Poria Five Combination Ingredients & Drug Interactions
by Ron Teeguarden's Dragon Herbs
What is this page for?
First and foremost: checking Poria Five Combination against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Poria Five Combination is a dietary supplement by Ron Teeguarden's Dragon Herbs with 5 active ingredients. Its ingredients are commonly taken for fluid retention and swelling, digestive complaints, sleep and calming support.Based on those ingredients, 1,267 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are White Atractylodes Rhizome Extract, Cinnamon twig extract, Poria sclerotium extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Poria Five Combination by Ron Teeguarden's Dragon Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Poria Five Combination by Ron Teeguarden's Dragon Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Poria Five Combination by Ron Teeguarden's Dragon Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Poria Five Combination contains five active ingredients in a proprietary extract blend. The two poria mushroom extracts — poria sclerotium and polyporus — make up the bulk of the formula and are traditionally used in Asian medicine.
The other three actives are cinnamon twig extract, white atractylodes rhizome extract, and alisma rhizome extract, all common ingredients in traditional herbal combinations. The capsules themselves contain inactive ingredients like pullulan polysaccharide (a plant-based capsule material), rice powder, bamboo extract powder, and rice extract blend, which serve as fillers and flow agents.
Does it work?
Couldn't assess
The evidence doesn't establish how well this product works for any condition. Poria mushroom, cinnamon twig, white atractylodes, and alisma rhizome all carry insufficient evidence ratings — meaning there isn't reliable research backing their use for conditions like diabetes, diarrhea, or the other conditions we have data for.
These ingredients have traditional use in herbal medicine, but that's different from proven effectiveness in clinical trials.
How safe is it?
Well-documented data
Poria mushroom and white atractylodes are generally well tolerated in traditional use, but human safety data are limited, so use with caution. Cinnamon twig is safe in food amounts, but supplement doses — especially high-dose or long-term use — carry a concern because cinnamon contains coumarin, which can damage the liver over time if you take very large amounts.
In trials, a small number of people reported rashes, allergic reactions including allergic rhinitis and asthma, nausea, and dry mouth. One person on cinnamon had a low blood sugar episode (hypoglycemia), though it's unclear whether cinnamon caused it.
During pregnancy, the safety data advise against poria mushroom and atractylodes. Cinnamon in food amounts is likely fine, but avoid medicinal doses.
No reliable data exist for atractylodes or poria during breastfeeding, so avoidance is recommended. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before you start, check with us if you take sedatives or other central nervous system depressants (Moderate severity), blood thinners or antiplatelet drugs like aspirin (Moderate severity), diabetes medications (Moderate severity), or medications that work through the liver. Cinnamon also has a theoretical concern with liver-damaging drugs.
The poria mushroom extracts may also interact with anticholinergic and cholinergic drugs — ask your pharmacist to check your exact list.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This is a traditional herbal blend with limited human safety and effectiveness data. If you take sedatives, blood thinners, diabetes medications, or medications that affect the liver, you should check with your pharmacist first.
Anyone pregnant or breastfeeding should talk with their doctor before starting it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Poria Five Combination, straight from the product label.
| Brand | Ron Teeguarden's Dragon Herbs |
|---|---|
| Barcode (UPC) | 679372003447 |
| Net contents | 100 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 316926 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Poria Five Combination by Ron Teeguarden's Dragon Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Formula | 1500 mg | -- |
| Poria sclerotium extract | 0 NP | -- |
| Cinnamon twig extract | 0 NP | -- |
| White Atractylodes Rhizome Extract | 0 NP | -- |
| Alisma Rhizome Extract | 0 NP | -- |
| Polyporus Extract | 0 NP | -- |
Other ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
A premium classic formulation made from the finest Chinese tonic herbs.
Poria Five Combination 100 Vegetarian Capsules, 500 mg each
Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.
Formulation
This formulation is extremely safe and effective.
Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
Ron Teeguarden's Dragon Herbs Health Deserves Cultivation
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take 3 capsules, 2 times per day or as directed by a healthcare professional.
Precautions
Keep out of the reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Poria Five Combination by Ron Teeguarden's Dragon Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Poria Five Combination by Ron Teeguarden's Dragon Herbs
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container33 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Formula
- › Poria sclerotium extract
- › Cinnamon twig extract
- › White Atractylodes Rhizome Extract
- › Alisma Rhizome Extract
- › Polyporus Extract
Other (inactive) ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend. These complete the product’s ingredient list but are not active constituents.
Poria Five Combination by Ron Teeguarden's Dragon Herbs Drug Interactions
HelloPharmacist Interaction Report
Poria Five Combination by Ron Teeguarden's Dragon Herbs contains multiple ingredients with documented interactions.
The most serious concern involves the poria mushroom extracts (poria sclerotium and polyporus), which may enhance the effects of sedatives and other central nervous system (CNS) depressants — this means they could make you drowsier or amplify side effects if you're taking sleep aids, anti-anxiety medications, or similar drugs. These effects have been seen in animal studies but not yet confirmed in humans.
