Prg-gen Ingredients & Drug Interactions
by Genestra Brands
What is this page for?
First and foremost: checking Prg-gen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Prg-gen is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for memory and concentration, digestive upset, hair growth.Based on those ingredients, 372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosemary (Rosmarinus officinalis) young shoot extract, Raspberry (Rubus idaeus) young shoot extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Prg-gen by Genestra Brands
Ask about any prescription or over-the-counter medication and we check it for interactions with Prg-gen by Genestra Brands — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Prg-gen by Genestra Brands
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Prg-gen is a liquid supplement with three active plant ingredients. Rosemary young shoot extract is traditionally used for memory and cognitive support.
Red raspberry leaf is included for general wellness—though the evidence for its claimed benefits is not yet established in our data. Spanish Chestnut bud extract makes up the third ingredient, but we hold no detailed information on its role or effects.
The product also contains inactive ingredients (purified water, ethanol, and glycerin) that serve as the liquid base and preservative.
Does it work?
Moderate evidence
Rosemary has possibly effective evidence for memory support—that's the strongest rating we hold for this product. For other uses listed in the data—age-related cognitive decline, hair loss (alopecia areata), and fatty liver disease—the evidence is insufficient to rate.
Red raspberry leaf's effectiveness for aging skin, heart health, respiratory infections, heart failure, and diabetes is also insufficient to rate in our data. In short, if you're taking this mainly for memory, the science shows some promise; for other claims, the evidence isn't yet established.
How safe is it?
Well-documented data
Rosemary in normal food amounts is considered safe, but concentrated extracts (which this liquid is) require caution. The safety data advises against medicinal doses during pregnancy—food amounts are likely fine, but high doses should be avoided.
For breastfeeding, food amounts are probably okay, but there isn't enough data on medicinal doses. Red raspberry leaf is generally well tolerated by most adults, though safety evidence is limited.
It's often used late in pregnancy with provider guidance, but safety isn't well established—talk to your doctor if you're pregnant or planning to be. There's not enough data to confirm safety while breastfeeding.
Adverse effects are uncommon at typical doses but can include allergic reactions, lip or gum swelling, skin rashes (especially with sun exposure), gastrointestinal upset, diarrhea, and rarely occupational asthma from inhalation.
Meds to double-check
Moderate interaction found
Double-check this product if you take anticoagulants or antiplatelet drugs (blood thinners like warfarin, apixaban, or clopidogrel; aspirin; or similar salicylate-based medications)—rosemary and raspberry may increase bleeding risk. Also flag insulin and other diabetes medications, since both ingredients may lower blood sugar.
If you take medications that rely on liver enzyme CYP1A2 to work (a minor concern), mention this to your pharmacist too.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you're taking blood thinners, diabetes medications, or aspirin, check with your pharmacist before starting this supplement—the interactions are theoretical but worth verifying for your specific medications. Otherwise, if you're interested in memory support and tolerate the ingredients well, Prg-gen is generally well tolerated.
Pregnant or breastfeeding? Talk to your provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Prg-gen, straight from the product label.
| Brand | Genestra Brands |
|---|---|
| Barcode (UPC) | 88319610901 |
| Net contents | 0.5 fl. Oz.; 15 mL |
| Market status | On market |
| Date entered into DSLD | Sep 22, 2016 |
| DSLD ID | 64526 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Prg-gen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Rosemary (Rosmarinus officinalis) young shoot extract | 0.09 mL | -- |
| Spanish Chestnut (Castanea sativa) bud extract | 0.09 mL | -- |
| Raspberry (Rubus idaeus) young shoot extract | 0.09 mL | -- |
Other ingredients: purified Water, Ethanol, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Phyto-Gen
Formula
- Spanish Chestnut - Rosemary - Raspberry
FDA Statement of Identity
Herbal Supplement
Precautions
Risk Information: If you are pregnant or breastfeeding, do not use, unless directed by your healthcare practitioner.
If symptoms persist or worsen, consult your healthcare practitioner.
Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if inner seal is missing or broken.
For risk information, see outer box. Do not use if seal is missing or broken.
Formulation
Guaranteed to contain no added wheat, starch, yeast, gluten, corn, soy, sodium, sugar, artificial coloring or flavoring, antimicrobial preservatives, dairy or animal products.
Ideal for vegans.
Storage
Store in a cool, dry place.
