Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

NeuRx-TF Ingredients & Drug Interactions

by Clinical Therapeutic Solutions

NeuRx-TF label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NeuRx-TF against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NeuRx-TF is a dietary supplement by Clinical Therapeutic Solutions with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 467 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Alpha Lipoic Acid, Vitamin B6, Methyl B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NeuRx-TF by Clinical Therapeutic Solutions

Ask about any prescription or over-the-counter medication and we check it for interactions with NeuRx-TF by Clinical Therapeutic Solutions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NeuRx-TF by Clinical Therapeutic Solutions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NeuRx-TF contains 4 active ingredients. Vitamin B6 (pyridoxine) is a B vitamin involved in nerve function and amino acid metabolism—it's effective for sideroblastic anemia and vitamin B6 deficiency, and possibly helpful for pregnancy-related nausea and high homocysteine levels.

Benfotiamine is a fat-soluble form of thiamine (vitamin B1) that's possibly effective for diabetic nerve damage. Alpha-lipoic acid is an antioxidant possibly effective for diabetic nerve damage, cholesterol levels, and weight management.

Methyl B12 is an active form of vitamin B12, effective for B12 deficiency and certain neurological conditions. The product contains no inactive ingredients or fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: peripheral nerve health and nerve function support.
  • We looked for evidence on: Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Carpal tunnel syndrome, Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Peripheral neuropathy, Nerve damage — and 2 related terms.
  • The strongest evidence on file: Alpha-lipoic Acid is rated "Possibly Effective" for Diabetic neuropathy (Natural Medicines).
  • Also on file: Benfotiamine is rated "Possibly Effective" for Diabetic neuropathy.
  • Also on file: Vitamin B6 is rated "Possibly Ineffective" for Carpal tunnel syndrome.

The evidence for this product's ingredients is mixed. Vitamin B6 is effective for treating sideroblastic anemia and B6 deficiency itself, and possibly effective for pregnancy-related nausea and elevated homocysteine.

Alpha-lipoic acid is possibly effective for diabetic nerve damage, high cholesterol, and obesity. Methyl B12 is effective for B12 deficiency and certain rare conditions.

Benfotiamine is possibly effective for diabetic nerve damage, though evidence for other uses is insufficient. Overall, the strongest evidence supports using these ingredients if you have specific deficiencies or diabetic nerve pain, but results for other conditions are less established.

The evidence, ingredient by ingredient Vitamin B6 Benfotiamine Alpha-lipoic Acid Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses below 100 mg daily, with common side effects including headache, nausea, and heartburn. High doses over time can cause nerve damage (sensory neuropathy), especially at 1,000 mg daily or higher.

It is likely safe in pregnancy at normal doses and likely safe while breastfeeding. Alpha-lipoic acid is generally well tolerated and may cause headache, nausea, or heartburn; it can lower blood sugar and should be used under medical guidance.

It is not recommended in pregnancy or while breastfeeding due to insufficient safety data. Methyl B12 is very safe with no established upper limit, and is considered safe in pregnancy and breastfeeding at recommended amounts.

Benfotiamine is generally well tolerated, though long-term safety is not fully known, and safety in pregnancy and breastfeeding has not been well studied.

Side effects, ingredient by ingredient Vitamin B6 Benfotiamine Alpha-lipoic Acid Vitamin B12

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Alpha-lipoic Acid, Vitamin B12, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications; Parkinson's medications.
  • For scale: 467 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NeuRx-TF, check with your doctor or pharmacist if you take seizure medications (phenytoin, phenobarbital), blood thinners or antiplatelet drugs, thyroid hormone replacement, chemotherapy, diabetes medications, blood pressure drugs, the heart rhythm drug amiodarone, or Parkinson's disease medications. Altogether, these interactions span 467 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

NeuRx-TF may be worth considering if you have diabetic nerve pain, elevated homocysteine, or a documented B vitamin deficiency—talk with your doctor about whether these ingredients fit your situation. If you take seizure medications, blood thinners, thyroid hormone, or diabetes drugs, check with your doctor or pharmacist before starting, since interactions are documented.

Vitamin B6 at high doses can damage nerves over time, so stick to recommended amounts unless your provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NeuRx-TF, straight from the product label.

Brand Clinical Therapeutic Solutions
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 239388
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NeuRx-TF by Clinical Therapeutic Solutions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Not Present
Maximum serving Sizes:
1 Not Present
IngredientAmount% DV
Vitamin B635 mg--
Benfotiamine300 mg--
Alpha Lipoic Acid350 mg--
Methyl B122 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Total formulation for peripheral nerve health

Clinical Therapeutic Solutions NeuRx-TF Tablets for nerve function support NeuRx-TF tablets are ideal for nerve function support, as they combine powerful antioxidants that help protect nerve cells from oxidative damage related to aging and environmental stress.

