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Dietary supplement

Skullcap 350 mg Ingredients & Drug Interactions

by Eclectic Herb

Skullcap 350 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap 350 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap 350 mg is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap, Freeze-Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Skullcap 350 mg by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap 350 mg by Eclectic Herb — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Skullcap 350 mg by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Skullcap 350 mg contains one active ingredient: freeze-dried skullcap, a botanical traditionally used for nervous system support. The capsule is filled out with hypromellose, an inert filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promotes relaxation.
  • We looked for evidence on: Anxiety, Stress, Insomnia, Sleep quality, Nervous tension, Muscle tension.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence we hold on skullcap doesn't support its use for any of the conditions listed on the label — epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder all show insufficient reliable evidence to rate. That means the research either hasn't been done or isn't strong enough for us to say whether it works.

If you're thinking about this for any of those reasons, talk with your doctor or pharmacist about what the science actually shows.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used short-term, but evidence on long-term safety is limited and product quality can vary — that's why we recommend using it with care. The most common side effects from oral doses are cognitive impairment, digestive disturbances, and sedation.

One patient taking 350 mg three times daily for two weeks reported vivid dreams, though it's unclear if skullcap caused it. Mild digestive upset was reported in around 9% of people at that same dose and duration.

During pregnancy, the safety data advises against it — there isn't enough information to know it's safe. The same goes for breastfeeding: safety is unknown, so it's best avoided.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check any CNS depressants you're on — that includes sleep aids, anti-anxiety medications, opioids, and alcohol. Skullcap can add to their sedating effects (Moderate severity), which is the only documented interaction we hold for this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap might appeal to you if you're drawn to botanical nervines, but the evidence we hold doesn't support it for any of the conditions on the label. The main safety concern is its interaction with CNS depressants — if you take any sedating medication, you'll want to check with us first.

Pregnancy and breastfeeding are also reasons to skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap 350 mg, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363305315
Net contents 50 Veg Cap(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 316877
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap 350 mg by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Cap(s)
Maximum serving Sizes:
3 Veg Cap(s)
Servings per container
50
UPC/BARCODE
023363305315
IngredientAmount% DV
Skullcap, Freeze-Dried350 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Concentrated 6X through freeze-drying Freeze dried for peak plant power Raw food Grown in the United States Naturally concentrated Freeze-drying keeps the plants nutrients in the same balance as found in nature by gently removing only the water. From farm to bottle, we use naturopathic wisdom and innovative processes to create exceptional products.

No fillers Non GMO Gluten free

Vegan

Promotes relaxation

Small batch freeze dried

Formula

Whole herb

100% Kosher

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1-3 capsules per day.

Precautions

Keep away from children. Consult your doctor about herbs with pregnancy, infants or prescription drugs.

Consult your doctor about herbs with pregnancy, infants or prescription drugs.

General Statements

@eclecticherb

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap 350 mg by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap 350 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap 350 mg by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Cap(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Skullcap, Freeze-Dried

Interacts with
248 drugs
350 mg per serving Form: Scutellaria lateriflora, Scutellaria lateriflora

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap, Freeze-Dried monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap 350 mg by Eclectic Herb Drug Interactions

Want to check YOUR meds against Skullcap 350 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap, Freeze-Dried 248

Individual Drug Interactions

The ingredients in Skullcap 350 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap 350 mg interact with drugs. Each result below shows which ingredient is responsible. Skullcap, Freeze-Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap 350 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap, Freeze-Dried1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap, Freeze-Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap 350 mg, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
OR
ZipCode
97030
Phone Number
503-668-4120
Web Address
eclecticherb.com
Pharmacist Counseling Corner

Skullcap 350 mg by Eclectic Herb: Common Questions

Does Skullcap 350 mg by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Skullcap 350 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap 350 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects of skullcap?
Cognitive impairment, digestive disturbances, and sedation are the main ones we see reported. Mild digestive upset showed up in about 9% of people taking 350 mg three times daily for two weeks. One person reported vivid dreams at that dose, though we can't say for certain it was the skullcap.
Is skullcap safe during pregnancy?
No — there isn't enough safety data, so it's best avoided during pregnancy. Talk with your doctor or pharmacist if you're pregnant and considering any supplement.
Is it safe to breastfeed while taking skullcap?
Safety is unknown while breastfeeding, so we advise avoiding it. If you're nursing and interested in skullcap for any reason, check with your pharmacist or doctor first.
Does skullcap really work for stress or anxiety?
We don't have reliable evidence to say. The data we hold rates skullcap's effectiveness for stress as insufficient, meaning the research either hasn't been done or isn't strong enough for us to recommend it for that purpose.
What happens if I take skullcap with a sleep aid?
Skullcap can add to the sedating effects of sleep aids and other CNS depressants — that's a Moderate interaction. You could end up more drowsy or mentally foggy than either one alone would cause. Check with us before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skullcap 350 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap 350 mg label
Go deeper

The Full Monographs Behind Skullcap 350 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap 350 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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