Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

ParaGone For Kids II Ingredients & Drug Interactions

by Renew Life

ParaGone For Kids II label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ParaGone For Kids II against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

ParaGone For Kids II is a dietary supplement by Renew Life with 5 active ingredients. Its ingredients are commonly taken for toothache and oral pain, digestive upset, antimicrobial and antifungal.Based on those ingredients, 2,156 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Marshmallow root, Clove, Orange. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ParaGone For Kids II by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with ParaGone For Kids II by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ParaGone For Kids II by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

ParaGone For Kids II contains five active plant ingredients: clove, black walnut, marshmallow root, orange (bitter orange), and wormwood. Each is a traditional herbal extract used in antiparasitic and digestive support formulas.

The product also contains inactive ingredients—vegetable glycerin, filtered water, natural cherry flavor, and grapefruit seed extract—which serve as the base, flavoring, and preservative.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: intestinal health and cleansing support.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Gastritis, Nausea and vomiting — and 3 related terms.
  • The closest evidence on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Flatulence, Nausea and vomiting.
  • Also on file: Wormwood is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Gastritis.

The evidence for these ingredients is limited. Clove has possibly effective evidence for ventilator-associated pneumonia (VAP) only; for cough, pain, and dyspepsia, the evidence is insufficient.

Black walnut, marshmallow root, orange, and wormwood all have insufficient reliable evidence to rate them for their traditional uses—including wound healing, respiratory infections, eczema, digestive disorders, and parasitic conditions. None of the ingredients have strong clinical proof of effectiveness for the conditions this product claims to address.

The evidence, ingredient by ingredient Clove Black Walnut Marshmallow Bitter Orange Wormwood

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Clove is well tolerated when used as a food spice, but concentrated clove oil is concerning in children: doses of only 5–10 mL have caused toxicity in kids, including serious effects like liver failure, seizures, and coma. Wormwood contains thujone, a nerve toxin; medicinal amounts can cause seizures, muscle aches, nausea, and kidney damage.

Orange (bitter orange) can raise blood pressure and heart rate and in rare cases has caused heart attacks, strokes, and seizures. Black walnut may cause stomach upset due to its tannin content and carries a tree nut allergy risk.

Marshmallow root is generally well tolerated for short-term use, though long-term safety is not well studied. Because this is a liquid for children, accidental overdose is a real risk—keep it out of reach and use only as directed.

Side effects, ingredient by ingredient Clove Black Walnut Marshmallow Bitter Orange Wormwood

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Clove, Wormwood, Marshmallow, Bitter Orange.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,157 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Stop and check with your pharmacist if your child takes monoamine oxidase inhibitors (MAOIs), midazolam, or any QT-prolonging heart drugs—these are Major interactions. Also check before use if your child takes antidiabetes drugs, stimulants, anticoagulants, antiplatelet drugs (like aspirin), anticonvulsants, lithium, or any drug metabolized by CYP2D6, CYP1A2, CYP3A4, or CYP2C9 liver enzymes.

Run the exact medication names through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

ParaGone For Kids II is a multiherbal liquid supplement with unproven effectiveness for parasites or digestive complaints and significant interaction risks—especially with antidepressants, sedatives, blood thinners, heart medications, and seizure drugs. It's not appropriate for children taking any regular medications, and some ingredients (especially clove and wormwood) carry toxicity concerns at higher doses.

Talk to your child's pediatrician or pharmacist before giving this product, especially if your child is on any prescription or over-the-counter medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ParaGone For Kids II, straight from the product label.

