Pro-Bio Ingredients & Drug Interactions
by Enzymedica
What is this page for?
First and foremost: checking Pro-Bio against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pro-Bio is a dietary supplement by Enzymedica with 8 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. acidophilus, Bacillus subtilis, L. bulgaricus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pro-Bio by Enzymedica
Ask about any prescription or over-the-counter medication and we check it for interactions with Pro-Bio by Enzymedica — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pro-Bio by Enzymedica
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Pro-Bio contains 8 active ingredients—all live-culture probiotics (beneficial bacteria and one Bacillus strain). The ones we have data for include Lactobacillus acidophilus, Lactobacillus delbrueckii, Bacillus subtilis, and four other Lactobacillus species.
These are meant to support your gut flora. The product also contains inactive ingredients (gellan gum, cellulose, and water) that serve as fillers and the capsule base.
Does it work?
Moderate evidence
The evidence for Pro-Bio is mixed and often limited. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.
Bacillus subtilis is possibly effective for antibiotic-associated diarrhea. For most other uses—asthma, eczema, hay fever, constipation, diabetes, athletic performance, and cirrhosis—the evidence either isn't established or is rated insufficient to say.
We don't hold effectiveness data for the other ingredients.
How safe is it?
Well-documented data
L. acidophilus is generally well tolerated in healthy adults and children. Bacillus subtilis and L. delbrueckii are also generally well tolerated in healthy adults, though safety varies by strain and product quality.
The main caution: all three checked ingredients contain live microorganisms, and in rare cases they've been linked to serious infections (bacteremia, sepsis, abscess, endocarditis, and meningitis), especially in people who are very ill or have a weakened immune system. Mild gastrointestinal side effects—bloating, gas, diarrhea, abdominal pain—can occur but are uncommon.
Check with your doctor before use, particularly if you're immunocompromised or very ill.
Meds to double-check
Moderate interaction found
Check your antibiotic drugs before taking Pro-Bio. Three of the strains in this product may lose effectiveness if antibiotics are taken at the same time, so you'll need to separate them by several hours.
If you take any prescription medications, run them through the checker below.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Pro-Bio is a multi-strain probiotic that may help with antibiotic-related diarrhea and a few other gut issues, though evidence is limited. If you take antibiotics, you'll need to time this product carefully to avoid reducing its effect.
Talk to your pharmacist before starting, especially if you have a weakened immune system or are seriously ill.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pro-Bio, straight from the product label.
| Brand | Enzymedica |
|---|---|
| Barcode (UPC) | 670480251102 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 328984 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pro-Bio by Enzymedica, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L. rhamnosus | 0 NP | -- |
| L. casei | 0 NP | -- |
| L. acidophilus | 0 NP | -- |
| L. plantarum | 0 NP | -- |
| L. paracasei | 0 NP | -- |
| Bacillus subtilis | 0 NP | -- |
| L. salivarius | 0 NP | -- |
| L. bulgaricus | 0 NP | -- |
| Pro-Bio Blend | 0 NP | -- |
Other ingredients: Gellan Gum, Cellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
A balanced environment of intestinal flora keeps the digestive system performing optimally, eliminating discomforts like irregularity and occasional gas and bloating.
#1 Selling enzyme brand
Formulation
Pro-Bio capsules are formulated to survive the acidic environment of the stomach, ensuring active probiotic function in the small intestine.
No fillers added
Made in USA with global ingredients
Non GMO
Supportive Guaranteed-Potency Probiotic Retains potency at room temperature
Vegetarian
Contains no: gluten, milk, casein, soy, egg, artificial colors or flavors.
Formula
The bacterial strains contained in Pro-Bio have been shown to promote a healthy microflora balance in the intestinal tract, aiding digestion and supporting immune function.
8 strains of probiotics provide 10 Billion CFUs per single-dose capsule
Suggested/Recommended/Usage/Directions
Recommended Use: 1 capsule daily with water. Best if taken on an empty stomach one hour before or two hours after a meal.
Brand IP Statement(s)
Enzymedica The Enzyme Experts
FDA Statement of Identity
Dietary Supplement
Precautions
Do not use if safety seal is broken or missing.
Please keep out of reach of children.
Storage
Keep closed in dry place; avoid excessive heat.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pro-Bio by Enzymedica label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pro-Bio by Enzymedica
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Targeted Delivery Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Pro-Bio Blend
- › L. rhamnosus
- › L. casei
- › L. acidophilus
- › L. plantarum
- › L. paracasei
- › Bacillus subtilis
- › L. salivarius
- › L. bulgaricus
Other (inactive) ingredients: Gellan Gum, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.
Pro-Bio by Enzymedica Drug Interactions
HelloPharmacist Interaction Report
Pro-Bio by Enzymedica contains multiple probiotic strains, and three of them have documented interactions with medications.
The most serious concern is with antibiotic drugs: Lactobacillus acidophilus, Bacillus subtilis, and Lactobacillus delbrueckii (the species in L. bulgaricus) all show Moderate-severity interactions. Because these are live microorganisms, antibiotics taken at the same time may kill them off and reduce the supplement's effectiveness.
You'll want to space them apart—ask your pharmacist or doctor exactly how far.
Read the full breakdown — every affected drug type, severity by severity
Additionally, we could not check four ingredients in this product: L. rhamnosus, L. casei, L. plantarum, and L. salivarius. We hold no interaction data for them, so we cannot say whether they interact with your medications.
Altogether, these interactions span 182 individual medications. Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pro-Bio?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pro-Bio interact with 182 drugs. Click any drug to see the details.
