Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Natural Chlorophyll Ingredients & Drug Interactions

by Rugby

Natural Chlorophyll label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Chlorophyll against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Chlorophyll is a dietary supplement by Rugby with 2 active ingredients. Its ingredients are commonly taken for body and breath odor control, wound and skin care, internal deodorant for ostomy or incontinence.Based on those ingredients, 335 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorophyllin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Chlorophyll by Rugby

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Chlorophyll by Rugby — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Chlorophyll by Rugby

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients. Chlorophyllin is a semi-synthetic form of chlorophyll, the green pigment in plants, and is the main active component here.

The other ingredient is thymol, a compound derived from thyme. The tablet also contains several inactive ingredients — sorbitol, microcrystalline cellulose, stearic acid, magnesium stearate, and spearmint and peppermint flavorings — which help form and flavor the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Chlorophyllin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: breath and body odor control.
  • We looked for evidence on: Body odor, Fecal odor, Urinary odor, Halitosis, Oral malodor.
  • The closest evidence on file: Chlorophyllin is rated "Possibly Ineffective" for Urinary odor (Natural Medicines).
  • Also on file: Chlorophyllin is rated "Insufficient Reliable Evidence To Rate" for Body odor, Fecal odor.

The evidence for chlorophyllin's effectiveness is mixed. For urinary odor, the data suggests it's likely not effective.

For acne, cancer prevention, constipation, flatulence, and low white blood cell count (leukopenia), we don't have reliable evidence to rate how well it works. We hold no effectiveness data for thymol.

The evidence, ingredient by ingredient Chlorophyllin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chlorophyllin is generally well tolerated in the short term, but quality evidence and long-term safety data are limited. Because chlorophyll (the natural source) can cause photosensitivity — making your skin more prone to sun damage — and has been linked in case reports to pseudoporphyria (a blistering condition), caution is warranted, especially with prolonged use.

Topical chlorophyll cream has also been reported to cause dermatitis. The safety data advises against use during pregnancy and breastfeeding because there isn't enough reliable information to know it's safe.

Side effects, ingredient by ingredient Chlorophyllin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chlorophyllin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 335 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any photosensitizing drugs — medications that increase your skin's sensitivity to sunlight. Chlorophyllin may add to this effect.

We couldn't check the product's other ingredient (thymol) for interactions, so mention all your medications when you review this product with your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Natural Chlorophyll by Rugby might appeal to you if you're exploring traditional remedies, but the evidence for what it actually does is weak or unclear for most uses. If you take any medications — especially ones that make you sun-sensitive — check with your doctor or pharmacist before starting.

Pregnant people and those breastfeeding should avoid it. Have a conversation with your own healthcare provider about whether this fits your health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Chlorophyll, straight from the product label.

Brand Rugby
Barcode (UPC) 005363451018
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 200515
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Chlorophyll by Rugby, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
UPC/BARCODE
005363451018
IngredientAmount% DV
Chlorophyllin3 mg--
Thymol0.6 mg--

Other ingredients: Sorbitol, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Spearmint flavor, Peppermint flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

Compressed tablets

75

Precautions

Tamper resistant - Do not use if imprinted safety seal under cap is broken or missing

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: One or two tablets daily. Chew an additional tablet for quick freshening of breath after eating, excessive drinking or smoking.

Formulation

Free of starch, sugar, sodium, preservatives, yeast, corn, gluten, animal by-products, articial colors.

Storage

To preserve quality and freshness, keep bottle tightly closed. Store between 15(0)-30(0)C (59(0)-86(0)F).

General

Rev. 12/16 R-29 3988-12-16 Re-order No. 370146

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Chlorophyll by Rugby label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Chlorophyll label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Chlorophyll by Rugby

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chlorophyllin

Interacts with
335 drugs
3 mg per serving

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing....

Chlorophyllin monograph & interactions

Thymol

0.6 mg per serving

Other (inactive) ingredients: Sorbitol, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Spearmint flavor, Peppermint flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Chlorophyll by Rugby Drug Interactions

Want to check YOUR meds against Natural Chlorophyll?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
335Drugs
335 Moderate

Ingredients driving the most interactions

Chlorophyllin 335

Individual Drug Interactions

The ingredients in Natural Chlorophyll interact with 335 drugs. Click any drug to see the details.

1 of the 2 ingredients in Natural Chlorophyll interact with drugs. Each result below shows which ingredient is responsible. Chlorophyllin

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Chlorophyll with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Chlorophyllin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Chlorophyll, from the product label.

Rugby

See all Rugby products
Name
Rugby Laboratories
Street Address
17177 N Laurel Park Drive, Suite 233
City
Livonia
State
MI
ZipCode
48152
Phone Number
1-800-645-2158
Web Address
www.rugbylaboratories.com
Pharmacist Counseling Corner

Natural Chlorophyll by Rugby: Common Questions

Does Natural Chlorophyll by Rugby interact with any medications?
Yes. Based on its ingredients, Natural Chlorophyll has a known interaction with 335 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Chlorophyll contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually reduce urinary odor?
The data suggests it's likely not effective for that purpose. If odor control is your main reason for considering it, you may want to explore other options and talk it over with your doctor or pharmacist.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy because there isn't enough reliable information. Safety while breastfeeding is also unknown, so avoidance is the safer choice. Talk with your doctor or pharmacist about what's right for you.
What's chlorophyllin, and how is it different from regular chlorophyll?
Chlorophyllin is a semi-synthetic version — a lab-modified form — of chlorophyll, the green pigment that gives plants their color. It's made to be more stable and easier for your body to absorb than natural chlorophyll.
Are there any side effects I should know about?
The main concern is photosensitivity — your skin becoming more sensitive to sunlight, potentially causing blistering or rash. Case reports have also linked chlorophyll to a condition called pseudoporphyria (blistering on the hands). Long-term safety data is limited, so we don't have a complete picture of all possible effects.
Is this product safe long-term?
It's generally well tolerated in the short term, but quality evidence and long-term safety data are limited. If you're thinking about taking it regularly, discuss the duration and your individual health picture with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Chlorophyll label
Go deeper

The Full Monographs Behind Natural Chlorophyll’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph →
Sources

Sources & How We Checked

Natural Chlorophyll's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chlorophyllin 6 references
  1. Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
  2. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  3. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
  6. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

See these in context on the Chlorophyllin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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