Brand Renew Life
Net contents 1 fl. Oz.
Market status On market
Date entered into DSLD Aug 25, 2015
DSLD ID 48086
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ParaGone For Kids II by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.33 mL
Maximum serving Sizes:
0.66 mL
Servings per container
90
IngredientAmount% DV
Clove10 mg--
Black Walnut25 mg--
Marshmallow root10 mg--
Orange10 mg--
Wormwood10 mg--

Other ingredients: Vegetable Glycerin, filtered Water, natural Cherry flavor, Grapefruit seed extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

2-part internal cleansing system

~ Includes 2 formulas with 12 natural herbal ingredients used traditionally to support intestinal health and cleansing* ~ Designed to be taken in harmony with normal daily activity ~ No fasting necessary ~ Made from the highest-quality natural ingredients ~ We recommend checking all of our ingredients in a reference book from your healthcare practitioner.

Quality and purity guaranteed

Manufactured in a GMP and Kosher facility

Natural system of herbs used traditionally to support intestinal health*

ParaGONE for Kids II

Why cleanse with ParaGONE for Kids? ParaGONE for Kids was formulated by Brenda Watson, C.N.C., presidnet of ReNew Life Formulas and the founder of five natural healthcare clinics specializing in digestive care. Brenda has found the ingredients in ParaGONE for Kids to be powerful aids for supporting intestinal health.

Formulation

Contains no gluten, binders, fillers or artificial ingredients

Gluten-Free

Alcohol free.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Renew Life(R) The Digestive Care Company

Suggested/Recommended/Usage/Directions

Directions: ParaGONE(TM) I and ParaGONE(TM) II are designed to be taken together. Children ages 4 to 8: Take 1 capsule twice daily. Children 9 to 12: Take 2 capsules twice daily. Please Note: It is important to read accompanying literature prior to using this product.

Take on an empty stomach; allow 30 minutes before eating. Use as directed for 15 days, followed by a 5-day rest period, followed by another 15 days as directed. Repeat cycle as needed. Drink plenty of water while using this product.

Suggested Use: ParaGONE for Kids I and II are designed to be taken together twice daily. Take on an empty stomach, allowing 30 minutes before eating. Take 1 to 2 capsules of ParaGONE for Kids I and 5 to 10 drops of ParaGONE for Kids II twice daily. The following guidelines: Children ages 4 to 8: 1 capsule and 5 drops twice daily. Children ages 9 to 12: 2 capsules and 10 drops twice daily. Drink plenty of water while taking ParaGONE for Kids I and II. ParaGONE for Kids should be taken for 15 days followed by a 5-day rest period, followed by 1 to 3 repetitions as needed.

Use as directed for 15 days, followed by a 5-day rest period, followed by another 15 days as directed. Repeat cycle as needed. Drink plenty of water while using this product.

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Ratio of herb to solvent: (grams of herb:ml of solvent) Black Walnut - 1:2 Other herbs - 1:5

Precautions

Keep out of reach of children.

Warning: Do not use this product if you are pregnant or nursing. Consult your physician before using this or any product if you are trying to conceive, taking medication or have a medical condition.

Not for prolonged use. Do not exceed recommended dose. Discontinue use if abdominal pain, nausea or vomiting occur, unless directed by your physician.

Storage

Store in a dry place at 59-86(0)F (15-30(0)C).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ParaGone For Kids II by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ParaGone For Kids II label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ParaGone For Kids II by Renew Life

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.33 mL Dosage formLiquid Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Clove

Interacts with
977 drugs
10 mg per serving

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main com...

Clove monograph & interactions

Black Walnut

No known
interactions
25 mg per serving

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these us...

Black Walnut monograph & interactions

Marshmallow root

Interacts with
2,040 drugs
10 mg per serving

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats,...

Marshmallow root monograph & interactions

Orange

Interacts with
957 drugs
10 mg per serving

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that i...

Orange monograph & interactions

Wormwood

Interacts with
50 drugs
10 mg per serving

Wormwood is a very bitter herb traditionally used to stimulate appetite and ease digestion, and it has early research interest in Crohn's disease. It...

Wormwood monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Filtered Water, Natural Cherry flavor, Grapefruit seed extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

ParaGone For Kids II by Renew Life Drug Interactions

Want to check YOUR meds against ParaGone For Kids II?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,156Drugs
10 Major 1,054 Moderate 1,092 Minor

Ingredients driving the most interactions

Marshmallow root 2,040
Clove 977
Orange 957
Wormwood 50

Individual Drug Interactions

The ingredients in ParaGone For Kids II interact with 2,156 drugs. Click any drug to see the details.

4 of the 5 ingredients in ParaGone For Kids II interact with drugs. Each result below shows which ingredient is responsible. Marshmallow root Clove Orange Wormwood

Each ingredient & the kinds of drugs it affects

For each ingredient in ParaGone For Kids II with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow root3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow root full monograph & interactions

Clove7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove full monograph & interactions

Orange13 drug types · 957 drugs

Midazolam (Versed)

Bitter orange might increase blood levels of midazolam.
One small clinical study shows that bitter orange juice can increase midazolam levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4). Theoretically, bitter orange might increase the risk of midazolam-related adverse effects.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to hypertensive crisis.
Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that drinking a tea containing bitter orange and Indian snakeroot reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are using antidiabetes drugs. However, it is unclear if these effects are due to bitter orange, Indian snakeroot, or the combination. An animal study also shows that p-synephrine in combination with gliclazide , a sulfonylurea, causes an additional 20% to 44% decrease in glucose levels when compared with gliclazide alone.

Likelihood Possible Evidence B
Caffeine

Bitter orange might increase blood pressure and heart rate when taken with caffeine.
Small clinical studies show that taking bitter orange in combination with caffeine can increase blood pressure and heart rate in otherwise healthy normotensive adults. Theoretically, this might increase the risk of serious cardiovascular adverse effects.

Likelihood Possible Evidence B
Colchicine

Bitter orange might affect colchicine levels.
Colchicine is a substrate of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Bitter orange has been reported to inhibit CYP3A4 and increase levels of CYP3A4 substrates. However, one small clinical study in healthy adults shows that drinking bitter orange juice 240 mL twice daily for 4 days and taking a single dose of colchicine 0.6 mg on the 4th day decreases colchicine peak serum levels by 24%, time to peak serum level by 1 hour, and overall exposure to colchicine by 20%. The clinical significance of this finding is unclear.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Bitter orange might increase levels of drugs metabolized by CYP3A4.
Small clinical studies suggest that single or multiple doses of freshly squeezed bitter orange juice 200-240 mL can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. However, the extent of the effect of bitter orange on CYP3A4-mediated drug interactions is unknown. Some evidence suggests that bitter orange selectively inhibits intestinal CYP3A4, but not hepatic CYP3A4. Its effect on P-glycoprotein, which strongly overlaps with CYP3A4 interactions, is unclear. One small clinical study shows that drinking 8 ounces of freshly squeezed bitter orange juice has no effect on cyclosporine, which seems to be more dependent on hepatic CYP3A4 and P-glycoprotein than intestinal CYP3A4.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Bitter orange might increase blood levels of dextromethorphan.
One small clinical study shows that bitter orange juice increases dextromethorphan levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for dextromethorphan-related adverse effects.

Likelihood Possible Evidence B
Felodipine (Plendil)

Bitter orange might increase blood levels of felodipine.
One small clinical study shows that bitter orange juice increases felodipine levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for felodipine-related adverse effects.

Likelihood Probable Evidence B
Indinavir (Crixivan)

Bitter orange might increase blood levels of indinavir.
One small clinical study shows that bitter orange juice slightly increases indinavir levels, but this effect is likely to be clinically insignificant. Bitter orange selectively inhibits intestinal cytochrome P450 3A4 (CYP3A4); however, the metabolism of indinavir seems to be more dependent on hepatic CYP3A4. The effect of bitter orange on other protease inhibitors has not been studied.

