Sea Moss Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sea Moss against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sea Moss is a dietary supplement by Signature Supplements with 3 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 891 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bladderwrack, Burdock. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sea Moss by Signature Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Sea Moss by Signature Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sea Moss by Signature Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 3 active ingredients. Burdock is a root traditionally used in herbal preparations.
Irish Sea Moss and Bladderwrack are both seaweeds—nutrient-dense marine plants that have been used in traditional diets for centuries. The capsules also contain cellulose and diatomaceous earth as inactive ingredients (the carriers and binders that make the capsule work).
Does it work?
Couldn't assess
The evidence for burdock's use in acne, aging skin, breast cancer, common cold, and eczema is insufficient—we don't have reliable data showing it works for these purposes in the studies we hold. We have no effectiveness ratings on file for Irish Sea Moss or Bladderwrack.
How safe is it?
Well-documented data
Burdock is generally well tolerated when eaten as a food and for short-term use in healthy adults, though human safety data are limited. Allergic reactions including contact dermatitis and anaphylaxis are rare but possible.
A case of liver injury was reported in someone taking a herbal mixture containing burdock, but it's unclear whether burdock itself was responsible. Contact dermatitis has occurred with prolonged use of burdock root oil and burdock plasters, sometimes appearing up to a week after application.
Burdock should be avoided in medicinal amounts during pregnancy due to lack of safety data and possible effects on the uterus. It should also be avoided while breastfeeding because there isn't enough safety information.
We have no pregnancy or breastfeeding safety data on file for Irish Sea Moss or Bladderwrack.
Meds to double-check
Moderate interaction found
Check before adding this product if you take blood thinners or antiplatelet drugs (like warfarin, apixaban, clopidogrel, or aspirin used for heart protection). We have no interaction data for Irish Sea Moss or Bladderwrack, so we couldn't screen those ingredients.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is best suited for people interested in traditional herbal use who don't take blood thinners or antiplatelet medications. If you're on any prescription drugs—especially for heart disease or clotting—check with your pharmacist before starting.
The evidence for what burdock does isn't established yet, so manage your expectations about results.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sea Moss, straight from the product label.
| Brand | Signature Supplements |
|---|---|
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 338938 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sea Moss by Signature Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Burdock | 75 mg | -- |
| Irish Sea Moss | 300 mg | -- |
| Bladderwrack | 100 mg | -- |
Other ingredients: Cellulose, Diatomaceous Earth
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Contains no: chemical fillers or binders, artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
From a GMP facility
Precautions
As a reminder, discuss the supplements and medications you take with your health care providers.
Warning: This product should not be taken by individuals with known hypersensitivity to iodine or hyperthyroidism
Not intended for use by pregnant or nursing women. If you are taking any medications, planning any medical or surgical procedure, or have any medical condition, consult your doctor before use.
Avoid this product if you are allergic to ragweed or daisy-like flowers.
If any adverse reactions occur, immediately stop using this product and consult your doctor.
Keep out of reach of children.
FDA Statement of Identity
Dietary Supplement
Formula
Sea Moss + bladderwrack & burdock Superfood
Suggested/Recommended/Usage/Directions
Directions: Adults, take two (2) capsules daily, more if needed.
Storage
Store in a dry place and avoid excessive heat
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sea Moss by Signature Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sea Moss by Signature Supplements
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Burdock
Interacts with122 drugs
Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and mo...
Burdock monograph & interactionsIrish Sea Moss
Bladderwrack
Interacts with891 drugs
Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin. There is l...
Bladderwrack monograph & interactionsOther (inactive) ingredients: Cellulose, Diatomaceous Earth. These complete the product’s ingredient list but are not active constituents.
Sea Moss by Signature Supplements Drug Interactions
HelloPharmacist Interaction Report
Signature Supplements' Sea Moss contains burdock, which has a documented interaction with blood thinners and antiplatelet drugs (medications that prevent clots).
Taking burdock with these drugs may increase your bleeding risk. Lab research shows that compounds in burdock can slow how platelets clump together, though this hasn't been observed in people yet—it's a theoretical concern based on the chemistry.
Read the full breakdown — every affected drug type, severity by severity
We weren't able to check Irish Sea Moss or Bladderwrack for interactions; we hold no data on either ingredient. Altogether, these interactions span 122 individual medications.
Before you start this product, run your exact medications through the checker below. If you take any blood thinners or antiplatelet agents (like warfarin, clopidogrel, or aspirin for heart protection), flag this with your pharmacist or doctor first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sea Moss?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sea Moss interact with 891 drugs. Click any drug to see the details.
2 of the 3 ingredients in Sea Moss interact with drugs. Each result below shows which ingredient is responsible. Bladderwrack Burdock
RivaroxabanXarelto
How Rivaroxaban interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Rivaroxaban interactionBladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Rivaroxaban interactionSelexipagUptravi
How Selexipag interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Selexipag interactionBladderwrackAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c8 (cyp2c8) Substrates Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Selexipag interactionSelumetinib SulfateKoselugo
How Selumetinib Sulfate interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Selumetinib Sulfate interactionBladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Selumetinib Sulfate interactionSorafenibNexavar
How Sorafenib interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Sorafenib interactionBladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Sorafenib interactionStreptokinaseKabikinase, Streptase
How Streptokinase interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Streptokinase interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Streptokinase interactionTenecteplaseTNKase
How Tenecteplase interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Tenecteplase interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Tenecteplase interactionTestosterone UndecanoateAndriol, Aveed, Jatenzo, Kyzatrex
How Testosterone Undecanoate interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Testosterone Undecanoate interactionThyroglobulinProloid
How Thyroglobulin interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Thyroglobulin interactionThyroid HormoneEtwon
How Thyroid Hormone interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Bladderwrack + Thyroid Hormone interactionTicagrelorBrilinta
How Ticagrelor interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Ticagrelor interactionBladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Ticagrelor interactionTiclopidineTiclid, Ticlopidine
How Ticlopidine interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Ticlopidine interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Ticlopidine interactionTinzaparinInnohep
How Tinzaparin interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Tinzaparin interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Tinzaparin interactionTirofibanAggrastat
How Tirofiban interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Tirofiban interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Tirofiban interactionTivozanib HydrochlorideFotivda
How Tivozanib Hydrochloride interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Tivozanib Hydrochloride interactionBladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Tivozanib Hydrochloride interactionTreprostinil
How Treprostinil interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Treprostinil interactionBladderwrackAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c8 (cyp2c8) Substrates Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Treprostinil interactionTreprostinil (iv)Remodulin
How Treprostinil (iv) interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Treprostinil (iv) interactionBladderwrackAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c8 (cyp2c8) Substrates Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Treprostinil (iv) interactionTreprostinil (inh)Tyvaso
How Treprostinil (inh) interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Treprostinil (inh) interactionBladderwrackAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c8 (cyp2c8) Substrates Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Treprostinil (inh) interactionTreprostinil (oral)Orenitram, Remodulin
How Treprostinil (oral) interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Treprostinil (oral) interactionBladderwrackAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c8 (cyp2c8) Substrates Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Treprostinil (oral) interactionUrokinaseAbbokinase
How Urokinase interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Urokinase interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Urokinase interactionVorapaxarZontivity
How Vorapaxar interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Vorapaxar interactionBladderwrackCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Vorapaxar interactionWarfarinWarfarin
How Warfarin interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Warfarin interactionBladderwrackCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +2 Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP2C9 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Warfarin Sodium interactionBladderwrackCytochrome P450 2c8 (cyp2c8) Substrates, Anticoagulant/antiplatelet Drugs +2 Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Warfarin Sodium interactionAnistreplase, ApsacEminase
How Anistreplase, Apsac interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Anistreplase, Apsac interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Anistreplase, Apsac interactionDabigatranPradax, Pradaxa
How Dabigatran interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Dabigatran interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Dabigatran interactionReteplaseRetevase
How Reteplase interacts with Sea Moss — through 2 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Reteplase interactionBladderwrackAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Bladderwrack + Reteplase interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Sea Moss — through 1 ingredient. Tap an ingredient for the detail:
BladderwrackCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Bladderwrack + Acalabrutinib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sea Moss with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bladderwrack
Amiodarone (Cordarone)
Theoretically, combining Fucus vesiculosus with amiodarone might cause excessively high iodine levels.
