Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Multi Collagen Peptides plus Hyaluronic Acid Unflavored Ingredients & Drug Interactions

by Dr. Emil Nutrition

Multi Collagen Peptides plus Hyaluronic Acid Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Multi Collagen Peptides plus Hyaluronic Acid Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Multi Collagen Peptides plus Hyaluronic Acid Unflavored is a dietary supplement by Dr. Emil Nutrition with 7 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 205 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Collagen Peptide Blend” is a proprietary blend — the label gives one combined amount (20 Gram(s)) without saying how much of each component you get.

This powder contains 6 active ingredients: sodium, bovine collagen (hydrolyzed), marine collagen from fish, a blend of collagen peptides, chicken collagen type II, an olive extract called goFAT Olive, and hyaluronic acid. The collagen sources are broken down into small peptides so your body can absorb them more easily.

There are no inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Skin hydration, joint comfort, and collagen support.
  • We looked for evidence on: Aging skin, Dry eye, Osteoarthritis, Wound healing, Joint health, Connective tissue support — and 1 related terms.
  • The strongest evidence on file: Hyaluronic Acid is rated "Possibly Effective" for Dry eye (Natural Medicines).
  • Also on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Osteoarthritis, Wound healing.

The evidence behind most of these ingredients is still being worked out. Sodium itself is studied mainly for medical conditions like cystic fibrosis (where it's likely effective) and as a protective measure against amphotericin B kidney damage (possibly effective); we don't have effectiveness ratings for collagen peptides or hyaluronic acid in our data for general joint or skin health.

Olive extract and hyaluronic acid have been studied for dry eye (possibly effective for hyaluronic acid) and a few other uses, but the evidence is either insufficient or still emerging.

The evidence, ingredient by ingredient Sodium Olive Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated in normal food amounts, but this product contains supplemental sodium. The main caution: too much sodium is linked to high blood pressure, heart strain, and kidney problems, and can increase gastric cancer risk over time.

Avoid sodium supplements or very high intake without medical advice. The other ingredients — olive and hyaluronic acid — are well tolerated in typical use, though long-term safety data on concentrated supplements is limited.

Hyaluronic acid especially has sparse oral safety information, so check with your doctor if you're concerned.

Side effects, ingredient by ingredient Sodium Olive Hyaluronic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 205 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications if you're on blood pressure drugs, lithium, corticosteroids (including prednisone or similar), didanosine (Videx), sodium phosphate products, tolvaptan (Samsca), or any other sodium-containing medications. The sodium in this product can reduce blood pressure medication effectiveness and cause problems with lithium levels, and it raises the risk of too-high sodium in your blood when combined with other sodium sources.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a collagen and hyaluronic acid blend with added sodium. If you take blood pressure medication, lithium, corticosteroids, or certain other drugs, the sodium content is a real concern — check with your pharmacist before starting.

If you have high blood pressure, heart disease, or kidney problems, talk to your doctor about whether the sodium load makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Multi Collagen Peptides plus Hyaluronic Acid Unflavored, straight from the product label.

Brand Dr. Emil Nutrition
Barcode (UPC) 850002956535
Net contents 633 Gram(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 321808
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
21.1 Gram(s)
Maximum serving Sizes:
21.1 Gram(s)
Servings per container
30
UPC/BARCODE
850002956535
IngredientAmount% DV
Calories80 Calorie(s)--
Sodium75 mg3%
Total Fat0.5 Gram(s)1%
Protein20 Gram(s)--
Bovine Collagen, Hydrolyzed0 NP--
Naticol Marine Collagen0 NP--
Collagen Peptide Blend20 Gram(s)--
Chicken Collagen Type II0 NP--
goFAT Olive1 Gram(s)--
Hyaluronic Acid90 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, mix 2 scoops of Multi Collagen + Hyaluronic Acid into 8 ounces of water, coffee, or your favorite beverage. Mix and enjoy.

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution: This product is not intended for pregnant or nursing mothers, children under the age of 18, or persons with a medical condition.

Caution: This product is not intended for pregnant or nursing mothers, children under the age of 18, or persons with a medical condition.

Consult with your health care provider before using this or any dietary supplement.

Contains fish (tilapia).

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Dairy free Non GMO Sugar free Gluten free

Skin elasticity Skin hydration Youthful appearance Hair, skin & nail support Healthy bones & joints Mixes in hot or cold

Skin, hair, nails & joint support

Product has been manufactured at a cGMP facility.

Formula

20 g collagen peptides

Paleo friendly

20 g collagen per serving goFAT Olive Oil

General Statements

New

Typical Amino Acid Profile Amount Per Serving Alanine 1.879 g Arginine 1.527 g Aspartic Acid 1.127 g Cysteine 0.000 g Glutamic Acid 1.964 g Glycine 4.550 g Histadine 0.120 g Hydroxylysine 0.199 g Hydroxyproline 2.255 g Isoleucine 0.258 g Leucine 0.574 g Lysine 0.713 g Methionine 0.100 g Phenylalanine 0.397 g Proline 2.612 g Serine 0.615 g Threonine 0.397 g Tryptophan 0.000 g Tyrosine 0.040 g Valine 0.474 g Essential Amino Acids BCAAs The L-Tryptophan indicated is from naturally occurring sources of protein.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Multi Collagen Peptides plus Hyaluronic Acid Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size21.1 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
75 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Protein

20 Gram(s) per serving

Collagen Peptide Blend

20 Gram(s) per serving
  • › Bovine Collagen, Hydrolyzed
  • › Naticol Marine Collagen
  • › Chicken Collagen Type II

GoFAT Olive

No known
interactions
1 Gram(s) per serving Form: Acacia, Extra Virgin Olive Oil, Powder

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

GoFAT Olive monograph & interactions

Hyaluronic Acid

No known
interactions
90 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions
Interaction report

Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition Drug Interactions

Want to check YOUR meds against Multi Collagen Peptides plus Hyaluronic Acid Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
205Drugs
205 Moderate

Ingredients driving the most interactions

Sodium 205

Individual Drug Interactions

The ingredients in Multi Collagen Peptides plus Hyaluronic Acid Unflavored interact with 205 drugs. Click any drug to see the details.

1 of the 7 ingredients in Multi Collagen Peptides plus Hyaluronic Acid Unflavored interact with drugs. Each result below shows which ingredient is responsible. Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Multi Collagen Peptides plus Hyaluronic Acid Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Multi Collagen Peptides plus Hyaluronic Acid Unflavored, from the product label.

Dr. Emil Nutrition

See all Dr. Emil Nutrition products
Name
Dr. Emil Nutrition
Street Address
3706 Butler Street
City
Pittsburgh
State
PA
ZipCode
15201
Phone Number
844-437-3645
Web Address
dremilnutrition.com
Pharmacist Counseling Corner

Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition: Common Questions

Does Multi Collagen Peptides plus Hyaluronic Acid Unflavored by Dr. Emil Nutrition interact with any medications?
Yes. Based on its ingredients, Multi Collagen Peptides plus Hyaluronic Acid Unflavored has a known interaction with 205 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Multi Collagen Peptides plus Hyaluronic Acid Unflavored contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is sodium in this product a problem if I have normal blood pressure?
Normal dietary sodium from food is fine, but supplemental sodium in a powder is different — it adds up quickly. If your blood pressure is normal, your doctor may still want you to keep sodium intake moderate. If you're already on any blood pressure medication, even with controlled numbers, this product's sodium can interfere with how well those drugs work.
Can I take this if I'm pregnant or breastfeeding?
The sodium in this product carries mixed safety data — rated likely safe but also possibly unsafe depending on context. We don't have pregnancy or breastfeeding safety information on file for the collagen ingredients or hyaluronic acid. Talk with your doctor or pharmacist before use if you're pregnant or nursing; they can weigh the risks for your individual situation.
What is hyaluronic acid supposed to do?
Hyaluronic acid is a naturally occurring compound your body uses to hold moisture in skin and joints. In supplements, it's been shown to possibly help with dry eye, but the evidence for skin aging or joint health is still being established.
Are there any side effects I should watch for?
The collagen ingredients appear well tolerated. Hyaluronic acid and olive extract are generally well tolerated too, though some people report headache or mild stomach discomfort with olive. The main concern is sodium — excess intake is linked to high blood pressure, worsened heart and kidney disease, and a higher risk of stomach cancer over time. Stick to normal amounts and avoid this product if you're sodium-sensitive.
Does collagen peptide actually work?
We don't have effectiveness data on file for collagen peptides as a supplement for joint health, skin, or bone. The product's collagen is hydrolyzed into small pieces for absorption, but whether that translates to real benefits for you is something our data doesn't establish.
What's the difference between all these collagen types?
They come from different animal sources — bovine (beef), marine (fish), and chicken. Each source may offer slightly different amino acid profiles, but the evidence for real differences in how they work is limited in our data. All are broken down (hydrolyzed) into peptides for easier absorption.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Multi Collagen Peptides plus Hyaluronic Acid Unflavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Multi Collagen Peptides plus Hyaluronic Acid Unflavored label
Go deeper

The Full Monographs Behind Multi Collagen Peptides plus Hyaluronic Acid Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph →
Sources

Sources & How We Checked

Multi Collagen Peptides plus Hyaluronic Acid Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 44 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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