Read the full breakdown — every affected drug type, severity by severity
Cinnamon twig extract may lower blood sugar and could have additive effects with diabetes medications, potentially requiring dose adjustments. It also poses a theoretical concern with liver-damaging drugs (hepatotoxic drugs), particularly at higher doses or with longer use, because cinnamon contains coumarin.
White atractylodes rhizome extract may increase bleeding risk if you take blood thinners or antiplatelet drugs like aspirin. It also has theoretical effects on certain hormone-blocking drugs (aromatase inhibitors) and could alter how your body metabolizes several medication types, though these haven't been proven in humans.
We couldn't check alisma rhizome extract — no interaction data is on file for it. Altogether, these interactions span 1,246 individual medications.
Please run your specific medications through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Poria Five Combination?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Poria Five Combination interact with 1,267 drugs. Click any drug to see the details.
3 of the 5 ingredients in Poria Five Combination interact with drugs. Each result below shows which ingredient is responsible. White Atractylodes Rhizome Extract Cinnamon twig extract Poria sclerotium extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
White Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Abciximab interactionAbiraterone
How Abiraterone interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Abiraterone interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Abiraterone Acetate interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
White Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Twig ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon Twig Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
White Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Poria Five Combination — through 1 ingredient. Tap an ingredient for the detail:
Polyporus ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Aspirin interactionWhite Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
White Atractylodes Rhizome ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Aspirin, Caffeine interactionCinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Butalbital interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Butalbital, Caffeine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionPolyporus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Polyporus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acetaminophen, Butalbital, Codeine interactionCinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Butalbital, Codeine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionPolyporus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionPolyporus ExtractAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Polyporus Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Caffeine, Codeine interactionPolyporus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acetaminophen, Caffeine, Codeine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Polyporus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionCinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Polyporus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionCinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Poria Five Combination — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Caffeine, Isometheptene interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Polyporus ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Polyporus Extract + Acetaminophen, Caffeine, Pyrilamine interactionCinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Caffeine, Pyrilamine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionPolyporus ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Polyporus Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionPolyporus ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Polyporus Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionWhite Atractylodes Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Polyporus ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Polyporus Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionCinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Poria Five Combination — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Twig ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Twig Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionPolyporus ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Polyporus Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionWhite Atractylodes Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full White Atractylodes Rhizome Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Poria Five Combination with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
White Atractylodes Rhizome Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Laboratory research suggests that atractylenolides II and III, constituents of atractylodes, reduce platelet activation. So far, this has not been shown in humans.
Aromatase Inhibitors
Theoretically, atractylodes may have an additive effect when used with other aromatase inhibitors.
Laboratory research suggests that atractylodes and its constituents exhibit aromatase inhibitor effects.
Hexobarbital
Theoretically, taking atractylodes may prolong the therapeutic and adverse effects of hexobarbital.
In animals, atractylodes has been shown to prolong the effects of hexobarbital. These effects have not been shown in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
In animals, atractylodes administered at high doses has been shown to induce CYP1A2 activity. This effect has not been shown in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
In animals, atractylodes administered at high doses has been shown to inhibit CYP3A1 activity, which is a homolog to the human CYP3A4 enzyme. This effect has not been shown in humans.
Cinnamon twig extract
Antidiabetes Drugs
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.
Hepatotoxic Drugs
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.
Poria sclerotium extract
Anticholinergic Drugs
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cholinergic Drugs
Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cns Depressants
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.
Brand information
Manufacturer and brand details for Poria Five Combination, from the product label.
Ron Teeguarden's Dragon Herbs
See all Ron Teeguarden's Dragon Herbs products- Name
- Ron Teeguarden's Dragon Herbs
- City
- Los Angeles
- State
- CA
- ZipCode
- 90036
- Phone Number
- (888) 558-6642
- Web Address
- www.dragonherbs.com
Poria Five Combination by Ron Teeguarden's Dragon Herbs: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Poria Five Combination’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Poria Mushroom
Interacts with 417 drugsPoria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...
Read the full Poria Mushroom monograph → Herb & supplement monographCassia Cinnamon
Interacts with 442 drugsCassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...
Read the full Cassia Cinnamon monograph → Herb & supplement monographAtractylodes
Interacts with 801 drugsAtractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue, often as part of multi-herb formulas. Modern resea...
Read the full Atractylodes monograph →Sources & How We Checked
Poria Five Combination's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Poria Mushroom 3 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
- Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.
Cassia Cinnamon 20 references
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
- De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
- Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
- Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
- Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
- Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
- Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
- Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
- Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
- Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
- Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
- Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
- Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
- Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
- Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
- Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
- Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
- Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
- Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed
Atractylodes 6 references
- Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed
- Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. PubMed
- Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. PubMed
- Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. PubMed
- Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. PubMed
- Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC