Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Rejuvenate Plus for Men Ingredients & Drug Interactions

by Nutrients for Health

Rejuvenate Plus for Men label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rejuvenate Plus for Men against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rejuvenate Plus for Men is a dietary supplement by Nutrients for Health with 7 active ingredients. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 466 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosemary extract, Saw Palmetto fruit extract, Stinging Nettle Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Rejuvenate Plus for Men by Nutrients for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Rejuvenate Plus for Men by Nutrients for Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Rejuvenate Plus for Men by Nutrients for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Rejuvenate Plus for Men contains 7 active ingredients chosen for men's health support. Lycopene is a red pigment from tomatoes; rosemary extract provides concentrated herbal compounds; pygeum is a tree bark traditional for prostate health; pumpkin seed concentrate supplies seed nutrients; saw palmetto is a palm berry used for prostate support; stinging nettle root extract comes from the herb's roots; and plant sterol complex is a blend of plant-derived compounds.

The product also contains inactive ingredients—hypromellose, microcrystalline cellulose, talc, silicon dioxide, magnesium stearate, and medium chain triglycerides—which serve as fillers, binders, and capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support prostate health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Prostate cancer, Prostatitis, Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), urinary flow, male urinary symptoms.
  • The strongest evidence on file: Pygeum is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Lycopene is rated "Possibly Effective" for Prostate cancer.
  • Also on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH).

Evidence for the active ingredients in this product is mixed. Lycopene is possibly effective for prostate cancer but possibly ineffective for bladder cancer and diabetes; evidence is insufficient for its role in high cholesterol (hyperlipidemia), ALS, and exercise-induced asthma.

Rosemary extract is possibly effective for memory but evidence is insufficient for age-related cognitive decline and several other conditions. Pygeum is likely effective for benign prostatic hyperplasia (BPH)—enlarged prostate—but evidence is insufficient for Alzheimer's disease, malaria, sexual desire, and psychosis.

Pumpkin seed concentrate is possibly effective for BPH but evidence is insufficient for male hair loss, bladder inflammation (interstitial cystitis), parasitic infections, and urinary tract infections. Saw palmetto is possibly effective for a specific prostate procedure (TURP) but possibly ineffective for BPH itself; evidence is insufficient for chronic bronchitis, hair loss, and lower urinary tract symptoms.

Stinging nettle root extract is possibly effective for diabetes but evidence is insufficient for hay fever, anemia, asthma, BPH, and gum disease.

The evidence, ingredient by ingredient Lycopene Rosemary Pygeum Pumpkin Saw Palmetto Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lycopene from food is well tolerated; supplement doses are generally well tolerated, though some people report diarrhea, gas, bloating, nausea, vomiting, indigestion, or loss of appetite. Rosemary extract is safe in normal food amounts but concentrated extracts require caution; undiluted oil may trigger seizures.

Topically, it can cause allergic reactions, lip and gum swelling, contact dermatitis, and light sensitivity in sensitive people. Pygeum is generally well tolerated short-term but long-term safety is not well studied; some people report nausea and abdominal pain, though these occurred at rates similar to placebo.

Pumpkin seed products are generally well tolerated; most common side effects are abdominal discomfort, diarrhea, nausea, and vomiting, though anaphylaxis has been reported rarely. Two case reports describe hair loss after consuming high-cucurbitacin pumpkin products.

Saw palmetto is well tolerated with mild, infrequent, reversible side effects including abdominal pain, constipation, low libido, diarrhea, dizziness, fatigue, headache, nausea, nasal symptoms, and vomiting; rare cardiovascular events have been reported. Stinging nettle is generally well tolerated; common oral side effects are constipation and diarrhea.

A rare case of liver injury has been reported. Topical contact with fresh plant causes itching, rash, and stinging; severe swelling and pain can occur if the fresh leaf is placed in the mouth.

Side effects, ingredient by ingredient Lycopene Rosemary Pygeum Pumpkin Saw Palmetto Stinging Nettle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Rosemary, Lycopene, Stinging Nettle, Pumpkin, Saw Palmetto.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 466 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Rejuvenate Plus for Men, double-check with your doctor or pharmacist if you are on any blood thinners (anticoagulants or antiplatelets) such as warfarin, aspirin, or clopidogrel—lycopene, rosemary, and saw palmetto may increase bleeding risk. If you take diabetes medications, stinging nettle and rosemary may lower blood sugar further.

If you take lithium for mood stabilization, pumpkin seed and stinging nettle may increase lithium levels and require a dose adjustment. If you take a diuretic (water pill), stinging nettle may add to its fluid-loss effects.

If you take estrogens or contraceptive pills, saw palmetto may reduce their effectiveness. If you take warfarin, stinging nettle's vitamin K content may interfere with its action.

Rosemary may also affect how your body processes certain medications your liver handles.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Rejuvenate Plus for Men is a multi-ingredient supplement aimed at prostate and male health, with the strongest evidence for pygeum in benign prostatic hyperplasia. However, it carries documented interactions with blood thinners, diabetes medications, lithium, diuretics, estrogens, and contraceptives—and several ingredients are not advised in pregnancy or while breastfeeding.

If you take any prescription medications, especially blood thinners, diabetes drugs, or mood stabilizers, check this product against your exact medications before starting, and talk it over with your own doctor or pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rejuvenate Plus for Men, straight from the product label.

