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Dietary supplement

Nucleotide Complex 500 Ingredients & Drug Interactions

by Bluebonnet

Nucleotide Complex 500 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nucleotide Complex 500 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Nucleotide Complex 500 is a dietary supplement by Bluebonnet with 1 active ingredient.Based on those ingredients, 47 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nucleotide Complex 500 by Bluebonnet

Ask about any prescription or over-the-counter medication and we check it for interactions with Nucleotide Complex 500 by Bluebonnet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nucleotide Complex 500 by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Nucleotides” is listed as a grouped ingredient — the label gives one combined amount (240 mg) without saying how much of each component you get.
  • “Nucleotide Complex” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

Nucleotide Complex 500 contains 4 active ingredients: a nucleotide blend, a nucleotide complex, adenosine, and cytidine. Nucleotides are the building blocks your cells use to make and repair DNA and RNA.

Adenosine is a chemical messenger your body produces naturally; in supplement form it's been studied for heart rhythm and cardiovascular diagnostic purposes. Cytidine (also called citicoline) is involved in brain cell structure and signaling.

The capsule itself is made from vegetable material, with vegetable magnesium stearate as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: nucleotides for RNA DNA and ATP energy.
  • We looked for evidence on: Athletic performance, Cellular energy production, DNA/RNA synthesis, Mitochondrial function.
  • The closest evidence on file: Adenosine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

Adenosine in this product has been studied for paroxysmal supraventricular tachycardia — a type of fast heart rhythm — and for cardiovascular disease diagnosis, where it's been rated effective. Cytidine shows possibly effective evidence for age-related cognitive decline and glaucoma, but the evidence for stroke is possibly ineffective, and there isn't enough data to rate it for Alzheimer disease, traumatic brain injury, or cardiac arrest.

The evidence we hold doesn't establish effectiveness for the other nucleotide components.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Adenosine given by IV in a medical setting is powerful and carries cardiovascular and respiratory risks — chest pain, dizziness, shortness of breath, flushing, and headache are common; serious effects like arrhythmias and cardiac arrest, though rare, have occurred. As an oral supplement, adenosine hasn't had thorough safety evaluation, so caution is warranted and it's best avoided.

Cytidine is generally well tolerated in studies, but long-term safety data is limited. For pregnancy: there isn't enough data to know whether adenosine is safe, so avoid it.

Cytidine also lacks safety data in pregnancy and should be avoided. Neither should be used while breastfeeding due to insufficient safety information.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Adenosine.
  • The most serious interaction on file is rated Major.
  • For scale: 47 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on dipyridamole (Persantine) for heart conditions, stop and talk to your doctor before this product — the interaction is serious and requires medical supervision. Carbamazepine (Tegretol) users should also clear it first because of heart block risk.

And if you take any methylxanthines — caffeine pills, aminophylline, or theophylline for asthma — avoid them for at least 24 hours before taking this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is designed around adenosine, which has real interactions with certain heart and seizure medications and with caffeine-like compounds. Because the adenosine content here is not given by IV like the prescription form, the safety profile is less established — but if you take dipyridamole, carbamazepine, or methylxanthine drugs, you need to talk with your own doctor or pharmacist before starting.

Pregnant or breastfeeding? The safety data isn't there, so check with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nucleotide Complex 500, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715012622
Net contents 30 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2018
DSLD ID 179326
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nucleotide Complex 500 by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
743715012622
IngredientAmount% DV
Nucleotides240 mg--
Nucleotide Complex500 mg--
Adenosine60 mg--
Cytidine50 mg--
Guanosine80 mg--
Uridine50 mg--

Other ingredients: Kosher Vegetable Capsules, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily or as directed by a healthcare practitioner.

Formula

Bluebonnet’s Nucleotide Complex 500 mg Capsules contain a complete array of nucleotides, including adenosine, cytidine, guanosine and uridine, which are the necessary basic building blocks of RNA, DNA and ATP - the energy molecule. This nucleotide complex is carefully derived from torula yeast.

Bluebonnet’s KOF-K Certification #K-0000700

RNA / DNA

General Statements

Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.

General

1262B

Seals/Symbols

Made with non GMO ingredients

Vegan K Parve Gluten free

Formulation

Made with non GMO ingredients

Vegan

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of corn, gluten, barley, rice and sugar.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nucleotide Complex 500 by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nucleotide Complex 500 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nucleotide Complex 500 by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Nucleotide Complex

500 mg per serving
  • › Nucleotides

Other (inactive) ingredients: Kosher Vegetable Capsules, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nucleotide Complex 500 by Bluebonnet Drug Interactions

Want to check YOUR meds against Nucleotide Complex 500?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
47Drugs
2 Major 1 Moderate 44 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Nucleotide Complex 500 interact with 47 drugs. Click any drug to see the details.

0 of the 1 ingredient in Nucleotide Complex 500 interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Nucleotide Complex 500 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Nucleotide Complex 500, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

Nucleotide Complex 500 by Bluebonnet: Common Questions

Does Nucleotide Complex 500 by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Nucleotide Complex 500 has a known interaction with 47 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nucleotide Complex 500 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is adenosine in supplement form as strong as the IV version?
No. The prescription IV form is powerful and must be given only in a medical setting. Oral adenosine hasn't been as thoroughly studied for safety or side effects, so the risks are different — but that also means we know less about it overall.
What is cytidine and why is it in here?
Cytidine (also called citicoline) is involved in building and maintaining brain cell membranes and signaling. It's been studied for age-related memory loss and glaucoma with some possibly effective evidence, though the data for other brain and heart conditions isn't strong enough yet.
Can I take this while pregnant or breastfeeding?
The facts show there isn't enough safety data for either adenosine or cytidine in pregnancy or while breastfeeding, so it's best avoided until you've talked with your doctor or pharmacist. They can weigh the benefits and risks for your situation.
Can I drink coffee or take caffeine while using this?
You should avoid caffeine and other methylxanthines for at least 24 hours before taking this supplement, because they block the effects of adenosine. After that, the interaction risk drops, but timing matters.
Are there any common side effects I should expect?
Cytidine is generally well tolerated, though some people report headache, insomnia, nausea, constipation, or diarrhea. For adenosine as an oral supplement, thorough safety data hasn't been collected, so we can't say what's common — but that's why caution is advised.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nucleotide Complex 500 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nucleotide Complex 500 label
Sources

Sources & How We Checked

Nucleotide Complex 500's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Adenosine 10 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

See these in context on the Adenosine monograph →

Citicoline 11 references
  1. Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
  2. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
  3. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
  4. Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
  5. Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
  6. Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
  7. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  8. Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
  9. Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
  10. Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
  11. Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed

See these in context on the Citicoline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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