Fucus vesiculosus contains high concentrations of iodine. Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.
Antithyroid Drugs
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using antithyroid drugs could alter the effects of the antithyroid drugs.
Lithium
Concomitant use of Fucus vesiculosus and lithium has resulted in hyperthyroidism.
There is a case of hyperthyroidism occurring in a patient taking Fucus vesiculosus and lithium. Monitor thyroid hormones closely in patients taking lithium and Fucus vesiculosus concomitantly.
Thyroid Hormone
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using thyroid hormone could alter the effects of thyroid hormone.
Anticoagulant/Antiplatelet Drugs
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
In vitro evidence suggests that a constituent of Fucus vesiculosus, known as fucoidan, has anticoagulant effects. However, in clinical research, fucoidan does not seem to have significant anticoagulant activity when taken orally, possibly due to poor absorption.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C8. This interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2C9 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C9. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, both inhibits and induces CYP2D6. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP3A4. This interaction has not been reported in humans.
Burdock
Anticoagulant/Antiplatelet Drugs
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Sea Moss, from the product label.
Signature Supplements
See all Signature Supplements products- Name
- Signature Supplements
- Street Address
- P.O. Box 1112
- City
- San Clemente
- State
- CA
- Web Address
- yoursignaturesupplements.com
Sea Moss by Signature Supplements: Common Questions
Does Sea Moss by Signature Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What is burdock used for in this supplement?
Are there any side effects I should know about?
What are Irish Sea Moss and Bladderwrack?
Is this product safe to take long-term?
Does this have any fillers or other ingredients I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sea Moss’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Burdock
Interacts with 122 drugsBurdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...
Read the full Burdock monograph → Herb & supplement monographFucus Vesiculosus
Interacts with 891 drugsFucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin. There is little solid human evidence to support mo...
Read the full Fucus Vesiculosus monograph →Sources & How We Checked
Sea Moss's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Burdock 11 references
- Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
- Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
- Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
- Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
- Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
- Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
- Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
- Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
- <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
- Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
- Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
Fucus Vesiculosus 15 references
- Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Phaneuf D, Cote I, Dumas P, et al. Evaluation of the contamination of marine algae (Seaweed) from the St. Lawrence River and likely to be consumed by humans. Environ Res 1999;80:S175-S182. PubMed
- Durig J, Bruhn T, Zurborn KH, et al. Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 1997;85:479-91. PubMed
- Conz PA, La Greca G, Benedetti P, et al. Fucus vesiculosus: a nephrotoxic alga? Nephrol Dial Transplant 1998;13:526-7.
- Ohye H, Fukata S, Kanoh M, et al. Thyrotoxicosis caused by weight-reducing herbal medicines. Arch Intern Med 2005;165:831-4. PubMed
- Okamura K, Inoue K, Omae T. A case of Hashimoto's thyroiditis with thyroid immunological abnormality manifested after habitual ingestion of seaweed. Acta Endocrinol (Copenh) 1978;88:703-12. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7. PubMed
- Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
- Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., Usov, A. I., Ustyuzhanina, N. E., Grachev, A. A., Sanderson, C. J., Kelly, M., Rabinovich, G. A., I
- Irhimeh, M. R., Fitton, J. H., and Lowenthal, R. M. Pilot clinical study to evaluate the anticoagulant activity of fucoidan. Blood Coagul.Fibrinolysis 2009;20(7):607-610. PubMed
- Arbaizar, B. and Llorca, J. [Fucus vesiculosus induced hyperthyroidism in a patient undergoing concomitant treatment with lithium]. Actas Esp.Psiquiatr. 2011;39(6):401-403.
- Church FC, Meade JB, Treanor RE, and et al. Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin. J Biol Chem 2-25-1989;264(6):3618-3623. DOI
- Mathew L, Burney M, Gaikwad A, et al. Preclinical evaluation of safety of fucoidan extracts from Undaria pinnatifida and Fucus vesiculosus for use in cancer treatment. Integr Cancer Ther 2017;16(4):572-84.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC