Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Sleep/GH Fruit Punch Ingredients & Drug Interactions

by Prime Nutrition Performance Series

Sleep/GH Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep/GH Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Sleep/GH Fruit Punch is a dietary supplement by Prime Nutrition Performance Series with 6 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 1,184 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Valerian root extract, GABA, Mucuna pruriens. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep/GH Fruit Punch by Prime Nutrition Performance Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep/GH Fruit Punch by Prime Nutrition Performance Series — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sleep/GH Fruit Punch by Prime Nutrition Performance Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (6.49 Gram(s)) without saying how much of each component you get.

Sleep/GH Fruit Punch has six active ingredients. L-Tyrosine is an amino acid that your body uses to make neurotransmitters and thyroid hormones.

L-Taurine is another amino acid with a role in heart and brain function. Valerian root extract is a traditional herbal used for sleep support.

GABA (gamma-aminobutyric acid) is a neurotransmitter thought to promote relaxation. Pikatropin (the brand name for picamilon) is a compound that breaks down into GABA and niacin after you take it.

Mucuna pruriens, also called cowhage, is a plant that naturally contains levodopa — an active pharmaceutical-grade compound — and is included for its effects on dopamine and growth hormone. The powder also contains inactive ingredients: citric acid, natural and artificial flavors, sucralose, acesulfame-K, and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote deep REM sleep and mental recovery.
  • We looked for evidence on: Insomnia, Sleep deprivation, Anxiety, Stress, Fatigue, Cognitive function — and 4 related terms.
  • The strongest evidence on file: Valerian is rated "Possibly Effective" for Insomnia (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia, Post-traumatic stress disorder (PTSD), Psychological well-being.

The evidence for this product's ingredients is mixed. L-Tyrosine is effective for a rare genetic condition called phenylketonuria (PKU) and possibly effective for cognitive function and memory, but possibly ineffective for athletic performance.

L-Taurine is possibly effective for certain liver and heart conditions but possibly ineffective for weight loss. Valerian is possibly effective for insomnia, though long-term effectiveness is less certain.

GABA, pikatropin, and Mucuna pruriens all lack reliable evidence in our data for the effects claimed in a sleep and growth-hormone product. If you're considering this for sleep or athletic performance, the ingredient support varies considerably.

The evidence, ingredient by ingredient Tyrosine Taurine Valerian Gamma-aminobutyric Acid (gaba) Picamilon Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Tyrosine is generally well tolerated but can cause fatigue, headache, heartburn, and nausea, especially at higher doses. L-Taurine is generally well tolerated short-term and was considered likely safe in pregnancy and lactation in the data we hold, though long-term safety is uncertain.

Valerian is generally well tolerated short-term but can cause dizziness, drowsiness, mental slowness, headache, and gastrointestinal upset; if you stop it suddenly after prolonged use, you may experience withdrawal symptoms like anxiety and insomnia — taper slowly. GABA may cause drowsiness, nausea, muscle weakness, and gastric upset, with insufficient long-term safety data.

Pikatropin has limited human safety data. Mucuna pruriens (cowhage) contains levodopa and carries warnings: it should be used carefully under professional guidance, and the data advises against it in pregnancy and while breastfeeding (levodopa can reduce milk supply).

Side effects, ingredient by ingredient Tyrosine Taurine Valerian Gamma-aminobutyric Acid (gaba) Picamilon Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Valerian, Cowhage, Taurine, Tyrosine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,185 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take methyldopa or a non-selective MAOI (Major risk). Also double-check any blood-pressure medications (antihypertensives), levodopa for Parkinson's, tricyclic antidepressants, antipsychotics, diabetes drugs, sedating drugs or alcohol, or medications processed through glucuronidation or metabolized by CYP2D6 and CYP3A4.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a complex, multi-ingredient product with potent compounds — especially cowhage's levodopa content — that warrants a conversation with your pharmacist or doctor before you start, particularly if you take any blood-pressure, psychiatric, or Parkinson's medication. The effectiveness evidence for sleep and growth-hormone support is weak across most ingredients.

If you're taking medications, check them against this product first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep/GH Fruit Punch, straight from the product label.

Brand Prime Nutrition Performance Series
Barcode (UPC) 689466706079
Net contents 7.4 oz.; 210 Gram(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42382
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep/GH Fruit Punch by Prime Nutrition Performance Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
7 Gram(s)
Servings per container
30
UPC/BARCODE
689466706079
IngredientAmount% DV
L-Tyrosine0 NP--
L-Taurine0 NP--
Proprietary Blend6.49 Gram(s)--
Valerian root extract0 NP--
GABA0 NP--
Pikatropin0 NP--
Mucuna pruriens0 NP--

Other ingredients: Citric Acid, Natural & Artificial flavors, Sucralose, Acesulfame-K, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

-THE BEST OR NOTHING-

SLEEP/GH Prime Nutrition Performance Series designed Sleep/GH to promote deep REM sleep,* mental/cognitive recovery,* well-being,* and an increase in GH release.* Sleep/GH also promotes a decrease in body fat and lower cortisol levels.

