Octacosanol 30% Polycosanol 99% Ingredients & Drug Interactions
by PureBulk.com
What is this page for?
First and foremost: checking Octacosanol 30% Polycosanol 99% against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Octacosanol 30% Polycosanol 99% is a dietary supplement by PureBulk.com with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart and blood vessel health, leg pain from poor circulation (intermittent claudication).Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polycosanol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Octacosanol 30% Polycosanol 99% by PureBulk.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Octacosanol 30% Polycosanol 99% by PureBulk.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Octacosanol 30% Polycosanol 99% by PureBulk.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This powder contains 3 active ingredients: hexacosanol, octacosanol, and triacontanol — all long-chain fatty alcohols that together make up the polycosanol blend. Octacosanol is the main component.
There are no inactive ingredients listed.
Does it work?
Strong evidence
Hexacosanol and triacontanol show likely effectiveness for intermittent claudication (leg pain on walking), but the evidence for coronary heart disease and familial high cholesterol is insufficient to rate. Octacosanol's effectiveness hasn't been established in our data for the conditions it's studied in — athletic performance, high cholesterol, Lou Gehrig's disease, and Parkinson disease all have insufficient evidence.
How safe is it?
Well-documented data
These ingredients are generally well tolerated in studied amounts, though long-term safety data are limited and real-world benefit is uncertain. Common side effects reported in trials include headache, dizziness, drowsiness, irritability, and insomnia — but a small number of study participants experienced these.
Weight loss has also been reported, though post-market data show it's uncommon. During pregnancy, there's not enough safety information, so it's best to avoid use.
The same applies to breastfeeding. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding before taking this product.
Meds to double-check
Moderate interaction found
Before you take this product, double-check with your doctor or pharmacist if you're on beta-blockers or propranolol (blood pressure medications), blood thinners or antiplatelet drugs like warfarin or aspirin, diabetes medications, levodopa/carbidopa for Parkinson disease, or nitroprusside. All of these have documented moderate-severity interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with leg pain from intermittent claudication, though evidence for other uses isn't established. It does interact with blood pressure drugs, blood thinners, diabetes medications, and Parkinson medications, so if you take any of those, check with your doctor or pharmacist first.
Avoid it during pregnancy and breastfeeding unless advised otherwise by your healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Octacosanol 30% Polycosanol 99%, straight from the product label.
| Brand | PureBulk.com |
|---|---|
| Net contents | 10 Gram(s); 0.35 oz. |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2013 |
| DSLD ID | 23197 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Octacosanol 30% Polycosanol 99% by PureBulk.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Hexacosanol | 1.3 mg | -- |
| Octacosanol | 3 mg | -- |
| Triacontanol | 4 mg | -- |
| Polycosanol | 10 mg | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Derived from sugar cane wax
Precautions
WARNING: Those taking antiocoagulants should use caution.
Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.
Consult your physician before use.
Keep out of reach of children.
Storage
Storage: Keep dry, cool & dark
Formulation
Free of: sugar, soy, dairy, yeast, gluten, corn and additives.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 10 mg once or twice daily (or as directed by physician). Because you only need a small amount of this product, use a milligram scale to measure accurately.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Octacosanol 30% Polycosanol 99% by PureBulk.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Octacosanol 30% Polycosanol 99% by PureBulk.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size10 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.
Polycosanol
Interacts with242 drugs
Policosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to low...
Polycosanol monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Octacosanol 30% Polycosanol 99% by PureBulk.com Drug Interactions
HelloPharmacist Interaction Report
Octacosanol 30% Polycosanol 99% by PureBulk.com does interact with medications through its hexacosanol, octacosanol, and triacontanol content.
The most serious concern is moderate-severity interactions with blood pressure medications. Beta-blockers (including propranolol) may cause too much of a blood pressure drop when combined with this product, since both work to lower blood pressure.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to be careful with blood thinners and antiplatelet drugs — aspirin, warfarin, and similar medications. This product may theoretically increase bleeding and bruising risk when used together.
Additionally, if you take diabetes medications, this product might lower your blood sugar further, raising the risk of low blood sugar (hypoglycemia). Octacosanol also has a separate documented interaction with levodopa/carbidopa (used for Parkinson disease), where it may worsen symptoms.
Finally, nitroprusside (a blood pressure medication) could have additive effects. Altogether, these interactions span 248 individual medications.
Before you start this product, run your exact prescriptions through the search tool on this page or talk with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Octacosanol 30% Polycosanol 99%?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Octacosanol 30% Polycosanol 99% interact with 248 drugs. Click any drug to see the details.
1 of the 1 ingredient in Octacosanol 30% Polycosanol 99% interact with drugs. Each result below shows which ingredient is responsible. Polycosanol
AbciximabReoPro
How Abciximab interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Abciximab interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Abrocitinib interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Acarbose interactionPolycosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Polycosanol + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolBeta-blockers Moderate
Interaction Summary
Concomitant use of policosanol with beta-blockers can cause additive blood pressure-lowering effects.