Formula

With Alpha Lipoic Acid 350mg Benfotiamine 300mg Vitamin B6 (Pyridoxal 5 Phosphate) 35mg Vitamin B12 (Methylcobalamin) 2000mcg

As a dietary supplement, NeuRx-TF tablets may help maintain healthy blood sugar levels and are recommended for diabetic patients.

FDA Statement of Identity

Dietary Supplement

General Statements

Dispensed only by physicians

A part of bako's Integrated Physician Solution Professional

NeuRx-TF tablets offers a no-risk, unconditional, direct money-back guarantee from the manufacturer.

Suggested/Recommended/Usage/Directions

Dosing: As a dietary supplement, take 1 tablet twice daily or as directed by a physician.

Precautions

Do not exceed the Recommended Daily Allowance (RDA).

Warnings: Not intended for persons under the age of 18.

Do not use if pregnant or nursing. Consult a health care professional prior to consumption if you have any pre-existing medical conditions or are taking any prescription medication.

Improper use of this product will not improve results and is potentially hazardous to a person's health. Use only as directed.

Keep out of the reach of children.

Do not use this product without a doctor's advice if you are pregnant, think you are pregnant or breast-feeding.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NeuRx-TF by Clinical Therapeutic Solutions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NeuRx-TF label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NeuRx-TF by Clinical Therapeutic Solutions

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Not Present Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
35 mg per serving

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Benfotiamine

No known
interactions
300 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Alpha Lipoic Acid

Interacts with
263 drugs
350 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

Methyl B12

Interacts with
20 drugs
2 mg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Methyl B12 monograph & interactions
Interaction report

NeuRx-TF by Clinical Therapeutic Solutions Drug Interactions

Want to check YOUR meds against NeuRx-TF?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
467Drugs
376 Moderate 91 Minor

Ingredients driving the most interactions

Alpha Lipoic Acid 263
Vitamin B6 210
Methyl B12 20

Individual Drug Interactions

The ingredients in NeuRx-TF interact with 467 drugs. Click any drug to see the details.

3 of the 4 ingredients in NeuRx-TF interact with drugs. Each result below shows which ingredient is responsible. Alpha Lipoic Acid Vitamin B6 Methyl B12

Each ingredient & the kinds of drugs it affects

For each ingredient in NeuRx-TF with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Methyl B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Methyl B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NeuRx-TF, from the product label.

Clinical Therapeutic Solutions

See all Clinical Therapeutic Solutions products
Name
Clinical Therapeutic Solutions
Pharmacist Counseling Corner

NeuRx-TF by Clinical Therapeutic Solutions: Common Questions

Does NeuRx-TF by Clinical Therapeutic Solutions interact with any medications?
Yes. Based on its ingredients, NeuRx-TF has a known interaction with 467 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NeuRx-TF contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Vitamin B6 is likely safe in pregnancy at normal doses and is sometimes used under medical guidance for morning sickness. Methyl B12 is safe at recommended amounts. However, alpha-lipoic acid should be avoided in pregnancy due to insufficient safety data, and benfotiamine's safety in pregnancy hasn't been well studied. Talk with your doctor or pharmacist before taking this product during pregnancy.
Can I take this while breastfeeding?
Vitamin B6 and methyl B12 are considered safe while breastfeeding at recommended amounts. Alpha-lipoic acid and benfotiamine have not been well studied during breastfeeding, so caution is advised. Ask your doctor or pharmacist whether it's appropriate for you.
Is vitamin B6 in this product safe at high doses?
No. Vitamin B6 is well tolerated below 100 mg daily, but high doses over time—especially 1,000 mg daily or higher—can cause nerve damage. Stick to recommended amounts unless your doctor advises otherwise.
What does alpha-lipoic acid do?
Alpha-lipoic acid is an antioxidant possibly effective for diabetic nerve pain, high cholesterol, and weight management. It is generally well tolerated but can lower blood sugar, so it should be used under medical guidance if you take diabetes medications.
Does this product work for diabetic neuropathy?
Two of the ingredients—benfotiamine and alpha-lipoic acid—are possibly effective for diabetic nerve damage. The evidence is not conclusive, so results vary. Talk with your doctor about whether this product is right for your situation.
Are there any fillers or inactive ingredients?
No. This product contains only the four active ingredients listed and no other fillers or excipients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NeuRx-TF label
Go deeper

The Full Monographs Behind NeuRx-TF’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

NeuRx-TF's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 111 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Benfotiamine 1 reference
  1. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed

See these in context on the Benfotiamine monograph →

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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