erythema (skin redness), high prolactin levels, muscle pain, Parkinson disease, or rheumatoid arthritis is insufficient—we don't have enough reliable data to rate how well it works for any of these uses. If you're considering it for a specific health goal, that's a conversation to have with your doctor or pharmacist.
How safe is it?
Well-documented data
Adverse effects from taking this product orally appear uncommon, though a thorough safety evaluation hasn't been completed. The most frequently reported side effects are diarrhea, flatulence, and mouth irritation; some people also report dry mouth, headaches, and occasionally nausea or vomiting.
In clinical studies, about 3% of people taking higher doses (22.5 to 67.5 grams daily, split across multiple doses) reported insomnia. Because this product contains L-dopa—an active drug-like compound—it should be used carefully under professional guidance.
The safety data advises against use during pregnancy due to insufficient safety information and its dopamine effects. Additionally, L-dopa can lower prolactin (a hormone important for milk production) and may reduce milk supply, so avoid this product while breastfeeding.
Meds to double-check
Major interaction found
Before taking this product, double-check with your pharmacist if you take any of these: non-selective monoamine oxidase inhibitors (MAOIs)—risk of dangerous high blood pressure; methyldopa or guanethidine for blood pressure—risk of dangerously low blood pressure; levodopa for Parkinson's disease—risk of increased side effects; diabetes medications—risk of low blood sugar; antipsychotics—may reduce their effectiveness; tricyclic antidepressants—may lower levodopa levels and raise blood pressure; or anesthetics, especially cyclopropane or halogenated hydrocarbons—risk of irregular heartbeat. No interactions are documented for other types of anesthetics.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This is a single-ingredient product centered on a plant compound that acts like an active drug in your body. It's not established whether it works for any specific health condition based on our current data.
Because it contains levodopa and interacts with many medications—some seriously—check with your own doctor or pharmacist before starting it. Pregnancy and breastfeeding are contraindicated.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Mucuna Pruriens Extract, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X001BGWBWX |
| Net contents | 500 Gram(s); 17.6 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Jul 18, 2023 |
| DSLD ID | 294797 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Mucuna Pruriens Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Mucuna pruriens Fruit Extract, Powder | 500 mg | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & Pure Bulk Supplements
Formulation
Color may vary
Free of: Added sugar, Soy, Dairy, Yeast, Gluten, Additives
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Keep out of reach of children.
Always consult a physician before taking any dietary supplement.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) up to two times daily, or as directed by a physician.
Storage
Store in a dry, cool place
General Statements
New
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Mucuna Pruriens Extract by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Mucuna Pruriens Extract by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.
Mucuna pruriens Fruit Extract, Powder
Interacts with193 drugs
Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...
Mucuna pruriens Fruit Extract, Powder monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Mucuna Pruriens Extract by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Mucuna Pruriens Extract by BulkSupplements.com has documented interactions with several medication types.
The ingredient—Mucuna pruriens fruit extract—contains levodopa (L-dopa), an active compound that interacts with blood pressure medications, certain psychiatric drugs, and anesthetics. The most serious concern is with monoamine oxidase inhibitors (MAOIs): combining this product with non-selective MAOIs could trigger a hypertensive crisis (dangerously high blood pressure).
Read the full breakdown — every affected drug type, severity by severity
Other Major-severity interactions include methyldopa (a blood pressure drug), where the combination risks low blood pressure (hypotension) and may raise levodopa levels in your brain; and levodopa itself—if you're already taking levodopa for Parkinson's disease, adding this product increases the risk of levodopa side effects. Additionally, there are Moderate-severity interactions with diabetes medications (risk of low blood sugar), antipsychotics (may weaken their effect), tricyclic antidepressants (may lower levodopa levels and raise blood pressure), anesthetics like cyclopropane or halogenated hydrocarbons (risk of irregular heartbeat), and guanethidine, a blood pressure drug (risk of low blood pressure).
Altogether, these interactions span 193 individual medications. Because this product contains an active drug-like compound, you'll want to run your exact medications through the interaction checker below before starting it.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Mucuna Pruriens Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Mucuna Pruriens Extract interact with 193 drugs. Click any drug to see the details.
1 of the 1 ingredient in Mucuna Pruriens Extract interact with drugs. Each result below shows which ingredient is responsible. Mucuna pruriens Fruit Extract, Powder
Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Aripiprazole Lauroxil interactionArticaine, EpinephrineSeptocaine
How Articaine, Epinephrine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Articaine, Epinephrine interactionAsenapineSaphris, Secuado
How Asenapine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Asenapine interactionBenzocaine, Cetylpyridinium ChlorideMax Lozenger
How Benzocaine, Cetylpyridinium Chloride interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Benzocaine, Cetylpyridinium Chloride interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Brexpiprazole interactionBupivacaineExparel, Marcaine, Posimir
How Bupivacaine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Bupivacaine interactionBupivacaine HciXaracoll
How Bupivacaine Hci interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Bupivacaine Hci interactionBupivacaine, MeloxicamZynrelef Kit
How Bupivacaine, Meloxicam interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Bupivacaine, Meloxicam interactionButaperazineRepoise
How Butaperazine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Butaperazine interactionCanagliflozinInvokana
How Canagliflozin interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Canagliflozin, Metformin Hydrochloride interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Cariprazine Hydrochloride interactionCarphenazineProketazin
How Carphenazine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Carphenazine interactionChloroprocaineNesacaine, Nescaine-MPF
How Chloroprocaine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Chloroprocaine interactionChloroprocaine HydrochlorideClorotekal
How Chloroprocaine Hydrochloride interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Chloroprocaine Hydrochloride interactionChlorpromazineThorazine, Thorazine Spansules
How Chlorpromazine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Chlorpromazine interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Chlorpropamide interactionChlorprothixeneTaractan
How Chlorprothixene interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Chlorprothixene interactionClomipramineAnafranil, Anafranil SR
How Clomipramine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderTricyclic Antidepressants (tcas) Moderate
Interaction Summary
Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Read the full Mucuna Pruriens Fruit Extract, Powder + Clomipramine interactionClozapineClozaril, Versacloz
How Clozapine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Clozapine interactionCyamemazineTercian
How Cyamemazine interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Fruit Extract, Powder + Cyamemazine interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Fruit Extract, Powder + Dasiglucagon Hydrochloride interactionDesfluraneSuprane
How Desflurane interacts with Mucuna Pruriens Extract — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Fruit Extract, PowderAnesthesia Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Read the full Mucuna Pruriens Fruit Extract, Powder + Desflurane interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Mucuna Pruriens Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Mucuna pruriens Fruit Extract, Powder
Levodopa
Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.
Methyldopa (Aldomet)
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.
Anesthesia
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.
Antidiabetes Drugs
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.
Antipsychotic Drugs
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.
Guanethidine (Ismelin)
Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.
Tricyclic Antidepressants (Tcas)
Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.
Brand information
Manufacturer and brand details for Mucuna Pruriens Extract, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Mucuna Pruriens Extract by BulkSupplements.com: Common Questions
Does Mucuna Pruriens Extract by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What exactly is in this powder?
Does this actually work for anything?
What side effects might I experience?
Can I take this while pregnant or breastfeeding?
Why does this interact with so many medications?
Is this safe to use with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Mucuna Pruriens Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Mucuna Pruriens Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Mucuna Pruriens Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cowhage 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
- HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
- Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
- Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
- Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
- Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
- Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
- Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
- Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
- Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC