Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Quantum Probiotic Support Ingredients & Drug Interactions

by Quantum Nutrition Labs

Quantum Probiotic Support label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Quantum Probiotic Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Quantum Probiotic Support is a dietary supplement by Quantum Nutrition Labs with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 1,441 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Probiotic Fermented Multi-Culture. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Quantum Probiotic Support by Quantum Nutrition Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Quantum Probiotic Support by Quantum Nutrition Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Quantum Probiotic Support by Quantum Nutrition Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 37 active ingredients.
  • “Fatty Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Probiotics” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Probiotic Fermented Multi-Culture” is listed as a grouped ingredient — the label gives one combined amount (840 mg) without saying how much of each component you get.

Quantum Probiotic Support contains 37 ingredients total, including multiple live probiotic strains (Bacillus coagulans, Bifidobacterium breve, Bifidobacterium longum, Lactobacillus helveticus, and Streptococcus thermophilus), fermented botanicals (prune and goji berry), fulvic acid, humic acids, citric acid, and various support compounds like fatty acids and lactic acid bacteria. The product also includes several inactive ingredients—water, safflower oil, beeswax, lecithin, tapioca, glycerin, carrageenan, and caramel—that help form and stabilize the softgel capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and probiotic balance.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Bacterial vaginosis, Celiac disease, Clostridioides difficile infection, Irritable bowel syndrome — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for this product's benefits is limited. Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS), and fermented prune (plum) is possibly effective for constipation.

For the other active ingredients—Bifidobacterium breve, Bifidobacterium longum, Lactobacillus helveticus, Streptococcus thermophilus, fulvic acid, goji, citric acid, and humic acids—the data we hold shows insufficient evidence to rate their effectiveness for the conditions listed, or in some cases no evidence at all. Many of these ingredients lack established clinical benefit.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Probiotics Postbiotics

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 17 of the 18 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 17 of 18.
  • General safety write-ups exist for 18 of 18.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the live probiotic strains in this product are generally well tolerated in healthy adults, though safety data vary and product quality is not guaranteed. A few cautions: Fulvic acid should be avoided during pregnancy and breastfeeding due to insufficient safety data.

The safety data on fermented goji during pregnancy advises against medicinal amounts because of limited safety information and traditional concerns. Citric acid in small food-supplement amounts is generally recognized as safe, but concentrated citrate supplements warrant a conversation with your doctor.

Rare but serious side effects have been reported with probiotics in critically ill or severely immunocompromised patients (bacteremia and sepsis), and probiotic strains can occasionally cause bloating, flatulence, diarrhea, or headache. Fermented prune may cause gastrointestinal effects like flatulence and diarrhea.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Probiotics Postbiotics

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 13 of the 18 matched ingredients can interact with medications — Fig, Maitake Mushroom, Lactobacillus Acidophilus, Blueberry, Goji, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,409 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take any of these: blood thinners or antiplatelet drugs (especially warfarin), immunosuppressants, thyroid hormone therapy, antibiotics, medications processed by liver enzymes (particularly those broken down by cytochrome P450 pathways), the heart rhythm drug flecainide, blood pressure medication, or diabetes medication. The most serious interaction is with warfarin, where goji berry can significantly increase bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you're a healthy adult looking for a multi-strain probiotic with fermented botanicals, this product may be worth considering—but check your medications first, especially if you take blood thinners, immunosuppressants, thyroid medication, or antibiotics. Pregnant or breastfeeding?

Talk with your pharmacist or doctor before starting, particularly because of the goji and fulvic acid content. If you're severely ill or immunocompromised, ask your healthcare provider before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 20 of 37 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Quantum Probiotic Support, straight from the product label.

