Interactions on record — worth a quick check against your medications. Based on 3 of 11 ingredients. Check your meds →
Dietary supplement

OilSMART Ingredients & Drug Interactions

by Renew Life

OilSMART label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OilSMART against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OilSMART is a dietary supplement by Renew Life with 11 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 844 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against OilSMART by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with OilSMART by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of OilSMART by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (850 mg) without saying how much of each component you get.
  • “Total Omega-6 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (730 mg) without saying how much of each component you get.
  • “Total Omega-9 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (490 mg) without saying how much of each component you get.

OilSMART contains 11 ingredients, of which the active players are vitamin E, several omega-3, omega-6, and omega-9 fatty acids (including eicosapentaenoic acid, docosahexaenoic acid, gamma-linolenic acid, oleic acid, linoleic acid, and alpha-linolenic acid), lipase (a digestive enzyme), and oleic acid. The inactive ingredients are certified organic cold-pressed flaxseed oil, cold-water fish oil, and cold-pressed borage oil—these are the delivery system and base for the active oils.

The omega fatty acids and vitamin E work together to support heart and brain health through anti-inflammatory and antioxidant pathways. Lipase is included to help your body break down and absorb these oils.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Balance omega fatty acid intake.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Atherosclerosis, Hypercholesterolemia, Hypertension, Congestive heart failure (CHF) — and 4 related terms.
  • The strongest evidence on file: Vitamin E is rated "Possibly Effective" for Nonalcoholic steatohepatitis (NASH) (Natural Medicines).
  • Also on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD), Hypercholesterolemia.
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Atherosclerosis, Congestive heart failure (CHF).

Vitamin E in this product is effective for vitamin E deficiency and a rare genetic condition called ataxia with vitamin E deficiency (AVED). It's possibly effective for Alzheimer disease, beta-thalassemia, G6PD deficiency, and intracranial hemorrhage, though the evidence for these uses is less solid.

Oleic acid (one of the omega-9 fatty acids here) is possibly effective for high cholesterol and heart disease risk. Lipase—the digestive enzyme in the formula—has insufficient evidence in our data to rate its effectiveness for inflammatory bowel disease or indigestion.

The other omega fatty acids in this product don't have established effectiveness ratings in our data.

The evidence, ingredient by ingredient Vitamin E Lipase Oleic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well-tolerated in usual dietary amounts, but high-dose long-term supplements carry real concerns: bleeding risk, a potential increased risk of hemorrhagic stroke (especially in male smokers on synthetic forms), and other complications. The safety data advises against high-dose supplements in pregnancy; amounts from food and prenatal vitamins are fine.

For breastfeeding, normal dietary amounts are safe, but avoid high-dose supplements unless your doctor directs it. Lipase is generally well tolerated and hasn't reported adverse effects in adults, though a full safety evaluation hasn't been done.

Little safety data exists for supplemental lipase in pregnancy or while breastfeeding—check with your healthcare provider first. Oleic acid, found in everyday foods like olive oil, is generally recognized as safe at food levels, but concentrated supplements haven't been well studied in pregnancy or lactation.

Side effects, ingredient by ingredient Vitamin E Lipase Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin E, Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 845 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking OilSMART, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel)—vitamin E raises bleeding risk. Also flag any chemotherapy drugs (alkylating agents or antitumor antibiotics), cyclosporine, selumetinib, diabetes medications, or CYP3A4 substrate drugs.

If you take niacin for cholesterol, vitamin E might blunt its benefits. No interactions are documented for the omega fatty acids we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

OilSMART may be worth considering if you're looking for omega fatty acid and vitamin E support, particularly for heart or brain health—but it's not for everyone. If you take blood thinners, antiplatelet drugs, diabetes medications, cyclosporine, certain chemotherapy agents, or selumetinib, you need to clear this with your doctor or pharmacist first because the interaction risk is real.

Talk with your own healthcare provider before starting, especially if you're pregnant, breastfeeding, or have a bleeding disorder.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OilSMART, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257734440
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71919
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OilSMART by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
30
UPC/BARCODE
631257734440
IngredientAmount% DV
Calories24 Calorie(s)--
Vitamin E30 IU100%
Calories from Fat24 Calorie(s)--
Eicosapentaenoic Acid168 mg--
Docosahexaenoic Acid105 mg--
Saturated Fat0.5 Gram(s)2%
Gamma-Linolenic Acid200 mg--
Total Fat2.4 Gram(s)3%
Trans Fat0 Gram(s)--
Total Omega-3 Fatty Acids850 mg--
Lipase15 mg--
Other Omega-3 Fatty Acids47 mg--
Total Omega-6 Fatty Acids730 mg--
Linoleic Acid510 mg--
Total Omega-9 Fatty Acids490 mg--
Oleic Acid410 mg--
Alpha-Linolenic Acid530 mg--
Other Omega-6 Fatty Acids20 mg--
Total Omega-3, 6, 9 Fatty Acids2070 mg--

Other ingredients: certified organic cold-pressed Flaxseed Oil, cold-water Fish Oil, cold-pressed Borage Oil, Other Ingredients:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Lipase-enhanced digestion

OilSMART is an advanced, Omega-3-6-9 formula with flax oil, cold-pressed borage oil, purified cold-water fish oil and lipase.

OilSMART features: ~ Omega-3, Omega-6 and Omega-9 ~ EPA, DHA, GLA, ALA and more ~ Lipase (a digestive enzyme) for optimum absorption

Advanced total-body omgea-3-6-9 formula from flax, borage & fish

Contains an ingredient derived from non-GMO soy.

Brand IP Statement(s)

Paten # US 6,228,367

Renew Life The digestive care experts

General Statements

~ Reduced fishy repeat or aftertaste ~ Purity, potency and freshness guaranteed The typical diet is rich in some fats but low in other, healthier fats. OilSMART can help balance this ratio.

Purified and third-party tested to exceed all published U.S. and international standards for PCBs, pesticides, heavy metals and dioxins.

Quality and purity guaranteed

Made in USA

Promotes healthy heart & immune function Supports healthy skin, joints & brain

Manufactured in a GMP facility

Formulation

Contains no GMOs, gluten, yeast, sugar, salt, dairy, eggs, nuts, wheat, corn, binders, preservatives or artificial ingredients.

Precautions

Keep out of reach of children.

Warning: Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking medication or have a medical condition.

Tamper Evident: Do not use if safety seal is broken or missing.

Contains an ingredient derived from non-GMO soy.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

#15636 010713

Seals/Symbols

Guaranteed purity potency

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 3 softgels daily with food, or as directed by your healthcare professional.

Storage

Store in a dry place at 59-86(0)F (15-30(0)C).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OilSMART by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OilSMART label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OilSMART by Renew Life

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
30 IU per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Total Omega-3 Fatty Acids

850 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omega-3 Fatty Acids
  • › Alpha-Linolenic Acid

Lipase

No known
interactions
15 mg per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Total Omega-6 Fatty Acids

730 mg per serving
  • › Gamma-Linolenic Acid
  • › Linoleic Acid
  • › Other Omega-6 Fatty Acids

Total Omega-9 Fatty Acids

490 mg per serving

Total Omega-3, 6, 9 Fatty Acids

2070 mg per serving

Other (inactive) ingredients: Certified organic cold-pressed Flaxseed Oil, Cold-water Fish Oil, Cold-pressed Borage Oil, Other Ingredients:. These complete the product’s ingredient list but are not active constituents.

Interaction report

OilSMART by Renew Life Drug Interactions

Want to check YOUR meds against OilSMART?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
844Drugs
843 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764
Oleic Acid 86

Individual Drug Interactions

The ingredients in OilSMART interact with 844 drugs. Click any drug to see the details.

2 of the 11 ingredients in OilSMART interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Oleic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in OilSMART with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Oleic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OilSMART, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

OilSMART by Renew Life: Common Questions

Does OilSMART by Renew Life interact with any medications?
Yes. Based on its ingredients, OilSMART has a known interaction with 844 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OilSMART contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will OilSMART thin my blood?
Vitamin E in this product can slow clotting and interfere with platelets, especially at higher doses—so yes, there's a real bleeding risk if you already take blood thinners or antiplatelet drugs. Even at normal supplement doses, the effect is dose-dependent, so talk with your doctor or pharmacist before combining it with any clotting medications.
Can I take OilSMART while I'm pregnant?
The safety data for vitamin E in pregnancy says amounts from food and prenatal vitamins are fine, but avoid high-dose supplements unless your doctor says otherwise. Oleic acid and lipase haven't been well studied at supplement levels in pregnancy, so check with your doctor before starting.
Is OilSMART safe while breastfeeding?
Normal dietary amounts of vitamin E are fine while breastfeeding, but avoid high-dose supplements without your doctor's guidance. Lipase and oleic acid haven't been well studied at supplement doses while nursing—talk with your healthcare provider first.
What is lipase, and why is it in this product?
Lipase is an enzyme that breaks down fat. It's included here to help your digestive system absorb the oils more efficiently. It's generally well tolerated, though people with serious digestive conditions should use it only under medical guidance.
Can this product help lower my cholesterol?
The oleic acid in OilSMART is possibly effective for high cholesterol and heart disease risk, based on research showing diets rich in oleic acid (like those from olive oil) help improve cholesterol levels. However, if you take niacin for cholesterol, vitamin E might weaken its benefits.
What are the omega fatty acids in OilSMART for?
The omega-3, omega-6, and omega-9 fatty acids work to support heart and brain health through anti-inflammatory and antioxidant effects. The specific effectiveness of individual omega acids in this product isn't established in our data, but they're considered important for overall wellness.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OilSMART label
Go deeper

The Full Monographs Behind OilSMART’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

OilSMART's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 84 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
  22. Carlsson CM, Papcke-Benson K, Carnes M, et al. Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults. Drugs Aging 2002;19:793-805. . PubMed
  23. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
  24. Schrogie JJ. Coagulopathy and fat-soluble vitamins (letter). JAMA 1975;232:19. DOI
  25. Celestini A, Pulcinelli FM, Pignatelli P, et al. Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets. Haematologica 2002;87:420-6.
  26. Stampfer MJ, Jakubowski JA, Faigel D, et al. Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. Am J Clin Nutr 1988;47:700-6. PubMed
  27. Jandak J, Steiner M, Richardson PD. Alpha-tocopherol, an effective inhibitor of platelet adhesion. Blood 1989;73:141-9. DOI
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See these in context on the Vitamin E monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
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  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
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  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
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See these in context on the Oleic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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