Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

StemHappy Ingredients & Drug Interactions

by StemFoods Holistics

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

StemHappy is a dietary supplement by StemFoods Holistics with 7 active ingredients. Its ingredients are commonly taken for low libido and sexual function, energy and stamina, menopause symptoms.Based on those ingredients, 1,331 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Siberian Rhodiola rosea, Horny Goat Weed, Saw Palmetto. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of StemHappy by StemFoods Holistics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,750 mg) without saying how much of each component you get.

StemHappy has seven active ingredients. Maca, Korean Red Ginseng, Saw Palmetto, Siberian Rhodiola rosea, Horny Goat Weed, Oat Straw, and Cacao Bean Extract, Raw are combined in a proprietary blend, meaning the exact amount of each isn't listed on the label.

The product also contains a vegetarian capsule as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support healthy hormone levels and libido.
  • We looked for evidence on: Age-related testosterone deficiency, Antidepressant-induced sexual dysfunction, Benign prostatic hyperplasia (BPH), Erectile dysfunction (ED), Male infertility, Menopausal symptoms — and 4 related terms.
  • The closest evidence on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Antidepressant-induced sexual dysfunction, Sexual desire, Age-related testosterone deficiency, Male infertility.
  • Also on file: Horny Goat Weed is rated "Insufficient Reliable Evidence To Rate" for Sexual dysfunction, Erectile dysfunction (ED).

The evidence for most ingredients in this product isn't established in our data. Oat Straw stands out — it's Likely Effective for managing cholesterol (dyslipidemia) and supporting heart health (coronary heart disease).

Saw Palmetto is Possibly Ineffective for benign prostatic hyperplasia, though it may be Possibly Effective for a specific prostate procedure. For the others — Maca, Korean Red Ginseng, Horny Goat Weed, and Rhodiola — we hold insufficient reliable evidence to rate their effectiveness for the conditions listed.

The evidence, ingredient by ingredient Maca Saw Palmetto Rhodiola Horny Goat Weed Oats

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saw Palmetto, Rhodiola, and Horny Goat Weed are all advise-against in pregnancy and breastfeeding due to insufficient safety data. Maca also advises against pregnancy use and lacks breastfeeding safety information.

Oat Straw, by contrast, is Likely Safe in both pregnancy and lactation when eaten as food, though concentrated supplement forms are less studied. All these ingredients are generally well tolerated short-term.

Saw Palmetto may cause mild side effects like nausea, diarrhea, or headache; rare cases have included heart rhythm changes. Rhodiola commonly causes dizziness or changes in saliva production.

Horny Goat Weed can cause dizziness, dry mouth, or nosebleed, with one rare case of respiratory arrest reported. Oat Straw may cause bloating, gas, or constipation when you first start — effects that usually fade with continued use.

Fresh, uncooked Maca may cause stomach pain.

Side effects, ingredient by ingredient Maca Saw Palmetto Rhodiola Horny Goat Weed Oats

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Horny Goat Weed, Oats, Rhodiola, Saw Palmetto.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,332 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using StemHappy if you take birth control or estrogen (Saw Palmetto and Horny Goat Weed are Moderate interactions); blood pressure medications — especially losartan — or blood thinners like warfarin or aspirin (Rhodiola, Horny Goat Weed, and Saw Palmetto); diabetes drugs or insulin (Rhodiola and Oat Straw); or medications that depend on liver enzymes (CYP1A2, CYP2B6, CYP2C9, CYP3A4) or P-glycoprotein transporters for how your body breaks them down (Rhodiola and Horny Goat Weed). We could not verify interactions for Korean Red Ginseng or Cacao Bean Extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take birth control pills, blood pressure medication, blood thinners, diabetes drugs, or insulin, talk to your pharmacist or doctor before starting StemHappy — multiple ingredients interact with these medication types. Oat Straw is the only ingredient with strong evidence of effectiveness (for cholesterol and heart health).

