Interactions on record — worth a quick check against your medications. Based on 8 of 18 ingredients. Check your meds →
Dietary supplement

Oxygen Elements Max Ingredients & Drug Interactions

by GHT Global Health Trax

Liquid Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Oxygen Elements Max is a dietary supplement by GHT Global Health Trax with 18 active ingredients. Its ingredients are commonly taken for food and drink flavoring or sourness, preservative and acidity adjuster, kidney stone prevention (as citrate salts).Based on those ingredients, 456 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fulvic Acid, Sodium Benzoate, Potassium Sorbate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Oxygen Elements Max by GHT Global Health Trax

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 18 active ingredients.
  • “Global Health Trax Proprietary Blend” is a proprietary blend — the label gives one combined amount (326 mg) without saying how much of each component you get.

Oxygen Elements Max contains 18 ingredients, including digestive enzymes (amylase, protease, lipase, and cellulase) that break down food; amino acids (methionine, arginine, glutamic acid, and ornithine) that support various body functions; fulvic acid, a compound from soil organic matter; and mineral and electrolyte sources (potassium sorbate, sodium benzoate, and ionic trace minerals). The product also contains citric acid for flavor and preservation, deionized water as the base, and glucono delta lactone, hydrogen sulfate, and rice vinegar.

There are no inactive fillers or binders listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Cystic fibrosis — rated "Likely Effective" (Sodium) (Natural Medicines).
  • On file: Neural tube birth defects — rated "Possibly Effective" (Methionine) (Natural Medicines).
  • On file: Athletic performance — rated "Possibly Effective" (Ornithine) (Natural Medicines).
  • On file: Amphotericin B nephrotoxicity — rated "Possibly Effective" (Sodium) (Natural Medicines).

The evidence for this product's ingredients is largely limited. Methionine is possibly effective for preventing neural tube birth defects, and ornithine is possibly effective for athletic performance.

Potassium sorbate is likely effective for cystic fibrosis, and sodium benzoate is possibly effective for amphotericin B kidney toxicity. For most other uses — including the enzymes' roles in digestion, fulvic acid for respiratory infections or fatigue, and citric acid for various skin and joint conditions — the data we hold rates the evidence as insufficient to make a reliable recommendation.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the checked ingredients are generally well tolerated. Citric acid is recognized as safe in the small amounts found in foods and supplements, though topically it may cause mild irritation, sun sensitivity, or tingling; concentrated supplement doses warrant a check with your doctor.

Protease and lipase are well tolerated orally for most adults, though protease may rarely trigger allergic reactions or occupational asthma in sensitive people, and both have limited safety data in pregnancy and breastfeeding — your doctor should advise before use if you're pregnant or nursing. Methionine is well tolerated in food amounts but high-dose supplements may cause dizziness, drowsiness, low blood pressure, vomiting, or increased homocysteine (a heart-disease risk factor).

Ornithine is well tolerated short-term, but long-term safety isn't well studied. Fulvic acid appears well tolerated orally in the short term, though it may cause headache, diarrhea, or sore throat; however, safety data in humans is limited.

Potassium and sodium — two key minerals in this product — are essential but can accumulate to dangerous levels; high potassium can cause heart arrhythmias and cardiac arrest, and high sodium is linked to high blood pressure, kidney damage, and gastric cancer risk in large doses. Several ingredients (amylase, cellulase, arginine, deionized water, glutamic acid, ionic trace minerals, and amino acid complex) have no interaction data on file with us.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 8 matched ingredients can interact with medications — Potassium, Fulvic Acid, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; lithium.
  • For scale: 456 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Oxygen Elements Max, double-check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (fulvic acid may reduce their effectiveness), immune-suppressing medications (fulvic acid may weaken them), or thyroid hormone (fulvic acid may interfere with thyroid control). Also confirm if you use potassium-sparing diuretics, ACE inhibitors, or angiotensin receptor blockers — the potassium in this product raises the risk of dangerously high blood potassium.

Similarly, tell your provider if you take blood-pressure medications, corticosteroids, lithium, didanosine, sodium phosphates, tolvaptan, or other sodium-containing drugs, since the sodium content may reduce effectiveness or raise sodium levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Oxygen Elements Max is built around digestive enzymes and amino acids, with an emphasis on fulvic acid and mineral content. It may appeal to people seeking enzyme support for digestion or those interested in fulvic acid's theoretical benefits, though the evidence for most of those benefits is not yet established.

