Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Primadophilus Probifia Pearls Ingredients & Drug Interactions

by Nature's Way

Primadophilus Probifia Pearls label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Primadophilus Probifia Pearls against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Primadophilus Probifia Pearls is a dietary supplement by Nature's Way with 5 active ingredients. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium breve. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Primadophilus Probifia Pearls by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Primadophilus Probifia Pearls by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Primadophilus Probifia Pearls by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (15 mg) without saying how much of each component you get.

Primadophilia Probifia Pearls contains 5 active ingredients: four species of beneficial bacteria (Bifidobacterium infantis, B. animalis lactis, B. longum, B. bifidum, and B. breve) packaged in what Nature's Way calls a proprietary probiotic blend. These are live-culture probiotics meant to support your gut bacteria.

The product also includes inactive ingredients like coconut oil, palm oil, fish gelatin, vegetable glycerin, soy lecithin, pectin, and silicon dioxide, which serve as fillers and to hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: colon health probiotic.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Constipation, Rotaviral diarrhea, Irritable bowel syndrome (IBS), and more.

The evidence for most uses of these Bifidobacterium species is limited or absent in our data. Bifidobacterium bifidum shows Possibly Effective ratings for irritable bowel syndrome (IBS) and respiratory tract infections, meaning some evidence supports it for these conditions, though more research would strengthen that case.

Most other claimed uses—including age-related cognitive decline, hay fever, anxiety, and asthma—have Insufficient Reliable Evidence To Rate in the data we hold. Bifidobacterium breve is rated Possibly Ineffective for age-related cognitive decline and sepsis.

If you're considering this product for a specific health goal, it's worth talking it through with your doctor to see whether the evidence matches what you're hoping for.

The evidence, ingredient by ingredient Bifidobacterium Longum Bifidobacterium Bifidum Bifidobacterium Breve

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The Bifidobacterium species in this product are generally well tolerated in healthy people, but caution is needed if you're seriously ill, immune-compromised, or have a weakened immune system. Rare gastrointestinal side effects have been reported with these probiotics, including abdominal discomfort, pain, distension, flatulence, constipation, and rare cases of gastrointestinal motor disorder when taken by mouth.

One person reported a dry cough. In rare cases, particularly in critically ill infants and adults, Bifidobacterium bacteria have entered the bloodstream (bacteremia), sometimes leading to sepsis.

Regarding pregnancy and breastfeeding: Bifidobacterium longum and B. bifidum are rated Possibly Safe in pregnancy, though safety data are limited. Breastfeeding safety data for these ingredients are also limited.

Talk with your doctor or pharmacist about whether this product is right for you if you are pregnant, breastfeeding, or have a serious illness or compromised immune system.

Side effects, ingredient by ingredient Bifidobacterium Longum Bifidobacterium Bifidum Bifidobacterium Breve

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Bifidobacterium Breve, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Primadophilia Probifia Pearls, double-check with your doctor or pharmacist if you take antibiotic drugs. Because this product contains live Bifidobacterium organisms, antibiotics taken at the same time could kill the bacteria and reduce the probiotic's intended effect.

Your healthcare provider can help you time the two so they don't interfere.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-strain probiotic meant for general gut health, with the strongest evidence backing Bifidobacterium bifidum for IBS and respiratory infections. If you're on antibiotics, you'll need to time this product carefully so the antibiotics don't kill the live bacteria—ask your doctor or pharmacist for a spacing schedule.

It's generally well tolerated in healthy people, but caution is advised if you're seriously ill or have a weakened immune system. Check with your own doctor or pharmacist before starting, especially if you take medications or have health conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Primadophilus Probifia Pearls, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674151242
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2014
DSLD ID 40037
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Primadophilus Probifia Pearls by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
033674151242
IngredientAmount% DV
Bifidobacterium infantis0 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium longum0 NP--
Bifidobacterium bifidum0 NP--
Bifidobacterium breve0 NP--
Proprietary Probiotic Blend15 mg--

Other ingredients: Coconut Oil, Palm Oil, Fish Gelatin, Vegetable Glycerin, Soy Lecithin, Pectin, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

May contain a minimal residual amount of milk protein.

ACTIVE BIFIDOBACTERIUM

Adult Formula

Brand IP Statement(s)

(C) 2013

Exclusively backed by TRUE GUARANTEE(TM)

True Potency(TM) ensures the stability of active cultures at room temperature for the entire shelf life. True Release(TM) ensures survival through stomach acid for maximum delivery into the intestinal tract. True Identity(TM) ensures that only the probiotic strains listed on the label are present in the product.