Avoid this product in pregnancy and breastfeeding unless you've cleared it with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about StemHappy, straight from the product label.

Brand StemFoods Holistics
Barcode (UPC) 850028477243
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 314198
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for StemHappy by StemFoods Holistics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
850028477243
IngredientAmount% DV
Proprietary Blend1750 mg--
Maca0 NP--
Korean Red Ginseng0 NP--
Saw Palmetto0 NP--
Siberian Rhodiola rosea0 NP--
Horny Goat Weed0 NP--
Oat Straw0 NP--
Cacao Bean Extract, Raw0 NP--

Other ingredients: Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 3 capsules daily.

Precautions

Warning: Consult your healthcare practitioner before taking any dietary supplements, especially if you are pregnant, nursing, taking any medication or have a medical condition.

Discontinue use and consult your healthcare practitioner if any adverse reaction occurs. Do not use if both inner and outer seals are missing or damaged.

Keep out of reach of children.

Allergy information: This product may be processed in equipment that may also process products containing milk, tree nuts, wheat, peanuts, and/or soy.

Storage

Store in a dry, cool, place.

Formulation

The word happy implies the feeling of well-being. Being happy enhances life, youthfulness and longevity. It is a holistic connection of body, mind, and spirit for a fuller life. StemHappy supports healthy hormone levels, enhanced libido, and improved mood to enjoy life with more energy, vitality and joy!

Hormone health, libido support & mood booster

100% vegan

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Protect our planet, please recycle

Formula

StemHappy with organic rhodiola, horny goat weed, ginseng & maca

For men & women

Seals/Symbols

100% organic

Manufactured with love in the U.S.A. GMP Certified Good Manufacturing Practice We follow strict cGMP protocols Not tested on animals We love all animals

FDA Statement of Identity

Dietary Supplement

See for yourself

StemHappy by StemFoods Holistics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in StemHappy by StemFoods Holistics

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1750 mg per serving

Other (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

StemHappy by StemFoods Holistics Drug Interactions

Want to check YOUR meds against StemHappy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,331Drugs
1,218 Moderate 113 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in StemHappy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Siberian Rhodiola rosea10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B

Horny Goat Weed6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D

Saw Palmetto3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B

Oat Straw2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.
Consuming oats can decrease blood glucose in patients with diabetes. In those who require insulin, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence D
Insulin

Concomitant use of oats and insulin might increase the risk of hypoglycemia.
In patients with insulin-dependent type 2 diabetes, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for StemHappy, from the product label.

StemFoods Holistics

See all StemFoods Holistics products
Name
StemFoods Holistics
City
Ontario
State
California
ZipCode
91764
Phone Number
(909) 458-0982
Web Address
stemfoods.com
Pharmacist Counseling Corner

StemHappy by StemFoods Holistics: Common Questions

Does StemHappy by StemFoods Holistics interact with any medications?
Yes. Based on its ingredients, StemHappy has a known interaction with 1,331 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
StemHappy contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take StemHappy if I'm pregnant or breastfeeding?
No, not safely based on the data we have. Saw Palmetto, Rhodiola, and Horny Goat Weed advise against both pregnancy and breastfeeding. Maca advises against pregnancy and lacks breastfeeding safety data. Talk to your doctor or midwife before considering any supplement during pregnancy or lactation.
What are the most common side effects I might notice?
Oat Straw may cause bloating, gas, or constipation when you first start — usually temporary. Rhodiola can cause dizziness or dry or excessive saliva. Saw Palmetto may trigger nausea, headache, diarrhea, or fatigue. Horny Goat Weed can cause dizziness, dry mouth, or nosebleed. If you notice side effects, dose slowly or stop and tell your pharmacist.
Does this product actually work?
Oat Straw has solid evidence for helping manage cholesterol and heart health — that part's supported. For the other ingredients — Maca, Korean Red Ginseng, Horny Goat Weed, and Rhodiola — we don't have enough reliable evidence to say whether they work for their claimed uses.
Why can't you check Korean Red Ginseng and Cacao Bean Extract for interactions?
We don't hold monographs (detailed safety and interaction data) for those two ingredients, so we can't evaluate them. That doesn't mean they're safe or unsafe — it just means our database doesn't cover them. Your pharmacist may have access to other sources.
What is Oat Straw and why is it in here?
Oat Straw is the leafy top part of the oat plant — not the grain itself. It's included because it's one of the few ingredients in this product with good evidence for lowering cholesterol and supporting heart health. It's generally well tolerated and safe in pregnancy and breastfeeding when used as food, though supplement forms are less studied.
If I'm on blood pressure medication, can I use this?
You should check with your pharmacist first. Rhodiola and Horny Goat Weed both can theoretically increase the risk of low blood pressure when combined with blood pressure drugs. If you're on losartan specifically, Rhodiola may also raise its levels. Your pharmacist can review your exact medication and dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if StemHappy is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