Brand Quantum Nutrition Labs
Barcode (UPC) 807735126803
Net contents 60 Vegetarian Softgel(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 304579
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Quantum Probiotic Support by Quantum Nutrition Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
807735126803
IngredientAmount% DV
Citric Acid0 NP--
Bacillus coagulans0 NP--
Polyphenols0 NP--
Fulvic Acid0 NP--
Fatty Acids0 NP--
Acetic Acid0 NP--
B. breve0 NP--
Probiotics0 NP--
Oligosaccharides0 NP--
Humic Acids0 NP--
3-Phenyllactic Acid0 NP--
Enterococcus faecalis TH-100 NP--
L. helveticus0 NP--
B. breve M-16V0 NP--
Probiotic Fermented Multi-Culture840 mg--
Lactic Acid Bacteria0 NP--
Bifidobacteria0 NP--
B. longum BB-5360 NP--
Lactobacillus helveticus ss. jugurti BBRC 38090 NP--
Streptococcus thermophilus NBRC 139570 NP--
Postbiotics0 NP--
Melanoidin0 NP--
Prebiotics0 NP--
Prune, Fermented0 NP--
Goji, Fermented0 NP--
Fig, Fermented0 NP--
Blueberry, Fermented0 NP--
Red Bayberry, Fermented0 NP--
Yuzu, Fermented0 NP--
Japanese Mugwort, Fermented0 NP--
Komatsuna, Fermented0 NP--
Shiitake, Fermented0 NP--
Agaricus, Fermented0 NP--
Maitake, Fermented0 NP--
Hijiki, Fermented0 NP--
Wakame, Fermented0 NP--
Kombu Kelp, Fermented0 NP--
B. longum infantis M-630 NP--
Lactobacilli0 NP--
Lactobacillus acidophilus ATC-SD52120 NP--
L. brevis NBRC 33450 NP--
L. bulgaricus NBRC 139530 NP--
L. casei TO-A0 NP--
L. fermentum NBRC 30700 NP--
L. plantarum TO-A0 NP--

Other ingredients: Water, Safflower Oil, Beeswax, Lecithin, Tapioca, Glycerin, Carrageenan, Caramel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

All strains may not be present in final product.

Immunity Digestion

Non gmo

Potency verified Purity verified Identity verified

Heavy metal tested

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 softgels daily. For best effect, take between meals or before bed.

Formula

3-year fermentation process using 12 strains of probiotic bacteria to produce a nourishing blend of prebiotics, probiotics and postbiotics

Quantum Probiotic Support with prebiotics & postbiotics 3-Year fermentation with a 14-plant super blend

Precautions

Tamper seal: use only if seal is intact.

Consult your healthcare practitioner if you are pregnant or nursing, taking medication or having a medical condition, before taking this product.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Scan to discover more

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See for yourself

Quantum Probiotic Support by Quantum Nutrition Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Quantum Probiotic Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Quantum Probiotic Support by Quantum Nutrition Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Probiotic Fermented Multi-Culture

Interacts with
182 drugs
840 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Fermented Multi-Culture monograph & interactions

Other (inactive) ingredients: Water, Safflower Oil, Beeswax, Lecithin, Tapioca, Glycerin, Carrageenan, Caramel. These complete the product’s ingredient list but are not active constituents.

Interaction report

Quantum Probiotic Support by Quantum Nutrition Labs Drug Interactions

Want to check YOUR meds against Quantum Probiotic Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,441Drugs
2 Major 1,406 Moderate 33 Minor

Ingredients driving the most interactions

Probiotic Fermented Multi-Culture 182

Individual Drug Interactions

The ingredients in Quantum Probiotic Support interact with 1,441 drugs. Click any drug to see the details.

1 of the 1 ingredient in Quantum Probiotic Support interact with drugs. Each result below shows which ingredient is responsible. Probiotic Fermented Multi-Culture

Each ingredient & the kinds of drugs it affects

For each ingredient in Quantum Probiotic Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Fermented Multi-Culture1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Fermented Multi-Culture full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Quantum Probiotic Support, from the product label.

Quantum Nutrition Labs

See all Quantum Nutrition Labs products
Name
Quantum Nutrition Labs
Pharmacist Counseling Corner

Quantum Probiotic Support by Quantum Nutrition Labs: Common Questions

Does Quantum Probiotic Support by Quantum Nutrition Labs interact with any medications?
Yes. Based on its ingredients, Quantum Probiotic Support has a known interaction with 1,441 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Quantum Probiotic Support contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for constipation or IBS?
Bacillus coagulans, one of the probiotic strains in here, is possibly effective for both constipation and IBS. Fermented prune is also possibly effective for constipation. For the other ingredients, there isn't enough evidence yet to say whether they help with these conditions.
Can I take this if I'm on antibiotics?
Not at the same time. Several of the live probiotic strains in this product—including Bacillus coagulans, Bifidobacterium breve, Bifidobacterium longum, and Lactobacillus helveticus—are vulnerable to antibiotics, which can kill them. If you're on an antibiotic, separate them by at least 2 hours (or ask your pharmacist for the best timing for your specific antibiotic).
Is this safe during pregnancy?
The live probiotics are generally considered safe, but the fermented goji berry and fulvic acid in this product should be avoided during pregnancy because there isn't enough safety data. Talk with your doctor or pharmacist before starting.
What are the main side effects I might notice?
Most people tolerate probiotics well, but you might experience bloating, flatulence, diarrhea, or headache, especially when you first start. These often settle down. Fermented prune can also cause diarrhea or gas. Serious side effects are rare in healthy people but have been reported in very ill or immunocompromised patients.
Can I take this with my blood thinner (warfarin)?
Not without talking to your doctor first. The fermented goji berry in this product can increase warfarin's effect and raise your bleeding risk—there are case reports of people on stable warfarin who had dangerous increases in their clotting time after adding goji juice. Also check with your pharmacist about fulvic acid, which theoretically may decrease blood-thinner effectiveness.
What is fulvic acid, and is it safe?
Fulvic acid is a compound that comes from soil and plants. Short-term use appears generally tolerated, but high-quality human safety data are limited. It should be avoided during pregnancy and breastfeeding. Check with your doctor if you take immunosuppressants or thyroid medication, as fulvic acid may interfere with these.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Quantum Probiotic Support is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Quantum Probiotic Support label
Go deeper

The Full Monographs Behind Quantum Probiotic Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Probiotics

Interacts with 222 drugs

Probiotics are live 'friendly' microbes that may help certain digestive conditions, such as antibiotic-associated diarrhea and some cases of IBS, though benefits depend heavily on the specif...

Read the full Probiotics monograph → Herb & supplement monograph

Postbiotics

Postbiotics are products made from non-living (inactivated) beneficial microbes and the helpful substances they produce. Early research suggests they may support gut and immune health, but t...

Read the full Postbiotics monograph →
Sources

Sources & How We Checked

Quantum Probiotic Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 281 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Citric Acid 10 references
  1. Kurtzweil P. Alpha-hydroxy acids for skin care: Smooth sailing or rough seas? FDA 1999. Available at: /www.fda.gov/fdac/features/1998/298_ahas.html (Accessed 18 August 2000). DOI
  2. Erbagci Z, Akcali C. Biweekly serial glycolic acid peels vs. long-term daily use of topical low-strength glycolic acid in the treatment of atrophic acne scars. Int J Dermatol 2000;39:789-94.. PubMed
  3. Ghadishah D, Gorchynski J. Airway compromise after routine alpha-hydroxy facial peel administration. J Emerg Med 2002;22:353-5.. PubMed
  4. Baumann LS, Oresajo C, Yatskayer M, Dahl A, Figueras K. Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment
  5. Emtestam L, Svensson Å, Rensfeldt K. Treatment of seborrhoeic dermatitis of the scalp with a topical solution of urea, lactic acid, and propylene glycol (K301): results of two double-blind, randomised, placebo-controlled studies. Mycoses. 2012 Sep;55(5):3 PubMed
  6. Kaminaka C, Uede M, Matsunaka H, Furukawa F, Yamomoto Y. Clinical evaluation of glycolic acid chemical peeling in patients with acne vulgaris: a randomized, double-blind, placebo-controlled, split-face comparative study. Dermatol Surg. 2014 Mar;40(3):314- PubMed
  7. Köse O, Özmen I, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013 Aug;24(4):300-4. PubMed
  8. Vachiramon V, Sahawatwong S, Sirithanabadeekul P. Treatment of melasma in men with low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet laser versus combined laser and glycolic acid peeling. Dermatol Surg. 2015 Apr;41(4):457-65. PubMed
  9. US Food and Drug Administration (FDA). Cosmetic Ingredients: Alpha Hydroxy Acids. August 2020. Available at: https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids. Accessed on October 19, 2021.
  10. Ormerod AD, van Voorst Vader PC, Majewski S, Vanscheidt W, Benjamin N, van der Meijden W. Evaluation of the efficacy, safety, and tolerability of 3 dose regimens of topical sodium nitrite with citric acid in patients with anogenital warts: A randomized cl DOI

See these in context on the Citric Acid monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Fulvic Acid 3 references
  1. Lu, FJ. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 6-15-1990;58(6):537-541. PubMed
  2. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed
  3. Gandy JJ, Meeding JP, Snyman JR, et al. Phase 1 clinical study of the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid. Clin Pharmacol. 2012;4:7-11. PubMed

See these in context on the Fulvic Acid monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Probiotics 77 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  3. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  4. Phuapradit P, Varavithya W, Vathanophas K, et al. Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J Med Assoc Thai 1999;82:S43-8.
  5. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
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Humic Acid 3 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
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See these in context on the Humic Acid monograph →

Lactobacillus Helveticus 2 references
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See these in context on the Lactobacillus Helveticus monograph →

Lactobacillus Acidophilus 15 references
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  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
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See these in context on the Lactobacillus Acidophilus monograph →

Lactic Acid 21 references
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See these in context on the Lactic Acid monograph →

Bifidobacterium Longum 21 references
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  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
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See these in context on the Bifidobacterium Longum monograph →

Streptococcus Thermophilus 21 references
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See these in context on the Streptococcus Thermophilus monograph →

Postbiotics 3 references
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See these in context on the Postbiotics monograph →

Plum 10 references
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See these in context on the Plum monograph →

Goji 14 references
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  12. Guzmán CE, Guzmán-Moreno CG, Assad-Morell JL, Edgar Francisco Carrizales-Sepúlveda EF. Flecainide toxicity associated with the use of goji berries: a case report. Eur Heart J Case Rep. 2021;5(6):ytab204. PubMed
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See these in context on the Goji monograph →

Fig 13 references
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  8. Ozdamar, E., Ozbek, S., and Akin, S. An unusual cause of burn injury: fig leaf decoction used as a remedy for a dermatitis of unknown etiology. J.Burn Care Rehabil. 2003;24(4):229-233. PubMed
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  10. Lembo, G., Lo, Presti M., and Balato, N. Phytophotodermatitis due to ficus carica. Photodermatol. 1985;2(2):119-120.
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See these in context on the Fig monograph →

Blueberry 7 references
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  2. Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
  3. Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
  4. Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
  5. Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
  6. Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
  7. Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed

See these in context on the Blueberry monograph →

Bayberry 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

See these in context on the Bayberry monograph →

Mugwort 7 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Borghesan F, Mistrello G, Amato S, Giuffrida MG, Villalta D, Asero R. Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5. Eur Ann Allergy Clin Immunol. 2013;45(4):130-7.
  4. Kim SH, Lee SM, Park HW, et al. Chinese bellflower root anaphylaxis: IgE-binding components and cross-reactivity with mugwort and birch. Korean J Intern Med. 2009;24(3):279-82. PubMed
  5. Silva R, Lopes C, Castro E, et al. Anaphylaxis to mango fruit and crossreactivity with Artemisia vulgaris pollen. J Investig Allergol Clin Immunol. 2009;19(5):420-2.
  6. Rodrigues-Alves R, Pregal A, Pereira-Santos MC, et al. Anaphylaxis to pine nut: cross-reactivity to Artemisia vulgaris? Allergol Immunopathol (Madr). 2008;36(2):113-6. PubMed
  7. Di Lorenzo C, Ferretti F, Moro E, et al. Identification and quantification of thujone in a case of poisoning due to repeated ingestion of an infusion of Artemisia vulgaris L. J Food Sci. 2018;83(8):2257-2264.

See these in context on the Mugwort monograph →

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Lactobacillus Delbrueckii 9 references
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  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
  8. Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
  9. Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.

See these in context on the Lactobacillus Delbrueckii monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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