PROMOTES DEEP REM SLEEP* PROMOTES DECREASED BODYFAT* PROMOTES INCREASED GH RELEASE*

WWW.PRIME NUTRITION.COM

30 SERVINGS

Naturally & Artificially Flavored

SUPPORTS R.E.M. SLEEP & GH RELEASE*

Suggested/Recommended/Usage/Directions

PERFORMANCE TRAINING USAGE: For use as a sleep aid consume 1 serving 15-20 minutes before going to sleep. For best results user may consume 2 servings after assessing tolerance with one serving. Do not consume food.

Formula

100% PURE MICRONIZED SLEEP/GH FORMULA

Precautions

WARNING: Not for use for individuals under the age of 18 years.

Do not use if you are pregnant or nursing.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience any adverse symptoms. Improper use of this product may be hazardous to a person's health. Exceeding recommended serving will not improve results.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

No Artificial Colors or Dyes

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

P

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep/GH Fruit Punch by Prime Nutrition Performance Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep/GH Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep/GH Fruit Punch by Prime Nutrition Performance Series

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

6.49 Gram(s) per serving

Other (inactive) ingredients: Citric Acid, Natural & Artificial flavors, Sucralose, Acesulfame-K, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep/GH Fruit Punch by Prime Nutrition Performance Series Drug Interactions

Want to check YOUR meds against Sleep/GH Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,184Drugs
17 Major 674 Moderate 493 Minor

Ingredients driving the most interactions

Valerian root extract 902
GABA 419
Mucuna pruriens 193
L-Taurine 173
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Sleep/GH Fruit Punch interact with 1,184 drugs. Click any drug to see the details.

6 of the 6 ingredients in Sleep/GH Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Valerian root extract GABA Mucuna pruriens L-Taurine L-Tyrosine Pikatropin

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep/GH Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Valerian root extract6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian root extract full monograph & interactions

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
GABA full monograph & interactions

Mucuna pruriens8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna pruriens full monograph & interactions

L-Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
L-Taurine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

Pikatropin1 drug type · 3 drugs

Niacin

Picamilon is broken down into gamma-aminobutyric acid (GABA) and niacin after oral administration. Concomitant use with niacin might cause additive effects and adverse effects. However, this interaction is only theoretical and has not been documented in humans.

Likelihood Possible Evidence D
Pikatropin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep/GH Fruit Punch, from the product label.

Prime Nutrition Performance Series

See all Prime Nutrition Performance Series products
Name
Prime Nutrition(R) Prime Nutrition LLC
Street Address
21218 St. Andrews Blvd. Suite 230
City
Boca Raton
State
FL
ZipCode
33434
Pharmacist Counseling Corner

Sleep/GH Fruit Punch by Prime Nutrition Performance Series: Common Questions

Does Sleep/GH Fruit Punch by Prime Nutrition Performance Series interact with any medications?
Yes. Based on its ingredients, Sleep/GH Fruit Punch has a known interaction with 1,184 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep/GH Fruit Punch contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have levodopa in it?
Yes. Mucuna pruriens, one of the six active ingredients, naturally contains levodopa — the same compound used to treat Parkinson's disease. Some cowhage products are standardized to contain 75–400 mg per dose, so the amount in this specific product may vary.
Can I take this if I'm pregnant or breastfeeding?
The data advises against valerian and Mucuna pruriens during pregnancy. For Mucuna pruriens specifically, avoid while breastfeeding because levodopa can lower prolactin and reduce milk supply. L-Tyrosine, GABA, and pikatropin don't have enough safety information — talk to your doctor or pharmacist for personalized advice. L-Taurine was rated likely safe, though that was only pregnancy data.
What are the most common side effects?
L-Tyrosine can cause fatigue, headache, heartburn, and nausea. L-Taurine may cause constipation, diarrhea, or indigestion. Valerian often causes dizziness, drowsiness, mental slowness, headache, and gastrointestinal upset. GABA can cause drowsiness, nausea, and muscle weakness.
Is this product proven to help sleep and growth hormone?
Valerian is possibly effective for insomnia, but the other ingredients lack reliable evidence in our data for sleep support or growth-hormone effects. The evidence is strongest for valerian alone; the broader formula's effectiveness hasn't been established.
What happens if I stop taking valerian abruptly?
After prolonged use, stopping valerian suddenly may cause withdrawal symptoms like anxiety, irritability, and insomnia. Taper your dose slowly if you've been using it long-term.
Is GABA in supplements actually absorbed?
The data we hold doesn't specify whether supplemental GABA crosses into your bloodstream or brain effectively; that's outside the facts provided. Ask your pharmacist if you want to dig into the research on that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep/GH Fruit Punch label
Go deeper

The Full Monographs Behind Sleep/GH Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monograph

Picamilon

Interacts with 3 drugs

Picamilon is a synthetic compound made by joining niacin (vitamin B3) and GABA, originally developed in the former Soviet Union as a prescription drug. It is sold in some countries as a supp...

Read the full Picamilon monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Sleep/GH Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 89 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
  10. Schoffl, I., Kothmann, J. F., Schoffl, V., Rupprecht, H. D., and Rupprecht, T. "Vodka energy": too much for the adolescent nephron? Pediatrics 2011;128(1):e227-e231. PubMed
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Gamma-aminobutyric Acid (gaba) 12 references
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Picamilon 3 references
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Cowhage 12 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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