Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Signature CBD Oil 25 mg Ingredients & Drug Interactions

by Bluebird Botanicals

Signature CBD Oil 25 mg label
See full label image
Liquid Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Signature CBD Oil 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Signature CBD Oil 25 mg is a dietary supplement by Bluebird Botanicals with 4 active ingredients. Its ingredients are commonly taken for skin and hair care, source of dietary fats (mcts), hydration with coconut water.Based on those ingredients, 1,317 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broad-Spectrum Hemp, Distillate, Black Cumin Seed Oil, Coconut Oil, Fractionated. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Signature CBD Oil 25 mg by Bluebird Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Signature CBD Oil 25 mg by Bluebird Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Signature CBD Oil 25 mg by Bluebird Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (470 mg) without saying how much of each component you get.

This product has four active ingredients: a proprietary blend (whose components are listed separately), fractionated coconut oil, broad-spectrum hemp distillate (CBD-rich), black cumin seed oil, and frankincense resin extract. The product contains no added inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Acne — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Asthma — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Chronic obstructive pulmonary disease (COPD) — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Black Seed) (Natural Medicines).

Evidence for this product's effects is limited. Black cumin seed oil is possibly effective for acne, allergic rhinitis (hay fever), asthma, Helicobacter pylori infection, and diabetes — those ratings come from clinical and animal studies showing benefit.

For coconut oil and hemp distillate, we hold insufficient evidence to rate their effectiveness for the conditions listed in the data. Frankincense resin extract also lacks sufficient reliable evidence in the data we hold.

The evidence, ingredient by ingredient Coconut Hemp Black Seed Frankincense

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coconut oil is generally well tolerated in normal food amounts, though concentrated supplement doses are less studied — your doctor should weigh in before taking high doses. Black cumin seed oil appears well tolerated short-term in food amounts, but larger medicinal doses are not well studied long-term.

The most common side effects from black seed include constipation, gastric burning or discomfort, nausea, and vomiting; one clinical trial reported relatively severe menstrual bleeding in one participant. Frankincense resin extract is generally well tolerated short-term when applied to skin or inhaled, though quality and dosing vary widely between products.

Allergic reactions (including anaphylaxis, hives, and contact dermatitis) have been reported rarely with frankincense and coconut oil. Hemp products are generally well tolerated, though rare cases of anaphylaxis, long QT syndrome, and elevated liver enzymes have been reported in the medical literature.

Side effects, ingredient by ingredient Coconut Hemp Black Seed Frankincense

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Black Seed, Coconut, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,318 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take serotonergic drugs (antidepressants, serotonin-based pain or migraine relief), blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), antihypertensive drugs (blood pressure medications), antidiabetes drugs, CNS depressants (sedatives, sleep aids, alcohol), immunosuppressants, diuretics, cyclosporine, or drugs metabolized by liver enzymes CYP1A2 or CYP3A4 (many statins, some heart and cancer drugs). These interactions are rated Moderate or Minor; the most serious is black seed with serotonergic drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines CBD with traditional herbs; black seed oil has the most evidence behind it, with possible benefit for acne, hay fever, asthma, and diabetes support. Because three of its four active ingredients interact with common medications — especially blood thinners, blood pressure drugs, antidepressants, and diabetes drugs — check your prescriptions with your doctor or pharmacist before starting.

Black seed is not recommended in pregnancy. If you take any regular medications, do not begin this product until you've cleared it with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Signature CBD Oil 25 mg, straight from the product label.

Brand Bluebird Botanicals
Barcode (UPC) 856888005336
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 314601
Product type Botanical With Nutrients
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Signature CBD Oil 25 mg by Bluebird Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
0.5 mL
Servings per container
120
UPC/BARCODE
856888005336
IngredientAmount% DV
Proprietary Blend470 mg--
Coconut Oil, Fractionated0 NP--
Broad-Spectrum Hemp, Distillate0 NP--
Black Cumin Seed Oil0 NP--
Frankincense Resin Extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

THC-Free Undetectable THC according to the third-party labs

Formula

Broad-spectrum hemp extract, black seed oil & frankincense CBD: 25 mg per serving CBD: 3000 mg per bottle

Non-synthetic cannabinoids derived from USA-grown hemp.

FDA Statement of Identity

Hemp Supplement

FDA Disclaimer Statement

This product has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA has not evaluated or approved this product for safety or efficacy.

Precautions

Do not exceed 1 mL (2 servings) per day.

Warning: Do not use if pregnant, nursing, or under 18 years of age. Consult your healthcare provider if you are using any prescription medications or have a medical condition.

Warning: Do not use if pregnant, nursing, or under 18 years of age.