StemHappy label
Go deeper

The Full Monographs Behind StemHappy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

StemHappy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 60 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

Saw Palmetto 22 references
  1. Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
  2. Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
  3. Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
  4. Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
  5. Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
  6. Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
  7. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  8. Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
  9. Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
  10. Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
  11. Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
  12. Wargo, K. A., Allman, E., and Ibrahim, F. A possible case of saw palmetto-induced pancreatitis. South.Med.J. 2010;103(7):683-685. PubMed
  13. Lapi, F., Gallo, E., Giocaliere, E., Vietri, M., Baronti, R., Pieraccini, G., Tafi, A., Menniti-Ippolito, F., Mugelli, A., Firenzuoli, F., and Vannacci, A. Acute liver damage due to Serenoa repens: a case report. Br.J.Clin.Pharmacol. 2010;69(5):558-560.
  14. Mantovani, F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol.Nefrol. 2010;62(4):335-340.
  15. Hanaka, M., Yoshii, C., Yatera, K., Ito, C., Chojin, Y., Nagata, S., Yamasaki, K., Nishida, C., Kawanami, T., Kawanami, Y., Ishimoto, H., and Mukae, H. [A case of rhabdomyolysis caused by saw palmetto of healthy foods]. J.UOEH. 6-1-2012;34(2):193-199. PubMed
  16. Miroddi, M., Carni, A., Mannucci, C., Moleti, M., Navarra, M., and Calapai, G. Hot flashes in a young girl: a wake-up call concerning Serenoa repens use in children. Pediatrics 2012;130(5):e1374-e1376.
  17. Braeckman J. The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study. Current Therapeutic Research 1994;55(7):776-785. DOI
  18. Jipescu D, Patel A, Bohra H, Pientka A. Rare case of saw palmetto induced heart block. JACC 2017;69(11) supplement:2310.
  19. Morabito P, Miroddi M, Giovinazzo S, Spina E, Calapai G. Serenoa repens as an endocrine disruptor in a 10-year-Old young girl: a new case report. Pharmacology. 2015;96(1-2):41-3. doi: 10.1159/000431327.
  20. Gammoudi R, Ameur K, Ouni B, et al. Fixed drug eruption to Serenoa repens: first case report and consideration of the use of herbal medicine. Dermatol Ther 2020 Aug 29:e14247.
  21. Paulis G, Paulis A, Perletti G. Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials. Arch Ital Urol Androl 2021;93(4):475-480. PubMed
  22. Venkateswaran S, Declet-Bauzo R, Shodeinde M, Gilford P. Postoperative Retroperitoneal Hematoma: A Case of Saw Palmetto and the Importance of Primary Care Intervention. HCA Healthc J Med 2020;1(5):279-282. PubMed

See these in context on the Saw Palmetto monograph →

Rhodiola 13 references
  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  4. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
  5. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
  6. Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
  7. Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
  8. Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
  9. Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
  10. Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31.
  11. Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
  12. Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. PubMed
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Horny Goat Weed 11 references
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Oats 13 references
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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