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Dietary supplement

Soothe & Immune Natural Apple Flavour Ingredients & Drug Interactions

by Higher Nature Kids

Soothe & Immune Natural Apple Flavour label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Soothe & Immune Natural Apple Flavour against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Soothe & Immune Natural Apple Flavour is a dietary supplement by Higher Nature Kids with 4 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 1,055 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manuka Honey, Beta-(1,3/1,6)-D-Glucans, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Soothe & Immune Natural Apple Flavour by Higher Nature Kids

Ask about any prescription or over-the-counter medication and we check it for interactions with Soothe & Immune Natural Apple Flavour by Higher Nature Kids — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Soothe & Immune Natural Apple Flavour by Higher Nature Kids

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 active ingredients. Vitamin C supports immune function and is effective for preventing vitamin C deficiency; it's also possibly effective for certain types of anemia, heart rhythm issues, cataracts, and respiratory infections triggered by exercise.

Black elderberry extract is included for immune support, though the evidence for hay fever, heart disease, fatigue, lung disease, brain function, and lower respiratory infections isn't established in our data. Beta-glucans are likely effective for cholesterol and heart disease and add immune-supporting activity.

Manuka honey is possibly effective for cold sores, cough, mouth sores, burns, and dry eye. The product also contains inactive ingredients listed as natural apple flavor, manuka honey powder, and ascorbic acid (a form of vitamin C).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune system support.
  • We looked for evidence on: Acute bronchitis, Allergic rhinitis (hay fever), Asthma, Cough, Exercise-induced respiratory infections, Common cold — and 3 related terms.
  • The strongest evidence on file: Honey is rated "Possibly Effective" for Cough (Natural Medicines).
  • Also on file: Vitamin C is rated "Possibly Effective" for Exercise-induced respiratory infections.
  • Also on file: Vitamin C is rated "Possibly Ineffective" for Acute bronchitis.

Vitamin C in this product is effective for preventing vitamin C deficiency and possibly effective for certain types of anemia, atrial fibrillation, cataracts, and respiratory infections after exercise. Beta-glucans are likely effective for high cholesterol and coronary heart disease.

Manuka honey is possibly effective for cold sores, cough, mouth sores from cancer treatment, burns, and dry eye. Black elderberry extract's effectiveness for its intended purposes — including allergic rhinitis, heart disease, fatigue, lung disease, brain function, and respiratory infections — hasn't been established in the data we hold.

The evidence, ingredient by ingredient Vitamin C Elderberry Beta-glucans Honey

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin C is generally well tolerated at normal dietary and supplement doses, though very high doses can cause stomach upset (cramps, heartburn, nausea, diarrhea) and, in people prone to them, kidney stones. Since this is a children's product, doses should be much lower than those causing these effects.

Black elderberry extract prepared from ripe fruit is well tolerated; adverse effects come from raw or unripe berries or plant parts. Beta-glucans from food are generally well tolerated, though concentrated supplements have limited safety data.

Manuka honey is generally safe for children over 1 year of age and well tolerated when eaten as food, though medicinal use should be discussed with your child's doctor. Regarding pregnancy and breastfeeding: vitamin C from normal food and prenatal vitamins is fine, but high-dose supplements should be avoided unless your doctor advises otherwise.

Black elderberry should be avoided during pregnancy and breastfeeding due to insufficient safety information. Beta-glucans lack pregnancy and breastfeeding data.

Manuka honey is likely safe in pregnancy and fine for a breastfeeding mother eating it as food, though medicinal use warrants a conversation with your provider.

