Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Probiotic Formula Ingredients & Drug Interactions

by Rugby

Probiotic Formula label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Formula is a dietary supplement by Rugby with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus LA14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Formula by Rugby

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Formula by Rugby — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Formula by Rugby

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This probiotic contains five live bacterial strains: Lactobacillus plantarum Lp-115, Bifidobacterium lactis Bl-04, Lactobacillus acidophilus LA14, Lactobacillus salivarius, and Lactobacillus casei. These are meant to support your gut bacteria and digestion.

The capsule also contains inactive ingredients like cellulose and magnesium stearate, which help hold the formula together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and probiotic balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Rotaviral diarrhea.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence for acute respiratory distress syndrome is insufficient, and it appears possibly ineffective for atopic disease (allergic conditions).

We don't have effectiveness data on file for the other four live strains in this formula.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like bloating, gas, abdominal discomfort, or mild diarrhea can happen when taking it with other probiotics, but these are uncommon.

In rare cases, the live organisms have been linked to serious infections in patients with severely weakened immunity or in those with certain medical devices; most experts believe this happens when bacteria spread from where they naturally live in the body. Check with your doctor before starting this product, especially if you have a compromised immune system.

For pregnancy, the data suggest it's possibly safe, though information is limited — talk with your doctor or pharmacist for personalized guidance. We don't have pregnancy or breastfeeding safety data on file for the other four strains.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any antibiotic drugs you're taking before you add this probiotic — timing matters. Make sure your doctor or pharmacist reviews all your medications with the checker on this page, since we have limited data for most of the bacterial strains here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have IBS, antibiotic-associated diarrhea, or certain other gut issues, Lactobacillus acidophilus may help. The big thing to know is that antibiotics can wipe out the live cultures, so you'd need to time them separately.

Talk with your doctor or pharmacist before you start, especially if your immune system is weak or you're pregnant.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Formula, straight from the product label.

Brand Rugby
Barcode (UPC) 005363116078
Net contents 30 Mini Vege-Capsule(s)
Market status On market
Date entered into DSLD Dec 24, 2013
DSLD ID 28247
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Formula by Rugby, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Mini Vege-Capsule(s)
Maximum serving Sizes:
1 Mini Vege-Capsule(s)
UPC/BARCODE
005363116078
IngredientAmount% DV
Lactobacillus plantarum Lp-1152000000000 CFU--
Bifidobacterium lactis Bl-042000000000 CFU--
Lactobacillus acidophilus LA142000000000 CFU--
Lactobacillus salivarius2000000000 CFU--
Lactobacillus casei2000000000 CFU--

Other ingredients: Hypromellose, purified Water, low moisture microcrystalline cellulose, Silicon Dioxide, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of starch, sodium, preservatives, egg, fish, shellfish, tree nuts, peanuts, soy, artificial colors-flavors.

Precautions

CAUTION: Before using any probiotic supplement, pregnant or lactating women should consult a physician or healthcare professional.

TAMPER RESISTANT - DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING

KEEP OUT OF REACH OF CHILDREN

Storage

Keep bottle tightly closed. Store between 15(0)-30(0)C (59(0)-86(0)F).

FDA Statement of Identity

DIETARY SUPPLEMENT

General Statements

Guaranteed 10 Billion Viable cfu per Vege-capsule

Questions or comments? Call 1-800-645-2158, weekdays 9 am-5 pm ET www.rugbylaboratories.com

Seals/Symbols

Rugby(R) SATISFACTION GUARANTEED OR YOUR MONEY BACK

Suggested/Recommended/Usage/Directions

DIRECTIONS: Adults:Take 1 capsule once daily with a meal.

General

75 R0511

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Formula by Rugby label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Formula by Rugby

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Mini Vege-Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus plantarum Lp-115

2000000000 CFU per serving

Bifidobacterium lactis Bl-04

2000000000 CFU per serving

Lactobacillus acidophilus LA14

Interacts with
182 drugs
2000000000 CFU per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus LA14 monograph & interactions

Lactobacillus salivarius

2000000000 CFU per serving

Lactobacillus casei

2000000000 CFU per serving

Other (inactive) ingredients: Hypromellose, Purified Water, Low moisture microcrystalline cellulose, Silicon Dioxide, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Formula by Rugby Drug Interactions

Want to check YOUR meds against Probiotic Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus LA14 182

Individual Drug Interactions

The ingredients in Probiotic Formula interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in Probiotic Formula interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus LA14

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus LA141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus LA14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Formula, from the product label.

Rugby

See all Rugby products
Phone Number
1-800-645-2158
Pharmacist Counseling Corner

Probiotic Formula by Rugby: Common Questions

Does Probiotic Formula by Rugby interact with any medications?
Yes. Based on its ingredients, Probiotic Formula has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Formula contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Antibiotics can kill the live organisms in this formula, so they may reduce how well the probiotic works. Your best bet is to talk with your doctor or pharmacist about spacing out when you take them — you may need to take them at different times of day.
Is this probiotic safe if I'm pregnant?
Lactobacillus acidophilus is rated possibly safe in pregnancy, though the data are limited. The pregnancy safety of the other four strains isn't established in our records. Discuss this product with your doctor or pharmacist to decide what's right for you.
What side effects might I get from this?
Most people tolerate it well, but some experience mild gas, bloating, abdominal pain, or loose stool, especially when first starting. These are uncommon and usually mild.
What is this probiotic supposed to help with?
The Lactobacillus acidophilus in here is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis. We don't have effectiveness data on file for the other four strains.
Does this probiotic contain any fillers?
Yes — the formula includes inactive ingredients like cellulose, silicon dioxide, and magnesium stearate to make the capsule work properly. These are standard in most supplements.
Is there any risk if my immune system is weak?
In very rare cases, live Lactobacillus acidophilus organisms have been linked to serious infections in people with severely weakened immunity. If your immune system is compromised, check with your doctor before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Formula is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Formula label
Go deeper

The Full Monographs Behind Probiotic Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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