Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

P-5-P 50 mg Ingredients & Drug Interactions

by Country Life

Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

P-5-P 50 mg is a dietary supplement by Country Life with 2 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pyridoxal 5-Phosphate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of P-5-P 50 mg by Country Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

P-5-P 50 mg has 2 active ingredients, both forms of vitamin B6: pyridoxal 5-phosphate and vitamin B6 (pyridoxine). Pyridoxal 5-phosphate is the active, ready-to-use form your body needs right away, while plain vitamin B6 needs to be converted in your liver before your cells can use it.

The product also contains inactive ingredients—cellulose, stearic acid, tapioca maltodextrin, sunflower lecithin, palm oil, guar gum, and silica—which are fillers and binders that hold the tablet together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: metabolize nutrients and support nervous system.
  • We looked for evidence on: Antipsychotic-induced hyperprolactinemia, Antipsychotic-induced metabolic side effects, Carpal tunnel syndrome, Cognitive function, Diabetic neuropathy, Dysmenorrhea — and 4 related terms.
  • The strongest evidence on file: Vitamin B6 is rated "Likely Effective" for Hyperhomocysteinemia (Natural Medicines).
  • Also on file: Vitamin B6 is rated "Possibly Effective" for Antipsychotic-induced hyperprolactinemia.
  • Also on file: Vitamin B6 is rated "Possibly Ineffective" for Carpal tunnel syndrome.

Vitamin B6 is effective for treating actual vitamin B6 deficiency and a rare inherited condition called pyridoxine-dependent epilepsy. It's also effective for sideroblastic anemia, a blood disorder.

For high homocysteine levels (a risk factor for heart disease), the evidence suggests it's likely effective. If you're pregnant and dealing with nausea and vomiting, B6 is possibly effective—it's often used at recommended levels for morning sickness, but only under a doctor's guidance.

The evidence we hold doesn't establish how well it works for other uses.

The evidence, ingredient by ingredient Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 at doses under 100 mg daily is generally well tolerated. At standard doses like this 50 mg tablet, the common side effects you might see—abdominal pain, allergic reactions, headache, heartburn, loss of appetite, nausea, or drowsiness—are infrequent.

The big concern is nerve damage (sensory neuropathy), which is rare but happens with high doses over time. Doses above 1,000 mg daily or very large total doses carry the most risk, though nerve damage can occur even at lower amounts with extended use.

There isn't enough data on file to say whether this product is safe in pregnancy or while breastfeeding—talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 210 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check if you're on any blood pressure medications, amiodarone (Cordarone) for heart rhythm, phenobarbital (Luminal) or phenytoin (Dilantin) for seizures, or levodopa without carbidopa for Parkinson's symptoms. These have documented moderate or minor interactions with vitamin B6.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have a B6 deficiency, seizures that need pyridoxine, or high homocysteine, this 50 mg dose is a reasonable choice. Be cautious if you take blood pressure medications, amiodarone, seizure drugs, or levodopa alone.

Check your exact medications with the tool on this page before you start, and avoid going much higher than this dose without a clinician's guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about P-5-P 50 mg, straight from the product label.

Brand Country Life
Barcode (UPC) 015794062370
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326829
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for P-5-P 50 mg by Country Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
UPC/BARCODE
015794062370
IngredientAmount% DV
Pyridoxal 5-Phosphate50 mg--
Vitamin B634 mg2000%

Other ingredients: Cellulose, Stearic Acid, Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vitamin B6 helps metabolize lipids, carbohydrates, and proteins into energy. It also supports the function and growth of red blood cells as well as supporting the nervous and immune systems. P-5-P is a biologically active form of Vitamin B6 and is utilized by the body.

Yes NON-GMO project verified Yes Certified Gluten-Free by GFCO.org No Yeast, corn or wheat No Soy, milk or salt No sugar or preservatives No artificial colors, flavors or sweeteners No magnesium stearate

Yes Certified Vegan by the AVA

Yes Manufacturing supports wind power

This product has been manufactured at a GMP Registered facility.

Certified Gluten-Free

Supports energy Supports nervous system health Active form of B6

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Yes Recyclable Packaging

Our Pledge of Integrity Authenticity Cleanliness Freshness Consistency Accuracy

Formula

Yes Kosher-Parve

P-5-P (Pyridoxal 5' Phosphate) 50 mg

Seals/Symbols

Certified B Corporation K Parve (Kosher) Certified Gluten Free GFCO.org

Non GMO Project Verified nongmoproject.org

Brand IP Statement(s)

Country Life Established 1971

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take one (1) tablet daily with food. For best utilization, take with food.

Precautions

As a reminder, discuss the supplements and medications that you take with your health care providers. Caution: If you are pregnant, nursing, or taking medication, have a medical condition or planning surgery, consult a doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur. Do not accept if seal is broken.

Keep out of the reach of children.

Storage

Store in a dry place between 59 degrees - 86 degrees F.

See for yourself

P-5-P 50 mg by Country Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in P-5-P 50 mg by Country Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pyridoxal 5-Phosphate

Interacts with
210 drugs
50 mg per serving

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Pyridoxal 5-Phosphate monograph & interactions

Vitamin B6

Interacts with
210 drugs
34 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

P-5-P 50 mg by Country Life Drug Interactions

Want to check YOUR meds against P-5-P 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
210Drugs
205 Moderate 5 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in P-5-P 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pyridoxal 5-Phosphate5 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for P-5-P 50 mg, from the product label.

Country Life

See all Country Life products
Name
Country Life, LLC.
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

P-5-P 50 mg by Country Life: Common Questions

Does P-5-P 50 mg by Country Life interact with any medications?
Yes. Based on its ingredients, P-5-P 50 mg has a known interaction with 210 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
P-5-P 50 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this dose safe for everyday use?
Yes, 50 mg is below the threshold where side effects become common—vitamin B6 is well tolerated at doses under 100 mg daily. Just steer clear of much higher doses over time, since prolonged high intake can damage nerves.
Can I take this if I'm pregnant or breastfeeding?
We don't have pregnancy or breastfeeding safety data on file for this product. B6 is often used at standard levels for morning sickness, but only under a doctor's supervision. Talk with your pharmacist or doctor about whether this dose is right for you right now.
What's the difference between pyridoxal 5-phosphate and regular vitamin B6?
Pyridoxal 5-phosphate is the active form your body uses directly, while plain vitamin B6 (pyridoxine) has to be converted by your liver first. Both are forms of vitamin B6, just at different stages of readiness.
Will this help my fatigue?
The evidence we hold shows vitamin B6 works for B6 deficiency, sideroblastic anemia, and high homocysteine. If fatigue is caused by one of those, it may help. If it's from something else, we can't say this will work.
Are there any fillers in this tablet?
Yes. The tablet contains cellulose, stearic acid, tapioca maltodextrin, sunflower lecithin, palm oil, guar gum, and silica—these are inactive ingredients that bind and give the tablet its form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if P-5-P 50 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

P-5-P 50 mg label
Sources

Sources & How We Checked

P-5-P 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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