Brand Nutrients for Health
Barcode (UPC) 854755007179
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 272514
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rejuvenate Plus for Men by Nutrients for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
854755007179
IngredientAmount% DV
Lycopene10 mg--
Plant Sterol Complex100 mg--
Rosemary extract10 mg--
Pygeum100 mg--
Pumpkin seed concentrate100 mg--
Saw Palmetto fruit extract320 mg--
Stinging Nettle Root Extract50 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Talc, Silicon Dioxide, Magnesium Stearate, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Rejuvenate Plus for Men is a comprehensive supplement to help support prostate health.

Prostate health complex

Suitable for vegans

Formula

The active principles in nettle, saw palmetto, pygeum and pumpkin seed are a group of closely related compounds known as phytosterols, comprised of beta-sitosterol, stigmasterol, and campesterol.

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules daily preferably with a meal or as directed by your healthcare provider.

Precautions

Caution: Consult your physician prior to using this product if you are under 18 years old or have any pre-existing conditions.

Keep out of the reach of children

Do not use if seal is broken

Storage

Store in a cool, dry place

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Nutrients for Health By W.T. Rawleigh

Rawleigh A Friend of the Family Since 1889

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rejuvenate Plus for Men by Nutrients for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rejuvenate Plus for Men label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rejuvenate Plus for Men by Nutrients for Health

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lycopene

Interacts with
122 drugs
10 mg per serving

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Plant Sterol Complex

100 mg per serving

Rosemary extract

Interacts with
372 drugs
10 mg per serving

Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory...

Rosemary extract monograph & interactions

Pygeum

No known
interactions
100 mg per serving

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...

Pygeum monograph & interactions

Pumpkin seed concentrate

Interacts with
1 drug
100 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed concentrate monograph & interactions

Saw Palmetto fruit extract

Interacts with
174 drugs
320 mg per serving Form: Total Fatty Acids

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto fruit extract monograph & interactions

Stinging Nettle Root Extract

Interacts with
164 drugs
50 mg per serving Form: Plant Sterols

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Stinging Nettle Root Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Talc, Silicon Dioxide, Magnesium Stearate, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rejuvenate Plus for Men by Nutrients for Health Drug Interactions

Want to check YOUR meds against Rejuvenate Plus for Men?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
466Drugs
340 Moderate 126 Minor

Ingredients driving the most interactions

Rosemary extract 372
Saw Palmetto fruit extract 174
Stinging Nettle Root Extract 164
Lycopene 122
Pumpkin seed concentrate 1

Individual Drug Interactions

The ingredients in Rejuvenate Plus for Men interact with 466 drugs. Click any drug to see the details.

5 of the 7 ingredients in Rejuvenate Plus for Men interact with drugs. Each result below shows which ingredient is responsible. Rosemary extract Saw Palmetto fruit extract Stinging Nettle Root Extract Lycopene Pumpkin seed concentrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Rejuvenate Plus for Men with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rosemary extract6 drug types · 372 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Aspirin

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.

Likelihood Possible Evidence D
Choline Magnesium Trisalicylate (Trilisate)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Salsalate (Disalcid)

Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Unlikely Evidence D
Rosemary extract full monograph & interactions

Saw Palmetto fruit extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto fruit extract full monograph & interactions

Stinging Nettle Root Extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Stinging Nettle Root Extract full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Pumpkin seed concentrate1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin seed concentrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rejuvenate Plus for Men, from the product label.

Nutrients for Health

Name
Vitamins Direct (USA), Inc.
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
866-354-8384
Web Address
www.wtrawleigh.com
Pharmacist Counseling Corner

Rejuvenate Plus for Men by Nutrients for Health: Common Questions

Does Rejuvenate Plus for Men by Nutrients for Health interact with any medications?
Yes. Based on its ingredients, Rejuvenate Plus for Men has a known interaction with 466 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rejuvenate Plus for Men contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lycopene and why is it in this product?
Lycopene is a red pigment found mainly in tomatoes. It's included because it's possibly effective for prostate cancer, which may be relevant to men's health support. The evidence for bladder cancer, diabetes, and high cholesterol is less clear.
Is pygeum really effective for prostate problems?
Pygeum is likely effective for benign prostatic hyperplasia (BPH)—enlarged prostate. However, saw palmetto, also in this product, is possibly ineffective for BPH, so the data is mixed across ingredients.
What are the most common side effects I might notice?
The most common side effects reported are gastrointestinal: diarrhea, gas, bloating, nausea, vomiting, abdominal discomfort, and indigestion. These are typically mild and reversible.
Can I take this if I'm on a blood thinner?
No—not without checking first with your doctor or pharmacist. Lycopene, rosemary, and saw palmetto in this product may increase bleeding risk when combined with blood thinners like warfarin or aspirin. You must confirm it's safe for your specific situation.
Is this safe to take while trying to conceive or while pregnant?
Several ingredients—rosemary, saw palmetto, and stinging nettle—are not advised in pregnancy or when trying to conceive, and pumpkin seed supplement safety is not well studied in pregnancy. Talk with your doctor or pharmacist about whether this product is right for you right now.
Can I take this with my diabetes medication?
Possibly, but you need to check first. Rosemary and stinging nettle may lower blood sugar, so combining them with diabetes drugs could increase the risk of low blood sugar. Your doctor or pharmacist can tell you whether it's safe and whether your dose needs adjusting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rejuvenate Plus for Men is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rejuvenate Plus for Men label
Go deeper

The Full Monographs Behind Rejuvenate Plus for Men’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Rosemary

Interacts with 372 drugs

Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...

Read the full Rosemary monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph →
Sources

Sources & How We Checked

Rejuvenate Plus for Men's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 83 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

Rosemary 20 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  6. Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
  7. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
  8. Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
  9. Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
  10. Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
  11. Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
  12. Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
  13. Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
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Saw Palmetto 22 references
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Stinging Nettle 23 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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