Major interaction on record — check this product against your medications before combining. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Nitraflex Guava Dragonfruit Ingredients & Drug Interactions

by GAT Sport

Nitraflex Guava Dragonfruit label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nitraflex Guava Dragonfruit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Nitraflex Guava Dragonfruit is a dietary supplement by GAT Sport with 5 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 1,573 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Niacin, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nitraflex Guava Dragonfruit by GAT Sport

Ask about any prescription or over-the-counter medication and we check it for interactions with Nitraflex Guava Dragonfruit by GAT Sport — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Nitraflex Guava Dragonfruit by GAT Sport

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 13 active ingredients.
  • “Vasoactive Arginase-Regulating NO Precursor Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Clinically-Studied Testosterone-Enhancing Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “NitraFlex Proprieceutical Blend” is a proprietary blend — the label gives one combined amount (6,521 mg) without saying how much of each component you get.

Nitraflex contains 13 active ingredients. The most prominent are niacin (a B vitamin), L-citrulline (an amino acid that supports blood flow), L-tyrosine (another amino acid), beta-alanine (an amino acid for muscular endurance), caffeine anhydrous (a stimulant), L-theanine (promotes calm focus), resveratrol (a polyphenol antioxidant), sodium, boron citrate, dimethylaminoethanol bitartrate (deanol), and three proprietary blends listed as a vasodilation complex, a testosterone-enhancing complex, and an acute energy and neuromodulating complex.

Three additional ingredients in those blends—pterostilbene, rauwolfia vomitoria root extract, and nitrosigine—could not be checked for interactions. The product also contains inactive ingredients including malic acid, calcium silicate, silica, natural flavors, sodium bicarbonate, sucralose, acesulfame potassium, erythritol, and oligosaccharides.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Pre-workout energy focus and muscle pump.
  • We looked for evidence on: Athletic performance, Cognitive function, Fatigue, Exercise endurance, Mental alertness, Muscle blood flow.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.

For niacin, there is likely effective evidence it prevents pellagra, and possibly effective evidence for dyslipidemia related to HIV/AIDS and metabolic syndrome. L-citrulline is possibly effective for athletic performance but possibly ineffective for age-related muscle loss (sarcopenia); evidence is insufficient for cardiovascular benefits, heart failure, or diabetes.

L-tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory, but possibly ineffective for athletic performance. Beta-alanine is possibly effective for athletic and physical performance but has insufficient evidence for cognitive decline, lung disease, or menopausal symptoms.

Caffeine is likely effective for mental alertness and athletic performance, and effective for neonatal apnea and postoperative headache. L-theanine is possibly effective for cognitive function but has insufficient evidence for dementia or anxiety disorders.

Resveratrol is possibly effective for obesity and hay fever but possibly ineffective for heart disease and cholesterol. Boron is likely effective for boron deficiency and possibly effective for vaginal yeast infections and skin irritation from radiation, but possibly ineffective for athletic performance.

Deanol is likely ineffective for Alzheimer disease and tardive dyskinesia, with insufficient evidence for skin aging or ADHD. Evidence is not established in our data for pterostilbene, rauwolfia vomitoria root extract, or nitrosigine.

The evidence, ingredient by ingredient Niacin Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Niacin at high supplemental doses can cause flushing (reported in up to 70% of patients), gastrointestinal upset (nausea, vomiting, heartburn, diarrhea), and liver damage, especially with sustained-release formulas. The safety notes advise against high-dose niacin in pregnancy unless prescribed; normal dietary amounts and standard prenatal vitamins are fine.

Avoid high-dose supplements while breastfeeding unless a doctor directs it. L-citrulline and L-theanine are generally well tolerated but lack long-term safety data; pregnancy and breastfeeding safety is insufficient, so avoid supplemental doses unless a doctor advises otherwise.

Beta-alanine commonly causes harmless tingling and flushing of the scalp and face; avoid in pregnancy and breastfeeding. Caffeine in moderate amounts is typically well tolerated but can cause anxiety, insomnia, jitteriness, nausea, headache, and dependence; high doses are linked to rare stroke.

