Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Probiotic & Antioxidant Ingredients & Drug Interactions

by Just Thrive

Probiotic & Antioxidant label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic & Antioxidant against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic & Antioxidant is a dietary supplement by Just Thrive with 4 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis HU58, Bacillus coagulans SC-208. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic & Antioxidant by Just Thrive

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic & Antioxidant by Just Thrive — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic & Antioxidant by Just Thrive

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (175 mg) without saying how much of each component you get.

This product contains four active ingredients: a proprietary probiotic blend plus three individual Bacillus strains — Bacillus subtilis HU58, Bacillus clausii SC-109, and Bacillus coagulans SC-208. Probiotics are live beneficial bacteria meant to support gut health.

The formula also contains cellulose and water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and immune support.
  • We looked for evidence on: Constipation, Diarrhea, Flatulence, Irritable bowel syndrome (IBS), Dyspepsia, Upper respiratory tract infection (URTI) — and 2 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.

Bacillus subtilis HU58 is possibly effective for antibiotic-associated diarrhea (loose stools caused by antibiotics), but the evidence is insufficient to rate it for athletic performance, cirrhosis, constipation, eczema, or diabetes. Bacillus coagulans SC-208 is possibly effective for constipation and irritable bowel syndrome (IBS), but evidence is insufficient to rate it for antibiotic-associated diarrhea, athletic performance, cancer, or fatty liver disease.

We have no effectiveness data on file for Bacillus clausii SC-109 and Bacillus indicus HU-36.

The evidence, ingredient by ingredient Bacillus Subtilis Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Bacillus subtilis HU58 and Bacillus coagulans SC-208 are generally well tolerated in healthy adults, though product quality can vary between brands. In clinical trials, headache was reported in a small number of participants taking Bacillus subtilis, and diarrhea has been reported rarely.

There is limited safety data overall, so talk with your doctor before use. Rare but serious infections (bacteremia and meningitis) have been reported in people with weakened immune systems or serious underlying illness who consumed very high amounts of fermented soy products containing Bacillus subtilis var. natto; this is not a typical concern for most users but underscores the importance of checking with your doctor if you are immunocompromised.

No pregnancy or breastfeeding safety information is available for these ingredients.

Side effects, ingredient by ingredient Bacillus Subtilis Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bacillus Coagulans, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to double-check before taking this product. Both Bacillus subtilis and Bacillus coagulans in this formula may be less effective if you take them at the same time as antibiotics, so your doctor or pharmacist can help you time them apart properly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Just Thrive Probiotic & Antioxidant may help with antibiotic-associated diarrhea, constipation, and IBS, though evidence varies by strain. The main thing to watch is spacing it apart from antibiotics.

If you take any prescriptions, run them through the checker here first, and talk it over with your doctor or pharmacist before you start — especially if you have a weakened immune system or are severely ill.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic & Antioxidant, straight from the product label.

Brand Just Thrive
Barcode (UPC) 674306989194
Net contents 90 Vegetable Cap(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 301435
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic & Antioxidant by Just Thrive, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
674306989194
IngredientAmount% DV
Proprietary Probiotic Blend175 mg--
Bacillus subtilis HU580 NP--
Bacillus clausii SC-1090 NP--
Bacillus coagulans SC-2080 NP--
Bacillus indicus HU-360 NP--

Other ingredients: Cellulose, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Age 8 +: 1 capsule per day with your largest meal or as directed by your physician. For kids 8 and under, capsules can be opened and mixed with food or drink. Children under 3, please consult your healthcare practitioner. No refrigeration needed.

Storage

No refrigeration needed.

Precautions

Caution: If you are pregnant or nursing; taking any medication; have a medical condition, consult your doctor before using this product.

Keep out of reach of children.

Use only if safety seal is intact.

General Statements

Great for kids too! Vitamin angels Proud supporter Your purchase helps support the health of a child for an entire year.

Formulation

Antioxidants (alpha and beta carotene, lycopene, lutein, astaxanthin and zeaxathin) are produced in the digestive system by this product; they are not added to capsules.

100% spore-based 1000x better survivability vs Greek yogurt & leading probiotics Pharma grade

Gluten free Dairy free Non GMO

Vegan

Verified survives gastric Verified DNA checked

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic & Antioxidant by Just Thrive label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic & Antioxidant label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic & Antioxidant by Just Thrive

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

175 mg per serving

Other (inactive) ingredients: Cellulose, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic & Antioxidant by Just Thrive Drug Interactions

Want to check YOUR meds against Probiotic & Antioxidant?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis HU58 182
Bacillus coagulans SC-208 182

Individual Drug Interactions

The ingredients in Probiotic & Antioxidant interact with 182 drugs. Click any drug to see the details.

2 of the 4 ingredients in Probiotic & Antioxidant interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis HU58 Bacillus coagulans SC-208

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic & Antioxidant with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis HU581 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis HU58 full monograph & interactions

Bacillus coagulans SC-2081 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans SC-208 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic & Antioxidant, from the product label.

Just Thrive

See all Just Thrive products
Name
DMS Natural Health, LLC
Street Address
810 Busse Highway
City
Park Ridge
State
IL
ZipCode
60068
Phone Number
800.455.8939
Web Address
Justthrivehealth.com
Pharmacist Counseling Corner

Probiotic & Antioxidant by Just Thrive: Common Questions

Does Probiotic & Antioxidant by Just Thrive interact with any medications?
Yes. Based on its ingredients, Probiotic & Antioxidant has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic & Antioxidant contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with an antibiotic?
Not at the same time. Antibiotics can kill off the live probiotic organisms, making the probiotic less effective. Ask your doctor or pharmacist how to space them apart — typically a few hours or more between doses works well.
Does this help with diarrhea?
Bacillus subtilis in this formula is possibly effective for diarrhea caused by antibiotics. Bacillus coagulans may help with general constipation and IBS symptoms, though the evidence is strongest for those two conditions.
Are there any side effects?
Both ingredients are generally well tolerated. Headache and diarrhea have been reported rarely in trials or use. Very serious infections are possible in people with severely weakened immune systems, so check with your doctor if that applies to you.
Is this safe in pregnancy or while breastfeeding?
We don't have safety data on file for these ingredients during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What are probiotics for?
Probiotics are live beneficial bacteria meant to support gut health and digestion. This product contains three different Bacillus strains, each studied for conditions like diarrhea, IBS, and constipation.
Why can't you check Bacillus clausii or Bacillus indicus for interactions?
We don't hold monograph data for those two strains, so we can't check what medications they might interact with. Use the medication checker on this page with your exact drugs, and ask your pharmacist if you have questions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic & Antioxidant is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic & Antioxidant label
Go deeper

The Full Monographs Behind Probiotic & Antioxidant’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Probiotic & Antioxidant's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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