If you take blood thinners, blood-pressure medications, thyroid hormone, immune-suppressing drugs, lithium, or potassium or sodium-regulating medications, you should discuss this product with your doctor or pharmacist before starting, since the potassium and sodium content and fulvic acid may affect how your medicines work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Oxygen Elements Max, straight from the product label.

Brand GHT Global Health Trax
Barcode (UPC) 816663001106
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34227
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Oxygen Elements Max by GHT Global Health Trax, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Drop(s)
Maximum serving Sizes:
7 Drop(s)
Servings per container
90
UPC/BARCODE
816663001106
IngredientAmount% DV
Citric Acid0 NP--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Methionine0 NP--
Cellulase0 NP--
Arginine0 NP--
deionized Water0 NP--
Glutamic Acid0 NP--
Ionic Trace Minerals0 NP--
Ornithine0 NP--
Fulvic Acid0 NP--
Amino Acid Complex0 NP--
Potassium Sorbate0 NP--
Sodium Benzoate0 NP--
Glucono Delta Lactone0 NP--
Hydrogen Sulfate0 NP--
Rice Vinegar0 NP--
Global Health Trax Proprietary Blend326 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Avoid contact with eyes. void contact with organic materials (cotton, linen, wool, silk, leather, formica, vinyls). Global Health Trax assumes no responsibility for damage that may occur to these types of materials due to contact with Oxygen Elements Max.

WARNINGS: KEEP OUT OF REACH OF CHILDREN.

Pregnant or nursing mothers, or if under medical care, consult your health practitioner prior to use.

Do not use if seal is broken or damaged.

Suggested/Recommended/Usage/Directions

Suggested Use: DILUTE 7 drops in a 6 to 8 oz. of drinking water or juice 3x daily. Children over 4 years of age may use 1/4 to 1/2 of the adult amount.

FDA Statement of Identity

DIETARY SUPPLEMENT

General Statements

Oe

Made in U.S.A.

Brand IP Statement(s)

PATENTED 6,383,534 B1

Seals/Symbols

ght(TM)

{Recycle}

General

P/N: OEM809000 Rev. 2

See for yourself

Oxygen Elements Max by GHT Global Health Trax label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Oxygen Elements Max by GHT Global Health Trax

These are the 18 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Drop(s) Dosage formLiquid Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Global Health Trax Proprietary Blend

326 mg per serving
Interaction report

Oxygen Elements Max by GHT Global Health Trax Drug Interactions

Want to check YOUR meds against Oxygen Elements Max?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
456Drugs
456 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Oxygen Elements Max with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fulvic Acid3 drug types · 257 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
In vitro evidence shows that fulvic acid, formed from the oxidation and polymerization of protocatechuic acid, can shorten prothrombin time in human plasma, increasing the risk of clot formation.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.
Animal research shows that fulvic acid stimulates immune function.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.
Animal research shows that fulvic acid increases the plasma level of thyroid-stimulating hormone (TSH) and decreases the thyroxine (T4):triiodothyronine (T3) ratio.

Likelihood Possible Evidence D

Sodium Benzoate7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C

Potassium Sorbate3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
The maker

Brand information

Manufacturer and brand details for Oxygen Elements Max, from the product label.

GHT Global Health Trax

See all GHT Global Health Trax products
Name
Global Health Trax Inc.
City
Vista
State
CA
ZipCode
92081
Phone Number
1-800-305-5710
Web Address
www.ghthealth.com
Pharmacist Counseling Corner

Oxygen Elements Max by GHT Global Health Trax: Common Questions

Does Oxygen Elements Max by GHT Global Health Trax interact with any medications?
Yes. Based on its ingredients, Oxygen Elements Max has a known interaction with 456 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Oxygen Elements Max contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any digestive enzymes in it?
Yes. Oxygen Elements Max contains amylase, protease, lipase, and cellulase — all digestive enzymes that break down different parts of food. Protease breaks down proteins, lipase breaks down fats, amylase breaks down carbohydrates, and cellulase breaks down fiber.
Is this safe to take during pregnancy?
The data on file varies by ingredient. Citric acid and methionine are rated likely safe; however, protease, lipase, ornithine, and fulvic acid don't have enough safety data, and fulvic acid is advised against. Since this is a multi-ingredient product with ingredients of mixed safety profiles, talk with your doctor or pharmacist before taking it if you're pregnant.
What is fulvic acid, and why is it in this product?
Fulvic acid is a compound formed from decomposed organic matter in soil. It's included here theoretically to support respiratory health, energy, and immune function, though the evidence for these uses in our data is not yet established. The supplement is generally well tolerated but has limited human safety data.
Can I take this if I'm on blood-pressure medication?
The sodium benzoate in this product may theoretically reduce how well blood-pressure drugs work, and the potassium content could also affect your blood pressure control. Check with your doctor or pharmacist before starting to make sure it's safe with your specific medications.
Does this product work for improving digestion?
The enzymes in Oxygen Elements Max are intended to support digestion, but the evidence we hold doesn't rate their effectiveness as established. Ask your pharmacist or doctor whether digestive enzymes might help with your specific situation.
What happens if I take this with blood thinners like warfarin?
Fulvic acid in this product may decrease the effectiveness of blood thinners and antiplatelet drugs, theoretically raising your clot risk. Do not take this product with blood thinners without first talking to your doctor or pharmacist about whether it's safe.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Oxygen Elements Max label
Go deeper

The Full Monographs Behind Oxygen Elements Max’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Citric Acid

Citric acid is a natural acid found in citrus fruits and is widely used as a safe food additive, flavoring, and preservative. In medicine, citrate forms (like potassium or sodium citrate) ar...

Read the full Citric Acid monograph →
Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph →
Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph →
Herb & supplement monograph

Fulvic Acid

Interacts with 257 drugs

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall wellness. Human research is very limited, so...

Read the full Fulvic Acid monograph →
Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Oxygen Elements Max's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 80 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Citric Acid 10 references
  1. Kurtzweil P. Alpha-hydroxy acids for skin care: Smooth sailing or rough seas? FDA 1999. Available at: /www.fda.gov/fdac/features/1998/298_ahas.html (Accessed 18 August 2000). DOI
  2. Erbagci Z, Akcali C. Biweekly serial glycolic acid peels vs. long-term daily use of topical low-strength glycolic acid in the treatment of atrophic acne scars. Int J Dermatol 2000;39:789-94.. PubMed
  3. Ghadishah D, Gorchynski J. Airway compromise after routine alpha-hydroxy facial peel administration. J Emerg Med 2002;22:353-5.. PubMed
  4. Baumann LS, Oresajo C, Yatskayer M, Dahl A, Figueras K. Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment
  5. Emtestam L, Svensson Å, Rensfeldt K. Treatment of seborrhoeic dermatitis of the scalp with a topical solution of urea, lactic acid, and propylene glycol (K301): results of two double-blind, randomised, placebo-controlled studies. Mycoses. 2012 Sep;55(5):3 PubMed
  6. Kaminaka C, Uede M, Matsunaka H, Furukawa F, Yamomoto Y. Clinical evaluation of glycolic acid chemical peeling in patients with acne vulgaris: a randomized, double-blind, placebo-controlled, split-face comparative study. Dermatol Surg. 2014 Mar;40(3):314- PubMed
  7. Köse O, Özmen I, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013 Aug;24(4):300-4. PubMed
  8. Vachiramon V, Sahawatwong S, Sirithanabadeekul P. Treatment of melasma in men with low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet laser versus combined laser and glycolic acid peeling. Dermatol Surg. 2015 Apr;41(4):457-65. PubMed
  9. US Food and Drug Administration (FDA). Cosmetic Ingredients: Alpha Hydroxy Acids. August 2020. Available at: https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids. Accessed on October 19, 2021.
  10. Ormerod AD, van Voorst Vader PC, Majewski S, Vanscheidt W, Benjamin N, van der Meijden W. Evaluation of the efficacy, safety, and tolerability of 3 dose regimens of topical sodium nitrite with citric acid in patients with anogenital warts: A randomized cl DOI

See these in context on the Citric Acid monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

Fulvic Acid 3 references
  1. Lu, FJ. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 6-15-1990;58(6):537-541. PubMed
  2. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed
  3. Gandy JJ, Meeding JP, Snyman JR, et al. Phase 1 clinical study of the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid. Clin Pharmacol. 2012;4:7-11. PubMed

See these in context on the Fulvic Acid monograph →

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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