Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

ReliefBiotic IB Ingredients & Drug Interactions

by Natural Factors

ReliefBiotic IB label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ReliefBiotic IB against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ReliefBiotic IB is a dietary supplement by Natural Factors with 4 active ingredients. Its ingredients are commonly taken for mood and stress support, digestive and gut health, sleep support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus helveticus (R0052), Bacillus subtilis (R0179). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ReliefBiotic IB by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with ReliefBiotic IB by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ReliefBiotic IB by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Synergistic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

ReliefBiotic IB contains four active probiotic ingredients — Lactobacillus rhamnosus, Enterococcus faecium, Lactobacillus helveticus, and Bacillus subtilis — all delivered in a capsule form. Probiotics are beneficial live bacteria intended to support digestive health.

The product also contains inactive ingredients including potato starch, lactose, a vegetarian capsule, whey powder, magnesium stearate, and ascorbic acid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote healthy gut and digestion.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Helveticus is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Rotaviral diarrhea, Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Dyspepsia.

The evidence for these probiotics is mixed and in many cases limited. Bacillus subtilis has been rated Possibly Effective for antibiotic-associated diarrhea — the most established use in this product.

For the other conditions we have data on — including hay fever, cognitive function, depression, and various types of diarrhea — the evidence for these ingredients is not strong enough to rate them reliably. The effectiveness information we hold for Lactobacillus rhamnosus and Enterococcus faecium is not established in our data.

The evidence, ingredient by ingredient Lactobacillus Helveticus Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus helveticus and Bacillus subtilis are generally well tolerated in healthy people, though the data is limited. Both come with cautions: people who are seriously ill or immunocompromised should check with their doctor first, and you should do the same before starting if you have any health concerns.

In rare cases, diarrhea or headache has been reported. Because these are live microorganisms, there is a theoretical concern — documented in case reports — that they could cause serious infection in certain patients, particularly those with weakened immunity; this is uncommon but something to discuss with your doctor if you're in that category.

Pregnancy and lactation safety data are not on file for these ingredients, so talk with your pharmacist or doctor before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Lactobacillus Helveticus Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Helveticus, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern — Moderate severity. Because these are live-organism probiotics, antibiotics can kill them and reduce how well the product works.

Space the two apart and ask your pharmacist how long to wait between doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

ReliefBiotic IB is a four-strain probiotic that may help with antibiotic-associated diarrhea, though evidence is strongest for one ingredient. The main thing to watch is timing it away from antibiotic medications.

If you're seriously ill, immunocompromised, pregnant, or nursing, check with your doctor first. Always run your full medication list through our checker before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ReliefBiotic IB, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958018614
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220942
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ReliefBiotic IB by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
068958018614
IngredientAmount% DV
Proprietary Synergistic Blend0 NP--
Lactobacillus rhamnosus (R0011)0 NP--
Enterococcus faecium (R0026)0 NP--
Lactobacillus helveticus (R0052)0 NP--
Bacillus subtilis (R0179)0 NP--

Other ingredients: Potato Starch, Lactose, Vegetarian Capsule, Whey powder, Magnesium Stearate, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

isura Non-GMO - Mass Spec Documentation Lab tested

Purity & Potency Guaranteed

Suggested/Recommended/Usage/Directions

Suggested Usage: 1 capsule per day with or without a meal, or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Contains milk and soy.

Formulation

ReliefBiotic IB is specifically formulated to promote a healthy gut and digestion while minimizing occasional gastrointestinal disturbances.

Manufactured by natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives, or sweeteners; no wheat, gluten, yeast, corn, egg, fish, shellfish, salt, tree nuts, or GMOs

Suitable for vegetarians.

Guaranteed minimum 7 billion CFU per capsule at expiry date. Guaranteed minimum 15 billion CFU per capsule at manufacture date.

Soothing support for the GI tract

Formula

This convenient one-a-day capsule contains 4 unique strains and guaranteed 7 billion active cells for maintaining healthy intestinal flora and supporting intestinal/gastrointestinal health.

7 billion live probiotic cultures

Storage

For freshness, store in a cool, dry place.

No refrigeration required but will prolong strength of product.

No refrigeration required

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Product of Canada Recyclable container and label.

Premium formula

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ReliefBiotic IB by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ReliefBiotic IB label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ReliefBiotic IB by Natural Factors

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Synergistic Blend

0 NP per serving

Other (inactive) ingredients: Potato Starch, Lactose, Vegetarian Capsule, Whey powder, Magnesium Stearate, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

ReliefBiotic IB by Natural Factors Drug Interactions

Want to check YOUR meds against ReliefBiotic IB?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus helveticus (R0052) 182
Bacillus subtilis (R0179) 182

Individual Drug Interactions

The ingredients in ReliefBiotic IB interact with 182 drugs. Click any drug to see the details.

2 of the 4 ingredients in ReliefBiotic IB interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus helveticus (R0052) Bacillus subtilis (R0179)

Each ingredient & the kinds of drugs it affects

For each ingredient in ReliefBiotic IB with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus helveticus (R0052)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus helveticus (R0052) full monograph & interactions

Bacillus subtilis (R0179)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis (R0179) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ReliefBiotic IB, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

ReliefBiotic IB by Natural Factors: Common Questions

Does ReliefBiotic IB by Natural Factors interact with any medications?
Yes. Based on its ingredients, ReliefBiotic IB has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ReliefBiotic IB contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotics?
Not at the same time. Antibiotics can kill the live bacteria in this product and make it less effective. You'll need to space them apart — your pharmacist can help you figure out the right timing based on your specific antibiotic.
Is this safe if I have a weakened immune system?
You should talk with your doctor first. The safety data is limited, and people who are seriously ill or immunocompromised should use caution with live-organism probiotics like these.
Can I take this while pregnant or breastfeeding?
There isn't enough data on file to know either way for these specific ingredients. Talk with your pharmacist or doctor before you start — they can give you personalized advice based on your situation.
What is this product supposed to do?
It's designed to support digestive health with live beneficial bacteria. The strongest evidence is for Bacillus subtilis helping with diarrhea related to antibiotic use, though evidence for the other conditions and ingredients is limited.
What side effects might I see?
Most people tolerate it well. Rarely, diarrhea or headache has been reported in trials. Because these contain live organisms, there's a theoretical concern about infection in very ill or immunocompromised patients, though that's uncommon.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ReliefBiotic IB is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ReliefBiotic IB label
Go deeper

The Full Monographs Behind ReliefBiotic IB’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

ReliefBiotic IB's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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