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Dietary supplement

Pregnenolone 100 mg + Lecithin Ingredients & Drug Interactions

by X Gold Health

Pregnenolone 100 mg + Lecithin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 100 mg + Lecithin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 100 mg + Lecithin is a dietary supplement by X Gold Health with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, liver health, brain and memory support.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 100 mg + Lecithin by X Gold Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 100 mg + Lecithin by X Gold Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 100 mg + Lecithin by X Gold Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Pregnenolone is a hormone precursor — your body can convert it into other hormones like estrogen, progesterone, and testosterone.

Lecithin is a fat-like substance found naturally in eggs and soybeans; it's included in many supplements for its role in cell structure and cell-to-cell signaling. The capsule also holds inactive ingredients (cellulose, rice flour, and magnesium stearate) that help hold the formula together and make it easy to swallow.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Hormone precursor to support memory and mood.
  • We looked for evidence on: Age-related cognitive decline, Memory, Anxiety, Stress, Depression, Fatigue — and 4 related terms.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Depression (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Fatigue, Memory, Stress.
  • Also on file: Lecithin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Anxiety, Dry skin.

For pregnenolone, the evidence isn't established in the data we hold — we have insufficient reliable evidence to rate it for alcohol use disorder, Alzheimer's disease, autism, back pain, bipolar disorder, and other conditions listed. Lecithin shows similar gaps: it's likely ineffective for Alzheimer's disease, and we have insufficient evidence for age-related cognitive decline, certain liver conditions, anxiety, and bipolar disorder.

If you're considering this product for a specific health goal, talk with your pharmacist or doctor about whether the evidence supports its use.

The evidence, ingredient by ingredient Lecithin Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is a hormone with limited human safety data, so use it only under guidance from a healthcare professional. It's not safe in pregnancy — the safety data advises against it — and there isn't enough information to know if it's safe while breastfeeding, so avoid it then too.

Lecithin is generally well tolerated in food and supplement amounts, though it can cause stomach upset (abdominal pain, diarrhea, nausea, or fullness). If you have an egg or soy allergy, lecithin may trigger allergic skin reactions.

Pregnenolone itself may cause acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, or tremor — one case of a photosensitivity-type rash has also been reported.

Side effects, ingredient by ingredient Lecithin Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check any estrogen-based medications (birth control, hormone replacement therapy), benzodiazepines (anti-anxiety or sleep drugs like diazepam), progestin, testosterone, or progesterone medications. Pregnenolone may enhance or reduce how these work.

Your exact medications matter — use the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone 100 mg + Lecithin is intended for people interested in hormone precursor supplementation, but it's a hormone product with real drug interaction risks and limited safety evidence, so it's not for everyone. If you take any estrogen, progestin, testosterone, progesterone, or benzodiazepine medication, you need to check with your pharmacist or doctor first — this product may change how those drugs work.

Anyone pregnant or breastfeeding should avoid it. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 100 mg + Lecithin, straight from the product label.

Brand X Gold Health
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 310946
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 100 mg + Lecithin by X Gold Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
60
IngredientAmount% DV
Lecithin100 mg--
Pregnenolone, Micronized100 mg--

Other ingredients: Cellulose, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Hormone precursor to support memory & mood 2-in-1 formula

Micronized for higher bioavailability Supports memory & cognitive function Supports hormone balance

Zero gluten, soy, eggs, dairy, nuts, preservatives or animal products

Non GMO Ingredients Verified

Manufactured and quality tested in the USA Ingredients carefully sourced from around the world

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement take two (2) capsules once a day with food and a full glass of water. Best when taken as directed by a qualified healthcare professional.

Precautions

Keep out of reach of children.

Not recommended for pregnant or lactating women.

Storage

Store tightly closed in a dry place at controlled room temperature of 50 degrees-86 degrees F.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Your health is gold! Be Happy!

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufactured Practice Third Party Tested Premium Quality Quality Control Approved Non GMO Ingredients Verified Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 100 mg + Lecithin by X Gold Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 100 mg + Lecithin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 100 mg + Lecithin by X Gold Health

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lecithin

No known
interactions
100 mg per serving Form: Soy

Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...

