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Dietary supplement

Probiotic Acidophilus Beads Ingredients & Drug Interactions

by Sundown Naturals

Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Probiotic Acidophilus Beads is a dietary supplement by Sundown Naturals with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probio-Guard(TM) Proprietary Acidolphilus Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Probiotic Acidophilus Beads by Sundown Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Probio-Guard(TM) Proprietary Acidolphilus Blend” is a proprietary blend — the label gives one combined amount (10.72 mg) without saying how much of each component you get.

This product contains 4 active ingredients: two Bifidobacterium species (Bifidobacterium animalis lactis and Bifidobacterium longum), two Lactobacillus species (Lactobacillus acidophilus and Lactobacillus plantarum), plus a proprietary blend called Probio-Guard that contains additional acidophilus. These are live probiotic bacteria meant to support gut health.

The inactive ingredients include coconut and palm kernel oils, gelatin, vegetable glycerine, soy lecithin, and pectin — these are the capsule and binding materials that hold the product together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: balance intestinal microflora for digestive system health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance.

The evidence for these probiotics is mixed and depends on what you're using them for. Lactobacillus acidophilus shows possibly effective evidence for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

However, for the other conditions in our data — including age-related cognitive decline, hay fever, anxiety, asthma, and athletic performance — the evidence is insufficient to rate these probiotics. If you're considering this product for a specific health goal, ask your pharmacist what the evidence actually supports.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Bifidobacterium longum and Lactobacillus acidophilus are generally well tolerated in healthy people and children, though caution is needed if you're seriously ill or have a weakened immune system. Rare gastrointestinal side effects have been reported, including abdominal discomfort, flatulence, bloating, diarrhea, and constipation.

Rarely, one person reported a dry cough. There is a small risk of infection (bacteremia or sepsis) in critically ill patients or preterm infants, so this product isn't appropriate for everyone — check with your doctor if you're in a high-risk group.

For pregnancy and lactation, Lactobacillus acidophilus is rated possibly safe, and Bifidobacterium longum is also rated possibly safe, but the data are limited — talk with your doctor before using while pregnant or breastfeeding.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Probiotic Acidophilus Beads, double-check any antibiotic drugs you're taking or may start soon — both Bifidobacterium longum and Lactobacillus acidophilus can be killed off by antibiotics taken at the same time, reducing the probiotics' effectiveness. Your pharmacist can help you schedule doses so they don't interfere with each other.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help if you're dealing with IBS, antibiotic-associated diarrhea, or certain bacterial infections, but the evidence is strongest for those specific uses. Timing with antibiotics is critical — you'll want to space them apart so the live cultures aren't killed.

If you're immunocompromised, critically ill, or in the first weeks of life, this product isn't safe without your doctor's go-ahead. Check your medications with your pharmacist or doctor before you start, especially if you take antibiotics.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Acidophilus Beads, straight from the product label.

Brand Sundown Naturals
Barcode (UPC) 030768186227
Net contents 30 Bead(s)
Market status On market
Date entered into DSLD Jan 24, 2014
DSLD ID 29546
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Acidophilus Beads by Sundown Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Bead(s)
Maximum serving Sizes:
1 Bead(s)
UPC/BARCODE
030768186227
IngredientAmount% DV
Bifidobacterium animalis lactis0 NP--
Bifidobacterium longum0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus plantarum0 NP--
Probio-Guard(TM) Proprietary Acidolphilus Blend10.72 mg--

Other ingredients: Coconut and Palm Kernel Oils, Gelatin, Vegetable Glycerine, Soy Lecithin, Pectin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Contains milk and soy ingredients.

The proprietary blend of Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus plantarum and Bifidobacterium lactis helps balance intestinal microflora for digestive system health.*

2 Billion Active Cultures**

Brand IP Statement(s)

Smart Facts Probio-Guard(TM) Probiotic Acidophilus Beads are formulated in a unique triple layer shell designed to help protect the active cultures delivered in every serving, so no refrigeration is needed.

Probio-Guard(TM)

(C)2012

Suggested/Recommended/Usage/Directions

DIRECTIONS: FOR ADULTS, TAKE ONE (1) BEAD DAILY, PREFERABLY WITH A MEAL.

General Statements

1 PER DAY

Promotes Digestion and Intestinal Health*

** 2 billion live organisms per bead at time of manufacture

As a reminder, discuss the supplements and medications you take with your health care providers.

FDA Statement of Identity

DIETARY SUPPLEMENT

General

Prod No. 18622 01A B18625 HAB

Precautions

Contains milk and soy ingredients.

Discontinue use and consult your doctor if any adverse reactions occur.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF BLISTER SEAL IS CUT, TORN OR OPEN.

Storage

No refrigeration needed.

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Wheat, No Fish. Sodium Free.

See for yourself

Probiotic Acidophilus Beads by Sundown Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Probiotic Acidophilus Beads by Sundown Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Bead(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

10.72 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probio-Guard(TM) Proprietary Acidolphilus Blend monograph & interactions

Other (inactive) ingredients: Coconut and Palm Kernel Oils, Gelatin, Vegetable Glycerine, Soy Lecithin, Pectin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Acidophilus Beads by Sundown Naturals Drug Interactions

Want to check YOUR meds against Probiotic Acidophilus Beads?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Acidophilus Beads with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probio-Guard(TM) Proprietary Acidolphilus Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Probiotic Acidophilus Beads, from the product label.

Pharmacist Counseling Corner

Probiotic Acidophilus Beads by Sundown Naturals: Common Questions

Does Probiotic Acidophilus Beads by Sundown Naturals interact with any medications?
Yes. Based on its ingredients, Probiotic Acidophilus Beads has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Acidophilus Beads contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Not at the same time. Antibiotics can kill off the live bacteria in this product, making it less effective. You'll need to separate the doses — ask your doctor or pharmacist exactly how far apart to space them based on your specific antibiotic.
Is this safe during pregnancy or breastfeeding?
Both Bifidobacterium longum and Lactobacillus acidophilus are rated possibly safe in pregnancy and lactation, but the safety data are limited. Talk with your doctor or midwife before you start — they know your full picture and can give you personalized advice.
What is this product supposed to do?
The strongest evidence supports Lactobacillus acidophilus for irritable bowel syndrome, antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis. For other uses like hay fever or anxiety, the evidence isn't established yet in our data.
What side effects might I notice?
Most people tolerate it well, but some experience rare gastrointestinal symptoms like bloating, gas, abdominal discomfort, or diarrhea. A single person reported a dry cough in a trial. If you're seriously ill or have a weakened immune system, there's a rare risk of infection — talk with your doctor first.
Does this product have fillers?
Yes — it contains inactive ingredients including gelatin, coconut and palm kernel oils, vegetable glycerine, soy lecithin, and pectin. These are binders and capsule materials that help hold the product together.
Will this work for everyone?
No. If you're critically ill, have a weakened immune system, or are a preterm infant, this product carries a rare but serious risk and shouldn't be used without your doctor's approval. For healthy people, it's generally well tolerated, but talk with your doctor about whether it's right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Acidophilus Beads is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Acidophilus Beads label
Sources

Sources & How We Checked

Probiotic Acidophilus Beads's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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