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Niacin, also known as vitamin B3, is a water-soluble vitamin found in a variety of foods, including meat, poultry, fish, and fortified grains. It plays a variety of roles in the body, including in the metabolism of carbohydrates, fats, and proteins. It is also necessary for the production of energy in the body and in the synthesis of different hormones. Niacin deficiency is rare in developed countries, however, supplementation has been shown to have several positive benefits. For example, it can reduce the risk of diabetic neuropathy (i.e., nerve pain) and has been shown effective for treating some types of high cholesterol (extended-release niacin is used as a prescription drug in the United States for this purpose). There is a multitude of niacin forms available as dietary supplements, including NADH, niacinamide, and nicotinamide riboside, all with different properties.

Biotin, also known as vitamin H or vitamin B7, is a water-soluble vitamin that plays a role in various metabolic processes in the body. It is necessary for the growth and maintenance of healthy skin, hair, and nails, and is also involved in the metabolism of carbohydrates, fats, and amino acids. Biotin is considered to be generally safe when consumed in the recommended daily amounts but it is important to note that consuming large amounts of biotin-containing supplements or products can cause falsely high or falsely low test results for certain laboratory tests, such as those for thyroid function, hormone levels, and certain biomarkers for certain diseases.

Magnesium is a mineral that is essential for the proper functioning of the body. It plays a role in many important physiological processes, including the contraction and relaxation of muscles, the transmission of nerve impulses, and the regulation of blood pressure. Magnesium is found in a variety of foods, including leafy green vegetables, nuts, and grains, and it is also available as a dietary supplement. There are several different forms of magnesium that are available as supplements, all of which can be used to prevent deficiency. Additionally, magnesium is purported to have several different health benefits, such as improving sleep, reducing muscle cramps, reducing anxiety, and preventing or treating migraines. Although magnesium is essential for health, magnesium-containing foods and supplements can interact with some prescription medications if used at the same time.

Zinc is a mineral that is essential for the proper functioning of the human body. It is involved in many important physiological processes, including immune system function, wound healing, taste, and smell. Zinc is found in a variety of foods, including meat, seafood, and whole grains, and it is also available as a dietary supplement. Zinc supplements may be used to treat or prevent zinc deficiency, which can occur due to certain medical conditions, such as gastrointestinal disorders, alcohol abuse, and certain medications. Zinc supplements may also be used for other purposes, such as to boost the immune system, improve acne, and reduce the severity and duration of colds. There are several different forms of zinc supplements available, including zinc gluconate, zinc acetate, and zinc sulfate. The most common form of zinc supplements is zinc gluconate, which is well absorbed and is less likely to cause stomach-related side effects than other forms of zinc.

Glucosamine is a natural compound found in the body, particularly in the fluid that surrounds joints. It is often used as a dietary supplement to help with joint health, particularly for conditions such as osteoarthritis. Glucosamine is believed to work by helping to reduce inflammation, promoting the repair of damaged cartilage, and slowing down the loss of cartilage. There are several different forms of glucosamine supplements, including glucosamine sulfate, glucosamine hydrochloride, and N-acetyl-glucosamine. Glucosamine sulfate is the most commonly used form in supplements. It is important to note that glucosamine sulfate is derived from shellfish (specifically the exoskeletons of shrimp, lobster, and crabs) and can be problematic for people with shellfish allergies.

Devil's claw (Harpagophytum procumbens) is a plant native to southern Africa and a member of the Pedaliaceae family. The plant has large, lobed leaves and produces small, purple flowers. It gets its name from the small, hard, black seeds that are contained within the plant's fruit, which are shaped like small claws or hooks. In traditional medicine, devil's claw is purported to have anti-inflammatory and analgesic (pain-relieving) properties. It has been used to treat a variety of health conditions, including arthritis, joint pain, and lower back pain.

American ginseng (Panax quinquefolius) is a type of plant that is native to the eastern United States. It is a member of the Araliaceae family and is closely related to Asian ginseng (Panax ginseng). American ginseng has a long history of use in traditional medicine and is believed to have a number of potential health benefits. American ginseng is often referred to as an "adaptogen," which means that it may help the body to adapt to stress and improve overall well-being. It is commonly used to improve energy and mental clarity, and it has been suggested that it may have potential benefits for immune function, heart health, and diabetes management. American ginseng dietary supplements are generally standardized to contain 0.052% to 15% total ginsenosides, a group of compounds found in the plant.

Astragalus is a genus of plants native to Asia and Northern Africa, and is known for its small, yellow or purple flowers and its long, tapering root. In traditional medicine, astragalus has been used to boost the immune system and treat a variety of conditions, including colds, flu, and upper respiratory infections. It is commonly referred to as an 'adaptogen', which are theorized to help the body resist stress.

Turmeric is a commonly used spice and a member of the ginger family (Zingiberaceae). It is native to India and other parts of South Asia and is known for its bright orange-yellow color and its warm, slightly bitter flavor. In traditional medicine, turmeric is believed to have a number of health benefits due to its high content of antioxidants and other compounds, such as curcumin. It is thought to have anti-inflammatory and antimicrobial properties, and it is often used to treat a variety of conditions, including joint pain, digestive problems, skin disorders, and respiratory infections. Most dietary supplements that utilize turmeric standardize their products based on a specific amount of curcumin (curcuminoids) per dose. Additionally, turmeric supplements are often paired with black pepper extract (piperine) to improve oral absorption.