Lecithin monograph & interactions

Pregnenolone, Micronized

Interacts with
82 drugs
100 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone, Micronized monograph & interactions

Other (inactive) ingredients: Cellulose, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 100 mg + Lecithin by X Gold Health Drug Interactions

Want to check YOUR meds against Pregnenolone 100 mg + Lecithin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone, Micronized 82

Individual Drug Interactions

The ingredients in Pregnenolone 100 mg + Lecithin interact with 82 drugs. Click any drug to see the details.

1 of the 2 ingredients in Pregnenolone 100 mg + Lecithin interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone, Micronized

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 100 mg + Lecithin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone, Micronized5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone, Micronized full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 100 mg + Lecithin, from the product label.

X Gold Health

See all X Gold Health products
Name
X Gold Health LLC
City
Miami
State
FL
ZipCode
33141
Web Address
www.xgoldhealth.com
Pharmacist Counseling Corner

Pregnenolone 100 mg + Lecithin by X Gold Health: Common Questions

Does Pregnenolone 100 mg + Lecithin by X Gold Health interact with any medications?
Yes. Based on its ingredients, Pregnenolone 100 mg + Lecithin has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 100 mg + Lecithin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lecithin safe if I have a soy or egg allergy?
Lecithin can cause allergic skin reactions in people with egg or soy allergies, so you need to talk with your doctor or pharmacist first. Many lecithin supplements are made from soy, so check the label and ask about the source.
Can I take this while pregnant or breastfeeding?
No — pregnenolone is not safe in pregnancy due to unknown risks, and there isn't enough safety information to use it while breastfeeding. Lecithin is likely safe during pregnancy and lactation, but the pregnenolone in this product makes it off-limits for both. Talk with your doctor for personalized advice.
What side effects might I notice?
Pregnenolone may cause acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, or tremor. Lecithin often causes mild stomach upset — abdominal pain, diarrhea, nausea, or fullness. A rare photosensitivity-type rash has been reported with pregnenolone and cleared on its own.
Does this product actually work for brain health or memory?
The evidence isn't there yet. Both pregnenolone and lecithin are insufficient evidence for age-related cognitive decline, and lecithin is likely ineffective for Alzheimer's disease. We don't have reliable data to back those claims.
Why do I need to check my medications with a pharmacist?
Pregnenolone interacts with hormone-based drugs and benzodiazepines — it can make some stronger and others weaker, which could be risky. Your specific medications and doses matter, so use the checker or ask your pharmacist directly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 100 mg + Lecithin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 100 mg + Lecithin label
Go deeper

The Full Monographs Behind Pregnenolone 100 mg + Lecithin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lecithin

Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...

Read the full Lecithin monograph → Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 100 mg + Lecithin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lecithin 9 references
  1. Buchman AL, Dubin M, Jenden D, et al. Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology 1992;102:1363-70.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Chatellier G, Lacomblez L. Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Francais d'Etude de la Tetrahydroaminoacridine. BMJ 1990;300:495-9.
  4. Gelenberg AJ, Dorer DJ, Wojcik JD, et al. A crossover study of lecithin treatment of tardive dyskinesia. J Clin Psychiatry 1990;51:149-53.
  5. Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1985;48:736-42. PubMed
  6. Palm M, Moneret-Vautrin DA, Kanny G, et al. Food allergy to egg and soy lecithins. Allergy 1999;54:1116-7. PubMed
  7. Drachman DA, Glosser G, Fleming P, et al. Memory decline in the aged: treatment with lecithin and physostigmine. Neurology 1982;32:944-50. PubMed
  8. Gelenberg, A. J., Doller-Wojcik, J. C., and Growdon, J. H. Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study. Am J Psychiatry 1979;136(6):772-776. PubMed
  9. Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 184: Direct food substances affirmed as Generally Recognized as Safe. Subpart B - listing of specific substances affirmed as GRAS. Sec. 184.1400 Lecithin. Available at: https:

See these in context on the Lecithin monograph →

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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