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Dietary supplement

Probiotics Extra Care Digestive 50 Billion CFU Ingredients & Drug Interactions

by Renew Life

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Probiotics Extra Care Digestive 50 Billion CFU is a dietary supplement by Renew Life with 2 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Probiotics Extra Care Digestive 50 Billion CFU by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Bifido Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Extra Care Probiotic Culture Blend” is a proprietary blend — the label gives one combined amount (152 mg) without saying how much of each component you get.
  • “Lacto Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This formula contains 12 active probiotic ingredients — live beneficial bacterial strains that support digestive health. The main players are two Lactobacillus acidophilus strains (LA-14 and NCFM), Bifidobacterium longum (BI-26), and eight others including Lactobacillus rhamnosus, Bifidobacterium animalis, and Lactobacillus plantarum.

Together they deliver 50 billion colony-forming units (CFU) per capsule. The capsule itself is made from inactive ingredients including microcrystalline cellulose, hypromellose, gellan gum, and medium chain triglyceride — these are binders and capsule materials, not active components.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Immune and digestive support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Common cold, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea.

The evidence for Lactobacillus acidophilus (two of your 12 strains) shows it's possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For Bifidobacterium longum, though — the other strain we have data on — the evidence isn't established yet for the conditions it's been studied in, including allergic rhinitis, antibiotic-associated diarrhea, anxiety, and asthma.

For the other eight probiotic strains in this formula, we don't hold effectiveness data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus and Bifidobacterium longum are both generally well tolerated in healthy adults and children. Uncommon gastrointestinal side effects can include abdominal discomfort, bloating, flatulence, diarrhea, and burping — usually mild.

Rare cases of infection (bacteremia or sepsis) have been reported in the medical literature, though most occurred in critically ill or immune-compromised patients. One clinical trial reported two cases of rash and one case of itching, though it wasn't clear if the probiotics themselves were responsible.

For pregnancy, Lactobacillus acidophilus is rated possibly safe. For Bifidobacterium longum, both pregnancy and lactation are rated possibly safe, though the data are limited and you should check with your doctor before use while breastfeeding.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antibiotic drug — Moderate interaction: antibiotics can kill the live organisms in this probiotic, making it less effective. Separate the timing of your antibiotic and the probiotic by a few hours.

Check with your pharmacist on the exact spacing that works for your prescription.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have IBS, antibiotic-associated diarrhea, or certain bacterial infections and want to try probiotics, this formula has some evidence behind it — especially for the Lactobacillus acidophilus strains. If you're on antibiotics, timing matters: space out when you take them and the probiotics so the antibiotic doesn't kill off the beneficial bugs.

If you're seriously ill or immune-compromised, check with your doctor first. Talk with your doctor or pharmacist before starting, especially if you take medications or have health concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotics Extra Care Digestive 50 Billion CFU, straight from the product label.

Brand Renew Life
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 306950
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotics Extra Care Digestive 50 Billion CFU by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
Lactococcus lactis LL-230 NP--
Lactobacillus casei LC-110 NP--
Lactobacillus paracasei LPC-370 NP--
Lactobacillus acidophilus LA-140 NP--
Lactobacillus brevis LBR-350 NP--
Lactobacillus rhamnosus GG0 NP--
Bifidobacterium animalis lactis BL-040 NP--
Bifidobacterium animalis lactis HN0190 NP--
Lactobacillus plantarum LP-1150 NP--
Bifido Probiotic Blend0 NP--
Bifidobacterium animalis lactis Bi-070 NP--
Bifidobacterium longum infantis BI-260 NP--
Lactobacillus acidophilus NCFM0 NP--
Extra Care Probiotic Culture Blend152 mg--
Lacto Probiotic Blend0 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Gellan Gum, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

#1 Most studied strain L. rhamnosus GG strain, PubMed Clinical Trials, August 2019

Clinically tested strains B. lactis HN019, B. lactis Bi-07, L. rhamnosus GG, B. lactis BI-04 Guaranteed live cultures

Probiotics Extra Care Digestive with probiotics strains 12 Diverse strains

We formulate with multiple diverse strains Clinically tested strains

General Statements

Inspired by nature, backed by science.

Questions or comments? 1-800-830-1800 or www.renewlife.com

Feeling gutsy for 25 years and counting. Join us.

Formulation

Immune and digestive support

Free of gluten, dairy and soy

Most potent Compared to extra care digestive 30 Billion CFU

Proven to support Digestive health Immune health Respiratory health

Non GMO Project Verified nongmoproject.org

Potency, quality and purity guaranteed through expiration.

Our promise to you Feel the difference or your money back. Potency through expiration Wait, there's more... Easy to swallow, delayed release, once daily vegetarian capsules and a recyclable bottle. Terms and conditions may apply. Call 1-800-830-1800.

Easy to swallow, delayed release, once daily vegetarian capsules and a recyclable bottle.

Made in the USA of global ingredients.

Suggested/Recommended/Usage/Directions

Only one capsule per day

Directions: For best results, take one (1) capsule daily, with or without food.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Probiotic Supplement

Seals/Symbols

Non GMO Project Verified nongmoproject.org

Storage

Store at 77 degrees F (25 degrees C) or below. Best if refrigerated.

Precautions

Keep out of reach of children.

Consult your physician prior to using this or any product if you are pregnant, nursing, taking any medication or have a medical condition.

Tamper evident: Do not use if safety seal on bottle is broken or missing.

Brand IP Statement(s)

Copyright 2021

See for yourself

Probiotics Extra Care Digestive 50 Billion CFU by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Probiotics Extra Care Digestive 50 Billion CFU by Renew Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Extra Care Probiotic Culture Blend

152 mg per serving
  • › Bifido Probiotic Blend
  • › Lacto Probiotic Blend

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Gellan Gum, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotics Extra Care Digestive 50 Billion CFU by Renew Life Drug Interactions

Want to check YOUR meds against Probiotics Extra Care Digestive 50 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotics Extra Care Digestive 50 Billion CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Probiotics Extra Care Digestive 50 Billion CFU, from the product label.

Renew Life

Name
Renew Life Formulas, LLC
City
Durham
State
NC
ZipCode
27701
Phone Number
1-800-830-1800
Web Address
www.RenewLife.com
Pharmacist Counseling Corner

Probiotics Extra Care Digestive 50 Billion CFU by Renew Life: Common Questions

Does Probiotics Extra Care Digestive 50 Billion CFU by Renew Life interact with any medications?
Yes. Based on its ingredients, Probiotics Extra Care Digestive 50 Billion CFU has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotics Extra Care Digestive 50 Billion CFU contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Yes, but timing is key. Antibiotics can kill the live beneficial bacteria in the probiotic, so separate them — don't take them at the same time. Your pharmacist can help you figure out the best spacing for your specific antibiotic.
Is this safe if I'm pregnant?
Lactobacillus acidophilus is rated possibly safe in pregnancy. Bifidobacterium longum is also rated possibly safe for both pregnancy and breastfeeding, though the data are limited. Talk with your doctor before starting during pregnancy or while breastfeeding.
What side effects might I notice?
Most people don't have problems, but some notice mild, temporary gastrointestinal side effects like bloating, gas, or loose stool when they first start. These are usually uncommon and tend to settle down. Rash and itching were reported rarely in one trial, though it's unclear if the probiotics were the cause.
Will this help with my IBS?
Lactobacillus acidophilus — which is in this formula — is possibly effective for IBS based on the evidence we have. That means there's some support for it, but results vary from person to person. Your doctor can help you decide if it's worth trying.
How many live bacteria are in each dose?
Each capsule delivers 50 billion CFU (colony-forming units) — that's the measure of live bacteria. The formula has 12 different probiotic strains working together.
Can this cause an infection?
Serious infections from probiotics are very rare and have mostly been reported in people who are critically ill or have weak immune systems. Healthy people taking this product are at very low risk, though your doctor should evaluate your individual situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotics Extra Care Digestive 50 Billion CFU is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotics Extra Care Digestive 50 Billion CFU label
Sources

Sources & How We Checked

Probiotics Extra Care Digestive 50 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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