Telos95 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Telos95 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Telos95 is a dietary supplement by Longevity by Nature with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, heart and circulation health, vein problems (such as varicose veins).Based on those ingredients, 910 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reverse-Vine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Telos95 by Longevity by Nature
Ask about any prescription or over-the-counter medication and we check it for interactions with Telos95 by Longevity by Nature — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Telos95 by Longevity by Nature
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Telos95 by Longevity by Nature contains 2 active ingredients: Telos95 and Reverse-Vine (grape). The product also includes hypromellose, an inactive ingredient used to form the capsule.
Grape seed and fruit extracts have been studied for their effects on blood flow and circulation, particularly in the legs and veins. We don't have data on file for Telos95's role or how these ingredients work together.
Does it work?
Moderate evidence
Reverse-Vine (grape) is rated possibly effective for chronic venous insufficiency (CVI) — a condition where blood pools in the veins of the legs — based on the data we hold. For other conditions like chemotherapy-induced nausea, hay fever, and obesity, grape is rated possibly ineffective.
We don't have effectiveness data on file for Telos95.
How safe is it?
Well-documented data
Grape extracts appear generally well tolerated in studies. The most common side effects reported orally are abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea.
A rare serious effect — anaphylaxis to grape skin — has been reported. Some people have also reported sore throat, cough, or allergic rhinitis with certain grape extracts, though these occurred at rates similar to placebo.
For pregnancy and breastfeeding: concentrated grape supplements and wine should be avoided during pregnancy due to limited safety data. There isn't enough information on concentrated grape supplements while breastfeeding, so talk with your doctor or pharmacist before use if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before taking Telos95, double-check with your pharmacist if you take anticoagulants or antiplatelet drugs (blood thinners like warfarin or aspirin). Also ask about drugs metabolized by CYP1A2, CYP2D6, CYP2E1, or CYP3A4 enzymes, cyclosporine (an immunosuppressant), or midazolam (a sedative) — especially if you plan to use this long-term.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Telos95 may help with chronic venous insufficiency, but it's not the right choice if you take blood thinners, certain sedatives, or immunosuppressants without checking first. Grape extracts are generally well tolerated, but they interact with enough medications that you need to run your prescriptions through the checker on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Telos95, straight from the product label.
| Brand | Longevity by Nature |
|---|---|
| Barcode (UPC) | 857549002268 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 320954 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Telos95 by Longevity by Nature, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Telos95 | 95 mg | -- |
| Reverse-Vine | 50 mg | -- |
Other ingredients: Hypromellose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Longevity breakthrough
Telos95 is an advanced proprietary plant based blend of highly therapeutic polyphenols that are naturally sourced from grapevine and organic olive leaf
Soy free Gluten free GMO free
Telomere health support Cell permeable & energy rich Lengthens telomeres & lowers Telo Year age Nutraceuticals from nature
Healthy Teloyear age
Filler & excipient free
Formula
Telos95 is an advanced proprietary plant based blend of highly therapeutic polyphenols that are naturally sourced from grapevine and organic olive leaf. These phytochemical compounds fight free radicals and nourish the cells with nutrients that promote telomere and cellular longevity.
Clinically proven nutrients Innovative food grade polyphenols
Precautions
Warning: Keep out of the reach of children and consult with a physician before taking this product if you are pregnant, nursing or have a medical condition.
Warning: Keep out of the reach of children and consult with a physician before taking this product if you are pregnant, nursing or have a medical condition.
Brand IP Statement(s)
Telos96 trademark of Certified Nutraceuticals Reverse-Vine trademark of Certified Nutraceuticals Copyright 2019 all rights reserved
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Dosage: Take 1-2 capsules daily with a meal.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Telos95 by Longevity by Nature label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Telos95 by Longevity by Nature
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Telos95
Reverse-Vine
Interacts with910 drugs
Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...
Reverse-Vine monograph & interactionsOther (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.
Telos95 by Longevity by Nature Drug Interactions
HelloPharmacist Interaction Report
Telos95 by Longevity by Nature contains Reverse-Vine (grape), which does interact with a number of medications.
The most serious documented effect involves blood thinner and antiplatelet drugs — grape extracts may increase bleeding risk if you're taking medications like warfarin or aspirin, though this is based on lab evidence rather than human studies.
Read the full breakdown — every affected drug type, severity by severity
Grape also affects how your liver processes several types of medications. It may reduce levels of drugs broken down by CYP1A2 enzymes (including phenacetin), increase levels of CYP2D6 and CYP2E1 substrates, and the CYP3A4 picture is unclear — research suggests it could go either way.
Additionally, grape juice specifically can cut cyclosporine (an immunosuppressant) absorption by up to 30%, so you'd need to space them at least 2 hours apart. Long-term grape seed extract may also reduce the effectiveness of midazolam (a sedative), though single doses don't appear to cause this.
We could not check the other active ingredient, Telos95, because we hold no interaction data for it.
Altogether, these interactions span 911 individual medications. Use the medication checker below to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Telos95?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Telos95 interact with 910 drugs. Click any drug to see the details.
1 of the 2 ingredients in Telos95 interact with drugs. Each result below shows which ingredient is responsible. Reverse-Vine
AzilsartanEdarbi
How Azilsartan interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Azilsartan, Chlorthalidone interactionBupivacaine, MeloxicamZynrelef Kit
How Bupivacaine, Meloxicam interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Bupivacaine, Meloxicam interactionCelecoxibCelebrex, Elyxyb
How Celecoxib interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Celecoxib interactionFlurbiprofenAnsaid, Flurbiprofen, Flurprofen, Froben, Froben SR, Ocufen
How Flurbiprofen interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Flurbiprofen interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Fluvastatin interactionFosphenytoinCerebyx
How Fosphenytoin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Fosphenytoin Sodium interactionGliclazideDiamicron
How Gliclazide interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Glipizide, Metformin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Glyburide, Metformin interactionHydrochlorothiazide, IrbesartanAvalide
How Hydrochlorothiazide, Irbesartan interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Hydrochlorothiazide, Irbesartan interactionHydrochlorothiazide, ValsartanDiovan HCT
How Hydrochlorothiazide, Valsartan interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Hydrochlorothiazide, Valsartan interactionIndomethacinIndo-Lemmon, Indocin, Indocin SR, Indomethagan, Tivorbex
How Indomethacin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Indomethacin interactionIrbesartanAprovel, Avapro
How Irbesartan interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Irbesartan interactionIrbesartan, HydrochlorothiazideCoAprovel
How Irbesartan, Hydrochlorothiazide interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Irbesartan, Hydrochlorothiazide interactionLesinuradZurampic
How Lesinurad interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Lesinurad interactionLesinurad, AllopurinolDuzallo
How Lesinurad, Allopurinol interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Lesinurad, Allopurinol interactionLumiracoxibPrexige
How Lumiracoxib interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Lumiracoxib interactionMefenamic AcidPonstel
How Mefenamic Acid interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Mefenamic Acid interactionMeloxicamAnjeso, Mobic, Qmiiz ODT, Vivlodex
How Meloxicam interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Meloxicam interactionMephenytoinMesantoin
How Mephenytoin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Mephenytoin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Metformin, Rosiglitazone interactionMontelukast SodiumSingulair
How Montelukast Sodium interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Montelukast Sodium interactionNateglinideStarlix
How Nateglinide interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Nateglinide interactionPhenobarbital, PhenytoinDilantin with PB
How Phenobarbital, Phenytoin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Phenobarbital, Phenytoin interactionPhenytoinDi-Phen, Dilantin, Dilantin Infatabs, Dilantin injection, Dilantin Kapseals, Phenytek
How Phenytoin interacts with Telos95 — through 1 ingredient. Tap an ingredient for the detail:
Reverse-vineCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Reverse-vine + Phenytoin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Telos95 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Reverse-Vine
Anticoagulant/Antiplatelet Drugs
Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.
Cyclosporine (Neoral, Sandimmune)
Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.
Midazolam (Versed)
Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.
Phenacetin
Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).
Cytochrome P450 2C9 (Cyp2C9) Substrates
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.
Brand information
Manufacturer and brand details for Telos95, from the product label.
Longevity by Nature
See all Longevity by Nature products- Name
- Longevity by Nature
- City
- Temecula
- State
- CA
- ZipCode
- 92590
- Phone Number
- 1-877-412-9888
- Web Address
- www.longevitybynature.biz
Telos95 by Longevity by Nature: Common Questions
Does Telos95 by Longevity by Nature interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does Telos95 have any serious side effects?
Can I take this while pregnant or breastfeeding?
What is Reverse-Vine and what does it do?
Does this product have fillers or other inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Telos95 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Telos95’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Telos95's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Grape 34 references
- Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
- Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
- Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
- Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
- Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
- Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
- O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
- Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
- Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
- de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. PubMed
- Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
- Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
- de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314 PubMed
- Etheridge, A. S., Black, S. R., Patel, P. R., So, J., and Mathews, J. M. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constitu
- Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. PubMed
- Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. PubMed
- Oliveira-Freitas, V. L., Dalla, Costa T., Manfro, R. C., Cruz, L. B., and Schwartsmann, G. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr. 2010;20(5):309-313. PubMed
- Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582. PubMed
- Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in
- Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc. PubMed
- Trotta, M., Cesaretti, M., Conzi, R., Derchi, L. E., and Borgonovo, G. Elderly male with mesogastric pain. Small bowel obstruction caused by an intact fresh grape. Ann.Emerg.Med 2011;58(4):e1-e2. PubMed
- McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato ha
- Winter, C. K. and Kurtz, P. H. Factors influencing grape worker susceptibility to skin rashes. Bull.Environ.Contam Toxicol. 1985;35(3):418-426. PubMed
- Yamasaki, R., Dekio, S., and Jidoi, J. Contact dermatitis from grape bud. Contact Dermatitis 1985;12(4):226-227. PubMed
- Cox, J. and Grigg, M. Small bowel obstruction by an intact grape. J Am Geriatr.Soc 1986;34(7):550. PubMed
- Faircloth, D. E. and Robison, W. J. Obstruction of the sigmoid colon by grape seeds. JAMA 11-27-1981;246(21):2430. PubMed
- Marguerie, C. and Drouet, M. [Occupational eosinophilic lung in a grape grower: role of sulfites]. Allerg.Immunol.(Paris) 1995;27(5):163-167.
- Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. J Allergy Clin Immunol 1999;103(2 Pt 1):262-266. PubMed
- Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41. PubMed
- Berry AC, Nakshabendi R, Abidali H, et al. Adverse effects of grape seed extract supplement: A clinical case and long-term follow-up. J Diet Suppl. 2016;13(2):232-5. PubMed
- Martínez-Maqueda D, Zapatera B, Gallego-Narbón A, Vaquero MP, Saura-Calixto F, Pérez-Jiménez J. A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome mark
- Moon SW, Shin YU, Cho H, Bae SH, Kim HK; and for the Mogen Study Group. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy. Medicine (Baltimore) 2019;98(21):e15515. PubMed
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