Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Shilajit 500 mg Ingredients & Drug Interactions

by Nugenix

Shilajit 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Shilajit 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Shilajit 500 mg is a dietary supplement by Nugenix with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, male fertility and testosterone support, general vitality and aging.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Shilajit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Shilajit 500 mg by Nugenix

Ask about any prescription or over-the-counter medication and we check it for interactions with Shilajit 500 mg by Nugenix — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Shilajit 500 mg by Nugenix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: shilajit extract at 500 mg per capsule. Shilajit is a mineral-rich substance traditionally used in Ayurvedic medicine.

The capsule itself is made from gelatin, rice flour, microcrystalline cellulose, magnesium stearate, and silica — all inactive ingredients that help hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Shilajit's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: men's health and overall well-being.
  • We looked for evidence on: Athletic performance, Male infertility, Muscle strength, Sexual desire, Sexual dysfunction, fatigue — and 2 related terms.
  • The closest evidence on file: Shilajit is rated "Insufficient Reliable Evidence To Rate" for Sexual dysfunction (Natural Medicines).
  • Also on file: Shilajit is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Sexual desire, Male infertility.

The evidence for shilajit isn't established yet for the conditions we have data on. Our monograph lists Alzheimer disease, sexual dysfunction, athletic performance, benign prostatic hyperplasia (enlarged prostate), and osteopenia (low bone density) — all with insufficient reliable evidence to rate whether it works.

That means human studies are either missing, too small, or inconclusive so far. More research is needed to know if this product delivers real benefits for any of these uses.

The evidence, ingredient by ingredient Shilajit

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Shilajit is generally well tolerated in short-term use, but there are cautions worth knowing. A rare allergic reaction — including anaphylaxis (a severe whole-body reaction) — has been reported in one person, and headache has been reported rarely in clinical research.

Heavy metal contamination is a real concern with unpurified shilajit, so only use purified, tested brands like this one. During pregnancy and breastfeeding, safety data is either absent or raises enough concern that you should avoid it — a single case of high blood pressure related to mineral imbalance was reported in a pregnant woman taking shilajit, though a causal link wasn't confirmed.

Side effects, ingredient by ingredient Shilajit

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Shilajit.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (like metformin, glibenclamide, insulin, or others), double-check with your pharmacist before starting shilajit — it may lower your blood sugar further and raise the risk of hypoglycemia. No other drug interactions are documented in our data for the ingredients we could check, but run your complete medication list through the interaction checker to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Shilajit may be worth considering if you're interested in traditional mineral supplementation and you don't take antidiabetes medications. If you take any diabetes drugs, talk to your pharmacist or doctor before starting — the blood-sugar-lowering effects could combine dangerously.

Pregnant or breastfeeding? Skip this one for now.

Always check your exact medications with the tool on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Shilajit 500 mg, straight from the product label.

Brand Nugenix
Barcode (UPC) 678829000381
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 337711
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Shilajit 500 mg by Nugenix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
678829000381
IngredientAmount% DV
Shilajit Extract500 mg--

Other ingredients: Gelatin, Rice Flour, Microcrystalline Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Powerful standardized extract

Formula

For centuries, Shilajit, sourced from rocks in the high altitudes of the Himalayan mountains, has been known to support men's health and overall well-being. Each capsule of our Shilajit provides 500 mg of a highly concentrated extract, standardized to 50% fulvic acids, ensuring guaranteed potency in every serving for maximum results.

Premium men's essentials series

Standardized to 50% fulvic acids

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Essentials

Suggested/Recommended/Usage/Directions

Adult usage: Take one (1) capsule daily, with or without food.

Precautions

Precautions: Use only as directed. Do not use if safety seal is missing.

Consult your health care practitioner if you have or suspect a medical condition or if you use any medications.

Keep out of reach of children.

Storage

Keep product at room temperature and humidity [59-86 degrees F (15-30 degrees C), 40% RH].

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Shilajit 500 mg by Nugenix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Shilajit 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Shilajit 500 mg by Nugenix

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Shilajit Extract

Interacts with
86 drugs
500 mg per serving Form: Fulvic Acid

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and v...

Shilajit Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Shilajit 500 mg by Nugenix Drug Interactions

Want to check YOUR meds against Shilajit 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Shilajit Extract 86

Individual Drug Interactions

The ingredients in Shilajit 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Shilajit 500 mg interact with drugs. Each result below shows which ingredient is responsible. Shilajit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Shilajit 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Shilajit Extract1 drug type · 86 drugs

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Shilajit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Shilajit 500 mg, from the product label.

Nugenix

Name
Adaptive Health
City
Charlotte
State
NC
ZipCode
28202
Phone Number
1-855-714-3234
Web Address
www.nugenix.com
Pharmacist Counseling Corner

Shilajit 500 mg by Nugenix: Common Questions

Does Shilajit 500 mg by Nugenix interact with any medications?
Yes. Based on its ingredients, Shilajit 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Shilajit 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take shilajit if I'm pregnant or breastfeeding?
No — safety data is either absent or raises enough concern that you should avoid it while pregnant or breastfeeding. Talk to your doctor or pharmacist if you're considering it for any reason during these times.
Does shilajit actually work for Alzheimer disease, sexual dysfunction, or athletic performance?
The evidence isn't established yet for any of those uses. We have insufficient reliable evidence to say whether it works, so more research is needed.
What are the side effects of shilajit?
Most people tolerate it well, but a rare allergic reaction — including severe whole-body reactions — has been reported in one case, and headache has been reported rarely in studies. Because of contamination risk, make sure you're using a purified, tested brand.
Is this product purified and tested for heavy metals?
The facts say to use only purified, tested brands — check the label or contact Nugenix directly to confirm their testing standards for this batch.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Shilajit 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Shilajit 500 mg label
Go deeper

The Full Monographs Behind Shilajit 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Shilajit

Interacts with 86 drugs

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and m...

Read the full Shilajit monograph →
Sources

Sources & How We Checked

Shilajit 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shilajit 8 references
  1. Sadeghi SMH, Hosseini Khameneh SM, Khodadoost M, et al. Efficacy of momiai in tibia fracture repair: A randomized double-blinded placebo-controlled clinical trial. J Altern Complement Med 2020;26(6):521-528.
  2. Losa F, Deidda M, Firinu D, Martino MLD, Barca MP, Giacco SD. Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor: A case report. World J Clin Cases 2019;7(5):623-627. PubMed
  3. Biswas TK, Pandit S, Mondal S, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia 2010;42(1):48-56. PubMed
  4. Stavropoulos K, Sotiriadis A, Patoulias D, et al. Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome. Gynecol Endocrinol 2018;34(12):1019-1021. PubMed
  5. Ghezelbash B, Shahrokhi N, Khaksari M, Ghaderi-Pakdel F, Asadikaram G. Hepatoprotective effects of shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. Horm Mol Biol Clin Investig 2020;41(1):/j/hmbci. PubMed
  6. Ghezelbash B, Shahrokhi N, Khaksari M, Asadikaram G, Shahrokhi M, Shirazpour S. Protective roles of shilajit in modulating resistin, adiponectin, and cytokines in rats with non-alcoholic fatty liver disease. Chin J Integr Med 2022;28(6):531-537. PubMed
  7. Jafari M, Forootanfar H, Ameri A, et al. Antioxidant, cytotoxic and hyperalgesia-suppressing activity of a native Shilajit obtained from Bahr Aseman mountains. Pak J Pharm Sci 2019;32(5):2167-2173. DOI
  8. Trivedi NA, Mazumdar B, Bhatt JD, Hemavathi KG. Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Ind. J. Pharmacol. 2004; 36(6):373-376.

See these in context on the Shilajit monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team