Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Saccharomyces Boulardii 8 Billion Ingredients & Drug Interactions

by KAL

Saccharomyces Boulardii 8 Billion label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saccharomyces Boulardii 8 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Saccharomyces Boulardii 8 Billion is a dietary supplement by KAL with 1 active ingredient. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Saccharomyces boulardii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Saccharomyces Boulardii 8 Billion by KAL

Ask about any prescription or over-the-counter medication and we check it for interactions with Saccharomyces Boulardii 8 Billion by KAL — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Saccharomyces Boulardii 8 Billion by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Saccharomyces boulardii, a live beneficial yeast strain. Each capsule delivers 8 billion CFU (colony-forming units) of this organism.

The capsule itself is made from vegetable cellulose, and it includes sorbitan monostearate as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: gut health and digestive support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Travelers' diarrhea, Rotaviral diarrhea, Irritable bowel syndrome (IBS), Crohn disease — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Saccharomyces Boulardii is rated "Insufficient Reliable Evidence To Rate" for Crohn disease, Ulcerative colitis, Irritable bowel syndrome (IBS).

The evidence suggests Saccharomyces boulardii may help with several types of diarrhea. Data shows it's possibly effective for rotaviral diarrhea, traveler's diarrhea, antibiotic-associated diarrhea, and diarrhea caused by Clostridioides difficile infection.

It's also possibly effective for necrotizing enterocolitis (NEC) in at-risk newborns and may help with Helicobacter pylori infection. These ratings mean the evidence is promising but not yet conclusive — more research is underway.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saccharomyces boulardii is generally well tolerated in healthy adults, but it's not appropriate for people who are critically ill, immunocompromised, or in intensive care — there have been rare reports of the yeast entering the bloodstream (a condition called fungemia) in those populations, especially those with central lines or on broad-spectrum antibiotics. In general use, a small number of people have reported mild gastrointestinal symptoms like abdominal cramps, gas, nausea, vomiting, or decreased appetite.

The safety data available is limited, so talk with your doctor before starting this supplement, particularly if you have any chronic illness or take immunosuppressant medications.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antifungal medications of any kind — including prescriptions or over-the-counter creams, tablets, or other forms — check with your pharmacist before starting this probiotic. Antifungals could reduce how well the probiotic works by killing the live yeast it contains.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This probiotic may help if you're dealing with diarrhea from antibiotics, travel, or certain infections — the evidence is promising but not airtight. It's generally safe for otherwise healthy people, but avoid it if you're critically ill, immunocompromised, or hospitalized.

Check with your doctor or pharmacist before taking it, especially if you take antifungal medications or have any serious health condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saccharomyces Boulardii 8 Billion, straight from the product label.

Brand KAL
Barcode (UPC) 021245933724
Net contents 60 Veg Cap(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 253252
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saccharomyces Boulardii 8 Billion by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
60
UPC/BARCODE
021245933724
IngredientAmount% DV
Saccharomyces boulardii440 mg--

Other ingredients: Vegetable Cellulose Capsule, Sorbitan Monostearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

KAL Innovative Quality Since 1932

Clear quality

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

1 Daily

Directions: Use only as directed. Take 1 VegCap daily with a meal or glass of water. Do not take within 2 hours of antiobiotics.

Formulation

Non-dairy probiotic

Non-GMO, Soy free and Vegetarian.

Non-GMO, Soy free and Vegetarian.

Minimum potency at time of manufacture. Live microrganisms per 1 serving.

Storage

No refrigeration needed

Store in a cool, dry place. Product is stable at room temperature. May be refrigerated to preserve freshness.

Saccharomyces boulardii is shelf-stable.

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Formula

Discussion: KAL Saccharomyces Boulardii is a yeast-based probiotic intended to help support healthy gastro-intestinal flora. Each serving provides over 8 billion CFUs of Saccharomyces boulardii.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Saccharomyces Boulardii 8 Billion by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saccharomyces Boulardii 8 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saccharomyces Boulardii 8 Billion by KAL

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Saccharomyces boulardii

Interacts with
40 drugs
440 mg per serving Form: Saccharomyces cerevisiae var. boulardii

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule, Sorbitan Monostearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saccharomyces Boulardii 8 Billion by KAL Drug Interactions

Want to check YOUR meds against Saccharomyces Boulardii 8 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

Saccharomyces boulardii 40

Individual Drug Interactions

The ingredients in Saccharomyces Boulardii 8 Billion interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in Saccharomyces Boulardii 8 Billion interact with drugs. Each result below shows which ingredient is responsible. Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in Saccharomyces Boulardii 8 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saccharomyces Boulardii 8 Billion, from the product label.

KAL

See all KAL products
Name
KAL
City
Park City
State
UT
ZipCode
84060
Phone Number
800-538-5888
Web Address
www.kalvitamins.com
Pharmacist Counseling Corner

Saccharomyces Boulardii 8 Billion by KAL: Common Questions

Does Saccharomyces Boulardii 8 Billion by KAL interact with any medications?
Yes. Based on its ingredients, Saccharomyces Boulardii 8 Billion has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saccharomyces Boulardii 8 Billion contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on antibiotics?
Saccharomyces boulardii is possibly effective for antibiotic-associated diarrhea, so many people take it alongside antibiotics for that reason. However, there isn't a documented drug interaction between this probiotic and antibiotics in our data. That said, talk with your pharmacist about timing — some guidance suggests spacing probiotics and antibiotics a few hours apart, though practices vary.
Will this help my traveler's diarrhea?
The evidence shows Saccharomyces boulardii is possibly effective for traveler's diarrhea, meaning it may help but isn't guaranteed. Many people take it preventively before travel or use it once symptoms start. Your individual results may vary.
Is this safe if I'm immunocompromised?
No — you should avoid this product if your immune system is weakened or if you're critically ill. There have been rare cases of the yeast entering the bloodstream in immunocompromised patients. Talk with your doctor before considering any probiotic if you fall into that category.
What are the side effects?
Most people tolerate it well. Rarely, some have experienced mild gastrointestinal symptoms like abdominal cramps, gas, nausea, vomiting, or loss of appetite. These typically resolve on their own.
Is it safe during pregnancy or breastfeeding?
Our data doesn't include safety information for pregnancy or lactation. Talk with your doctor or midwife before taking this while pregnant or nursing — they can weigh the potential benefit against any unknown risks for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Saccharomyces Boulardii 8 Billion is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saccharomyces Boulardii 8 Billion label
Go deeper

The Full Monographs Behind Saccharomyces Boulardii 8 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

Saccharomyces Boulardii 8 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team