Suggested/Recommended/Usage/Directions
Recommended Dose: Adults and Children (over 12 years): Take 10 drops once daily, or as recommended by your healthcare practitioner.
General
895
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Prg-gen by Genestra Brands label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Prg-gen by Genestra Brands
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.28 mL Dosage formLiquid Servings per container53 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Rosemary (Rosmarinus officinalis) young shoot extract
Interacts with372 drugs
Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory...
Rosemary (Rosmarinus officinalis) young shoot extract monograph & interactionsSpanish Chestnut (Castanea sativa) bud extract
Raspberry (Rubus idaeus) young shoot extract
Interacts with135 drugs
Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific eviden...
Raspberry (Rubus idaeus) young shoot extract monograph & interactionsOther (inactive) ingredients: Purified Water, Ethanol, Glycerin. These complete the product’s ingredient list but are not active constituents.
Prg-gen by Genestra Brands Drug Interactions
HelloPharmacist Interaction Report
Prg-gen by Genestra Brands contains two ingredients with documented interactions with medications.
Rosemary is the source of the most serious concerns: it may increase bleeding risk if you're taking anticoagulants or antiplatelet drugs (blood thinners, aspirin, or related salicylate drugs). The mechanism isn't proven in humans, but lab and animal work suggests rosemary inhibits platelet function and contains salicylates itself.
Read the full breakdown — every affected drug type, severity by severity
Both rosemary and red raspberry leaf may lower blood sugar, raising the theoretical risk of low blood sugar (hypoglycemia) if you're on insulin or other diabetes medications. Red raspberry leaf also carries a moderate risk of bleeding with anticoagulants and antiplatelet drugs, based on lab evidence of antiplatelet activity—though this hasn't been reported in actual patients.
Rosemary may also slightly reduce how your liver processes certain medications (CYP1A2 substrates), though this effect is minor and hasn't been confirmed in humans.
We could not check Spanish Chestnut bud extract—we hold no interaction data for it. Altogether, these interactions span 371 individual medications.
Run your exact prescriptions through the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Prg-gen?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Prg-gen interact with 372 drugs. Click any drug to see the details.
2 of the 3 ingredients in Prg-gen interact with drugs. Each result below shows which ingredient is responsible. Rosemary (Rosmarinus officinalis) young shoot extract Raspberry (Rubus idaeus) young shoot extract
Canagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Canagliflozin, Metformin Hydrochloride interactionCangrelorKengreal
How Cangrelor interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Cangrelor interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Cangrelor interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Chlorpropamide interactionCholine Magnesium TrisalicylateTricosal, Trilisate
How Choline Magnesium Trisalicylate interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractCholine Magnesium Trisalicylate (trilisate) Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Choline Magnesium Trisalicylate interactionCilostazolPletal
How Cilostazol interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Cilostazol interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Cilostazol interactionClopidogrelPlavix
How Clopidogrel interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Clopidogrel interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Clopidogrel interactionDalteparinFragmin
How Dalteparin interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Raspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Dalteparin interactionRosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dalteparin interactionDanaparoidOrgaran
How Danaparoid interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Danaparoid interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Danaparoid interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dasiglucagon Hydrochloride interactionDefibrotide SodiumDefitelio
How Defibrotide Sodium interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Defibrotide Sodium interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Defibrotide Sodium interactionDiclofenacZorvolex
How Diclofenac interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Raspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Diclofenac interactionRosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Diclofenac interactionDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
How Diclofenac Potassium interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Raspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Diclofenac Potassium interactionRosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Diclofenac Potassium interactionDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Raspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Diclofenac Sodium interactionRosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Diclofenac Sodium, Misoprostol interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Diclofenac Epolamine interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Diclofenac Epolamine interactionDicumarolDicumarol
How Dicumarol interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dicumarol interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Dicumarol interactionDiphenhydramine Hydrochloride, Naproxen SodiumAleve PM
How Diphenhydramine Hydrochloride, Naproxen Sodium interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Raspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Diphenhydramine Hydrochloride, Naproxen Sodium interactionRosemary (rosmarinus Officinalis) Young Shoot ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Diphenhydramine Hydrochloride, Naproxen Sodium interactionDipyridamoleDipyridamole, Persantin, Persantin Injection, Persantin Retard, Persantine
How Dipyridamole interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dipyridamole interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Dipyridamole interactionDulaglutideTrulicity
How Dulaglutide interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Dulaglutide interactionEdoxabanSavaysa
How Edoxaban interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Edoxaban interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Edoxaban interactionEffientPrasugrel
How Effient interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Raspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Effient interactionRosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Effient interactionEmpagliflozinJardiance
How Empagliflozin interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Prg-gen — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Empagliflozin, Metformin Hydrochloride interactionEnoxaparinLovenox
How Enoxaparin interacts with Prg-gen — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Young Shoot Extract + Enoxaparin interactionRaspberry (rubus Idaeus) Young Shoot ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Read the full Raspberry (rubus Idaeus) Young Shoot Extract + Enoxaparin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Prg-gen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Rosemary (Rosmarinus officinalis) young shoot extract
Anticoagulant/Antiplatelet Drugs
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.
Aspirin
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.
Choline Magnesium Trisalicylate (Trilisate)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.
Salsalate (Disalcid)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.
Raspberry (Rubus idaeus) young shoot extract
Anticoagulant/Antiplatelet Drugs
Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that red raspberry leaf extract has antiplatelet activity and enhances the in vitro effects of the antiplatelet medication cangrelor. This interaction has not been reported in humans.
Insulin
Red raspberry leaf might reduce glucose levels in patients being treated with insulin.
In one case report, a 38-year-old patient with gestational diabetes, whose blood glucose was being controlled with medical nutrition therapy and insulin, developed hypoglycemia after consuming two servings of raspberry leaf tea daily for 3 days beginning at 32 weeks' gestation. The patient required an insulin dose reduction. The hypoglycemia was considered to be probably related to use of red raspberry leaf tea.
Brand information
Manufacturer and brand details for Prg-gen, from the product label.
Genestra Brands
- Name
- Seroyal USA
- City
- Wood Dale
- State
- Illinois
- ZipCode
- 60191
- Phone Number
- 1-888-737-6925
Prg-gen by Genestra Brands: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Prg-gen’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Rosemary
Interacts with 372 drugsRosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...
Read the full Rosemary monograph → Herb & supplement monographRed Raspberry
Interacts with 135 drugsRed raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific evidence for these uses is limited. It is gene...
Read the full Red Raspberry monograph →Sources & How We Checked
Prg-gen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Rosemary 20 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
- Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
- Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
- Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
- Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
- Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
- Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
- Naemura A, Ura M, Yamashita T, et al. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008;122(4):517-22. PubMed
- Lee JJ, Jin YR, Lim Y, et al. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vascul Pharmacol 2006;45:148-53. PubMed
- Bakirel, T., Bakirel, U., Keles, O. U., Ulgen, S. G., and Yardibi, H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2-28-2008;116(1):64-73. PubMed
- Erenmemisoglu, A., Saraymen, R., and Ustun, S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie 1997;52(8):645-646.
- Valones MAA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF Jr, Carvalho AAT. Clinical assessment of rosemary-based toothpaste (Rosmarinus officinalis Linn.): A randomized controlled double-blind study. Braz Dent J. 2019;30(2):146-151. PubMed
- Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, et al. A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD). J Popul Ther Clin Pharmacol. 2019;26(4):e18-e28.
- Al Jamal A. Effect of rosemary (Rosmarinus officinalis) on lipid profiles and blood glucose in human diabetic patients (type-2). African J. Biochem. Res. 2014;8(8):147-50. DOI
Red Raspberry 8 references
- Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
- Parsons M, Simpson M, Ponton T. Raspberry leaf and its effects on labour: safety and efficacy. Aust Coll Midwives Inc J 1999;12:20-5.
- Simpson M, Parsons M, Greenwood J, Wade K. Raspberry leaf in pregnancy: its safety and efficacy in labor. J Midwifery Womens Health 2001;46:51-9.. PubMed
- Mullen W, McGinn J, Lean ME, et al. Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem 2002;50:5191-6.. PubMed
- Sherson, D., Andersen, B., Hansen, I., and Kjoller, H. Occupational asthma due to freeze-dried raspberry. Ann Allergy Asthma Immunol. 2003;90(6):660-663. PubMed
- Cheang KI, Nguyen TT, Karjane NW, Salley KE. Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus. Obstet Gynecol. 2016;128(6):1421-4. PubMed
- Dudzinska D, Bednarska K, Boncler M, Luzak B, Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433-9.
- Henrotin Y, Cozannet RL, Fança-Berthon P, et al. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. BMC Musculoskelet Disord 2022;23(1):650. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC