Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Prostinex Ingredients & Drug Interactions

by PurMEDICA

Prostinex label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Prostinex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Prostinex is a dietary supplement by PurMEDICA with 6 active ingredients. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 401 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saw Palmetto berry extract, Nettle (Utica dioica) root extract, Lycopene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Prostinex by PurMEDICA

Ask about any prescription or over-the-counter medication and we check it for interactions with Prostinex by PurMEDICA — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Prostinex by PurMEDICA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Prostinex contains six active ingredients. Lycopene is a carotenoid antioxidant from tomatoes and other red fruits.

Zinc is an essential mineral that supports immune function and wound healing. Pumpkin (Cucurbita pepo) seed oil is traditionally used for urinary and prostate health.

Saw palmetto berry extract is a plant used for prostate concerns. Pygeum africanum bark extract is another botanical for prostate support.

Nettle (Urtica dioica) root extract is used for urinary and prostate health. The product also contains inactive ingredients including soybean oil, beeswax, lecithin, caramel color, water, and gelatin capsules.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Prostate health and urinary function support.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Urinary symptoms in men, Prostate inflammation, Lower urinary tract symptoms.
  • The strongest evidence on file: Pygeum is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).

For prostate-related concerns, the evidence is mixed. Saw palmetto and pumpkin seed oil are both rated possibly effective for benign prostatic hyperplasia (BPH), and pygeum is rated likely effective for BPH.

Lycopene is possibly effective for prostate cancer prevention. Nettle root extract has insufficient reliable evidence for BPH at this time.

Zinc is effective for zinc deficiency itself and possibly effective for diabetes. The other uses listed in the data—such as lycopene for bladder cancer or diabetes, pumpkin for androgenic alopecia, and nettle for conditions like hay fever—either show insufficient evidence or are rated possibly ineffective, meaning the data doesn't currently support those claims.

The evidence, ingredient by ingredient Lycopene Zinc Pumpkin Saw Palmetto Pygeum Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The ingredients are generally well tolerated at recommended doses. Lycopene from supplements may cause gastrointestinal side effects like diarrhea, nausea, or abdominal distension.

Zinc is well tolerated below the upper safe intake level of 40 mg daily for adults; higher doses can cause nausea, diarrhea, and metallic taste, and there's long-term concern about copper deficiency with high-dose use. Pumpkin seed oil may cause mild abdominal discomfort, nausea, or diarrhea.

Saw palmetto is generally well tolerated with mild, reversible side effects like abdominal pain, diarrhea, or dizziness; rare cases of heart rhythm changes have been reported. Pygeum causes nausea and abdominal pain in some trials at rates similar to placebo.

Nettle root extract is generally well tolerated, though a case of drug-induced liver disease has been reported with herbal supplements containing nettle. Pregnancy and breastfeeding safety varies by ingredient: lycopene supplements lack sufficient study in pregnancy and lactation; pumpkin seed oil concentrated supplements are not well studied in either; saw palmetto and nettle root are advised against in both pregnancy and lactation due to insufficient safety data; and pygeum is best avoided in both.

Zinc is rated likely safe in both pregnancy and lactation at normal amounts.

Side effects, ingredient by ingredient Lycopene Zinc Pumpkin Saw Palmetto Pygeum Stinging Nettle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Lycopene, Stinging Nettle, Pumpkin, Saw Palmetto, Zinc.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 401 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Prostinex, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel)—lycopene, saw palmetto, and nettle may increase bleeding risk. If you take diabetes medications, diuretics, lithium, estrogens, contraceptives, quinolone or tetracycline antibiotics, cephalexin, penicillamine, ritonavir, cisplatin, integrase inhibitors like bictegravir/emtricitabine/tenofovir alafenamide, or the HIV combination bictarvy, zinc and other ingredients may reduce their effectiveness or raise their levels.

Timing zinc away from antibiotics (at least 2 hours before or 4–6 hours after) and lithium-containing supplements away from pumpkin or nettle may help, but speak with your pharmacist about your specific regimen.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Prostinex is designed for men concerned about prostate and urinary health, combining ingredients with some evidence for benign prostatic hyperplasia. If you take blood thinners, diabetes medications, diuretics, lithium, or certain antibiotics, check with your doctor or pharmacist before starting this product—several ingredients can interact with these drugs.

Women who are pregnant or breastfeeding should talk with their healthcare provider, as safety data on most of these ingredients at supplement doses is limited or advises against use. If you have no contraindications and want to try it, discuss your individual health picture with your own doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prostinex, straight from the product label.

Brand PurMEDICA
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 200354
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prostinex by PurMEDICA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel Capsule(s)
Maximum serving Sizes:
1 Softgel Capsule(s)
IngredientAmount% DV
Lycopene1 mg--
Zinc5 mg33%
Pumpkin (Cucurbita pepo) seed oil40 mg--
Saw Palmetto berry extract80 mg--
Pygeum africanum bark extract25 mg--
Nettle (Utica dioica) root extract75 mg--

Other ingredients: Capsules, Soybean Oil, Beeswax, Lecithin, Caramel color, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) softgel capsule, up to four (4) times daily with meals, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

Precautions

Keep out of reach of children

Contains soy. Manufactured on equipment that processes peanuts. May contain traces of peanuts.

Formula

Our Saw Palmetto Pygeum Plus Softgels are made with the highest quality European Standardized Extracts of Saw Palmetto and Pygeum. Pumpkin Seed Oil, Nettle Root Extract, Lycopene and L-OptiZinc work synergistically to enhance the proven benefits of Saw Palmetto and Pygeum.

From L-OptiZinc, a patented form of zinc. L-OptiZinc is a trademark of Inter-Health Company.

Prostate support

Contains soy.

General Statements

Quality and potency guaranteed.

Naturally healthy

Formulation

Contains No sugar, salt, dairy, yeast, wheat, corn, preservatives, artificial colors or flavors.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

Seals/Symbols

Made in USA

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Prostinex by PurMEDICA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Prostinex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Prostinex by PurMEDICA

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel Capsule(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lycopene

Interacts with
122 drugs
1 mg per serving Form: Tomatoes

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Zinc

Interacts with
67 drugs
5 mg per serving Form: Zinc Monomethionine

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Pumpkin (Cucurbita pepo) seed oil

Interacts with
1 drug
40 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin (Cucurbita pepo) seed oil monograph & interactions

Saw Palmetto berry extract

Interacts with
174 drugs
80 mg per serving Form: fatty acids and sterols

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto berry extract monograph & interactions

Pygeum africanum bark extract

No known
interactions
25 mg per serving Form: Beta-Sitosterol

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...

Pygeum africanum bark extract monograph & interactions

Nettle (Utica dioica) root extract

Interacts with
164 drugs
75 mg per serving Form: Total Amino Acids

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Nettle (Utica dioica) root extract monograph & interactions

Other (inactive) ingredients: Capsules, Soybean Oil, Beeswax, Lecithin, Caramel color, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prostinex by PurMEDICA Drug Interactions

Want to check YOUR meds against Prostinex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
401Drugs
398 Moderate 3 Minor

Ingredients driving the most interactions

Saw Palmetto berry extract 174
Nettle (Utica dioica) root extract 164
Lycopene 122
Zinc 67
Pumpkin (Cucurbita pepo) seed oil 1

Individual Drug Interactions

The ingredients in Prostinex interact with 401 drugs. Click any drug to see the details.

5 of the 6 ingredients in Prostinex interact with drugs. Each result below shows which ingredient is responsible. Saw Palmetto berry extract Nettle (Utica dioica) root extract Lycopene Zinc Pumpkin (Cucurbita pepo) seed oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Prostinex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Saw Palmetto berry extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto berry extract full monograph & interactions

Nettle (Utica dioica) root extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettle (Utica dioica) root extract full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

Pumpkin (Cucurbita pepo) seed oil1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin (Cucurbita pepo) seed oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Prostinex, from the product label.

PurMEDICA

See all PurMEDICA products
Name
PurMEDICA
Street Address
P.O. Box 57894
City
Chicago
State
IL
ZipCode
60657
Phone Number
(888) 754-0313
Web Address
www.purmedica.com
Pharmacist Counseling Corner

Prostinex by PurMEDICA: Common Questions

Does Prostinex by PurMEDICA interact with any medications?
Yes. Based on its ingredients, Prostinex has a known interaction with 401 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prostinex contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for an enlarged prostate?
Saw palmetto and pumpkin seed oil are possibly effective for benign prostatic hyperplasia, and pygeum is likely effective. Nettle root has insufficient evidence at this time. The blend may support prostate health, but individual results vary—talk with your doctor about whether it fits your situation.
Can I take this if I'm on a blood thinner like warfarin?
No, not without checking with your doctor first. Both lycopene and saw palmetto carry a moderate interaction risk with warfarin and similar drugs, potentially increasing bleeding. Your doctor will need to weigh the risks and may need to monitor you or adjust your medication.
What side effects should I watch for?
Most common are gastrointestinal: diarrhea, nausea, abdominal discomfort, and dizziness. These are usually mild and reversible. If you develop a rash, severe nausea, or chest pain, stop and contact your healthcare provider.
Is it safe to take while pregnant or breastfeeding?
The safety data on these supplement doses during pregnancy and breastfeeding is either limited or advises against use—especially saw palmetto and nettle root. Talk with your doctor or pharmacist about whether it's right for you in either situation.
What is zinc doing in a prostate supplement?
Zinc supports immune function and is involved in prostate health. It's also included because it's effective for zinc deficiency and possibly effective for diabetes. However, if you take antibiotics, separate them by at least 2–4 hours from your zinc dose to avoid reduced antibiotic absorption.
Can I take this with my diabetes medication?
Nettle root may lower blood sugar on its own, and combining it with diabetes drugs could lower your levels too much. Check with your doctor or pharmacist before adding this product to your regimen.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prostinex label
Go deeper

The Full Monographs Behind Prostinex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph →
Sources

Sources & How We Checked

Prostinex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 151 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
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Pygeum 3 references
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  19. Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
  20. Maor D, Little M. Skin contact with a stinging tree requiring intensive care unit admission. Contact Dermatitis. 2017 Nov;77(5):335-37. PubMed
  21. Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJ. Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea. Am J Case Rep 2021;22:e933999. PubMed
  22. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
  23. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

See these in context on the Stinging Nettle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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