Pregnancy safety data suggests limiting intake and discussing safe limits with your doctor; small amounts pass into breast milk but moderate intake is usually acceptable. Resveratrol may cause diarrhea and digestive upset; avoid concentrated supplements in pregnancy and while breastfeeding.

Boron is generally safe below 20 mg daily but avoid supplements in pregnancy and breastfeeding. Deanol may cause constipation, diarrhea, nausea, vomiting, drowsiness, or insomnia, and doses above 1000 mg daily have been reported to cause mood changes in patients with psychiatric conditions; avoid in pregnancy and breastfeeding.

Sodium in excess raises blood pressure and strains the heart; the notes advise caution with supplemental sodium and mention one Possibly Unsafe rating for pregnancy.

Side effects, ingredient by ingredient Niacin Sodium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 8 of the 10 matched ingredients can interact with medications — Resveratrol, Deanol, Niacin, Caffeine, Tyrosine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,574 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use ephedrine (Major risk with caffeine), blood pressure medications, diabetes drugs, blood thinners or antiplatelet drugs, statins, gout medications, hepatotoxic drugs, barbiturates, antiseizure drugs (carbamazepine, phenobarbital), the antipsychotic clozapine, heartburn medications (cimetidine), certain antibiotics (quinolones), the blood vessel dilator dipyridamole, levodopa, thyroid hormones, sedating drugs, anticholinergic or cholinergic medications, corticosteroids, or lithium.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Nitraflex is a pre-workout supplement aimed at athletic performance, muscle endurance, focus, and blood flow. If you take any prescription medications—especially blood pressure drugs, diabetes medications, blood thinners, statins, barbiturates, antiseizure drugs, thyroid hormones, lithium, or psychiatric medications—check your exact drugs against the interaction tool before starting.

Caffeine-sensitive individuals and anyone with heart conditions, high blood pressure, or anxiety should be cautious. Talk to your pharmacist before using.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nitraflex Guava Dragonfruit, straight from the product label.

Brand GAT Sport
Barcode (UPC) 816170022564
Net contents 10.4 Ounce(s); 294 Gram(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 321515
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nitraflex Guava Dragonfruit by GAT Sport, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4.9 Gram(s)
Maximum serving Sizes:
9.8 Gram(s)
Servings per container
30
UPC/BARCODE
816170022564
IngredientAmount% DV
Calories5 Calorie(s)--
Niacin25 mg156%
L-Citrulline0 NP--
L-Tyrosine0 NP--
Beta-Alanine0 NP--
Caffeine Anhydrous0 NP--
L-Theanine0 NP--
Resveratrol0 NP--
Sodium85 mg4%
Boron Citrate200 mg--
Pterostilbene0 NP--
Dimethylaminoethanol Bitartrate0 NP--
Vasoactive Arginase-Regulating NO Precursor Complex0 NP--
Rauwolfia vomitoria Root Extract0 NP--
Clinically-Studied Testosterone-Enhancing Complex0 NP--
Nitrosigine0 NP--
NitraFlex Proprieceutical Blend6521 mg--
Acute Energy, Focus, Intensity, Neuromodulating, Endurance Complex0 NP--

Other ingredients: Malic Acid, Calcium Silicate, Silica, Natural Flavors, Sodium Bicarbonate, Sucralose, Acesulfame Potassium, Erythritol, Oligosaccharides, Natural Flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Do not exceed recommended daily dose

Do not exceed 1 scoop in a single 24-hour period. Do not take Nitraflex within 5 hours of bedtime.

Do not use if neck seal is broken or missing.

Warning: Do not take more than 1 scoop per serving

Contains 325mg Caffeine Anhydrous

Warning: Not for use by individuals under the age of 18.

Do not use if pregnant or nursing. Do not use if you have a medical condition or are taking any prescription medication. Do not use this product if you are using a monoamine oxidase (MAOI) or any other dietary supplement, prescription drug or any over-the-counter drug containing ephedrine, pseudoephedrine, phenylpropanolamine or other stimulant.

If you experience any other adverse reaction discontinue use immediately and consult a physician. Individuals who consume caffeine with this product or who are sensitive to caffeine may experience serious adverse health effects. Do not exceed recommended serving. Do not consume with alcohol or other stimulants. Do not use if you are prone to overheating or dehydration.

Discontinue at least 2 weeks prior to surgery.

Keep out of reach of children.

Do not take within 5 hours of bedtime.

(Do not take more than 1 scoop within 24 hours)

Warning: Consuming this product can expose you to chemicals including lead which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov

Formula

Nutraceutical Facts: Now with nitrosigine for even greater pumps! For nearly a decade, Nitraflex has been the name you trust when it comes to pre-workout formulas. And now, Nitraflex ups the ante by introducing Nitrosigine to the mix, and adding even more pure Citrulline to the formula.

Unique properties of some of the key compounds in nitraflex: Powered by Nitrosigine: This new formula boasts nitrosigine as it only source of arginine. Nitrosigine has been shown to inhibit the enzyme responsible for breaking down arginine, making it superior choice of arginine supplementation and a perfect synergistic partner to L-citrulline. Nitrosigine has scientifically validated that benefits last up to 6 hours after dosing. In addition to vasodilation (pump) and overall performance-enhancing benefits, Nitrosigine is clinically shown to increase mental focus, making it a truly well-rounded and multi-faceted addition to any effective pre-workout formula.

200mg of boron citrate in every dose of nitraflex. This trace mineral has been shown to lower estrogen, while raising free testosterone by 28.3% in as little as 7 days. Scientific references: 1. Romero MJ et al. Cardiovasc Drug Rev 2006; 24(3-4): 275. 2. Sureda A et al. Free Rad Res 2009; 43(9): 828. 3. Komorowski J, Perez Ojalvo S, Sylla S, Veledar E. Arginase inhibition by inositol-stabilized arginine silicate (ASI; Nitrosigine); a novel mechanism by which ASI enhances arginine bioavailability. Current Developments in Nutrition. 2018;2(11):P08-054. 4. Rood-Ojalvo S, Sandler D, Veledar E, Komorowsko J. The benefits of inositol-stabilized arginine silicate as a workout ingredient. JISSN. 2015;12(Suppl 1):P14. 5. Komorowski J, Perez Ojalvo S. A pharmacokinetic evaluation of the duration of effect of inositol-stabilized arginine silicate and arginine hydrochloride in healthy adult males. The FASEB Journal. 2016;30(Suppl 1):690.17. 6. Kalman D, Harvey PD, Perez Ojalvo S, Komorowski J. Randomized prospective double-blind studies to evaluated the cognitive effect of inositol-stabilized arginine silicate in healthy physically active adults. Nutrients. 2016;8(11):736. 7. Evans M, Zakaria N, Marzuk M, Perez Ojalvo S, Sylla S, Komorowski J. An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) in preventing the decline in cognitive function caused by strenuous exercise. JISSN. 2018;15(Suppl 1):A50. 8. J Trace Elem Med Biol. 2011 Jan;25(1):54-8. doi: 10.1016/j.jtemb.2010.10.001. Epub 2010 Dec 3.

Note: One serving contains 325 mg caffeine, 1000mg of nitrosigine, and a clinically researched dose of boron. Scientific references: 1. Romero MJ et al. Cardiovasc Drug Rev 2006; 24(3-4): 275. 2. Sureda A et al. Free Rad Res 2009; 43(9): 828. 3. Komorowski J, Perez Ojalvo S, Sylla S, Veledar E. Arginase inhibition by inositol-stabilized arginine silicate (ASI; Nitrosigine); a novel mechanism by which ASI enhances arginine bioavailability. Current Developments in Nutrition. 2018;2(11):P08-054. 4. Rood-Ojalvo S, Sandler D, Veledar E, Komorowsko J. The benefits of inositol-stabilized arginine silicate as a workout ingredient. JISSN. 2015;12(Suppl 1):P14. 5. Komorowski J, Perez Ojalvo S. A pharmacokinetic evaluation of the duration of effect of inositol-stabilized arginine silicate and arginine hydrochloride in healthy adult males. The FASEB Journal. 2016;30(Suppl 1):690.17. 6. Kalman D, Harvey PD, Perez Ojalvo S, Komorowski J. Randomized prospective double-blind studies to evaluated the cognitive effect of inositol-stabilized arginine silicate in healthy physically active adults. Nutrients. 2016;8(11):736. 7. Evans M, Zakaria N, Marzuk M, Perez Ojalvo S, Sylla S, Komorowski J. An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) in preventing the decline in cognitive function caused by strenuous exercise. JISSN. 2018;15(Suppl 1):A50. 8. J Trace Elem Med Biol. 2011 Jan;25(1):54-8. doi: 10.1016/j.jtemb.2010.10.001. Epub 2010 Dec 3.

Guava dragonfruit Naturally flavored

Now with: Nitrosigine Bonded arginine silicate 325mg caffeine Clinically tested boron

Formulation

This 1-2 punch greatly increases pumps beyond expectations. The volume has been turned up on the energy, focus, and flavor as well.

Lastly, there's no more artificial dyes in the formulas.

Physiological basis: "Reactive hyperemia" describes the increase in muscle blood flow that occurs during high-intensity resistance exercise and products the "pump" associated with increases in the muscle size. The Nitraflex pre-training formula contains ingredients that in animal, in vitro and clinical studies suggest possess properties that may help advanced athletes maximize energy, intensity, vascularity and reactive hyperemia (pumps) during their workouts, and provide long-term support of testosterone and Nitric Oxide level in the healthy range when used as directed. Scientific references: 1. Romero MJ et al. Cardiovasc Drug Rev 2006; 24(3-4): 275. 2. Sureda A et al. Free Rad Res 2009; 43(9): 828. 3. Komorowski J, Perez Ojalvo S, Sylla S, Veledar E. Arginase inhibition by inositol-stabilized arginine silicate (ASI; Nitrosigine); a novel mechanism by which ASI enhances arginine bioavailability. Current Developments in Nutrition. 2018;2(11):P08-054. 4. Rood-Ojalvo S, Sandler D, Veledar E, Komorowsko J. The benefits of inositol-stabilized arginine silicate as a workout ingredient. JISSN. 2015;12(Suppl 1):P14. 5. Komorowski J, Perez Ojalvo S. A pharmacokinetic evaluation of the duration of effect of inositol-stabilized arginine silicate and arginine hydrochloride in healthy adult males. The FASEB Journal. 2016;30(Suppl 1):690.17. 6. Kalman D, Harvey PD, Perez Ojalvo S, Komorowski J. Randomized prospective double-blind studies to evaluated the cognitive effect of inositol-stabilized arginine silicate in healthy physically active adults. Nutrients. 2016;8(11):736. 7. Evans M, Zakaria N, Marzuk M, Perez Ojalvo S, Sylla S, Komorowski J. An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) in preventing the decline in cognitive function caused by strenuous exercise. JISSN. 2018;15(Suppl 1):A50. 8. J Trace Elem Med Biol. 2011 Jan;25(1):54-8. doi: 10.1016/j.jtemb.2010.10.001. Epub 2010 Dec 3.

Cognitive enhancers: Nitraflex contains unique ratios of scientifically validated compounds that help you remain alert, intense and focused while you're flying from set to set with veins fully dilated and muscles pumped to extreme.

Scientifically advanced

Creatine-free

Hyperemia & testosterone enhancing powder Energy Focus Pump Strength 30 Pre-workout servings increased performance

3x strength Insane pumps Seething intensity

Vasodilation Testosterone Reactive Hyperemia (muscle pumps) Strength

General Statements

All in all, this is the strongest and best-tasting nitraflex yet!

Scan for authenticity Verify with your phone's QR app! Follow site directions Download latest QR reader app to your smart phone.

"I stand firmly behind our unconditional 30-day money-back guarantee on all our products. Stay Strong!" Charles Moser President & CEO Comments or questions? Toll-Free 1-888-811-4286 or 1-203-880-5800

Suggested/Recommended/Usage/Directions

1-scoop serving: Nitraflex is so potent, only 1 scoop (1 serving) is necessary.

After 8 weeks of use, take 1 week off before resuming use.

Recommended dosage Begin by assessing your tolerance with half a serving of Nitraflex mixed with 5oz of cold water. Consume within 30 minutes before working out. Depending on tolerance, mix 1 serving (1 scoop) of Nitraflex with 8-10oz cold water and consume within 30 minutes before working out.

Special time of use Before powerlifting meets Any type of weight training Anytime extreme energy/focus is needed

Storage

Store in a cool, dry place.

Contents are measured/sealed by weight, not volume

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Copyright 2020 GAT/World Health Products LLC. All world rights reserved. Nitraflex is a registered trademark of World Health Products LLC. The GAT logo and the stylized GAT Sport "Peak" symbol are trademarks or registered trademarks by region. Nitrosigine Bonded Arginine Silicate Nitrosigine including logo, is a registered trademark of Nutrition 21, LLC. Nitrosigine is patent protected.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in the United States with Domestic and Foreign Ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nitraflex Guava Dragonfruit by GAT Sport label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nitraflex Guava Dragonfruit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nitraflex Guava Dragonfruit by GAT Sport

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4.9 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Niacin

Interacts with
727 drugs
25 mg per serving

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Sodium

Interacts with
205 drugs
85 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

NitraFlex Proprieceutical Blend

6521 mg per serving
  • › Vasoactive Arginase-Regulating NO Precursor Complex
  • › Clinically-Studied Testosterone-Enhancing Complex
  • › Acute Energy, Focus, Intensity, Neuromodulating, Endurance Complex

Other (inactive) ingredients: Malic Acid, Calcium Silicate, Silica, Natural Flavors, Sodium Bicarbonate, Sucralose, Acesulfame Potassium, Erythritol, Oligosaccharides, Natural Flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nitraflex Guava Dragonfruit by GAT Sport Drug Interactions

Want to check YOUR meds against Nitraflex Guava Dragonfruit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,573Drugs
8 Major 1,348 Moderate 217 Minor

Ingredients driving the most interactions

Niacin 727
Sodium 205

Individual Drug Interactions

The ingredients in Nitraflex Guava Dragonfruit interact with 1,573 drugs. Click any drug to see the details.

2 of the 5 ingredients in Nitraflex Guava Dragonfruit interact with drugs. Each result below shows which ingredient is responsible. Niacin Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Nitraflex Guava Dragonfruit with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nitraflex Guava Dragonfruit, from the product label.

GAT Sport

See all GAT Sport products
Name
GAT Sport
Street Address
578 Pepper Street
City
Monroe
State
CT
ZipCode
06468
Phone Number
1-888-811-4286
Pharmacist Counseling Corner

Nitraflex Guava Dragonfruit by GAT Sport: Common Questions

Does Nitraflex Guava Dragonfruit by GAT Sport interact with any medications?
Yes. Based on its ingredients, Nitraflex Guava Dragonfruit has a known interaction with 1,573 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nitraflex Guava Dragonfruit contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Pregnancy and breastfeeding safety varies by ingredient. Niacin at normal dietary amounts is fine in pregnancy, but avoid high-dose supplements unless prescribed; safety data is insufficient for L-citrulline, L-tyrosine, beta-alanine, L-theanine, resveratrol, deanol, and boron in pregnancy, so avoid supplemental doses. Caffeine should be limited in pregnancy—ask your doctor about safe limits. Avoid boron, beta-alanine, and resveratrol supplements while breastfeeding. Talk to your doctor or pharmacist for personalized guidance on whether this product is right for you.
What does caffeine anhydrous do in this product?
Caffeine anhydrous is a stimulant that boosts mental alertness and athletic performance. It can improve focus and endurance during workouts, but it carries the risk of anxiety, insomnia, jitteriness, and nausea, especially in sensitive individuals or at high doses.
Why is there niacin in a pre-workout?
Niacin is a B vitamin that supports energy metabolism and blood flow. At high supplemental doses it can cause flushing (a sudden warming and redness of the face and body), but this is harmless and usually decreases with continued use.
Will this product help with athletic performance?
Several ingredients have possibly effective evidence for athletic or physical performance: L-citrulline, beta-alanine, and caffeine. Beta-alanine is possibly effective for physical performance and endurance, while L-citrulline may support blood flow and athletic output, and caffeine is likely effective for alertness and performance. Results vary by individual.
What's the tingling feeling some people report with pre-workouts?
That's beta-alanine, an amino acid in this product that commonly causes paresthesia — a dose-dependent feeling of pins and needles, especially on the scalp and face. It typically starts within 20 minutes and lasts about an hour. It's harmless and often decreases with continued use.
Are there any ingredients you couldn't check for drug interactions?
Yes. We hold no interaction data for pterostilbene, rauwolfia vomitoria root extract, or nitrosigine. That doesn't mean they're unsafe, but if you take medications, mention those names to your pharmacist when you ask about this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nitraflex Guava Dragonfruit label
Go deeper

