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Dietary supplement

Strontium 680 mg Ingredients & Drug Interactions

by Best Naturals

Strontium 680 mg label
See full label image
Capsule Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Strontium 680 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Strontium 680 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, reducing fracture risk, tooth sensitivity (in some toothpastes).Based on those ingredients, 101 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Strontium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Strontium 680 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Strontium 680 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Strontium 680 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: strontium at 680 mg per capsule. The inactive ingredients are gelatin (the capsule shell), rice powder, and magnesium stearate (a lubricant).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: bone health and skeletal system support.
  • We looked for evidence on: Osteoporosis, Fractures, Bone density, Bone strength.
  • The strongest evidence on file: Strontium is rated "Likely Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Strontium is rated "Insufficient Reliable Evidence To Rate" for Fractures.

Strontium is rated effective for dental hypersensitivity and painful bony metastases (cancer-related bone pain). It's likely effective for osteoporosis — the condition it's most commonly used for — and possibly effective for osteoarthritis and prostate cancer.

The strength of evidence varies by condition, so talk with your doctor about whether it fits your specific situation.

The evidence, ingredient by ingredient Strontium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Strontium is generally well tolerated at doses up to 2 grams daily long-term, with common side effects being diarrhea, nausea, headache, and skin reactions like atopic dermatitis or eczema. However, strontium — especially the ranelate form — carries serious cardiovascular and clotting risks: clinical research shows it increases the risk of blood clots (venous thromboembolism and pulmonary embolism) by about 50% and heart attack risk by about 1.6-fold in people with osteoporosis.

Rare but serious effects also include weak or soft bones (osteomalacia) and heart attack. During pregnancy, safety has not been established — the data advises against use.

While breastfeeding, there isn't enough safety information, so avoid it. Talk with your doctor or pharmacist about your individual situation before taking strontium if you are pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Strontium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Strontium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 101 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take estrogens, androgens (testosterone or similar), quinolone antibiotics (like ciprofloxacin), tetracycline antibiotics (like doxycycline), or antacids. Spacing strontium 2 hours away from antibiotics and antacids is essential to keep them working.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Strontium may help with bone pain, osteoporosis, and related conditions, but it carries real cardiovascular and clotting risks that need to weigh into your decision. If you take hormone medications, antibiotics, or antacids, timing matters — spacing them hours apart is critical.

Discuss the benefits and risks with your own doctor or pharmacist before starting, especially if you have heart or clotting concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Strontium 680 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716016191
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270125
Product type Mineral
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Strontium 680 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
817716016191
IngredientAmount% DV
Strontium680 mg--

Other ingredients: Gelatin, Rice powder, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Strontium is one of the most abundant organic trace mineral on earth. It's molecularly similar to calcium and is found in healthy bones and teeth. Strontium citrate concentrates in the skeletal system, where it plays a a key role in supporting bone tissue density. Certain research publications indicate that Strontium may help support the following: Supports bone health Supports joint health Supports dental health

Strontium 680 mg/serving

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take (2) capsules once daily, or as recommended by a healthcare practitioner. For optimal absorption, take on empty stomach and at least two hours apart from calcium, magnesium or antacids.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

Formulation

Premium formula

3rd party lab tested

No artificial color, flavor or sweetener, no preservatives, no sugar, no milk, no corn, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Strontium 680 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Strontium 680 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Strontium 680 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Strontium

Interacts with
101 drugs
680 mg per serving Form: Strontium Citrate

Strontium is a mineral that has been studied mainly for bone health and osteoporosis. The prescription form (strontium ranelate) showed benefit for fr...

Strontium monograph & interactions

Other (inactive) ingredients: Gelatin, Rice powder, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Strontium 680 mg by Best Naturals Drug Interactions

Want to check YOUR meds against Strontium 680 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
101Drugs
101 Moderate

Ingredients driving the most interactions

Strontium 101

Individual Drug Interactions

The ingredients in Strontium 680 mg interact with 101 drugs. Click any drug to see the details.

1 of the 1 ingredient in Strontium 680 mg interact with drugs. Each result below shows which ingredient is responsible. Strontium

Each ingredient & the kinds of drugs it affects

For each ingredient in Strontium 680 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Strontium5 drug types · 101 drugs

Androgens

Theoretically, androgens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.
A small clinical study suggests that treatment with androgens such as testosterone, nandrolone, oxandrolone, and oxymetholone for 5-6 weeks might decrease urinary strontium excretion. The clinical significance of this interaction is unknown.

Likelihood Possible Evidence D
Antacids

Antacids can reduce the absorption of strontium, potentially decreasing its effectiveness.
Aluminum hydroxide and magnesium hydroxide can reduce absorption of strontium ranelate by 20% to 25%. Calcium can reduce its absorption to 60% to 70%. Avoid taking antacids within 2 hours of a dose of strontium ranelate. This interaction has also been reported with orally-administered radioactive strontium-85. It will likely also occur with other forms of strontium.

Likelihood Probable Evidence C
Estrogens

Theoretically, estrogens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.
A small clinical study suggests that treatment with estrogens for 5-6 weeks might decrease urinary strontium excretion. The clinical significance of this interaction is unknown.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, strontium might decrease the absorption of quinolone antibiotics.
Strontium is a divalent cation with similar properties to calcium. It is likely to form complexes with quinolones in the gastrointestinal (GI) tract, preventing absorption of the antibiotic. Recommend taking strontium supplements at least 2 hours before or after quinolones to avoid an interaction.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, strontium might decrease the absorption of tetracycline antibiotics.
Strontium is a divalent cation with similar properties to calcium. It is likely to form complexes with tetracyclines in the gastrointestinal (GI) tract, preventing absorption of the antibiotic. Recommend taking strontium supplements at least 2 hours before or after tetracyclines to avoid an interaction.

Likelihood Probable Evidence D
Strontium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Strontium 680 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

Strontium 680 mg by Best Naturals: Common Questions

Does Strontium 680 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, Strontium 680 mg has a known interaction with 101 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Strontium 680 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take strontium while pregnant or breastfeeding?
During pregnancy, safety hasn't been established and it's best avoided. While breastfeeding, there isn't enough safety data either — avoid it then too. Talk with your doctor or pharmacist about what's right for you.
What are the most common side effects?
Diarrhea, nausea, headache, and skin reactions like eczema or dermatitis are the most common. These are typically mild, though you should report persistent or bothersome symptoms to your doctor.
Does strontium work for osteoporosis?
Yes — it's rated likely effective for osteoporosis. That said, it does carry cardiovascular and clotting risks that need to be part of the conversation with your doctor about whether it's right for you.
Why do I need to space strontium away from my antibiotics?
Strontium binds to certain antibiotics in your stomach, preventing them from being absorbed and making them less effective. Taking them 2 hours apart prevents this problem.
Can strontium interact with my antacid?
Yes — antacids can cut strontium absorption significantly. Space them at least 2 hours apart so each one works as intended.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Strontium 680 mg label
Go deeper

The Full Monographs Behind Strontium 680 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Strontium

Interacts with 101 drugs

Strontium is a mineral that has been studied mainly for bone health and osteoporosis. The prescription form (strontium ranelate) showed benefit for fracture risk but carries serious heart-re...

Read the full Strontium monograph →
Sources

Sources & How We Checked

Strontium 680 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Strontium 22 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350:459-68.. PubMed
  3. El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? N Engl J Med 2004;350:504-6. PubMed
  4. Verberckmoes SC, De Broe ME, D'Haese PC. Dose-dependent effects of strontium on osteoblast function and mineralization. Kidney Int 2003;64:534-43. . PubMed
  5. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87:2060-6.. DOI
  6. Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med 1993;95:69S-74S. . PubMed
  7. Eisenberg E. Effects of androgens, estrogens and corticoids on strontium kinetics in man. J Clin Endocrinol Metab 1966;26:566-72.
  8. Metastron prescribing information. Medi-Physics, Inc., Amersham Healthcare, Arlington Heights, IL, 1998. http://www.cancerpaintherapy.com/METATECHPAGE.htm. (Accessed 13 March 2004).
  9. Protelos European Summary of Product Characteristics. Les Laboratoires Servier, 2006. Available at: www.servier.com/pro/osteoporose/protelos/protelos_spc.asp. (Accessed 01 August 2006).
  10. US Department of Health and Human Services, Public Health Service. Agency for Toxic Substances and Disease Registry. Toxicological profile for strontium. April 2004. Available at: www.atsdr.cdc.gov/toxprofiles/tp159.pdf. (Accessed 8 August 2006).
  11. Apostolidis N, Paradellis T, Karydas A, et al. Calcium and strontium metabolic studies in patients on CAPD. Perit Dial Int 1998;18:410-4. DOI
  12. Ozgur S, Sumer H, Kocoglu G. Rickets and soil strontium. Arch Dis Child 1996;75:524-6. PubMed
  13. Schrooten I, Elseviers MM, Lamberts LV, et al. Increased serum strontium levels in dialysis patients: an epidemiological survey. Kidney Int 1999;56:1886-92. PubMed
  14. D'Haese PC, Couttenye MM, Lamberts LV, et al. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Clin Chem 1999;45:1548-56. DOI
  15. Pennington JA, Jones JW. Molybdenum, nickel, cobalt, vanadium, and strontium in total diets. J Am Diet Assoc 1987;87:1644-50. DOI
  16. O'Donnell S, Cranney A, Wells GA, et al. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane Musculoskeletal Group. Cochrane Database Syst Rev 2006;(4):CD005326. PubMed
  17. Protelos European Public Assessment Report, Scientific Discussion. European Medicines Agency, 2005. Available at: www.emea.eu.int/humandocs/Humans/EPAR/protelos/protelos.htm. (Accessed 10 October 2006).
  18. Rousselet F, El Solh N, Maurat JP, et al. Strontium and calcium metabolism. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9.
  19. O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane.Database.Syst.Rev. 2006;3:CD005326. PubMed
  20. Rizzoli R, Chapurlat RD, Laroche JM, et al. Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study. Osteoporosis Int. 2012. 23(1):305-315. doi: 10.1007/s00198-011-1758-z. PubMed
  21. Reginster JY, Kaufman JM, Goemaere S, et al. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. Osteoporos Int. 2012;23(3):1115-1122. doi: 10.1007/s00198-011-1847-z. PubMed
  22. Protos [Product Information]. Available at: http://www.guildlink.com.au/gc/ws/servier/pi.cfm?product=sepproto. Accessed May 1, 2018.

See these in context on the Strontium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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