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Dietary supplement

Passion Flower Glycerite Ingredients & Drug Interactions

by Eclectic Herb

Passion Flower Glycerite label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Passion Flower Glycerite against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Passion Flower Glycerite is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Passionflower Flower, Leaf Glycerite, Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Passion Flower Glycerite by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Passion Flower Glycerite by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Passion Flower Glycerite by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: passionflower flower and leaf glycerite, dried, which is a liquid extract made with glycerin. Its role is the calming, sedating activity that the passionflower plant is traditionally used for.

The inactive ingredients listed are glycerin and filtered water. These are the carrier and solvent that hold the extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promotes relaxation.
  • We looked for evidence on: anxiety, nervous tension, restlessness, sleep difficulty.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).

For insomnia (trouble sleeping), passionflower is rated Possibly Effective. For pre-procedural anxiety (nervousness before a medical procedure), it is also rated Possibly Effective.

For alcohol use disorder and benzodiazepine withdrawal, the evidence is rated Insufficient Reliable Evidence To Rate, so we cannot say whether it helps in those situations.

The evidence, ingredient by ingredient Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Passionflower is generally well tolerated short-term, but it can cause drowsiness. The most common adverse effects reported are confusion, dizziness, hypersensitivity, and sedation.

One reported case describes allergic-type skin reactions in a patient taking a combination product that included passionflower extract, though it is unclear whether passionflower itself was responsible. A case report describes a hospitalization with severe nausea, vomiting, drowsiness, a prolonged QT interval (a heart rhythm change), and episodes of irregular heartbeat after high doses of a passionflower tablet.

Symptoms resolved after passionflower was stopped. During pregnancy, the safety data advises against use because there is a lack of safety data and possible effects on the uterus.

Our safety notes also advise avoiding it while breastfeeding because there isn't enough safety information. Talk with your own doctor or pharmacist about your situation.

Side effects, ingredient by ingredient Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Passion Flower.
  • The most serious interaction on file is rated Moderate.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check sedative drugs, such as lorazepam, first, since that interaction is rated Moderate. Also check drugs that rely on liver transporter proteins (OATP substrates) and drugs broken down by the CYP3A4 liver enzyme (CYP3A4 substrates), both rated Minor.

Review all of these with your own doctor or pharmacist before combining them with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Passionflower may be worth discussing if you're looking for help with occasional sleeplessness or pre-procedure nerves, since those are the uses rated Possibly Effective. If you take sedatives or other prescription medications, or you are pregnant or breastfeeding, be extra careful.

Talk it over with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Passion Flower Glycerite, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363222261
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 316856
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Passion Flower Glycerite by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Full Dropper(s)
Maximum serving Sizes:
1 Full Dropper(s)
UPC/BARCODE
023363222261
IngredientAmount% DV
Passionflower Flower, Leaf Glycerite, Dried0 NP--

Other ingredients: Glycerin, Water, Filtered

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Promotes relaxation Herbal glycerite

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Shake well; mix 1 full dropper in water; take 3 times daily.

Storage

Store upright.

Precautions

Keep out of reach of children. Consult your health care advisor regarding the use of herbs during pregnancy, with infants or prescription drugs.

Discontinue use if unusual symptoms occur.

Consult your health care advisor regarding the use of herbs during pregnancy, with infants or prescription drugs.

Formula

100% Kosher

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent diseases.

General Statements

@Eclecticherb

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Passion Flower Glycerite by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Passion Flower Glycerite label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Passion Flower Glycerite by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Full Dropper(s) Dosage formLiquid Amounts shown are per serving.

Passionflower Flower, Leaf Glycerite, Dried

Interacts with
838 drugs
0 NP per serving Form: Passionflora incarnata Flower Glycerite, Dried, Passionflora incarnata Leaf Glycerite, Dried

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passionflower Flower, Leaf Glycerite, Dried monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Filtered. These complete the product’s ingredient list but are not active constituents.

Interaction report

Passion Flower Glycerite by Eclectic Herb Drug Interactions

Want to check YOUR meds against Passion Flower Glycerite?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
248 Moderate 590 Minor

Ingredients driving the most interactions

Passionflower Flower, Leaf Glycerite, Dried 838

Individual Drug Interactions

The ingredients in Passion Flower Glycerite interact with 838 drugs. Click any drug to see the details.

1 of the 1 ingredient in Passion Flower Glycerite interact with drugs. Each result below shows which ingredient is responsible. Passionflower Flower, Leaf Glycerite, Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Passion Flower Glycerite with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Passionflower Flower, Leaf Glycerite, Dried3 drug types · 838 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower Flower, Leaf Glycerite, Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Passion Flower Glycerite, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Passion Flower Glycerite by Eclectic Herb: Common Questions

Does Passion Flower Glycerite by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Passion Flower Glycerite has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Passion Flower Glycerite contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take passion flower glycerite while pregnant?
Our pregnancy data rates it Possibly Unsafe, and the safety data advises against using it during pregnancy. Please talk with your own doctor or pharmacist about your personal situation.
Is it safe to use while breastfeeding?
Our safety notes advise avoiding it while breastfeeding because there isn't enough safety information. Talk with your own doctor or pharmacist before deciding anything for your situation.
Does passion flower work for insomnia?
It is rated Possibly Effective for insomnia, which means the evidence is promising but not firmly established. Passionflower can cause drowsiness, so keep that in mind if you plan to use it.
What are the most common side effects?
The most common adverse effects reported are confusion, dizziness, hypersensitivity, and sedation. Passionflower is generally well tolerated short-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Passion Flower Glycerite is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Passion Flower Glycerite label
Go deeper

The Full Monographs Behind Passion Flower Glycerite’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Passion Flower

Interacts with 838 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Passion Flower Glycerite's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
  16. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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