The Full Monographs Behind Nitraflex Guava Dragonfruit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Nitraflex Guava Dragonfruit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 416 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Niacin 66 references
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  8. Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol 1998;82:74-81;disc. 85U-6U. PubMed
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  18. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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  39. Drinka PJ. Alterations in thyroid and hepatic function tests associated with preparations of sustained-release niacin. Mayo Clin Proc. 1992;67(12):1206. PubMed
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  41. Etchason JA, Miller TD, Squires RW, et al. Niacin-induced hepatitis: a potential side effect with low-dose time-release niacin. Mayo Clin Proc. 1991;66(1):23-8. PubMed
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  44. Brown BG, Bardsley J, Poulin D, et al. Moderate dose, three-drug therapy with niacin, lovastatin, and colestipol to reduce low-density lipoprotein cholesterol <100 mg/dl in patients with hyperlipidemia and coronary artery disease. Am J Cardiol. 1997;80(2)
  45. Goldberg A, Alagona P Jr, Capuzzi DM, et al. Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia. Am J Cardiol. 2000;85(9):1100-5. PubMed
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  47. Morgan JM, Capuzzi DM, Guyton JR, et al. Treatment Effect of Niaspan, a Controlled-release Niacin, in Patients With Hypercholesterolemia: A Placebo-controlled Trial. J Cardiovasc Pharmacol Ther. 1996;1(3):195-202. PubMed
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  51. Gharavi AG, Diamond JA, Smith DA, Phillips RA. Niacin-induced myopathy. Am J Cardiol. 1994;74(8):841-2. PubMed
  52. Litin SC, Anderson CF. Nicotinic acid-associated myopathy: a report of three cases. Am J Med. 1989;86(4):481-3. PubMed
  53. Fraunfelder FW, Fraunfelder FT, Illingworth DR. Adverse ocular effects associated with niacin therapy. Br J Ophthalmol 1995;79:54-56. PubMed
  54. Ali EH, McJunkin B, Jubelirer S, Hood W. Niacin induced coagulopathy as a manifestation of occult liver injury. W V Med J. 2013 Jan-Feb;109(1):12-4
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  56. Bassan M. A case for immediate-release niacin. Heart Lung. 2012 Jan-Feb;41(1):95-8. PubMed
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  59. Loebl T, Raskin S. A novel case report: acute manic psychotic episode after treatment with niacin. J Neuropsychiatry Clin Neurosci. 2013 Fall;25(4):E14. PubMed
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  61. Goldie C, Taylor AJ, Nguyen P, McCoy C, Zhao XQ, Preiss D. Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomized controlled trials. Heart. 2016 Feb;102(3):198-203.
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See these in context on the Niacin monograph →

L-citrulline 8 references
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See these in context on the L-citrulline monograph →

Tyrosine 4 references
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See these in context on the Tyrosine monograph →

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
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  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

Caffeine 236 references
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See these in context on the Sodium monograph →

Boron 6 references
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See these in context on the Boron monograph →

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
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See these in context on the Deanol monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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