Interactions on record — worth a quick check against your medications. Based on 9 of 22 ingredients. Check your meds →
Dietary supplement

Probiotic Ingredients & Drug Interactions

by Allegany Nutrition

Probiotic label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic is a dietary supplement by Allegany Nutrition with 22 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 308 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus bulgaricus (Lb-87), Lactobacillus acidophilus (La-14), Bifidobacterium breve (Bb-03). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Probiotic by Allegany Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic by Allegany Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Probiotic by Allegany Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 22 active ingredients.

This formula contains 22 ingredients, including 11 probiotic strains (live beneficial bacteria and yeast), digestive enzymes, and a prebiotic fiber. The probiotics are Lactobacillus bulgaricus, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus lactis, Bifidobacterium breve, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium animalis lactis, Streptococcus thermophilus, and Saccharomyces boulardii (a beneficial yeast).

The digestive enzymes—Protease, Cellulase, Hemicellulase, Amylase, Glucoamylase, and Invertase—help break down food. Frutafit (inulin) is a prebiotic that feeds beneficial bacteria in your gut.

The product also contains a trace mineral blend and inactive ingredients including a vegetarian capsule and rice extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and gut microbiome balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Crohn disease, Diarrhea, irritable bowel syndrome — and 3 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS).

Evidence for what this probiotic can do varies by strain and condition. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is possibly effective for IBS and respiratory tract infections. Saccharomyces boulardii is possibly effective for rotaviral diarrhea, traveler's diarrhea, antibiotic-associated diarrhea, necrotizing enterocolitis, Clostridioides difficile infection, and Helicobacter pylori.

Frutafit (inulin) is possibly effective for obesity, constipation, and diabetes. For many other conditions listed on the label—hay fever, asthma, cognitive decline—the evidence is insufficient to rate the product's benefit.

Talk with your doctor about whether this probiotic is right for your situation.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lactobacillus Delbrueckii Lactobacillus Acidophilus Bifidobacterium Breve Streptococcus Thermophilus Bifidobacterium Bifidum Bifidobacterium Longum Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotic strains and enzymes here are generally well tolerated in healthy adults and children. However, caution is advised for people who are very ill, critically ill, or have weakened immune systems, as live organisms in probiotics carry a rare but documented risk of infection (bacteremia or sepsis) in these vulnerable populations.

Gastrointestinal side effects—bloating, flatulence, gas, abdominal discomfort, and diarrhea—are the most common adverse effects, especially when first starting or at higher doses of the inulin component. Protease, found in the product, rarely causes allergic reactions and can trigger allergic rhinitis or asthma in people exposed to occupational dust.

For pregnancy, Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium longum, Streptococcus thermophilus, and Frutafit are rated possibly safe, though probiotic supplements in pregnancy are not well studied—check with your doctor before use. Protease is not recommended during pregnancy unless prescribed.

For breastfeeding, limited safety data exist for most strains; consult your healthcare provider before using this product if you're nursing.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lactobacillus Delbrueckii Lactobacillus Acidophilus Bifidobacterium Breve Streptococcus Thermophilus Bifidobacterium Bifidum Bifidobacterium Longum Saccharomyces Boulardii

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 9 matched ingredients can interact with medications — Saccharomyces Boulardii, Lactobacillus Acidophilus, Inulin, Bifidobacterium Breve, Bifidobacterium Bifidum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 308 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this probiotic, check with your doctor or pharmacist if you're on antibiotic drugs (Moderate severity). Antibiotics can kill the live organisms in this product and reduce how well it works, so you'll likely need to separate the timing.

Also double-check if you're taking antifungals or diabetes medications—antifungals may reduce the yeast component's effectiveness (Minor), and diabetes drugs may see a minor theoretical increase in low blood sugar risk (Minor) when combined with the inulin here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-strain probiotic with digestive enzymes and prebiotic fiber, possibly helpful for IBS, traveler's diarrhea, and antibiotic-associated diarrhea, depending on the strain. It's generally well tolerated in healthy people but should be avoided or used cautiously if you're critically ill or immunocompromised.

If you take antibiotics, diabetes drugs, or antifungals, talk with your doctor or pharmacist before starting—the timing of these together matters. Discuss this product with your own healthcare provider to see if it fits your health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 22 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic, straight from the product label.