Read the full Polycosanol + Acebutolol interactionOctacosanolBeta-blockers Moderate
Interaction Summary
Theoretically, concomitant use of octacosanol with beta-blockers might result in additive hypotensive effects.
Read the full Octacosanol + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acenocoumarol interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Acetaminophen, Aspirin interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetaminophen, Aspirin, Caffeine interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Acetaminophen, Ibuprofen interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Acetohexamide interactionPolycosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Polycosanol + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Acetylsalicylic Acid interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Polycosanol + Albiglutide interactionOctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Alogliptin interactionPolycosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Polycosanol + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Polycosanol + Alogliptin, Metformin interactionOctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Alogliptin, Pioglitazone interactionPolycosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Polycosanol + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Alteplase, Tpa interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Anacaulase-bcdb interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Anagrelide interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Anisindione interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, octacosanol might have additive effects when used in combination with antidiabetes drugs.
Read the full Octacosanol + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionPolycosanolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Polycosanol + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Antithrombin Iii interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Apixaban interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Argatroban interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aspirin, Butalbital, Caffeine interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
OctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionPolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Octacosanol 30% Polycosanol 99% — through 2 ingredients. Tap an ingredient for the detail:
PolycosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Polycosanol + Aspirin, Butalbital, Caffeine, Phenacetin interactionOctacosanolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically significant.
Read the full Octacosanol + Aspirin, Butalbital, Caffeine, Phenacetin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Octacosanol 30% Polycosanol 99% with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Polycosanol
Anticoagulant/Antiplatelet Drugs
Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. Although, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response. Furthermore, a study in patients undergoing percutaneous coronary intervention with a drug-eluting stent found that taking policosanol 40 mg plus clopidogrel and aspirin daily for 30 days modestly reduced the risk for minor bleeding events when compared with taking clopidogrel and aspirin alone. Until more is known, use with caution.
Antidiabetes Drugs
Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Clinical research shows that policosanol can lower blood glucose levels.
Beta-Blockers
Concomitant use of policosanol with beta-blockers can cause additive blood pressure-lowering effects.
Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the blood-pressure lowering effects of propranolol.
Nitroprusside (Nitropress)
Theoretically, concomitant use of policosanol with nitroprusside might cause additive blood pressure-lowering effects.
Animal research shows that taking policosanol along with nitroprusside can increase the blood pressure-lowering effects of nitroprusside.
Propranolol (Inderal)
Animal research shows that taking policosanol along with propranolol can increase the blood pressure-lowering effects of propranolol.
Warfarin (Coumadin)
Theoretically, taking policosanol with warfarin might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response.
Brand information
Manufacturer and brand details for Octacosanol 30% Polycosanol 99%, from the product label.
PureBulk.com
See all PureBulk.com products- Name
- PureBulk.com
- City
- Roseburg
- State
- OR
- ZipCode
- 97471
- Phone Number
- (541) 679-1500
- Web Address
- PureBulk.com
Octacosanol 30% Polycosanol 99% by PureBulk.com: Common Questions
Does Octacosanol 30% Polycosanol 99% by PureBulk.com interact with any medications?
How can one product interact with so many drugs?
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What is octacosanol, and why is it in this product?
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Is this the same as regular policosanol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Octacosanol 30% Polycosanol 99%’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Policosanol
Interacts with 242 drugsPolicosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to lower cholesterol. Early studies from Cuba...
Read the full Policosanol monograph → Herb & supplement monographOctacosanol
Interacts with 248 drugsOctacosanol is a waxy long-chain alcohol from plant sources that is most often promoted for exercise endurance and cholesterol support, but solid human evidence is limited and results are mi...
Read the full Octacosanol monograph →Sources & How We Checked
Octacosanol 30% Polycosanol 99%'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Policosanol 15 references
- Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
- Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
- Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
- Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
- Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
- Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
- Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
- Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
- Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
- Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
- Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
- Fernandez L, Mas R, Illnait J, Fernandez JC. Policosanol: results of a postmarketing surveillance study of 27,879 patients. Curr Ther Res 1998;59(10):717-22. DOI
- Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
- Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
- Li C, Ding Y, Si Q, Li K, Xu K. Multiple functions of policosanol in elderly patients with dyslipidemia. J Int Med Res. 2020;48(7):300060520936082. PubMed
Octacosanol 16 references
- Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
- Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
- Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
- Snider S. Octacosanol in parkinsonism. Ann Neurol 1984;16:723. PubMed
- Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
- Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
- Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
- Menendez, R., Mas, R., Amor, A. M., Gonzalez, R. M., Fernandez, J. C., Rodeiro, I., Zayas, M., and Jimenez, S. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modificat
- Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
- Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
- Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
- Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
- Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
- Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
- Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
- Li C, Ding Y, Si Q, Li K, Xu K. Multiple functions of policosanol in elderly patients with dyslipidemia. J Int Med Res. 2020;48(7):300060520936082. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC