Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Probiotic Pearls Immune Ingredients & Drug Interactions

by Nature's Way

Probiotic Pearls Immune label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Pearls Immune against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Pearls Immune is a dietary supplement by Nature's Way with 5 active ingredients. Its ingredients are commonly taken for iron deficiency and anemia support, immune support, gut health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are HOWARU L. acidophilus NCFM, Bifidobacterium longum BB536. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Pearls Immune by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Pearls Immune by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Probiotic Pearls Immune by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (7 mg) without saying how much of each component you get.

Probiotic Pearls Immune contains 5 active ingredients — all live bacterial cultures designed to support digestive and immune health. Lactoferrin is a protein found naturally in milk that your body uses to help with iron absorption and immune function.

The other four are probiotic bacteria: Lactobacillus plantarum Lp-115, Bifidobacterium lactis Bl-04, Lactobacillus acidophilus NCFM, and Bifidobacterium longum BB536. These "good" bacteria are meant to help maintain a healthy gut environment.

The softgel capsule also contains inactive ingredients — fish gelatin (the capsule shell), plus palm oil, glycerin, soy lecithin, silica, and pectin as binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive balance and immune support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Common cold, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Bacterial vaginosis, Helicobacter pylori.

Lactoferrin shows possibly effective evidence for sepsis and pregnancy-related iron deficiency, but the data show it's likely ineffective for reducing fetal and premature infant death or for necrotizing enterocolitis (a serious bowel condition in newborns). Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

For Bifidobacterium longum, the evidence we hold is insufficient to rate it for the conditions studied — including antibiotic-associated diarrhea, hay fever, anxiety, asthma, and athletic performance. The other two bacterial strains (Lactobacillus plantarum and Bifidobacterium lactis) have no effectiveness ratings in our data.

The evidence, ingredient by ingredient Lactoferrin Lactobacillus Acidophilus Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactoferrin is rated likely safe in pregnancy and possibly safe when used as a supplement; lactation is rated likely safe, though long-term safety data are limited and the safety of supplements while breastfeeding hasn't been well studied — use only under medical supervision in pregnancy and discuss breastfeeding use with your healthcare provider. At typical doses, lactoferrin is well tolerated, but doses of 7.2 grams daily or higher have been linked to constipation, diarrhea, anorexia, fatigue, and chills.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children and is rated possibly safe in pregnancy; its lactation rating is incomplete in our data. Rare cases of serious infection (bacteremia, sepsis, abscess) have been reported, though most occur in hospitalized or vulnerable patients.

Mild gastrointestinal side effects like bloating, flatulence, and diarrhea can occur but are uncommon. Bifidobacterium longum is rated possibly safe for both pregnancy and lactation but carries limited safety data — check with your doctor before use, especially if you're seriously ill or have a weakened immune system.

Rare bacteremia and sepsis cases have occurred in critically ill infants; mild abdominal discomfort and flatulence are rare.

Side effects, ingredient by ingredient Lactoferrin Lactobacillus Acidophilus Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on antibiotic drugs — they can decrease how well the live bacteria in this supplement work. Space out the timing if your healthcare provider gives you the go-ahead.

If you're hospitalized, have a weakened immune system, or are seriously ill, mention this product to your care team before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with certain digestive issues if you're not taking antibiotics — but timing matters, since antibiotics can interfere with it. Lactoferrin has limited long-term safety data, and the bacterial strains are generally well tolerated in healthy people, though serious infections are rare and have mainly been reported in hospitalized or immune-compromised patients.

If you're pregnant, breastfeeding, seriously ill, or taking antibiotics, talk with your doctor or pharmacist before starting this product. Use the medication checker below to see if any of your prescriptions interact.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Pearls Immune, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948044030
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 267894
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Pearls Immune by Nature's Way , sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
763948044030
IngredientAmount% DV
Lactoferrin10 mg--
Lactobacillus plantarum Lp-1150 NP--
Bifidobacterium lactis Bl-040 NP--
Proprietary Probiotic Blend7 mg--
HOWARU L. acidophilus NCFM0 NP--
Bifidobacterium longum BB5360 NP--

Other ingredients: Palm Oil, Fish Gelatin, Glycerin, Soy Lecithin, Silica, Pectin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

No refrigeration

Store at room temperature. Avoid excessive heat and direct sunlight.

General Statements

Survives stomach acid

Survives stomach acid Probiotic Pearls uses an advanced triple-layer softgel that protects probiotics from heat, air, moisture and stomach acid to maximize survival and delivery to the intestine where needed most.

Scan here for more information. Call 1-800-962-8873 for more food information.

Brand IP Statement(s)

The Smarter Probiotic

Howaru Probiotic Quality You Can Feel HOWARU is a registered trademark of DuPont. 2021 Distributed by Nature's Way Brands, LLC

Formulation

Survives stomach acid to release in the intestine

Designed to survive stomach acid

Regularity + Immunity

Small & easy to swallow

Contains no salt, wheat, or artificial colors.

Product of Japan

Formula

4 strains + lactoferrin for digestive balance and immune support 1 Billion cultures

4 Strains & lactoferrin for immune support Most of your body’s immune defense comes from the digestive tract. Taking Probiotic Pearls Immune fortifies your system with L. plantarum, L. acidophilus, B. lactis, B. longum and Lactoferrin to help: Support healthy immune system function Promote digestive balance and protect against occasional bloating, constipation and digestive comfort.

FDA Statement of Identity

Probiotic Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Once daily

Recommendation: Take 1 softgel daily. May be taken with or without food. Do not chew or crush. If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Precautions

Contains milk, soy and fish (Tilapia).

Keep out of reach of children.

This product has a tamper-evident foil pouch. Do not use if foil or plastic is punctured.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Pearls Immune by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Pearls Immune label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Pearls Immune by Nature's Way

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactoferrin

No known
interactions
10 mg per serving

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is...

Lactoferrin monograph & interactions

Proprietary Probiotic Blend

7 mg per serving

Other (inactive) ingredients: Palm Oil, Fish Gelatin, Glycerin, Soy Lecithin, Silica, Pectin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Pearls Immune by Nature's Way Drug Interactions

Want to check YOUR meds against Probiotic Pearls Immune?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

HOWARU L. acidophilus NCFM 182
Bifidobacterium longum BB536 182

Individual Drug Interactions

The ingredients in Probiotic Pearls Immune interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Probiotic Pearls Immune interact with drugs. Each result below shows which ingredient is responsible. HOWARU L. acidophilus NCFM Bifidobacterium longum BB536

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Pearls Immune with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

HOWARU L. acidophilus NCFM1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
HOWARU L. acidophilus NCFM full monograph & interactions

Bifidobacterium longum BB5361 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum BB536 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Pearls Immune, from the product label.

Nature's Way

Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
pearlsprobiotics.com
Pharmacist Counseling Corner

Probiotic Pearls Immune by Nature's Way : Common Questions

Does Probiotic Pearls Immune by Nature's Way interact with any medications?
Yes. Based on its ingredients, Probiotic Pearls Immune has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Pearls Immune contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on antibiotics?
Not at the same time — antibiotics will kill the beneficial bacteria in this supplement, making it ineffective. Talk with your doctor or pharmacist about the best timing to take them separately. They're the right person to advise you based on which antibiotic you're on and how you're taking it.
Is Probiotic Pearls Immune safe in pregnancy?
Lactoferrin is rated likely safe to possibly safe in pregnancy; the bacterial strains are rated possibly safe. But long-term safety data are limited, so use only under medical supervision. Talk with your OB or pharmacist before starting, especially since every pregnancy is different.
Will this help with my irritable bowel syndrome or IBS?
Lactobacillus acidophilus in this product is rated possibly effective for IBS. That means the evidence suggests it might help, but results aren't guaranteed. Your experience will depend on your individual situation — your doctor can tell you whether it's worth trying for your symptoms.
What are the most common side effects?
Gastrointestinal side effects like bloating, flatulence, and diarrhea can occur but are uncommon in most people. At the dose in this softgel, side effects are generally mild. If you notice persistent discomfort, mention it to your pharmacist or doctor.
Can I take this while breastfeeding?
Lactoferrin is rated likely safe while breastfeeding, but its safety in supplements hasn't been well studied. The bacterial strains (L. acidophilus and B. longum) are rated possibly safe, though long-term data are limited. Talk with your doctor or pharmacist about whether this product is right for you during breastfeeding.
Why does this product contain fish gelatin?
Fish gelatin is the material that makes up the softgel capsule shell — it holds the active ingredients inside. It's an inactive ingredient, not an active component of the formula. If you're allergic to fish or follow a vegetarian diet, this is important to know before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Pearls Immune is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Pearls Immune label
Go deeper

The Full Monographs Behind Probiotic Pearls Immune’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactoferrin

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is being studied for immune support, iron l...

Read the full Lactoferrin monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Probiotic Pearls Immune's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactoferrin 6 references
  1. Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
  2. Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. PubMed
  3. Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. PubMed
  4. Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun PubMed
  5. ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9.
  6. Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. PubMed

See these in context on the Lactoferrin monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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