Brand Allegany Nutrition
Barcode (UPC) 094922374134
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276049
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic by Allegany Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
094922374134
IngredientAmount% DV
Protease0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Lactobacillus bulgaricus (Lb-87)0 NP--
Amylase0 NP--
Glucoamylase0 NP--
Invertase0 NP--
Lactobacillus acidophilus (La-14)0 NP--
Lactobacillus casei (Lc-11)0 NP--
Lactobacillus rhamnosus (Lr-32)0 NP--
Lactobacillus salivarius (Ls-33)0 NP--
Bifidobacterium breve (Bb-03)0 NP--
Lactobacillus plantarum (Lp-115)0 NP--
Streptococcus thermophilus (St-21)0 NP--
Bifidobacterium bifidum (Bb-02)0 NP--
Bifidobacterium longum (Bl-05)0 NP--
Trace Mineral Blend10 mg--
Lactobacillus paracasei (LPC-37)0 NP--
Bifidobacterium animalis lactis (Bl-07)0 NP--
Saccharomyces boulardii (I-3799)0 NP--
Lactobacillus lactis (Ll-34)0 NP--
Frutafit400 mg--

Other ingredients: Vegetarian Capsule, Rice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take two capsules daily on an empty stomach or as recommended by your health practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: if you are under a physician's care or taking other medication, consult with your healthcare professional before using this product. Consult with your doctor if you are pregnant, lactating, nursing, or have an existing ulcer.

Caution: Do not use if tamper seal is broken or missing.

Keep out of reach of children.

Formula

This probiotic is formulated to provide 51 billion live cultures per serving at time of consumption up until the best by date if stored under recommended storage conditions.

14 probiotic strains with enzymes & FOS 51 billion live cultures per serving

The enzymes in this formula are derived from plant source.

Storage

This probiotic is formulated to provide 51 billion live cultures per serving at time of consumption up until the best by date if stored under recommended storage conditions. Store in a dry place at 73 degrees F or below. Storage and handling conditions may vary, and may affect the total amount of cultures delivered at consumption. Best if refrigerated but not necessary.

No refrigeration needed

Formulation

Delayed release capsules Survives stomach acid & bile

Wheat & gluten free Contains no GMO, soy, shellfish, eggs, dairy, tree nuts

Vegan & organic

Vegan & organic

GMP certified Made in USA

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Allegany Nutrition The Digestive Specialists

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic by Allegany Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic by Allegany Nutrition

These are the 22 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Cellulase

0 NP per serving

Hemicellulase

0 NP per serving

Lactobacillus bulgaricus (Lb-87)

Interacts with
182 drugs
0 NP per serving

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is g...

Lactobacillus bulgaricus (Lb-87) monograph & interactions

Amylase

0 NP per serving

Glucoamylase

0 NP per serving

Invertase

0 NP per serving

Lactobacillus acidophilus (La-14)

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus (La-14) monograph & interactions

Lactobacillus casei (Lc-11)

0 NP per serving

Lactobacillus rhamnosus (Lr-32)

0 NP per serving

Lactobacillus salivarius (Ls-33)

0 NP per serving

Bifidobacterium breve (Bb-03)

Interacts with
182 drugs
0 NP per serving

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies...

Bifidobacterium breve (Bb-03) monograph & interactions

Lactobacillus plantarum (Lp-115)

0 NP per serving

Streptococcus thermophilus (St-21)

No known
interactions
0 NP per serving

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally w...

Streptococcus thermophilus (St-21) monograph & interactions

Bifidobacterium bifidum (Bb-02)

Interacts with
182 drugs
0 NP per serving

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance....

Bifidobacterium bifidum (Bb-02) monograph & interactions

Bifidobacterium longum (Bl-05)

Interacts with
182 drugs
0 NP per serving

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most...

Bifidobacterium longum (Bl-05) monograph & interactions

Trace Mineral Blend

10 mg per serving Form: Zeolite

Lactobacillus paracasei (LPC-37)

0 NP per serving

Bifidobacterium animalis lactis (Bl-07)

0 NP per serving

Saccharomyces boulardii (I-3799)

Interacts with
40 drugs
0 NP per serving

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii (I-3799) monograph & interactions

Lactobacillus lactis (Ll-34)

0 NP per serving

Frutafit

Interacts with
86 drugs
400 mg per serving Form: Inulin

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Frutafit monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Rice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic by Allegany Nutrition Drug Interactions

Want to check YOUR meds against Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
308Drugs
182 Moderate 126 Minor

Ingredients driving the most interactions

Lactobacillus bulgaricus (Lb-87) 182
Lactobacillus acidophilus (La-14) 182
Bifidobacterium breve (Bb-03) 182
Bifidobacterium bifidum (Bb-02) 182
Bifidobacterium longum (Bl-05) 182

Individual Drug Interactions

The ingredients in Probiotic interact with 308 drugs. Click any drug to see the details.

