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Dietary supplement

ReplENZYMES Ingredients & Drug Interactions

by Zenwise Health

ReplENZYMES label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ReplENZYMES against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ReplENZYMES is a dietary supplement by Zenwise Health with 3 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ReplENZYMES by Zenwise Health

Ask about any prescription or over-the-counter medication and we check it for interactions with ReplENZYMES by Zenwise Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ReplENZYMES by Zenwise Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (10 mg) without saying how much of each component you get.

ReplENZYMES contains 3 active ingredients: papain (an enzyme from papaya), bromelain (an enzyme from pineapple), and protease (a general protein-digesting enzyme). These are proteolytic enzymes—they break down proteins.

The product also contains inactive ingredients: microcrystalline cellulose (a binder), a vegetable capsule, and medium chain triglyceride (an oil).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzyme support to aid digestion.
  • We looked for evidence on: digestive insufficiency, enzyme deficiency, protein digestion.
  • The closest evidence on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (Natural Medicines).

The effectiveness data for ReplENZYMES is limited. Papain has insufficient reliable evidence to rate it for cancer, dental cavities, radiation skin damage, exercise-related muscle soreness, shingles, or intestinal parasites.

Bromelain similarly has insufficient evidence for hay fever, burns, cancer, chemotherapy nerve damage, poor circulation in the legs, or diabetes. We hold no effectiveness ratings for protease.

The evidence, ingredient by ingredient Papain Bromelain Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain and bromelain are generally well tolerated at short-term, appropriate doses, but the evidence on long-term use is sparse. Common side effects are mild: digestive upset (diarrhea, gas, stomach discomfort), headache, or allergic reactions in sensitive people (itchy eyes, runny nose, sneezing, abdominal cramps).

Rare serious effects from high oral doses include esophageal perforation and severe stomach inflammation. If you're allergic to papaya or pineapple, you may react to these enzymes.

For pregnancy: papain is possibly unsafe and best avoided; bromelain is not safe enough and should be avoided. For breastfeeding: papain lacks reliable safety data, so supplemental use is not advised; bromelain is also best avoided.

Protease safety has not been established in pregnancy and is not recommended while breastfeeding without medical advice. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Papain Bromelain Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting ReplENZYMES, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants) like warfarin, or antiplatelet medications like aspirin or clopidogrel—there's a Moderate risk of increased bleeding. Also check if you're on tetracycline antibiotics, as bromelain may affect how your body absorbs them (Minor concern).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

ReplENZYMES is an enzyme blend without strong evidence that it works for any specific condition. If you take a blood thinner like warfarin, an antiplatelet drug like aspirin, or a tetracycline antibiotic, you'll need to check your exact medications before starting it.

It's generally well tolerated, but allergies and digestive upset are possible. Talk with your doctor or pharmacist before taking it, especially if you're pregnant, breastfeeding, or on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ReplENZYMES, straight from the product label.

Brand Zenwise Health
Barcode (UPC) X002G36XIX
Net contents 125 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 257219
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ReplENZYMES by Zenwise Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
125
UPC/BARCODE
X002G36XIX
IngredientAmount% DV
Proprietary Blend10 mg--
Papain0 NP--
Bromelain0 NP--
Protease0 NP--

Other ingredients: Microcrystalline Cellulose, Vegetable Capsule, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Zenwise ReplENZYMES helps supplement your digestive enzyme levels, which decrease after age 20. Made with out proprietary Daily Pre-Meal Enzyme Blend and delivered in easy-to-swallow Slim ZenCaps, ReplENZYMES provide the enzymes you need to help your gut conquer hard-to-digest foods.

Includes 11 digestive enzymes

Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule immediately before each meal.

Precautions

Caution: Keep out of reach of children.

Do not exceed recommended dosage.

As with any dietary supplement, consult a healthcare professional prior to use if you are pregnant or nursing, under the age of 18, have a known medial condition, are taking any medications, or are planning a medical procedure.

As with any dietary supplement, consult a healthcare professional prior to use if you are pregnant or nursing, under the age of 18, have a known medial condition, are taking any medications, or are planning a medical procedure.

Discontinue use immediately if new or worsening symptoms appear. Do not use if safety seal is broken or missing.

Storage

Store at room temperature away from light.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Slim ZenCaps

Support enzyme levels Digestive support

Vegetarian certified

Non-GMO

General Statements

New!

8 10030 59033 0

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

AVA Certified Vegetarian American Vegetarian Association

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ReplENZYMES by Zenwise Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ReplENZYMES label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ReplENZYMES by Zenwise Health

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container125 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

10 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Capsule, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

ReplENZYMES by Zenwise Health Drug Interactions

Want to check YOUR meds against ReplENZYMES?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in ReplENZYMES interact with 141 drugs. Click any drug to see the details.

2 of the 3 ingredients in ReplENZYMES interact with drugs. Each result below shows which ingredient is responsible. Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in ReplENZYMES with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ReplENZYMES, from the product label.

Zenwise Health

See all Zenwise Health products
Name
Zenwise
Street Address
12124 High Tech Ave Suite 220
City
Orlando
State
FL
ZipCode
32817
Phone Number
(800) 940-1972
Pharmacist Counseling Corner

ReplENZYMES by Zenwise Health: Common Questions

Does ReplENZYMES by Zenwise Health interact with any medications?
Yes. Based on its ingredients, ReplENZYMES has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ReplENZYMES contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ReplENZYMES if I'm on warfarin?
Not without checking first. Papain in this product may increase warfarin's effects and raise your bleeding risk—one case report documented a patient's blood-thinning level jump after taking a papain supplement. Talk with your doctor or pharmacist before combining them.
What are the most common side effects?
Mild digestive upset—diarrhea, gas, or stomach discomfort—and headache are the most common. Allergic reactions (itchy eyes, runny nose, sneezing, abdominal cramps) can happen in people sensitive to papain or bromelain. Rare high doses may cause serious stomach problems.
Is ReplENZYMES safe to take while pregnant?
No. Papain is possibly unsafe in pregnancy, and bromelain should be avoided—the safety data doesn't support their use. Talk with your doctor before taking any supplements while pregnant.
Can I take this if I'm breastfeeding?
The safety data isn't there to recommend it. Papain lacks reliable safety information, bromelain should be avoided, and protease isn't recommended without medical advice. Check with your doctor or pharmacist first.
Does ReplENZYMES actually work for anything?
We hold insufficient evidence to rate papain or bromelain for any condition in our data—cancer, burns, circulation problems, diabetes, hay fever, and others all lack reliable proof. No effectiveness ratings are on file for protease.
What if I'm allergic to pineapple or papaya?
You should avoid ReplENZYMES. Bromelain comes from pineapple and papain from papaya; allergic reactions—itching, rashes, throat swelling, and breathing trouble—are possible in sensitive people.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ReplENZYMES is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ReplENZYMES label
Go deeper

The Full Monographs Behind ReplENZYMES’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

ReplENZYMES's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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