3 of the 8 ingredients in Pro-Bio interact with drugs. Each result below shows which ingredient is responsible. L. acidophilus Bacillus subtilis L. bulgaricus
AmikacinAmikin, Arikayce
How Amikacin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Amikacin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Amikacin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Amikacin interactionAmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
How Amoxicillin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Amoxicillin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Amoxicillin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Amoxicillin interactionAmoxicillin VeterinaryBiomox
How Amoxicillin Veterinary interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Amoxicillin Veterinary interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Amoxicillin Veterinary interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Amoxicillin Veterinary interactionAmoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
How Amoxicillin, Clavulanate Potassium interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Amoxicillin, Clavulanate Potassium interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Amoxicillin, Clavulanate Potassium interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Amoxicillin, Clavulanate Potassium interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Amphotericin, Tetracycline interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Amphotericin, Tetracycline interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Amphotericin, Tetracycline interactionAmpicillinOmnipen, Omnipen-N, Penbritin, Principen, Rimacillin
How Ampicillin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Ampicillin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Ampicillin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Ampicillin interactionAmpicillin, SulbactamUnasyn
How Ampicillin, Sulbactam interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Ampicillin, Sulbactam interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Ampicillin, Sulbactam interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Ampicillin, Sulbactam interactionAvibactam Sodium, CeftazidimeAvycaz
How Avibactam Sodium, Ceftazidime interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Avibactam Sodium, Ceftazidime interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Avibactam Sodium, Ceftazidime interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Avibactam Sodium, Ceftazidime interactionAzithromycinAzasite, Zithromax, Zmax
How Azithromycin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Azithromycin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Azithromycin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Azithromycin interactionAztreonamAzactam
How Aztreonam interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Aztreonam interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Aztreonam interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Aztreonam interactionBacampicillinPenglobe
How Bacampicillin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Bacampicillin interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Bacampicillin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Bacampicillin interactionBacitracinBaci-IM, Baciguent, Bacitracin Ointment
How Bacitracin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Bacitracin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Bacitracin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Bacitracin interactionBenznidazoleBenznidazole
How Benznidazole interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Benznidazole interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Benznidazole interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Benznidazole interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionCapreomycinCapastat
How Capreomycin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Capreomycin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Capreomycin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Capreomycin interactionCarbenicillin Indanyl SodiumGeocillin
How Carbenicillin Indanyl Sodium interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Carbenicillin Indanyl Sodium interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Carbenicillin Indanyl Sodium interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Carbenicillin Indanyl Sodium interactionCefaclorCeclor, Ceclor CD
How Cefaclor interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefaclor interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefaclor interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefaclor interactionCefadroxilCef-Tab, Duricef, Ultracef
How Cefadroxil interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefadroxil interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefadroxil interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefadroxil interactionCefamandoleMandol
How Cefamandole interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefamandole interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefamandole interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefamandole interactionCefazolinAncef
How Cefazolin interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefazolin interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefazolin interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefazolin interactionCefdinirOmnicef
How Cefdinir interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefdinir interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefdinir interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefdinir interactionCefditoren PivoxilSpectracef
How Cefditoren Pivoxil interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefditoren Pivoxil interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefditoren Pivoxil interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefditoren Pivoxil interactionCefepimeMaxipime
How Cefepime interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefepime interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefepime interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefepime interactionCefiderocol Sulfate TosylateFetroja
How Cefiderocol Sulfate Tosylate interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefiderocol Sulfate Tosylate interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefiderocol Sulfate Tosylate interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefiderocol Sulfate Tosylate interactionCefiximeSuprax
How Cefixime interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefixime interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefixime interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefixime interactionCefmetazoleZefazone
How Cefmetazole interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefmetazole interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefmetazole interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefmetazole interactionCefonicidMonocid
How Cefonicid interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefonicid interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefonicid interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefonicid interactionCefoperazoneCefobid
How Cefoperazone interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
Bacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefoperazone interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefoperazone interactionL. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefoperazone interactionCefotaximeClaforan
How Cefotaxime interacts with Pro-Bio — through 3 ingredients. Tap an ingredient for the detail:
L. AcidophilusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Acidophilus + Cefotaxime interactionBacillus SubtilisAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.
Read the full Bacillus Subtilis + Cefotaxime interactionL. BulgaricusAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.
Read the full L. Bulgaricus + Cefotaxime interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pro-Bio with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
L. acidophilus
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Bacillus subtilis
Antibiotic Drugs
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.
L. bulgaricus
Antibiotic Drugs
Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.
Brand information
Manufacturer and brand details for Pro-Bio, from the product label.
Enzymedica
See all Enzymedica products- Name
- Enzymedica, Inc.
- Street Address
- 771 Commerce Drive
- City
- Venice
- State
- FL
- ZipCode
- 34292
- Phone Number
- 1-888-918-1118
- Web Address
- enzymedica.com
Pro-Bio by Enzymedica: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pro-Bio is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pro-Bio’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographBacillus Subtilis
Interacts with 182 drugsBacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...
Read the full Bacillus Subtilis monograph → Herb & supplement monographLactobacillus Delbrueckii
Interacts with 182 drugsLactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...
Read the full Lactobacillus Delbrueckii monograph →Sources & How We Checked
Pro-Bio's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Bacillus Subtilis 10 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
- La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
- Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
- Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
- Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
- Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
- Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
- Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
- Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.
Lactobacillus Delbrueckii 9 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
- Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
- Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
- Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
- Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
- Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
- Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.
See these in context on the Lactobacillus Delbrueckii monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC