Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Sure Stevia Plus Monk Fruit Ingredients & Drug Interactions

by KAL

Sure Stevia Plus Monk Fruit label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sure Stevia Plus Monk Fruit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sure Stevia Plus Monk Fruit is a dietary supplement by KAL with 2 active ingredients. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sure Stevia Plus Monk Fruit by KAL

Ask about any prescription or over-the-counter medication and we check it for interactions with Sure Stevia Plus Monk Fruit by KAL — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sure Stevia Plus Monk Fruit by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains two active ingredients: stevia leaf extract and monk fruit juice concentrate. Stevia is a zero-calorie sweetener derived from the stevia plant, and monk fruit juice concentrate is another natural sweetener with no calories.

Both are used in place of sugar or artificial sweeteners.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Stevia product and its label doesn't state a use — see Stevia's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that stevia works for diabetes, high blood pressure, or weight loss — the data rates these uses as insufficient. While a small amount of research suggests stevia may lower blood sugar or blood pressure in some people, other studies contradict those findings, so we can't say for certain how well it works for these purposes.

The evidence, ingredient by ingredient Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Purified stevia in typical food amounts is generally well tolerated. At supplement doses — especially high-dose supplements — safety data are limited, so use caution.

The most common side effects (seen in a small number of trial participants) were abdominal bloating, dizziness, headache, muscle pain, nausea, and numbness; most of these resolve after the first week. Allergic reactions are rare but possible.

Data on safety during pregnancy and lactation are not on file for stevia, so you'd need to talk with your doctor or pharmacist about whether it's right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications if you take lithium (a mood stabilizer), any blood pressure medication, or diabetes medication. Stevia can affect how these drugs work in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Sure Stevia Plus Monk Fruit is a calorie-free sweetener option. If you take lithium, blood pressure medication, or diabetes medication, check with your pharmacist first — stevia can interact with these drugs.

If you're pregnant or breastfeeding, talk with your doctor, since safety data are limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sure Stevia Plus Monk Fruit, straight from the product label.

Brand KAL
Barcode (UPC) 021245103264
Net contents 100 Packet(s); 3.5 Ounce(s); 100 Gram(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 253240
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sure Stevia Plus Monk Fruit by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
100
UPC/BARCODE
021245103264
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Stevia leaf extract186 mg--
Monk Fruit juice concentrate12.5 mg--

Other ingredients: Maltodextrin, Inulin, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Use 1 packet as desired with a beverage or meal.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

KAL Innovative Quality Since 1932

Great taste

Convenient single-serving packets Should not affect blood sugar levels in most individuals

Try other terrific KAL Stevia products: Stevia liquid Stevia extract powder

FDA Statement of Identity

Dietary Supplement

Formulation

Zero calories No unpleasant aftertaste

Low glycemic

Formula

KAL Stevia + Monk Fruit is a pleasant tasting blend of both ingredietns.

Monk fruit contains Mogroside V, an active ingredient which is 300x sweeter than cane sugar and low in calories

What is Stevia? Stevia extract is derived from the leaves of a small shrub of the chrysanthemum family called stevia. It grows wild in Paraguay and Brazil and is cultivated in Japan and China. Stevia extract contains steviosides, a substance that makes it unique among over 300 species of stevia plants. The extract is calorie-free and should not affect blood glucose levels in most individuals. Unlike the whole herb, the extract does not have a pronounced aftertaste. Monk Fruit, also known as Luo Han, comes from the plant Momordica grosvenori. It contains an active ingredient called Mogroside V that is intensely sweet. Monk fruit is 300 times sweeter than common table sugar or sucrose. It is low calorie and low glycemic, and should not affect blood sugar levels in most individuals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sure Stevia Plus Monk Fruit by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sure Stevia Plus Monk Fruit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sure Stevia Plus Monk Fruit by KAL

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Stevia leaf extract

Interacts with
259 drugs
186 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia leaf extract monograph & interactions

Monk Fruit juice concentrate

12.5 mg per serving

Other (inactive) ingredients: Maltodextrin, Inulin, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sure Stevia Plus Monk Fruit by KAL Drug Interactions

Want to check YOUR meds against Sure Stevia Plus Monk Fruit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia leaf extract 259

Individual Drug Interactions

The ingredients in Sure Stevia Plus Monk Fruit interact with 259 drugs. Click any drug to see the details.

1 of the 2 ingredients in Sure Stevia Plus Monk Fruit interact with drugs. Each result below shows which ingredient is responsible. Stevia leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sure Stevia Plus Monk Fruit with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sure Stevia Plus Monk Fruit, from the product label.

KAL

See all KAL products
Name
KAL
City
Park City
State
UT
ZipCode
84060
Phone Number
800-538-5888
Web Address
www.kalvitamins.com
Pharmacist Counseling Corner

Sure Stevia Plus Monk Fruit by KAL: Common Questions

Does Sure Stevia Plus Monk Fruit by KAL interact with any medications?
Yes. Based on its ingredients, Sure Stevia Plus Monk Fruit has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sure Stevia Plus Monk Fruit contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is stevia safe to use every day?
Purified stevia in food amounts is generally well tolerated. At supplement doses, though, safety data are limited, so we advise caution with regular high-dose use. Talk with your pharmacist about what's right for you.
What are the most common side effects?
The most common side effects are abdominal bloating, dizziness, headache, muscle pain, nausea, and numbness. Most of these resolve after the first week of use.
Can I use this product while pregnant?
Data on stevia's safety during pregnancy aren't on file for us, so we can't say either way. Talk with your doctor or pharmacist for advice tailored to your situation.
Does this powder help with weight loss?
The evidence we hold doesn't establish that stevia works for weight loss — we rate that use as insufficient. While it's calorie-free, we can't claim it helps you lose weight based on the data available.
What is monk fruit juice concentrate?
Monk fruit juice concentrate is a natural sweetener made from monk fruit, with no calories. We have no interaction data for it, so we can't comment on how it may interact with medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sure Stevia Plus Monk Fruit is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sure Stevia Plus Monk Fruit label
Go deeper

The Full Monographs Behind Sure Stevia Plus Monk Fruit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

Sure Stevia Plus Monk Fruit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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