7 of the 22 ingredients in Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus bulgaricus (Lb-87) Lactobacillus acidophilus (La-14) Bifidobacterium breve (Bb-03) Bifidobacterium bifidum (Bb-02) Bifidobacterium longum (Bl-05) Frutafit Saccharomyces boulardii (I-3799)

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus bulgaricus (Lb-87)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus bulgaricus (Lb-87) full monograph & interactions

Lactobacillus acidophilus (La-14)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (La-14) full monograph & interactions

Bifidobacterium breve (Bb-03)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve (Bb-03) full monograph & interactions

Bifidobacterium bifidum (Bb-02)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum (Bb-02) full monograph & interactions

Bifidobacterium longum (Bl-05)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum (Bl-05) full monograph & interactions

Frutafit1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Frutafit full monograph & interactions

Saccharomyces boulardii (I-3799)1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii (I-3799) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic, from the product label.

Allegany Nutrition

See all Allegany Nutrition products
Name
Allegany Nutrition
Street Address
P.O. Box 70
City
Allegany
State
NY
ZipCode
14706
Pharmacist Counseling Corner

Probiotic by Allegany Nutrition: Common Questions

Does Probiotic by Allegany Nutrition interact with any medications?
Yes. Based on its ingredients, Probiotic has a known interaction with 308 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic contains 22 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
You can, but timing matters. Because antibiotics kill bacteria and yeast, they'll reduce the number of live organisms you get from this product. Talk to your doctor or pharmacist about spacing them out—usually several hours apart is recommended—so the probiotic has a better chance of working.
Will this give me bloating or gas?
Yes, it may. Bloating, flatulence, and gas are the most common side effects, especially when you first start or if you take higher doses of the inulin (Frutafit) in this formula. These usually settle down as your gut adjusts, but start with a lower dose if you're sensitive.
Is this safe if I'm pregnant or breastfeeding?
Several of the probiotic strains here are rated possibly safe in pregnancy, and the inulin is likely safe, but probiotic supplements haven't been deeply studied in pregnancy or while breastfeeding. Talk with your doctor before you start—they can weigh the potential benefit against what's known about your specific strains.
Does this probiotic actually work for digestive problems?
Some strains here have decent evidence. Lactobacillus acidophilus, Bifidobacterium bifidum, and Saccharomyces boulardii are all possibly effective for IBS and antibiotic-associated diarrhea, and Saccharomyces boulardii is possibly effective for traveler's diarrhea. For other conditions on the label, like asthma or hay fever, evidence is too limited to say whether it helps.
What are the digestive enzymes in here for?
Protease, cellulase, hemicellulase, amylase, glucoamylase, and invertase are enzymes that help break down different parts of your food—proteins, fibers, and carbohydrates. They work alongside the probiotics to support digestion.
Is this product safe if I have a weakened immune system?
Caution is needed. Although these probiotics are generally well tolerated in healthy people, they carry a rare but real risk of infection (like bacteremia) in people who are very ill or immunocompromised. Talk with your doctor before using—they may advise against it or want to monitor you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic label
Go deeper

The Full Monographs Behind Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph → Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph →
Sources

Sources & How We Checked

Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 128 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactobacillus Delbrueckii 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
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  7. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
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  9. Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.

See these in context on the Lactobacillus Delbrueckii monograph →

Lactobacillus Acidophilus 15 references
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  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
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  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
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  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
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  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Breve 9 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
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  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Streptococcus Thermophilus 21 references
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  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
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  11. Dolatkhah N, Hajifaraji M, Abbasalizadeh F, Aghamohammadzadeh N, Mehrabi Y, Abbasi MM. Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial. J Health Popul Nutr. 2015;33:25. PubMed
  12. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  13. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
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  21. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Streptococcus Thermophilus monograph →

Bifidobacterium Bifidum 7 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
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  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
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See these in context on the Bifidobacterium Longum monograph →

Saccharomyces Boulardii 26 references
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  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
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  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
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See these in context on the Saccharomyces Boulardii monograph →

Inulin 17 references
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  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
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See these in context on the Inulin monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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