Side effects, ingredient by ingredient Vitamin C Elderberry Beta-glucans Honey

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Elderberry, Honey, Vitamin C, Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 1,056 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before giving this product to your child, double-check with your pharmacist or doctor if they take blood thinners like warfarin, birth control pills or hormone therapy, antiseizure medications like phenytoin, heart or blood pressure medications, immunosuppressant drugs, any chemotherapy drugs, the HIV medication indinavir, the antipsychotic fluphenazine, thyroid medication levothyroxine, or any antiplatelet drugs. Vitamin C's effect on some of these medications depends on dose; since this is a children's product, the risk may be lower, but confirmation with your child's healthcare provider is important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines immune-supporting ingredients, some with established effectiveness (vitamin C for deficiency, beta-glucans for cholesterol and heart health, manuka honey for cough and cold sores) and others with limited evidence in our data. It's generally well tolerated at the doses expected in a children's formulation.

If your child takes any prescription medication — especially blood thinners, birth control, antiseizure drugs, heart medications, or immunosuppressants — or has upcoming chemotherapy, talk with your child's doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Soothe & Immune Natural Apple Flavour, straight from the product label.

Brand Higher Nature Kids
Barcode (UPC) 5031013107450
Net contents 10 Sachet(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42211
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Soothe & Immune Natural Apple Flavour by Higher Nature Kids, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Gram(s)
Maximum serving Sizes:
4 Gram(s)
UPC/BARCODE
5031013107450
IngredientAmount% DV
Vitamin C200 mg250%
Black Elderberry extract200 mg--
Beta-(1,3/1,6)-D-Glucans100 mg--
Manuka Honey750 mg--

Other ingredients: natural Apple, Manuka Honey powder, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

IMMUNE SYSTEM SUPPORT

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

This product is not tested on animals.

A000 10001 P026266

Formula

with vit c, beta glucans & manuka honey (NPA 10+)

This soothing hot drink, with manuka honey, black elderberry extract and beta glucans, is ideal for when your kids are not quite feeling themselves.

This soothing hot drink, with manuka honey, black elderberry extract and beta glucans, is ideal for when your kids are not quite feeling themselves. With added vitamin C, which contributes to the normal functioning of the immune system. with sweetener (stevia)

Suitable for children over 3 years.

FDA Statement of Identity

FOOD SUPPLEMENT

Storage

STORAGE: Store in a cool, dry, steam free environment out of reach of children.

Precautions

Store in a cool, dry, steam free environment out of reach of children.

WARNING: Consult your health care professional before taking in cases of auto-immune disorders or organ transplant.

Formulation

DOES NOT CONTAIN: Artificial colours, flavourings, preservatives or sweeteners, dairy products, gluten, lactose, salt, soya, wheat.

Suitable for vegetarians.

General

KSI010 101 KSI-391-01

Suggested/Recommended/Usage/Directions

JUST ADD HOT WATER

DIRECTIONS: Blend one sachet (4g) into a mug of ho water until it dissolves. Take daily or as your health professional advises, Do not exceed recommended daily intake.

Seals/Symbols

{Recycle}

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See for yourself

Soothe & Immune Natural Apple Flavour by Higher Nature Kids label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Soothe & Immune Natural Apple Flavour label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Soothe & Immune Natural Apple Flavour by Higher Nature Kids

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Gram(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin C

Interacts with
207 drugs
200 mg per serving

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Black Elderberry extract

Interacts with
121 drugs
200 mg per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Black Elderberry extract monograph & interactions

Beta-(1,3/1,6)-D-Glucans

Interacts with
293 drugs
100 mg per serving

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta-(1,3/1,6)-D-Glucans monograph & interactions

Manuka Honey

Interacts with
736 drugs
750 mg per serving

Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka...

Manuka Honey monograph & interactions

Other (inactive) ingredients: Natural Apple, Manuka Honey powder, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Soothe & Immune Natural Apple Flavour by Higher Nature Kids Drug Interactions

Want to check YOUR meds against Soothe & Immune Natural Apple Flavour?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,055Drugs
397 Moderate 658 Minor

Ingredients driving the most interactions

Manuka Honey 736
Beta-(1,3/1,6)-D-Glucans 293
Vitamin C 207
Black Elderberry extract 121

Individual Drug Interactions

The ingredients in Soothe & Immune Natural Apple Flavour interact with 1,055 drugs. Click any drug to see the details.

4 of the 4 ingredients in Soothe & Immune Natural Apple Flavour interact with drugs. Each result below shows which ingredient is responsible. Manuka Honey Beta-(1,3/1,6)-D-Glucans Vitamin C Black Elderberry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Soothe & Immune Natural Apple Flavour with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Manuka Honey3 drug types · 736 drugs

Phenytoin (Dilantin)

Theoretically, honey might increase levels of phenytoin.
In an animal model, the rate and extent of absorption of phenytoin was increased by honey. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro, honey inhibits platelet aggregation and increases the time to clotting. Furthermore, animal research suggests that feeding mice large doses of honey for 12 days increases bleeding time when compared with no intervention. However, these effects have not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.

Likelihood Possible Evidence B
Manuka Honey full monograph & interactions

Beta-(1,3/1,6)-D-Glucans2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta-(1,3/1,6)-D-Glucans full monograph & interactions

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Black Elderberry extract2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Black Elderberry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Soothe & Immune Natural Apple Flavour, from the product label.

Higher Nature Kids

See all Higher Nature Kids products
Name
Higher Nature
City
Burwash Common
State
East Sussex
ZipCode
TN19 7LX
Web Address
www.highernature.com
Pharmacist Counseling Corner

Soothe & Immune Natural Apple Flavour by Higher Nature Kids: Common Questions

Does Soothe & Immune Natural Apple Flavour by Higher Nature Kids interact with any medications?
Yes. Based on its ingredients, Soothe & Immune Natural Apple Flavour has a known interaction with 1,055 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Soothe & Immune Natural Apple Flavour contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Why does this product have vitamin C, elderberry, beta-glucans, and honey together?
Each ingredient is included for immune support. Vitamin C is a classic immune nutrient; elderberry, beta-glucans, and honey all have traditional immune-boosting roles. Together, they're meant to work as a multi-ingredient immune formula.
Is it safe for children to take daily?
Vitamin C, beta-glucans from food, manuka honey, and properly prepared elderberry extract are generally well tolerated in children. Since this is formulated as a kids' product, the doses should be appropriate for that age group — but always follow the label instructions and talk to your child's doctor if they're on any medications or have health concerns.
What if my child has a nut or bee allergy?
The product facts don't specify allergen information beyond the ingredients listed. Since it contains manuka honey (a bee product) and natural apple flavor, check the full label or contact the manufacturer to confirm whether it's safe for your child's specific allergies.
Can I give this if my child is on antibiotics?
The product facts don't show interactions with standard antibiotics, but several of the ingredients — especially the immunostimulants in elderberry and beta-glucans — theoretically interfere with immunosuppressant drugs. If your child is on any prescription medication, check with your doctor or pharmacist before adding this product.
Does this cure a cold or flu?
The product facts show that manuka honey is possibly effective for cough, and vitamin C is possibly effective for exercise-related respiratory infections — but the evidence that these ingredients prevent or cure colds or flu is not established in our data. It's meant as a supportive immune supplement, not a treatment.
What's manuka honey and why is it in here instead of regular honey?
Manuka honey is a type of honey from New Zealand that's been studied more extensively for medicinal use than regular honey. It's included because research suggests it may help with cough, cold sores, mouth sores, and burns — making it a more targeted choice for a kids' immune product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Soothe & Immune Natural Apple Flavour label
Go deeper

The Full Monographs Behind Soothe & Immune Natural Apple Flavour’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph → Herb & supplement monograph

Honey

Interacts with 736 drugs

Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka honey is used. It is generally safe for...

Read the full Honey monograph →
Sources

Sources & How We Checked

Soothe & Immune Natural Apple Flavour's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 108 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
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Elderberry 6 references
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Beta-glucans 11 references
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Honey 40 references
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See these in context on the Honey monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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