Why take Primadophilus(R) Probifia(R)? As adults age the amount of bifidobacteria in the colon declines. Taking Primadophilus(R) Probifia(R) fortifies the colon with health-promoting bifidobacteria.*

True Release(TM) Protected from Stomach Acid

General Statements

COLON HEALTH PROBIOTIC

Product of Japan

Triple-Layer Capsule {Capsule} Actual Size

Active Bifidobacteria cultures (such as B. longum, B. breve, B. lactis, B. infantis, and B. bifidum) are an essential part of the human intestinal microflora in the colon (large intestine). Studies show maintaining a proper balance of bifidobacteria within the colon can help: - support overall digestive and colon health* - reduce putrefactive (foul-smelling) substances in the colon* - maintain regularity and proper stool consistency* - promote healthy immune function

{Chart} Level of Bifidobacteria in the Colon With Bifidobacterium Supplementation Without Bifidobacterium Supplementation Adult Age

Capsule color variations are normal.

TRIPLE LAYER SHELL {Capsule)

100% Stable at Room Temperature

ONCE DAILY Individually Sealed for Use Anytime!

Seals/Symbols

TRUE POTENCY(TM) SYNERGY BLEND

Nature's Way(R)

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Freshness & safety sealed for your protection. Each capsule is enclosed in an individually sealed blister. Do not use if any seal is broken, punctured or missing.

May contain a minimal residual amount of milk protein.

General

LBN15124.02 (B711272) (C8077)

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 capsule daily with or without food. Do not chew or crush.

Storage

Store in a cool, dry place.

No Refrigeration Required

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Primadophilus Probifia Pearls by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Primadophilus Probifia Pearls label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Primadophilus Probifia Pearls by Nature's Way

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

15 mg per serving

Other (inactive) ingredients: Coconut Oil, Palm Oil, Fish Gelatin, Vegetable Glycerin, Soy Lecithin, Pectin, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Primadophilus Probifia Pearls by Nature's Way Drug Interactions

Want to check YOUR meds against Primadophilus Probifia Pearls?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum 182
Bifidobacterium bifidum 182
Bifidobacterium breve 182

Individual Drug Interactions

The ingredients in Primadophilus Probifia Pearls interact with 182 drugs. Click any drug to see the details.

3 of the 5 ingredients in Primadophilus Probifia Pearls interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum Bifidobacterium bifidum Bifidobacterium breve

Each ingredient & the kinds of drugs it affects

For each ingredient in Primadophilus Probifia Pearls with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Primadophilus Probifia Pearls, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Products, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
www.naturesway.com
Pharmacist Counseling Corner

Primadophilus Probifia Pearls by Nature's Way: Common Questions

Does Primadophilus Probifia Pearls by Nature's Way interact with any medications?
Yes. Based on its ingredients, Primadophilus Probifia Pearls has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Primadophilus Probifia Pearls contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
It's best to space them out. Taking probiotics and antibiotics at the same time might reduce how well the probiotic works, since antibiotics can kill the live bacteria in this product. Check with your doctor or pharmacist about the timing that works best for you.
Is this safe if I'm pregnant or breastfeeding?
The Bifidobacterium species in this product are rated Possibly Safe in pregnancy, but safety data are limited. For breastfeeding, we don't have enough data to say either way. Talk with your doctor or pharmacist before using it if you're pregnant or breastfeeding to see if it's right for your situation.
What are these Bifidobacterium bacteria supposed to do?
They're live beneficial bacteria meant to support your gut microbiome. The strongest evidence backs Bifidobacterium bifidum for irritable bowel syndrome and respiratory tract infections, though evidence for many other uses is limited or still being studied.
What side effects are possible?
Most people tolerate it well, but rare side effects include abdominal discomfort, pain, bloating, flatulence, constipation, and one report of a dry cough. In very rare cases—mainly in critically ill patients—Bifidobacterium bacteria have entered the bloodstream. If you're seriously ill or have a weakened immune system, check with your doctor first.
Does this product have fillers or other inactive ingredients?
Yes. Along with the active probiotic bacteria, it contains coconut oil, palm oil, fish gelatin, vegetable glycerin, soy lecithin, pectin, and silicon dioxide to help with the formula and capsule.
Why can't you check two of the ingredients?
We don't hold interaction data for Bifidobacterium infantis and Bifidobacterium animalis lactis, so we can't tell you whether they interact with medications. The other three Bifidobacterium species in the product do have documented interactions with antibiotics.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Primadophilus Probifia Pearls is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Primadophilus Probifia Pearls label
Go deeper

The Full Monographs Behind Primadophilus Probifia Pearls’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph →
Sources

Sources & How We Checked

Primadophilus Probifia Pearls's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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