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Dietary supplement

Super Flex-UC-II Ingredients & Drug Interactions

by NewtonEverett

Super Flex-UC-II label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Flex-UC-II against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Flex-UC-II is a dietary supplement by NewtonEverett with 5 active ingredients. Its ingredients are commonly taken for bone health, joint and arthritis support, hormone (testosterone/estrogen) support.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium Chloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Flex-UC-II by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Flex-UC-II by NewtonEverett — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Flex-UC-II by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 5 active ingredients.
  • “UC-II standardized Cartilage” is listed as a grouped ingredient — the label gives one combined amount (40 mg) without saying how much of each component you get.

Super Flex-UC-II contains 5 active ingredients aimed at joint and skin health. Boron Glycinate is included for bone and joint support.

Potassium Chloride supplies potassium, an electrolyte your body needs for muscle and heart function. Hyaluronic Acid is a natural compound found in joints and skin that may help with moisture retention.

The remaining three ingredients — Cartilage, total Collagen, and UC-II standardized Cartilage — are structural proteins from animal sources meant to support cartilage and connective tissue. The capsule also contains inactive ingredients: HPMC vegetable capsule material, rice flour, magnesium stearate, and silicon dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: joint, cartilage and bone health.
  • We looked for evidence on: Osteoarthritis, Osteoporosis, Joint mobility, Cartilage support, Bone strength.
  • The closest evidence on file: Boron is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis (Natural Medicines).
  • Also on file: Boron is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.

The evidence for this product's ingredients is mixed. Boron is likely effective for boron deficiency and possibly effective for vaginal yeast infections and radiation skin damage, though those last two are not the typical reason someone takes a joint-support supplement.

Hyaluronic acid is possibly effective for dry eye and leg ulcers, but evidence for skin aging, hay fever, and sexual function is insufficient to rate. We don't have effectiveness data on file for potassium, cartilage, collagen, or the UC-II blend as they're used in this product.

The evidence, ingredient by ingredient Boron Hyaluronic Acid Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boron Glycinate is generally well tolerated in small supplement doses, but high amounts can be toxic and cause skin problems and hair loss. Avoid boron supplements during pregnancy — high doses may harm the fetus — and while breastfeeding due to limited safety data.

Potassium Chloride is generally well tolerated at normal dietary levels, but supplement doses can be risky, especially for people with kidney disease; it may cause nausea, vomiting, belly pain, or diarrhea, and in rare cases heart rhythm problems and dangerously low blood pressure. Use potassium supplements only under medical guidance during pregnancy and breastfeeding.

Hyaluronic Acid appears well tolerated, though long-term safety data for supplements is limited. We have no safety information on file for the cartilage and collagen ingredients.

Side effects, ingredient by ingredient Boron Hyaluronic Acid Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check any ACE inhibitors or ARBs you take for blood pressure — potassium in this product can raise your blood potassium to unsafe levels with these drugs (Moderate severity). Also check potassium-sparing diuretics, which carry the same Moderate-severity risk.

If you have kidney disease or take any heart or blood pressure medication, double-check your exact drugs with the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking for joint support and have no kidney disease or blood pressure medication concerns, this might be worth a try — but the potassium content is the red flag. Anyone on ACE inhibitors, ARBs, or potassium-sparing diuretics should absolutely check with us or their doctor first.

Pregnancy and breastfeeding call for a conversation with your pharmacist or doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Flex-UC-II, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 689076075145
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 66555
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Flex-UC-II by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
689076075145
IngredientAmount% DV
Boron Glycinate5 mg--
Potassium Chloride0 NP--
Hyaluronic Acid3.3 mg--
Cartilage0 NP--
total Collagen10 mg--
UC-II standardized Cartilage40 mg--

Other ingredients: HPMC Vegetable Capsule, Rice Flour, vegetarian Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Superflex-UC-II with undenatured type II collagen provides convenient & effective joint, cartilage and bone health.

1) UC-II is derived from protein found in natural cartilage. It works to promote a healthy immune response for improved joint and cartilage health 2) Hyaluronic acid provides cushioning and lubrication for joint comfort 3)Boron improves absorption of calcium, magnesium and vitamin D for strong, healthy bones

UC-II collagen 40mg Boron 5mg Hyaluronic acid 3.3mg

General Statements

Just one small capsule daily contains three advanced ingredients for increased comfort and mobility to support your active lifestyle.

Joint, Cartilage & Bone Advanced action

Flexability - Comfort - Mobility

Actual size

Made in USA

Brand IP Statement(s)

UC-II is a registered trademark of InterHealth N.I.

UC-II brand collagen with undenatured type II collagend (U.S. Patents 7,846,487 7,083,820 and EPO Patent EP1435906B1; canadian patent CA 2459981C; adn Japanese Patent JP 4800574B2).

UC-II

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Just 1 small capsule per day

Suggested Use: As a dietary supplement, take (1) capsule daily.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult a physician before using if pregnant, nursing or on medication.

Do not use if safety seal is broken. Do not exceed suggested daily intake.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General

C16

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Flex-UC-II by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Flex-UC-II label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Flex-UC-II by NewtonEverett

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Boron Glycinate

No known
interactions
5 mg per serving

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron Glycinate monograph & interactions

Hyaluronic Acid

No known
interactions
3.3 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

UC-II standardized Cartilage

40 mg per serving

Other (inactive) ingredients: HPMC Vegetable Capsule, Rice Flour, Vegetarian Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Flex-UC-II by NewtonEverett Drug Interactions

Want to check YOUR meds against Super Flex-UC-II?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium Chloride 62

Individual Drug Interactions

The ingredients in Super Flex-UC-II interact with 62 drugs. Click any drug to see the details.

1 of the 5 ingredients in Super Flex-UC-II interact with drugs. Each result below shows which ingredient is responsible. Potassium Chloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Flex-UC-II with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium Chloride3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium Chloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Flex-UC-II, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Biotech
City
Scottsdale
State
AZ
ZipCode
85255
Phone Number
866.593.3424
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

Super Flex-UC-II by NewtonEverett: Common Questions

Does Super Flex-UC-II by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Super Flex-UC-II has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Flex-UC-II contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The boron in this product should be avoided in pregnancy — high doses may harm the fetus. Potassium from food is fine, but supplements need medical guidance. There's not enough safety data on hyaluronic acid, cartilage, or collagen to know either way. Talk with your doctor or pharmacist before starting.
Is this safe while breastfeeding?
Boron supplements aren't recommended while breastfeeding due to limited safety data. Dietary potassium is appropriate, but check with your doctor before using potassium supplements. We don't have enough information on hyaluronic acid, cartilage, or collagen to advise — ask your pharmacist for personalized guidance.
Will this actually help my joint pain?
We don't have effectiveness data on file for collagen or cartilage in joint support, so the evidence isn't established in our records. Hyaluronic acid is possibly effective for dry eye and leg ulcers, but not specifically for joint pain. Your pharmacist can discuss what the research shows for these ingredients and whether they're right for you.
What side effects might I notice?
Boron is usually well tolerated, though nausea and indigestion can happen. Potassium may cause belly pain, nausea, diarrhea, or gas — and at high doses, heart rhythm problems. Hyaluronic acid appears well tolerated. Start with the lowest dose and call us if you notice anything unusual.
Can I take this with my blood pressure medication?
This depends on which one you take. Potassium in this product can dangerously raise your blood potassium if you're on ACE inhibitors, ARBs, or potassium-sparing diuretics. Check your exact medication with our tool on this page, or ask your pharmacist before starting.
Is there potassium in this, and how much?
Yes, Potassium Chloride is one of the 5 active ingredients. The product facts don't tell us the exact dose per capsule, so ask your pharmacist or check the label for the amount — that matters especially if you have kidney disease or take blood pressure drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Flex-UC-II is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Flex-UC-II label
Go deeper

The Full Monographs Behind Super Flex-UC-II’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Super Flex-UC-II's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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