Likelihood Possible Evidence B
Qt Interval-Prolonging Drugs

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
One case report suggests that taking bitter orange in combination with other stimulants such as caffeine might prolong the QT interval in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Bitter orange juice might increase blood levels of sildenafil.
A small clinical study in healthy adult males shows that drinking freshly squeezed bitter orange juice 250 mL daily for 3 days and taking a single dose of sildenafil 50 mg on the 3rd day increases the peak plasma concentration of sildenafil by 18% and the overall exposure to sildenafil by 44%. Theoretically, this may be due to inhibition of cytochrome P450 3A4 by bitter orange.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.
Bitter orange appears to have stimulant effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
In vitro research shows that octopamine, a constituent of bitter orange, weakly inhibits CYP2D6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Orange full monograph & interactions

Wormwood1 drug type · 50 drugs

Anticonvulsants

Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Thujone, a constituent of wormwood, has convulsant effects.

Likelihood Possible Evidence D
Wormwood full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ParaGone For Kids II, from the product label.

Renew Life

Name
Renew Life Formulas
City
Clearwater
State
FL
ZipCode
33765
Phone Number
866-450-1787
Web Address
www.renewlife.com
Pharmacist Counseling Corner

ParaGone For Kids II by Renew Life: Common Questions

Does ParaGone For Kids II by Renew Life interact with any medications?
Yes. Based on its ingredients, ParaGone For Kids II has a known interaction with 2,156 medications, including 10 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ParaGone For Kids II contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child if they're on allergy or cold medicine?
Many cold and allergy medications contain stimulants, antihistamines, or cough suppressants that could interact with bitter orange or clove in this product. Check the exact medication names with the interaction tool on this page, or ask your pharmacist before giving ParaGone For Kids II.
Is this product safe to give to kids?
Clove oil at high doses is toxic in children—even 5–10 mL has caused serious harm. Wormwood is also a neurotoxin at medicinal doses. This product must be used exactly as directed and kept out of reach. Because it's a liquid, overdose is a real risk. Talk to your pediatrician first.
Does black walnut in this product have any drug interactions?
No interactions are documented in our data for black walnut.
What does each ingredient do?
These are traditional herbal ingredients used in antiparasitic and digestive support formulas, but the evidence that they actually work is insufficient for most of these claims. Only clove has possibly effective evidence—for ventilator-associated pneumonia, which is not what this product is marketed for.
What happens if my child gets a bigger dose by accident?
Clove oil and wormwood can cause serious toxicity at higher doses, including seizures, muscle aches, vomiting, and kidney damage. If your child overdoses, call Poison Control (1-800-222-1222) right away.
Can I use this while breastfeeding?
Orange (bitter orange) and wormwood are possibly unsafe during breastfeeding according to our safety data. Black walnut is best avoided while breastfeeding. Talk to your doctor or pharmacist before using this product if you are nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ParaGone For Kids II label
Go deeper

The Full Monographs Behind ParaGone For Kids II’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph → Herb & supplement monograph

Black Walnut

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...

Read the full Black Walnut monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Bitter Orange

Interacts with 957 drugs

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that it works for weight loss or performance i...

Read the full Bitter Orange monograph → Herb & supplement monograph

Wormwood

Interacts with 50 drugs

Wormwood is a very bitter herb traditionally used to stimulate appetite and ease digestion, and it has early research interest in Crohn's disease. It contains thujone, which can be toxic in...

Read the full Wormwood monograph →
Sources

Sources & How We Checked

ParaGone For Kids II's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 91 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Clove 26 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  4. Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. PubMed
  5. Malson JL, Lee EM, Murty R, et al. Clove cigarette smoking: biochemical, physiological, and subjective effects. Pharmacol Biochem Behav 2003;74:739-45. PubMed
  6. Kirsch CM, Yenokida GG, Jensen WA, et al. Non-cardiogenic pulmonary oedema due to the intravenous administration of clove oil. Thorax 1990;45:235-6. PubMed
  7. Pallares, D. E. Link between clove cigarettes and urticaria? Postgrad.Med 10-1-1999;106(4):153. PubMed
  8. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
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Bitter Orange 47 references
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