Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

TobacOff Ingredients & Drug Interactions

by Pacific BioLogic

TobacOff label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TobacOff against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

TobacOff is a dietary supplement by Pacific BioLogic with 4 active ingredients. Its ingredients are commonly taken for stress and energy support, immune support and colds, blood sugar management.Based on those ingredients, 246 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are American Ginseng, Vietnamese Sophora. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against TobacOff by Pacific BioLogic

Ask about any prescription or over-the-counter medication and we check it for interactions with TobacOff by Pacific BioLogic — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of TobacOff by Pacific BioLogic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (600 mg) without saying how much of each component you get.

TobacOff contains four active ingredients in a proprietary blend: American ginseng, polygala, houttuynia, and Vietnamese sophora. American ginseng is a root traditionally used to support immune function and has some evidence for upper respiratory health.

Vietnamese sophora (also called pagoda tree) and the other two are traditional ingredients; we hold limited effectiveness data on them. The capsules are plant-based.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Upper respiratory tract infection (URTI) — rated "Possibly Effective" (American Ginseng) (Natural Medicines).

American ginseng in this product is possibly effective for upper respiratory tract infections (colds and sore throats). For other uses — anemia of chronic disease and breast cancer — the evidence isn't established.

Vietnamese sophora's effectiveness for hemorrhoids or menopausal symptoms hasn't been reliably studied. We don't have effectiveness data on file for polygala or houttuynia.

The evidence, ingredient by ingredient American Ginseng Pagoda Tree

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

American ginseng is generally well tolerated in short-term use by healthy adults, but quality and dosing vary across products, and long-term safety isn't well studied. Headache has been reported.

The safety data advises against American ginseng during pregnancy and breastfeeding. Vietnamese sophora is generally used in traditional medicine with limited human safety data, so use it cautiously.

The seed specifically may cause serious problems with long-term use, including edema (fluid buildup) and death — avoid it. The safety data advises against Vietnamese sophora during pregnancy and breastfeeding.

Side effects, ingredient by ingredient American Ginseng Pagoda Tree

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Pagoda Tree, American Ginseng.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 246 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take warfarin (Major interaction with American ginseng), immunosuppressants, antidiabetes medications, MAOIs, or consume caffeine regularly (Moderate interactions). These need dose adjustment or closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

TobacOff may be worth considering if you want to support upper respiratory health with ginseng and traditional ingredients, and you don't take warfarin, blood sugar medications, immunosuppressants, or MAOIs. If you take any medications — especially blood thinners or antidiabetes drugs — talk with your pharmacist before starting.

Pregnant or breastfeeding? Skip it and speak with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TobacOff, straight from the product label.

Brand Pacific BioLogic
Barcode (UPC) 065367420779
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 218390
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TobacOff by Pacific BioLogic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
22
UPC/BARCODE
065367420779
IngredientAmount% DV
Proprietary Blend600 mg--
American Ginseng0 NP--
Polygala0 NP--
Houttuynia0 NP--
Vietnamese Sophora0 NP--

Other ingredients: Capsules of plant origin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Dosage: Start program by taking 3-4 capsules before bedtime on the first day. The following days, take 3-4 capsules one hour before meals.

Precautions

Caution: Do not take if pregnant or nursing.

For some individuals, nausea may be experienced if smoking is continued.

Formulation

TobacOff is manufactured in an FDA compliant facility in the United States of America from imported and domestic ingredients

Storage

Store in a cool, dry place, do not refrigerate.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Powerful tools for gentle healing 600 mg

To report a serious adverse event or obtain product information, contact (800) 869-8783

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Product of USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TobacOff by Pacific BioLogic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TobacOff label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TobacOff by Pacific BioLogic

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container22 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

600 mg per serving

Other (inactive) ingredients: Capsules of plant origin. These complete the product’s ingredient list but are not active constituents.

Interaction report

TobacOff by Pacific BioLogic Drug Interactions

Want to check YOUR meds against TobacOff?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
246Drugs
2 Major 244 Moderate

Ingredients driving the most interactions

American Ginseng 217
Vietnamese Sophora 29

Individual Drug Interactions

The ingredients in TobacOff interact with 246 drugs. Click any drug to see the details.

2 of the 4 ingredients in TobacOff interact with drugs. Each result below shows which ingredient is responsible. American Ginseng Vietnamese Sophora

Each ingredient & the kinds of drugs it affects

For each ingredient in TobacOff with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

American Ginseng4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
American Ginseng full monograph & interactions

Vietnamese Sophora1 drug type · 29 drugs

Caffeine

Theoretically, pagoda tree might reduce the clearance of caffeine.
Pagoda tree contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. This effect has been attributed to inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if this effect occurs with the lower amounts of genistein found in pagoda tree.

Likelihood Possible Evidence D
Vietnamese Sophora full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TobacOff, from the product label.

Pacific BioLogic

See all Pacific BioLogic products
Name
Pacific BioLogic Co.
City
Concord
State
CA
ZipCode
94521
Phone Number
800 869-8783
Web Address
www.pacificbiologic.com
Pharmacist Counseling Corner

TobacOff by Pacific BioLogic: Common Questions

Does TobacOff by Pacific BioLogic interact with any medications?
Yes. Based on its ingredients, TobacOff has a known interaction with 246 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TobacOff contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take TobacOff if I'm pregnant or breastfeeding?
No. The safety data advises against both American ginseng and Vietnamese sophora during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about safer options.
What is American ginseng supposed to do?
American ginseng is possibly effective for upper respiratory infections — that's the main evidence we have. It's thought to support immune function, though long-term safety and other uses aren't well studied.
Will TobacOff help me quit smoking?
We don't have effectiveness data in our records that addresses smoking cessation for TobacOff or its individual ingredients. Your best bet is to talk with your doctor about evidence-based quit-smoking programs and medications.
What side effects might I experience?
Headache has been reported with American ginseng. Vietnamese sophora's flower and fruit form are generally well tolerated, but the seed may cause serious harm with long-term use. Always start cautiously and report any unusual symptoms to your pharmacist.
Should I worry about the proprietary blend — what's actually in there?
The four active ingredients are listed individually: American ginseng, polygala, houttuynia, and Vietnamese sophora. We don't have exact doses for each because they're in a proprietary blend, so you won't know the strength of each one — that's a fair concern to raise with the maker.
Is TobacOff safe to use long-term?
American ginseng's long-term safety isn't well studied, and the Vietnamese sophora seed is possibly unsafe long-term. Short-term use is the safer bet. Check with your pharmacist about your personal situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TobacOff is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TobacOff label
Go deeper

The Full Monographs Behind TobacOff’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

American Ginseng

Interacts with 217 drugs

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...

Read the full American Ginseng monograph → Herb & supplement monograph

Pagoda Tree

Interacts with 29 drugs

Pagoda Tree (Styphnolobium japonicum, also called the Japanese pagoda tree) is a traditional Asian medicinal plant best known as a natural source of the flavonoid rutin. While it has a long...

Read the full Pagoda Tree monograph →
Sources

Sources & How We Checked

TobacOff's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

American Ginseng 12 references
  1. Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. PubMed
  2. Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. PubMed
  3. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. PubMed
  4. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13. PubMed
  5. Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. PubMed
  6. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  7. McElhaney JE, Gravenstein S, Cole SK, et al. A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Institutionalized Older Adults. J Am Geriatr Soc 2004;52:13-9. PubMed
  8. Yuan CS, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med 2004;141:23-7.
  9. Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ 2005;173:1043-8.. PubMed
  10. McElhaney JE, Goel V, Toane B, et al. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 2006;12:153-7. PubMed
  11. Predy GN, Goel V, Lovlin RE, et al. Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults. J Clin Biochem Nutr 2006;39:162-167. DOI
  12. Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-6. PubMed

See these in context on the American Ginseng monograph →

Pagoda Tree 2 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed

See these in context on the Pagoda Tree monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team