Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Papaya Enzyme Chewable Ingredients & Drug Interactions

by CHK Nutrition

Papaya Enzyme Chewable label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Papaya Enzyme Chewable against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Papaya Enzyme Chewable is a dietary supplement by CHK Nutrition with 2 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Papaya Enzyme Chewable by CHK Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Enzyme Chewable by CHK Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Papaya Enzyme Chewable by CHK Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Papaya Enzyme Chewable contains one active ingredient: papain, an enzyme from the papaya fruit that's been used traditionally to support digestion and protein breakdown. The product also includes inactive ingredients — sucrose, fructose, tart cherry powder, stearic acid, natural cherry flavor, silica, citric acid, and magnesium stearate — which serve as sweeteners, binders, and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Papain product and its label doesn't state a use — see Papain's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for papain is not yet established in our data. It's been studied for cancer, dental cavities, radiation skin irritation, exercise muscle soreness, shingles, and intestinal parasites, but we don't hold reliable evidence supporting its use for any of these.

If you're considering it for a specific reason, talk with your doctor about what the science currently shows.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated as a food, but supplements may irritate your digestive tract or trigger allergic reactions in sensitive people. The facts show it can cause itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea in those allergic to it.

High doses may be unsafe and can rarely cause serious issues like esophageal perforation or severe stomach inflammation. For pregnancy, the safety data advises against concentrated papain and unripe papaya products.

While breastfeeding, there isn't enough reliable information to know either way — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, double-check with your doctor or pharmacist before using this product — papain may increase the drug's effects and your bleeding risk. No other drug interactions are documented for the ingredients we hold data on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Papaya Enzyme Chewable is best for people without a blood thinner prescription and no known papain allergy. If you take warfarin or another blood thinner, check with your doctor or pharmacist before starting.

Because evidence for its intended uses isn't yet established, ask your healthcare provider whether it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Papaya Enzyme Chewable, straight from the product label.

Brand CHK Nutrition
Barcode (UPC) 871230004843
Net contents 90 Chewable Tablet(s)
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 174244
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Papaya Enzyme Chewable by CHK Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
UPC/BARCODE
871230004843
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Sugar1 Gram(s)--
Papain0 NP--

Other ingredients: Sucrose, Fructose, Tart Cherry powder, Stearic Acid, natural Cherry flavor, Silica, Citric Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Chew 1 tablet following meals.

Precautions

Note: If you have any health conditions or are taking any medications, consult your health care practitioner before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General Statements

Manufactured in a cGMP certified facility.

Post consumer recycled bottle

New day. Fresh start. Better health.

Seals/Symbols

Made in USA from domestic and foreign materials

FDA Statement of Identity

Dietary Supplement

General

P484

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Papaya Enzyme Chewable by CHK Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Papaya Enzyme Chewable label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Papaya Enzyme Chewable by CHK Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Papain

Interacts with
2 drugs
0 NP per serving Form: Papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Sucrose, Fructose, Tart Cherry powder, Stearic Acid, Natural Cherry flavor, Silica, Citric Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Papaya Enzyme Chewable by CHK Nutrition Drug Interactions

Want to check YOUR meds against Papaya Enzyme Chewable?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Papaya Enzyme Chewable interact with 2 drugs. Click any drug to see the details.

1 of the 2 ingredients in Papaya Enzyme Chewable interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Papaya Enzyme Chewable with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Papaya Enzyme Chewable, from the product label.

CHK Nutrition

See all CHK Nutrition products
Name
CHK Nutrition
Street Address
3930 E Calvary Rd
City
Duluth
State
MN
ZipCode
55803
Pharmacist Counseling Corner

Papaya Enzyme Chewable by CHK Nutrition: Common Questions

Does Papaya Enzyme Chewable by CHK Nutrition interact with any medications?
Yes. Based on its ingredients, Papaya Enzyme Chewable has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Papaya Enzyme Chewable contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data advises against concentrated papain and unripe papaya products during pregnancy. Since this is a papain supplement, talk with your doctor or pharmacist about whether it's appropriate for you before taking it.
Is papain safe while breastfeeding?
There isn't enough reliable safety information on supplemental papain during breastfeeding. Before using it, check with your doctor or pharmacist to make sure it's right for your situation.
What are the common side effects?
In people sensitive to papain, allergic reactions can occur — itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea. Digestive tract irritation is also possible. High doses may cause more serious problems, so stick to the recommended dose.
Does papain actually work for what it claims?
The evidence for papain isn't yet established in our data. It's been studied for several uses — digestion support, muscle soreness, dental cavities, and others — but we don't hold reliable evidence confirming it works for any of them. Talk with your doctor about your specific needs.
What does papain do?
Papain is an enzyme from papaya fruit traditionally used to support digestion and break down proteins. How well it works for those purposes in supplement form isn't established in our current data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Papaya Enzyme Chewable is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Papaya Enzyme Chewable label
Go deeper

The Full Monographs Behind Papaya Enzyme Chewable’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Papaya Enzyme Chewable's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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