Interactions on record — worth a quick check against your medications. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Natto LP Ingredients & Drug Interactions

by Allegany Nutrition

Natto LP label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natto LP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natto LP is a dietary supplement by Allegany Nutrition with 8 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natto LP by Allegany Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Natto LP by Allegany Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natto LP by Allegany Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.

Natto LP contains 8 active ingredients, most of them digestive enzymes. Protease, amylase, lipase, cellulase, peptidase, and glucoamylase are all enzymes that help break down different types of food — proteins, carbohydrates, fats, and fiber.

Nattokinase is a fibrin-dissolving enzyme derived from natto (fermented soybeans) that may have blood-thinning effects. The product also contains ionic trace minerals.

The capsule itself is made from vegetable cellulose, and the formula includes water and rice extract as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Heart and circulatory health with systemic enzymes.
  • We looked for evidence on: Angina, Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence on effectiveness in our data is limited. For the enzymes in this product — protease, lipase — we have insufficient reliable evidence to rate them for digestive complaints like dyspepsia (indigestion) or inflammatory bowel disease.

Nattokinase similarly has insufficient reliable evidence for cardiovascular conditions like angina, atherosclerosis, or heart disease. So while these ingredients are in the formula, we don't have solid clinical proof they work for any of those purposes.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The digestive enzymes protease and lipase are generally well tolerated by most adults, though some people report mild digestive upset or allergic reactions. Protease has rarely triggered allergic reactions in occupational settings through airborne exposure.

Nattokinase is generally tolerated short-term, but its blood-thinning effect means caution for anyone with bleeding risk. During pregnancy, protease and nattokinase safety data is limited — protease and nattokinase are best avoided in pregnancy unless your doctor prescribes them, and lipase should only be used if your doctor advises it.

For breastfeeding, protease, lipase, and nattokinase all have insufficient safety data; check with your healthcare provider before using any of them.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Natto LP, double-check with your own doctor or pharmacist if you take blood thinners or antiplatelet drugs like warfarin, apixaban, dabigatran, heparin, or aspirin — nattokinase raises bleeding risk. Also flag any blood pressure medications you're on, as nattokinase may lower pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Natto LP is primarily a digestive enzyme supplement, but it contains nattokinase, which can affect blood thinners and blood pressure medications — so it's not the right choice if you take those drugs without checking first. If you're pregnant or breastfeeding, talk it over with your doctor or pharmacist before starting.

For digestive support specifically, the evidence on these enzymes is thin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natto LP, straight from the product label.

Brand Allegany Nutrition
Barcode (UPC) 094922740441
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276048
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natto LP by Allegany Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
094922740441
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Peptidase0 NP--
Glucoamylase0 NP--
Nattokinase0 NP--
Ionic Trace Minerals40 mg--

Other ingredients: Vegetable Cellulose, Water, Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take one capsule in the morning on an empty stomach and one capsule in the evening on an empty stomach for maintenance dosage (60 day supply). Or take two capsules twice daily for therapeutic dose. Always take with 8 oz. of water. We also suggest taking our digestive enzymes with meals.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are under a physician's care or taking other medication, consult with your healthcare professional before using this product. Consult with your doctor if you are pregnant, lactating, nursing, or have an existing ulcer.

Do not use if you have a blood coagulation disorder. Caution: Do not use if tamper seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Allegany Nutrition The enzyme specialists

Formula

Nattokinase with systemic enzymes

Plant based enzymes

The enzymes in this formula are derived from plant source.

Formulation

Ultra high activity proteolytic and lipolytic enzyme formulation

Heart health Blood pressure Fat metabolism Tissue repair Circulation Blood clots Fibrin

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natto LP by Allegany Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natto LP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natto LP by Allegany Nutrition

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amylase

0 NP per serving

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Cellulase

0 NP per serving

Peptidase

0 NP per serving

Glucoamylase

0 NP per serving

Nattokinase

Interacts with
289 drugs
0 NP per serving

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Ionic Trace Minerals

40 mg per serving

Other (inactive) ingredients: Vegetable Cellulose, Water, Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natto LP by Allegany Nutrition Drug Interactions

Want to check YOUR meds against Natto LP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Natto LP interact with 289 drugs. Click any drug to see the details.

1 of the 8 ingredients in Natto LP interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Natto LP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natto LP, from the product label.

Allegany Nutrition

See all Allegany Nutrition products
Name
Allegany Nutrition
Street Address
P.O. Box 70
City
Allegany
State
NY
ZipCode
14706
Pharmacist Counseling Corner

Natto LP by Allegany Nutrition: Common Questions

Does Natto LP by Allegany Nutrition interact with any medications?
Yes. Based on its ingredients, Natto LP has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natto LP contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Natto LP if I'm on aspirin or another blood thinner?
No — not without checking with your doctor or pharmacist first. Nattokinase in this product has blood-thinning effects of its own, and combining it with anticoagulants or antiplatelets can increase your bleeding risk. There's even a case report of someone who had brain bleeding after adding nattokinase to aspirin. Clear it with your healthcare provider before starting.
Is Natto LP safe during pregnancy or breastfeeding?
The safety data is too limited to say yes. Nattokinase, protease, and lipase all lack solid safety information in pregnancy and breastfeeding. Talk with your doctor or pharmacist — they can weigh the risks and benefits for your specific situation.
What does nattokinase do?
Nattokinase is an enzyme from fermented soybeans that can thin the blood and dissolve fibrin (a protein involved in clots). In this product it's meant to support circulation, but we don't have reliable evidence it works for heart disease, atherosclerosis, or other cardiovascular conditions.
Will these enzymes help my digestion?
The product contains several digestive enzymes — protease, lipase, amylase, cellulase, peptidase, and glucoamylase — but the clinical evidence for them in conditions like indigestion or inflammatory bowel disease is insufficient. So we can't say whether they'll work for you.
Does Natto LP contain any major allergens?
It's made from natto (fermented soybeans), so nattokinase comes from soy. If you're allergic to natto or soy, you should avoid this product — allergic reactions to nattokinase have been reported and can include anaphylaxis in sensitive people.
Are there any other ingredients I should know about?
The capsule is vegetable cellulose, and the formula includes water and rice extract as fillers. Most of the active ingredients are enzymes that help break down different types of food, plus ionic trace minerals for mineral supplementation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natto LP is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natto LP label
Go deeper

The Full Monographs Behind Natto LP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Natto LP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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