This product contains hemp with less than or equal to 0.3% Delta-9-THC on a dry-weight basis. Consumption could result in a failed drug test.

Warning: Consuming this product during pregnancy exposes your child to Delta-9-THC, which can affect your child's behavior and learning ability. For more information go to www.P65Warnings.ca.gov/cannabis

Keep out of reach of children.

Total THC less than or equal to 0.01%

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 serving (15 drops) by mouth, up to twice per day, or as directed by a medical professional.

General Statements

Scan for details

Storage

Store in a cool, dark place.

Seals/Symbols

US Hemp Authority Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Signature CBD Oil 25 mg by Bluebird Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Signature CBD Oil 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Signature CBD Oil 25 mg by Bluebird Botanicals

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Interaction report

Signature CBD Oil 25 mg by Bluebird Botanicals Drug Interactions

Want to check YOUR meds against Signature CBD Oil 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,317Drugs
952 Moderate 365 Minor

Ingredients driving the most interactions

Broad-Spectrum Hemp, Distillate 940
Black Cumin Seed Oil 913
Coconut Oil, Fractionated 86

Individual Drug Interactions

The ingredients in Signature CBD Oil 25 mg interact with 1,317 drugs. Click any drug to see the details.

3 of the 4 ingredients in Signature CBD Oil 25 mg interact with drugs. Each result below shows which ingredient is responsible. Broad-Spectrum Hemp, Distillate Black Cumin Seed Oil Coconut Oil, Fractionated

Each ingredient & the kinds of drugs it affects

For each ingredient in Signature CBD Oil 25 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Broad-Spectrum Hemp, Distillate6 drug types · 940 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Broad-Spectrum Hemp, Distillate full monograph & interactions

Black Cumin Seed Oil14 drug types · 913 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D
Black Cumin Seed Oil full monograph & interactions

Coconut Oil, Fractionated1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
Coconut Oil, Fractionated full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Signature CBD Oil 25 mg, from the product label.

Bluebird Botanicals

See all Bluebird Botanicals products
Name
Bluebird Botanicals
City
Louisville
State
CO
ZipCode
80027
Phone Number
(720) 726-5132
Web Address
BluebirdBotanicals.com
Pharmacist Counseling Corner

Signature CBD Oil 25 mg by Bluebird Botanicals: Common Questions

Does Signature CBD Oil 25 mg by Bluebird Botanicals interact with any medications?
Yes. Based on its ingredients, Signature CBD Oil 25 mg has a known interaction with 1,317 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Signature CBD Oil 25 mg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Black cumin seed oil in this product is rated likely unsafe in pregnancy, so you should avoid it. Coconut oil is likely safe, but we don't have enough data on hemp distillate or frankincense in pregnancy. Talk with your doctor or pharmacist about whether this specific product is right for you.
What is broad-spectrum hemp distillate?
It's a concentrated form of hemp that contains cannabinoids and other plant compounds but is typically lower in THC than full-spectrum products. In this product, it's the source of CBD.
Does black cumin seed oil really work for diabetes?
Black seed is rated possibly effective for diabetes support based on some clinical research and animal studies. However, if you take diabetes medication, combining this product with your drug could increase your risk of low blood sugar — you'll need to talk it over with your doctor or pharmacist first.
What are the most common side effects?
From black cumin seed oil, you might experience constipation, stomach burning or discomfort, nausea, or vomiting. Coconut and hemp products are generally well tolerated, though allergic reactions including anaphylaxis and hives are rare.
Is frankincense safe to use?
Frankincense resin extract is generally well tolerated short-term, but quality and dosing vary widely between products. Allergic skin reactions, including contact dermatitis, have been reported rarely. We don't have enough safety information to recommend it during pregnancy or breastfeeding.
Can I take this with alcohol?
Black cumin seed oil may have additive effects with CNS depressants — a category that includes alcohol and its sedative effects. Talk with your doctor or pharmacist before combining this product with alcohol or other sedating drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Signature CBD Oil 25 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Signature CBD Oil 25 mg label
Go deeper

The Full Monographs Behind Signature CBD Oil 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph → Herb & supplement monograph

Hemp

Interacts with 940 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph → Herb & supplement monograph

Black Seed

Interacts with 913 drugs

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...

Read the full Black Seed monograph → Herb & supplement monograph

Frankincense

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for condition...

Read the full Frankincense monograph →
Sources

Sources & How We Checked

Signature CBD Oil 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 84 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

See these in context on the Coconut monograph →

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Black Seed 60 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
  3. Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
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See these in context on the Black Seed monograph →

Frankincense 2 references
  1. Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
  2. Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.

See these in context on the Frankincense monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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