Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

NO Max Ingredients & Drug Interactions

by HoltraCeuticals

NO Max label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NO Max against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

NO Max is a dietary supplement by HoltraCeuticals with 2 active ingredients. Its ingredients are commonly taken for muscle building and recovery, increasing daily protein intake, weight management.Based on those ingredients, 53 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are ACTINOS2(TM) Whey Peptide Fraction. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against NO Max by HoltraCeuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with NO Max by HoltraCeuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of NO Max by HoltraCeuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NO Max contains 2 active ingredients: arginine alpha-ketoglutarate and a whey protein ingredient called ACTINOS2(TM) Whey Peptide Fraction. Whey protein is a concentrated form of the protein found in milk; it's used in supplements for athletic performance support and bone health.

The product also includes inactive ingredients—dicalcium phosphate, cellulose compounds, pectin, seaweed extract, corn extract, and magnesium stearate—which serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Whey Protein's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: maintain healthy blood pressure and cardiovascular health.
  • We looked for evidence on: Hypertension, Endothelial function, Arterial stiffness, Cardiovascular disease.
  • The closest evidence on file: Whey Protein is rated "Insufficient Reliable Evidence To Rate" for Hypertension (Natural Medicines).

Whey protein in this product is rated possibly effective for athletic performance. For bone health in osteoporosis, for lung function in COPD, for memory as you age, and for weight support in HIV-related illness, the evidence we hold is either possibly ineffective or too limited to rate.

If you're considering NO Max for one of those other reasons, talk with your doctor about whether the supporting evidence is there.

The evidence, ingredient by ingredient Whey Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Whey protein is generally well tolerated by most healthy adults when taken as directed. The most common side effects are dose-related and include bloating, cramps, diarrhea, nausea, headache, fatigue, reflux, acne, reduced appetite, and thirst.

Acne is notable: multiple reports link whey protein supplements to new acne or worsening of existing acne, particularly in teens and young adults, and it often clears when the supplement is stopped. Because concentrated whey supplements aren't as well studied as whey as a food, check with your doctor before starting high-dose products like this one.

Side effects, ingredient by ingredient Whey Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Whey Protein.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 53 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NO Max, double-check if you take levodopa for Parkinson's disease (Major severity—whey can worsen symptom control). Also flag any quinolone antibiotics, tetracycline antibiotics, or bisphosphonates you're on (all Moderate severity—whey reduces absorption).

Your doctor or pharmacist can help you space doses safely.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

NO Max might work for you if you're an athlete looking for protein support and you don't take levodopa or antibiotics. Because whey protein can interfere with how several medications are absorbed, check your exact prescriptions with your doctor or pharmacist before you start.

If you develop acne after taking it, that's a known possible side effect—talk it over with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NO Max, straight from the product label.

Brand HoltraCeuticals
Barcode (UPC) 871149006082
Net contents 180 Caplet(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19814
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NO Max by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Caplet(s)
Maximum serving Sizes:
3 Caplet(s)
Servings per container
60
UPC/BARCODE
871149006082
IngredientAmount% DV
Arginine alpha-ketoglutarate1980 mg--
ACTINOS2(TM) Whey Peptide Fraction150 mg--

Other ingredients: Dicalcium Phosphate, cellulose ethers and composites, pectin, Seaweed extract, corn extract, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

{recycle}

Suggested/Recommended/Usage/Directions

Directions: Take three caplets twice per day: 3 caplets 30 minutes before breakfast and 3 caplets again 30 minutes before lunch with 8 ounces of water.

General Statements

By providing vasodilation throughout the day, NO Max helps maintain healthy blood pressure already in the normal range, promotes healthy arterial walls, and aids in overall cardiovascular health.*

Extended-Release Arginine Alpha-Ketoglutarate

ACTINOS2 is a trademark of Glanbia plc. This package is completely recyclable

HOLTORF MEDICAL GROUP, INC. CENTER FOR HORMONE IMBALANCE, HYPOTHYROIDISM AND FATIGUE

Protected by U.S. Patent # 6,905,707

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORAGE:

Store at 59-86(0)F (15-30(0)C). Protect from light and moisture.

Precautions

Keep out of the reach of children.

Do not use if seal is broken.

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, including high blood pressure and a history of cold sores, are taking prescription drugs, or have allergies to Arginine, corn, or citrus fruit.

Do not use if you are pregnant or lactating.

Not intended for use by individuals under the age of 18 years.

Do not exceed the recommended intake.

Formulation

FREE OF: Wheat, soy, dairy, egg, fish/shellfish, or nuts/tree nuts.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

UP-REGULATED WITH: ACTINOS2(TM) NOS-Enhancing Peptide Fraction

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NO Max by HoltraCeuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NO Max label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NO Max by HoltraCeuticals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Arginine alpha-ketoglutarate

1980 mg per serving

ACTINOS2(TM) Whey Peptide Fraction

Interacts with
53 drugs
150 mg per serving

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

ACTINOS2(TM) Whey Peptide Fraction monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Cellulose ethers and composites, Pectin, Seaweed extract, Corn extract, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

NO Max by HoltraCeuticals Drug Interactions

Want to check YOUR meds against NO Max?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
53Drugs
5 Major 48 Moderate

Ingredients driving the most interactions

ACTINOS2(TM) Whey Peptide Fraction 53

Individual Drug Interactions

The ingredients in NO Max interact with 53 drugs. Click any drug to see the details.

1 of the 2 ingredients in NO Max interact with drugs. Each result below shows which ingredient is responsible. ACTINOS2(TM) Whey Peptide Fraction

Each ingredient & the kinds of drugs it affects

For each ingredient in NO Max with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ACTINOS2(TM) Whey Peptide Fraction4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
ACTINOS2(TM) Whey Peptide Fraction full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NO Max, from the product label.

HoltraCeuticals

See all HoltraCeuticals products
Name
Kent Holtorf, M.D., & the Holtorf Medical Group., Inc
City
Torrance
State
CA
Pharmacist Counseling Corner

NO Max by HoltraCeuticals: Common Questions

Does NO Max by HoltraCeuticals interact with any medications?
Yes. Based on its ingredients, NO Max has a known interaction with 53 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NO Max contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any fillers?
Yes. NO Max contains dicalcium phosphate, cellulose compounds, pectin, seaweed extract, corn extract, and magnesium stearate as inactive ingredients that help form and stabilize the product.
Can I take this if I'm pregnant or breastfeeding?
The product facts we hold don't include safety data for pregnancy or lactation. Talk with your doctor or pharmacist—they can give you personalized advice based on your situation.
Will this help me build muscle?
Whey protein is rated possibly effective for athletic performance. If muscle building is your goal, whey protein as part of a training program may help, but the evidence isn't definitive for all uses.
What's arginine alpha-ketoglutarate in this product for?
We don't hold details on that ingredient's intended use or benefits in the product facts. You could ask the manufacturer or check with your pharmacist for more specifics.
If I get acne from taking this, will it go away if I stop?
Yes—multiple case reports show that acne triggered or worsened by whey protein supplements typically clears when you stop taking it. People who weren't responding to acne treatments while on whey often started responding after they quit.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NO Max is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NO Max label
Go deeper

The Full Monographs Behind NO Max’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph →
Sources

Sources & How We Checked

NO Max's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Whey Protein 25 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  3. Bell SJ. Whey protein concentrates with and without immunoglobulins: a review. J Med Food 2000;3:1-13. PubMed
  4. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  5. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  6. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  7. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  8. Semla TP, Beizer JL, Higbee MD. Geriatric Dosage Handbook. 4th ed. Hudson, OH: Lexicomp, 1998.
  9. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  10. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  11. Micke, P., Beeh, K. M., and Buhl, R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur.J Nutr 2002;41(1):12-18. PubMed
  12. Chitapanarux, T., Tienboon, P., Pojchamarnwiputh, S., and Leelarungrayub, D. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients. J Gastroenterol.Hepatol. 2009;24(6):1045-1050. PubMed
  13. Sataloff, R. T., Bittermann, T., Marks, L., Lurie, D., and Hawkshaw, M. The effects of glutathione enhancement on sensorineural hearing loss. Ear Nose Throat J 2010;89(9):422-433.
  14. Zhu, K., Meng, X., Kerr, D. A., Devine, A., Solah, V., Binns, C. W., and Prince, R. L. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal
  15. Bjorkman, M. P., Pilvi, T. K., Kekkonen, R. A., Korpela, R., and Tilvis, R. S. Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. J Nutr Health A
  16. Brun, A. C., Stordal, K., Johannesdottir, G. B., Bentsen, B. S., and Medhus, A. W. The effect of protein composition in liquid meals on gastric emptying rate in children with cerebral palsy. Clin.Nutr 2012;31(1):108-112. PubMed
  17. Gouni-Berthold, I., Schulte, D. M., Krone, W., Lapointe, J. F., Lemieux, P., Predel, H. G., and Berthold, H. K. The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised plac
  18. Errichiello, L., Pezzella, M., Santulli, L., Striano, S., Zara, F., Minetti, C., Mainardi, P., and Striano, P. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. Mov Disord. 2011;26(14):2573-2575. PubMed
  19. Carcillo, J. A., Dean, J. M., Holubkov, R., Berger, J., Meert, K. L., Anand, K. J., Zimmerman, J., Newth, C. J., Harrison, R., Burr, J., Willson, D. F., and Nicholson, C. The randomized comparative pediatric critical illness stress-induced immune suppres
  20. Chungchunlam, S. M., Moughan, P. J., Henare, S. J., and Ganesh, S. Effect of time of consumption of preloads on measures of satiety in healthy normal weight women. Appetite 2012;59(2):281-288. PubMed
  21. Rencuzogullari I, Börekçi A, Karakoyun S, et al. Coronary thrombosis in three coronary arteries due to whey protein. Am J Emerg Med. 2017;35(4):664.e3-664.e4. PubMed
  22. Silverberg NB. Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes. Case Reports Cutis. 2012;90(2):70-2.
  23. Simonart T. Acne and whey protein supplementation among bodybuilders. Dermatology. 2012;225(3):256-8. PubMed
  24. Pontes TC, Costa Fernandes Filho GM, Pereira Trindade AS, Sobral Filho JF. Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of João Pessoa-PB. An Bras Dermatol. 2013;88(6):907-12.
  25. Adebamowo CA, Spiegelman D, Berkey CS, et al. Milk consumption and acne in teenaged boys. J Am Acad Dermatol. 2008 May;58(5):787-93. PubMed

See these in context on the Whey Protein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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